Christian Weihsbach

Ziad Al-Haj Hemidi, Christian Weihsbach, Mattias P. Heinrich

Motion artifacts in Magnetic Resonance Imaging (MRI) arise due to relatively long acquisition times and can compromise the clinical utility of acquired images. Traditional motion correction methods often fail to address severe motion, leading to distorted and unreliable results. Deep Learning (DL) alleviated such pitfalls through generalization with the cost of vanishing structures and hallucinations, making it challenging to apply in the medical field where hallucinated structures can tremendously impact the diagnostic outcome. In this work, we present an instance-wise motion correction pipeline that leverages motion-guided Implicit Neural Representations (INRs) to mitigate the impact of motion artifacts while retaining anatomical structure. Our method is evaluated using the NYU fastMRI dataset with different degrees of simulated motion severity. For the correction alone, we can improve over state-of-the-art image reconstruction methods by $+5\%$ SSIM, $+5\:db$ PSNR, and $+14\%$ HaarPSI. Clinical relevance is demonstrated by a subsequent experiment, where our method improves classification outcomes by at least $+1.5$ accuracy percentage points compared to motion-corrupted images.

Christian Weihsbach, Christian N. Kruse, Alexander Bigalke et al.

Purpose: Applying pre-trained medical deep learning segmentation models on out-of-domain images often yields predictions of insufficient quality. In this study, we propose to use a powerful generalizing descriptor along with augmentation to enable domain-generalized pre-training and test-time adaptation, achieving high-quality segmentation in unseen domains. Materials and Methods: In this retrospective study five different publicly available datasets (2012 to 2022) including 3D CT and MRI images are used to evaluate segmentation performance in out-of-domain scenarios. The settings include abdominal, spine, and cardiac imaging. The data is randomly split into training and test samples. Domain-generalized pre-training on source data is used to obtain the best initial performance in the target domain. We introduce the combination of the generalizing SSC descriptor and GIN intensity augmentation for optimal generalization. Segmentation results are subsequently optimized at test time, where we propose to adapt the pre-trained models for every unseen scan with a consistency scheme using the same augmentation-descriptor combination. The segmentation is evaluated using Dice similarity and Hausdorff distance and the significance of improvements is tested with the Wilcoxon signed-rank test. Results: The proposed generalized pre-training and subsequent test-time adaptation improves model performance significantly in CT to MRI cross-domain prediction for abdominal (+46.2% and +28.2% Dice), spine (+72.9%), and cardiac (+14.2% and +55.7% Dice) scenarios (p<0.001). Conclusion: Our method enables optimal, independent usage of medical image source and target data and bridges domain gaps successfully with a compact and efficient methodology. Open-source code available at: https://github.com/multimodallearning/DG-TTA