Zhuonan Wang

Zhuonan Wang, Wenjie Yan, Wenqiao Zhang et al.

Medical image classification is a core task in computer-aided diagnosis (CAD), playing a pivotal role in early disease detection, treatment planning, and patient prognosis assessment. In ophthalmic practice, fluorescein fundus angiography (FFA) and indocyanine green angiography (ICGA) provide hemodynamic and lesion-structural information that conventional fundus photography cannot capture. However, due to the single-modality nature, subtle lesion patterns, and significant inter-device variability, existing methods still face limitations in generalization and high-confidence prediction. To address these challenges, we propose CLEAR-Mamba, an enhanced framework built upon MedMamba with optimizations in both architecture and training strategy. Architecturally, we introduce HaC, a hypernetwork-based adaptive conditioning layer that dynamically generates parameters according to input feature distributions, thereby improving cross-domain adaptability. From a training perspective, we develop RaP, a reliability-aware prediction scheme built upon evidential uncertainty learning, which encourages the model to emphasize low-confidence samples and improves overall stability and reliability. We further construct a large-scale ophthalmic angiography dataset covering both FFA and ICGA modalities, comprising multiple retinal disease categories for model training and evaluation. Experimental results demonstrate that CLEAR-Mamba consistently outperforms multiple baseline models, including the original MedMamba, across various metrics-showing particular advantages in multi-disease classification and reliability-aware prediction. This study provides an effective solution that balances generalizability and reliability for modality-specific medical image classification tasks.

Haoyu Zheng, Tianwei Lin, Wei Wang et al.

Real-world industrial inspection requires not only localizing defects, but also explaining them in natural language and generating controlled defect edits. However, existing approaches fail to jointly support all three capabilities within a unified framework and evaluation protocol. We propose IAD-Unify, a dual-encoder unified framework in which a frozen DINOv2-based region expert supplies precise anomaly evidence to a shared Qwen3.5-4B vision-language backbone via lightweight token injection, jointly enabling anomaly segmentation, region-grounded understanding, and mask-guided generation. To enable unified evaluation, we further construct Anomaly-56K, a comprehensive unified multi-task IAD evaluation platform, spanning 59,916 images across 24 categories and 104 defect variants. Controlled ablations yield four findings: (i) region grounding is the decisive mechanism for understanding, removing it degrades location accuracy by >76 pp; (ii) predicted-region performance closely matches oracle, confirming deployment viability; (iii) region-grounded generation achieves the best full-image fidelity and masked-region perceptual quality; and (iv) pre-initialized joint training improves understanding at negligible generation cost (-0.16 dB). IAD-Unify further achieves strong performance on the MMAD benchmark, including categories unseen during training, demonstrating robust cross-category generalization.

Jie Cao, Zhenxuan Fan, Zhuonan Wang et al.

Large language models (LLMs) achieve remarkable performance on diverse downstream and domain-specific tasks via parameter-efficient fine-tuning (PEFT). However, existing PEFT methods, particularly MoE-LoRA architectures, suffer from limited parameter efficiency and coarse-grained adaptation due to the proliferation of LoRA experts and instance-level routing. To address these issues, we propose Core Space Mixture of LoRA (\textbf{CoMoL}), a novel MoE-LoRA framework that incorporates expert diversity, parameter efficiency, and fine-grained adaptation. Specifically, CoMoL introduces two key components: core space experts and core space routing. Core space experts store each expert in a compact core matrix, preserving diversity while controlling parameter growth. Core space routing dynamically selects and activates the appropriate core experts for each token, enabling fine-grained, input-adaptive routing. Activated core experts are then merged via a soft-merging strategy into a single core expert, which is combined with a shared LoRA to form a specialized LoRA module. Besides, the routing network is projected into the same low-rank space as the LoRA matrices, further reducing parameter overhead without compromising expressiveness. Extensive experiments demonstrate that CoMoL retains the adaptability of MoE-LoRA architectures while achieving parameter efficiency comparable to standard LoRA, consistently outperforming existing methods across multiple tasks.