Mengyang Zhao

Mengyang Zhao, Xinhua Zeng, Yang Liu et al.

Video anomaly detection (VAD) has been intensively studied for years because of its potential applications in intelligent video systems. Existing unsupervised VAD methods tend to learn normality from training sets consisting of only normal videos and regard instances deviating from such normality as anomalies. However, they often consider only local or global normality in the temporal dimension. Some of them focus on learning local spatiotemporal representations from consecutive frames to enhance the representation for normal events. But powerful representation allows these methods to represent some anomalies and causes miss detection. In contrast, the other methods are devoted to memorizing prototypical normal patterns of whole training videos to weaken the generalization for anomalies, which also restricts them from representing diverse normal patterns and causes false alarm. To this end, we propose a two-branch model, Local-Global Normality Network (LGN-Net), to simultaneously learn local and global normality. Specifically, one branch learns the evolution regularities of appearance and motion from consecutive frames as local normality utilizing a spatiotemporal prediction network, while the other branch memorizes prototype features of the whole videos as global normality by a memory module. LGN-Net achieves a balance of representing normal and abnormal instances by fusing local and global normality. In addition, the fused normality enables LGN-Net to generalize to various scenes more than exploiting single normality. Experiments demonstrate the effectiveness and superior performance of our method. The code is available online: https://github.com/Myzhao1999/LGN-Net.

Tianyuan Yao, Chang Qu, Jun Long et al.

With the rapid development of self-supervised learning (e.g., contrastive learning), the importance of having large-scale images (even without annotations) for training a more generalizable AI model has been widely recognized in medical image analysis. However, collecting large-scale task-specific unannotated data at scale can be challenging for individual labs. Existing online resources, such as digital books, publications, and search engines, provide a new resource for obtaining large-scale images. However, published images in healthcare (e.g., radiology and pathology) consist of a considerable amount of compound figures with subplots. In order to extract and separate compound figures into usable individual images for downstream learning, we propose a simple compound figure separation (SimCFS) framework without using the traditionally required detection bounding box annotations, with a new loss function and a hard case simulation. Our technical contribution is four-fold: (1) we introduce a simulation-based training framework that minimizes the need for resource extensive bounding box annotations; (2) we propose a new side loss that is optimized for compound figure separation; (3) we propose an intra-class image augmentation method to simulate hard cases; and (4) to the best of our knowledge, this is the first study that evaluates the efficacy of leveraging self-supervised learning with compound image separation. From the results, the proposed SimCFS achieved state-of-the-art performance on the ImageCLEF 2016 Compound Figure Separation Database. The pretrained self-supervised learning model using large-scale mined figures improved the accuracy of downstream image classification tasks with a contrastive learning algorithm. The source code of SimCFS is made publicly available at https://github.com/hrlblab/ImageSeperation.

Yang Liu, Jing Liu, Mengyang Zhao et al.

Video anomaly detection is a challenging task in the computer vision community. Most single task-based methods do not consider the independence of unique spatial and temporal patterns, while two-stream structures lack the exploration of the correlations. In this paper, we propose spatial-temporal memories augmented two-stream auto-encoder framework, which learns the appearance normality and motion normality independently and explores the correlations via adversarial learning. Specifically, we first design two proxy tasks to train the two-stream structure to extract appearance and motion features in isolation. Then, the prototypical features are recorded in the corresponding spatial and temporal memory pools. Finally, the encoding-decoding network performs adversarial learning with the discriminator to explore the correlations between spatial and temporal patterns. Experimental results show that our framework outperforms the state-of-the-art methods, achieving AUCs of 98.1% and 89.8% on UCSD Ped2 and CUHK Avenue datasets.

Mengyang Zhao, Yang Liu, Jing Li et al.

Video anomaly detection (VAD) remains a challenging task in the pattern recognition community due to the ambiguity and diversity of abnormal events. Existing deep learning-based VAD methods usually leverage proxy tasks to learn the normal patterns and discriminate the instances that deviate from such patterns as abnormal. However, most of them do not take full advantage of spatial-temporal correlations among video frames, which is critical for understanding normal patterns. In this paper, we address unsupervised VAD by learning the evolution regularity of appearance and motion in the long and short-term and exploit the spatial-temporal correlations among consecutive frames in normal videos more adequately. Specifically, we proposed to utilize the spatiotemporal long short-term memory (ST-LSTM) to extract and memorize spatial appearances and temporal variations in a unified memory cell. In addition, inspired by the generative adversarial network, we introduce a discriminator to perform adversarial learning with the ST-LSTM to enhance the learning capability. Experimental results on standard benchmarks demonstrate the effectiveness of spatial-temporal correlations for unsupervised VAD. Our method achieves competitive performance compared to the state-of-the-art methods with AUCs of 96.7%, 87.8%, and 73.1% on the UCSD Ped2, CUHK Avenue, and ShanghaiTech, respectively.

Ke Niu, Zhuofan Chen, Haiyang Yu et al.

Computer-Aided Design (CAD) plays a pivotal role in industrial manufacturing. Orthographic projection reasoning underpins the entire CAD workflow, encompassing design, manufacturing, and simulation. However, prevailing deep-learning approaches employ standard 3D reconstruction pipelines as an alternative, which often introduce imprecise dimensions and limit the parametric editability required for CAD workflows. Recently, some researchers adopt vision-language models (VLMs), particularly supervised fine-tuning (SFT), to tackle CAD-related challenges. SFT shows promise but often devolves into pattern memorization, yielding poor out-of-distribution performance on complex reasoning tasks. To address these gaps, we introduce CReFT-CAD, a two-stage fine-tuning paradigm that first employs a curriculum-driven reinforcement learning stage with difficulty-aware rewards to build reasoning ability steadily, and then applies supervised post-tuning to hone instruction following and semantic extraction. Complementing this, we release TriView2CAD, the first large-scale, open-source benchmark for orthographic projection reasoning, comprising 200,000 synthetic and 3,000 real-world orthographic projections with precise dimension annotations and six interoperable data modalities. We benchmark leading VLMs on orthographic projection reasoning and demonstrate that CReFT-CAD substantially improves reasoning accuracy and out-of-distribution generalizability in real-world scenarios, offering valuable insights for advancing CAD reasoning research.

Xu Zhang, Qinghua Wang, Mengyang Zhao et al.

Crime disrupts societal stability, making law essential for balance. In multidefendant cases, assigning responsibility is complex and challenges fairness, requiring precise role differentiation. However, judicial phrasing often obscures the roles of the defendants, hindering effective AI-driven analyses. To address this issue, we incorporate sentencing logic into a pretrained Transformer encoder framework to enhance the intelligent assistance in multidefendant cases while ensuring legal interpretability. Within this framework an oriented masking mechanism clarifies roles and a comparative data construction strategy improves the model's sensitivity to culpability distinctions between principals and accomplices. Predicted guilt labels are further incorporated into a regression model through broadcasting, consolidating crime descriptions and court views. Our proposed masked multistage inference (MMSI) framework, evaluated on the custom IMLJP dataset for intentional injury cases, achieves significant accuracy improvements, outperforming baselines in role-based culpability differentiation. This work offers a robust solution for enhancing intelligent judicial systems, with publicly code available.

Kaixin Peng, Mengyang Zhao, Haiyang Yu et al.

As the oldest mature writing system, Oracle Bone Script (OBS) has long posed significant challenges for archaeological decipherment due to its rarity, abstractness, and pictographic diversity. Current deep learning-based methods have made exciting progress on the OBS decipherment task, but existing approaches often ignore the intricate connections between glyphs and the semantics of OBS. This results in limited generalization and interpretability, especially when addressing zero-shot settings and undeciphered OBS. To this end, we propose an interpretable OBS decipherment method based on Large Vision-Language Models, which synergistically combines radical analysis and pictograph-semantic understanding to bridge the gap between glyphs and meanings of OBS. Specifically, we propose a progressive training strategy that guides the model from radical recognition and analysis to pictographic analysis and mutual analysis, thus enabling reasoning from glyph to meaning. We also design a Radical-Pictographic Dual Matching mechanism informed by the analysis results, significantly enhancing the model's zero-shot decipherment performance. To facilitate model training, we propose the Pictographic Decipherment OBS Dataset, which comprises 47,157 Chinese characters annotated with OBS images and pictographic analysis texts. Experimental results on public benchmarks demonstrate that our approach achieves state-of-the-art Top-10 accuracy and superior zero-shot decipherment capabilities. More importantly, our model delivers logical analysis processes, possibly providing archaeologically valuable reference results for undeciphered OBS, and thus has potential applications in digital humanities and historical research. The dataset and code will be released in https://github.com/PKXX1943/PD-OBS.

Teng Fu, Yuwen Chen, Zhuofan Chen et al.

Multi-object tracking is a classic field in computer vision. Among them, pedestrian tracking has extremely high application value and has become the most popular research category. Existing methods mainly use motion or appearance information for tracking, which is often difficult in complex scenarios. For the motion information, mutual occlusions between objects often prevent updating of the motion state; for the appearance information, non-robust results are often obtained due to reasons such as only partial visibility of the object or blurred images. Although learning how to perform tracking in these situations from the annotated data is the simplest solution, the existing MOT dataset fails to satisfy this solution. Existing methods mainly have two drawbacks: relatively simple scene composition and non-realistic scenarios. Although some of the video sequences in existing dataset do not have the above-mentioned drawbacks, the number is far from adequate for research purposes. To this end, we propose a difficult large-scale dataset for multi-pedestrian tracking, shot mainly from the first-person view and all from real-life complex scenarios. We name it ``CrowdTrack'' because there are numerous objects in most of the sequences. Our dataset consists of 33 videos, containing a total of 5,185 trajectories. Each object is annotated with a complete bounding box and a unique object ID. The dataset will provide a platform to facilitate the development of algorithms that remain effective in complex situations. We analyzed the dataset comprehensively and tested multiple SOTA models on our dataset. Besides, we analyzed the performance of the foundation models on our dataset. The dataset and project code is released at: https://github.com/loseevaya/CrowdTrack .

Le You, Han Jiang, Jinyong Hu et al.

Handling clustering problems are important in data statistics, pattern recognition and image processing. The mean-shift algorithm, a common unsupervised algorithms, is widely used to solve clustering problems. However, the mean-shift algorithm is restricted by its huge computational resource cost. In previous research[10], we proposed a novel GPU-accelerated Faster Mean-shift algorithm, which greatly speed up the cosine-embedding clustering problem. In this study, we extend and improve the previous algorithm to handle Euclidean distance metrics. Different from conventional GPU-based mean-shift algorithms, our algorithm adopts novel Seed Selection & Early Stopping approaches, which greatly increase computing speed and reduce GPU memory consumption. In the simulation testing, when processing a 200K points clustering problem, our algorithm achieved around 3 times speedup compared to the state-of-the-art GPU-based mean-shift algorithms with optimized GPU memory consumption. Moreover, in this study, we implemented a plug-and-play model for faster mean-shift algorithm, which can be easily deployed. (Plug-and-play model is available: https://github.com/masqm/Faster-Mean-Shift-Euc)

Tianyuan Yao, Chang Qu, Quan Liu et al.

Unsupervised learning algorithms (e.g., self-supervised learning, auto-encoder, contrastive learning) allow deep learning models to learn effective image representations from large-scale unlabeled data. In medical image analysis, even unannotated data can be difficult to obtain for individual labs. Fortunately, national-level efforts have been made to provide efficient access to obtain biomedical image data from previous scientific publications. For instance, NIH has launched the Open-i search engine that provides a large-scale image database with free access. However, the images in scientific publications consist of a considerable amount of compound figures with subplots. To extract and curate individual subplots, many different compound figure separation approaches have been developed, especially with the recent advances in deep learning. However, previous approaches typically required resource extensive bounding box annotation to train detection models. In this paper, we propose a simple compound figure separation (SimCFS) framework that uses weak classification annotations from individual images. Our technical contribution is three-fold: (1) we introduce a new side loss that is designed for compound figure separation; (2) we introduce an intra-class image augmentation method to simulate hard cases; (3) the proposed framework enables an efficient deployment to new classes of images, without requiring resource extensive bounding box annotations. From the results, the SimCFS achieved a new state-of-the-art performance on the ImageCLEF 2016 Compound Figure Separation Database. The source code of SimCFS is made publicly available at https://github.com/hrlblab/ImageSeperation.

Quan Liu, Peter C. Louis, Yuzhe Lu et al.

Contrastive learning is a key technique of modern self-supervised learning. The broader accessibility of earlier approaches is hindered by the need of heavy computational resources (e.g., at least 8 GPUs or 32 TPU cores), which accommodate for large-scale negative samples or momentum. The more recent SimSiam approach addresses such key limitations via stop-gradient without momentum encoders. In medical image analysis, multiple instances can be achieved from the same patient or tissue. Inspired by these advances, we propose a simple triplet representation learning (SimTriplet) approach on pathological images. The contribution of the paper is three-fold: (1) The proposed SimTriplet method takes advantage of the multi-view nature of medical images beyond self-augmentation; (2) The method maximizes both intra-sample and inter-sample similarities via triplets from positive pairs, without using negative samples; and (3) The recent mix precision training is employed to advance the training by only using a single GPU with 16GB memory. By learning from 79,000 unlabeled pathological patch images, SimTriplet achieved 10.58% better performance compared with supervised learning. It also achieved 2.13% better performance compared with SimSiam. Our proposed SimTriplet can achieve decent performance using only 1% labeled data. The code and data are available at https://github.com/hrlblab/SimTriple.

Mengyang Zhao, Aadarsh Jha, Quan Liu et al.

Recently, single-stage embedding based deep learning algorithms gain increasing attention in cell segmentation and tracking. Compared with the traditional "segment-then-associate" two-stage approach, a single-stage algorithm not only simultaneously achieves consistent instance cell segmentation and tracking but also gains superior performance when distinguishing ambiguous pixels on boundaries and overlaps. However, the deployment of an embedding based algorithm is restricted by slow inference speed (e.g., around 1-2 mins per frame). In this study, we propose a novel Faster Mean-shift algorithm, which tackles the computational bottleneck of embedding based cell segmentation and tracking. Different from previous GPU-accelerated fast mean-shift algorithms, a new online seed optimization policy (OSOP) is introduced to adaptively determine the minimal number of seeds, accelerate computation, and save GPU memory. With both embedding simulation and empirical validation via the four cohorts from the ISBI cell tracking challenge, the proposed Faster Mean-shift algorithm achieved 7-10 times speedup compared to the state-of-the-art embedding based cell instance segmentation and tracking algorithm. Our Faster Mean-shift algorithm also achieved the highest computational speed compared to other GPU benchmarks with optimized memory consumption. The Faster Mean-shift is a plug-and-play model, which can be employed on other pixel embedding based clustering inference for medical image analysis. (Plug-and-play model is publicly available: https://github.com/masqm/Faster-Mean-Shift)

Mengyang Zhao, Longlong Li, Cunquan Qu

Graph Contrastive Learning (GCL) has emerged as a prominent framework for unsupervised graph representation learning. However, relying on augmentation design alone to define the invariances learned by GCL can be brittle under structural perturbations. To address this issue, we propose Cheeger--Hodge Contrastive Learning (CHCL), a framework that aligns a perturbation-stable Cheeger--Hodge joint signature across augmented views for robust graph representation learning. The proposed signature combines a Cheeger-inspired connectivity signature derived from the algebraic connectivity \(λ_2\) with the low-frequency spectrum of the 1-Hodge Laplacian, thereby capturing both global connectivity and higher-order structural information. By aligning encoder representations with the proposed Cheeger--Hodge joint signature across augmented views, CHCL learns graph embeddings that are robust to local structural perturbations. Extensive experiments on standard benchmarks, transfer settings demonstrate that CHCL consistently improves performance, robustness, and generalization.

Ke Niu, Haiyang Yu, Mengyang Zhao et al.

Person re-identification (Re-ID) is a crucial task in computer vision, aiming to recognize individuals across non-overlapping camera views. While recent advanced vision-language models (VLMs) excel in logical reasoning and multi-task generalization, their applications in Re-ID tasks remain limited. They either struggle to perform accurate matching based on identity-relevant features or assist image-dominated branches as auxiliary semantics. In this paper, we propose a novel framework ChatReID, that shifts the focus towards a text-side-dominated retrieval paradigm, enabling flexible and interactive re-identification. To integrate the reasoning abilities of language models into Re-ID pipelines, We first present a large-scale instruction dataset, which contains more than 8 million prompts to promote the model fine-tuning. Next. we introduce a hierarchical progressive tuning strategy, which endows Re-ID ability through three stages of tuning, i.e., from person attribute understanding to fine-grained image retrieval and to multi-modal task reasoning. Extensive experiments across ten popular benchmarks demonstrate that ChatReID outperforms existing methods, achieving state-of-the-art performance in all Re-ID tasks. More experiments demonstrate that ChatReID not only has the ability to recognize fine-grained details but also to integrate them into a coherent reasoning process.

Zhangxun Li, Mengyang Zhao, Xuan Yang et al.

Video anomaly detection (VAD) has been extensively researched due to its potential for intelligent video systems. However, most existing methods based on CNNs and transformers still suffer from substantial computational burdens and have room for improvement in learning spatial-temporal normality. Recently, Mamba has shown great potential for modeling long-range dependencies with linear complexity, providing an effective solution to the above dilemma. To this end, we propose a lightweight and effective Mamba-based network named STNMamba, which incorporates carefully designed Mamba modules to enhance the learning of spatial-temporal normality. Firstly, we develop a dual-encoder architecture, where the spatial encoder equipped with Multi-Scale Vision Space State Blocks (MS-VSSB) extracts multi-scale appearance features, and the temporal encoder employs Channel-Aware Vision Space State Blocks (CA-VSSB) to capture significant motion patterns. Secondly, a Spatial-Temporal Interaction Module (STIM) is introduced to integrate spatial and temporal information across multiple levels, enabling effective modeling of intrinsic spatial-temporal consistency. Within this module, the Spatial-Temporal Fusion Block (STFB) is proposed to fuse the spatial and temporal features into a unified feature space, and the memory bank is utilized to store spatial-temporal prototypes of normal patterns, restricting the model's ability to represent anomalies. Extensive experiments on three benchmark datasets demonstrate that our STNMamba achieves competitive performance with fewer parameters and lower computational costs than existing methods.

Yuchuan Wu, Minghan Zhuo, Teng Fu et al.

Document understanding with multimodal large language models (MLLMs) requires not only accurate answers but also explicit, evidence-grounded reasoning, especially in high-stakes scenarios. However, current document MLLMs still fall short of forming a complete, human-like reasoning process, because even when they improve both layout encoding and CoT-style prompting, the interaction between the two is typically learned implicitly and remains loosely coupled rather than being enforced as a systematic mechanism. So we propose DocCogito, a unified framework that integrates global layout perception with structured, region-grounded reasoning. DocCogito introduces a lightweight layout tower that distills page structure into learnable global layout prior tokens, and a deterministic Visual-Semantic Chain (VSC)-a concise structured representation less ambiguous than free-form natural-language CoT-to supervise fine-grained intermediate reasoning aligned with evidence regions. Training follows a progressive recipe, including layout perception pretraining, VSC-guided cold start, rejection sampling, and GRPO. To further strengthen the internal coupling between layout priors and VSC execution, we augment standard rewards with a fine-grained region-confidence signal that encourages reasoning traces to stay aligned with corresponding evidence regions. Extensive experiments on six benchmarks (DocVQA, WTQ, ChartQA, TextVQA, OCRBench, and InfoVQA) demonstrate strong generalization, achieving state-of-the-art results on four benchmarks.

Mengyang Zhao, Teng Fu, Haiyang Yu et al.

Few-Shot Industrial Anomaly Detection (FS-IAD) has important applications in automating industrial quality inspection. Recently, some FS-IAD methods based on Large Vision-Language Models (LVLMs) have been proposed with some achievements through prompt learning or fine-tuning. However, existing LVLMs focus on general tasks but lack basic industrial knowledge and reasoning capabilities related to FS-IAD, making these methods far from specialized human quality inspectors. To address these challenges, we propose a unified framework, IADGPT, designed to perform FS-IAD in a human-like manner, while also handling associated localization and reasoning tasks, even for diverse and novel industrial products. To this end, we introduce a three-stage progressive training strategy inspired by humans. Specifically, the first two stages gradually guide IADGPT in acquiring fundamental industrial knowledge and discrepancy awareness. In the third stage, we design an in-context learning-based training paradigm, enabling IADGPT to leverage a few-shot image as the exemplars for improved generalization to novel products. In addition, we design a strategy that enables IADGPT to output image-level and pixel-level anomaly scores using the logits output and the attention map, respectively, in conjunction with the language output to accomplish anomaly reasoning. To support our training, we present a new dataset comprising 100K images across 400 diverse industrial product categories with extensive attribute-level textual annotations. Experiments indicate IADGPT achieves considerable performance gains in anomaly detection and demonstrates competitiveness in anomaly localization and reasoning. We will release our dataset in camera-ready.

Teng Fu, Mengyang Zhao, Ke Niu et al.

LVLMs have been shown to perform excellently in image-level tasks such as VQA and caption. However, in many instance-level tasks, such as visual grounding and object detection, LVLMs still show performance gaps compared to previous expert models. Meanwhile, although pedestrian tracking is a classical task, there have been a number of new topics in combining object tracking and natural language, such as Referring MOT, Cross-view Referring MOT, and Semantic MOT. These tasks emphasize that models should understand the tracked object at an advanced semantic level, which is exactly where LVLMs excel. In this paper, we propose a new unified Pedestrian Tracking framework, namely OmniPT, which can track, track based on reference and generate semantic understanding of tracked objects interactively. We address two issues: how to model the tracking task into a task that foundation models can perform, and how to make the model output formatted answers. To this end, we implement a training phase consisting of RL-Mid Training-SFT-RL. Based on the pre-trained weights of the LVLM, we first perform a simple RL phase to enable the model to output fixed and supervisable bounding box format. Subsequently, we conduct a mid-training phase using a large number of pedestrian-related datasets. Finally, we perform supervised fine-tuning on several pedestrian tracking datasets, and then carry out another RL phase to improve the model's tracking performance and enhance its ability to follow instructions. We conduct experiments on tracking benchmarks and the experimental results demonstrate that the proposed method can perform better than the previous methods.

Leela Krishna, Mengyang Zhao, Saicharithreddy Pasula et al.

Training robust world models requires large-scale, precisely labeled multimodal datasets, a process historically bottlenecked by slow and expensive manual annotation. We present a production-tested GAZE pipeline that automates the conversion of raw, long-form video into rich, task-ready supervision for world-model training. Our system (i) normalizes proprietary 360-degree formats into standard views and shards them for parallel processing; (ii) applies a suite of AI models (scene understanding, object tracking, audio transcription, PII/NSFW/minor detection) for dense, multimodal pre-annotation; and (iii) consolidates signals into a structured output specification for rapid human validation. The GAZE workflow demonstrably yields efficiency gains (~19 minutes saved per review hour) and reduces human review volume by >80% through conservative auto-skipping of low-salience segments. By increasing label density and consistency while integrating privacy safeguards and chain-of-custody metadata, our method generates high-fidelity, privacy-aware datasets directly consumable for learning cross-modal dynamics and action-conditioned prediction. We detail our orchestration, model choices, and data dictionary to provide a scalable blueprint for generating high-quality world model training data without sacrificing throughput or governance.

Harshit Rajgarhia, Shivali Dalmia, Mengyang Zhao et al.

Adapting advertisements for multilingual audiences requires more than simple text translation; it demands preservation of visual consistency, spatial alignment, and stylistic integrity across diverse languages and formats. We introduce a structured framework that combines automated components with human oversight to address the complexities of advertisement localization. To the best of our knowledge, this is the first work to integrate scene text detection, inpainting, machine translation (MT), and text reimposition specifically for accelerating ad localization evaluation workflows. Qualitative results across six locales demonstrate that our approach produces semantically accurate and visually coherent localized advertisements, suitable for deployment in real-world workflows.

Ke Niu, Haiyang Yu, Zhuofan Chen et al.

Computer-Aided Design (CAD) plays a vital role in engineering and manufacturing, yet current CAD workflows require extensive domain expertise and manual modeling effort. Recent advances in large language models (LLMs) have made it possible to generate code from natural language, opening new opportunities for automating parametric 3D modeling. However, directly translating human design intent into executable CAD code remains highly challenging, due to the need for logical reasoning, syntactic correctness, and numerical precision. In this work, we propose CAD-RL, a multimodal Chain-of-Thought (CoT) guided reinforcement learning post training framework for CAD modeling code generation. Our method combines CoT-based Cold Start with goal-driven reinforcement learning post training using three task-specific rewards: executability reward, geometric accuracy reward, and external evaluation reward. To ensure stable policy learning under sparse and high-variance reward conditions, we introduce three targeted optimization strategies: Trust Region Stretch for improved exploration, Precision Token Loss for enhanced dimensions parameter accuracy, and Overlong Filtering to reduce noisy supervision. To support training and benchmarking, we release ExeCAD, a noval dataset comprising 16,540 real-world CAD examples with paired natural language and structured design language descriptions, executable CADQuery scripts, and rendered 3D models. Experiments demonstrate that CAD-RL achieves significant improvements in reasoning quality, output precision, and code executability over existing VLMs.

Mengyang Zhao, Quan Liu, Aadarsh Jha et al.

Recent advances in bioimaging have provided scientists a superior high spatial-temporal resolution to observe dynamics of living cells as 3D volumetric videos. Unfortunately, the 3D biomedical video analysis is lagging, impeded by resource insensitive human curation using off-the-shelf 3D analytic tools. Herein, biologists often need to discard a considerable amount of rich 3D spatial information by compromising on 2D analysis via maximum intensity projection. Recently, pixel embedding-based cell instance segmentation and tracking provided a neat and generalizable computing paradigm for understanding cellular dynamics. In this work, we propose a novel spatial-temporal voxel-embedding (VoxelEmbed) based learning method to perform simultaneous cell instance segmenting and tracking on 3D volumetric video sequences. Our contribution is in four-fold: (1) The proposed voxel embedding generalizes the pixel embedding with 3D context information; (2) Present a simple multi-stream learning approach that allows effective spatial-temporal embedding; (3) Accomplished an end-to-end framework for one-stage 3D cell instance segmentation and tracking without heavy parameter tuning; (4) The proposed 3D quantification is memory efficient via a single GPU with 12 GB memory. We evaluate our VoxelEmbed method on four 3D datasets (with different cell types) from the ISBI Cell Tracking Challenge. The proposed VoxelEmbed method achieved consistent superior overall performance (OP) on two densely annotated datasets. The performance is also competitive on two sparsely annotated cohorts with 20.6% and 2% of data-set having segmentation annotations. The results demonstrate that the VoxelEmbed method is a generalizable and memory-efficient solution.

Quan Liu, Isabella M. Gaeta, Mengyang Zhao et al.

Background: The quantitative analysis of microscope videos often requires instance segmentation and tracking of cellular and subcellular objects. The traditional method consists of two stages: (1) performing instance object segmentation of each frame, and (2) associating objects frame-by-frame. Recently, pixel-embedding-based deep learning approaches these two steps simultaneously as a single stage holistic solution. In computer vision, annotated training data with consistent segmentation and tracking is resource intensive, the severity of which is multiplied in microscopy imaging due to (1) dense objects (e.g., overlapping or touching), and (2) high dynamics (e.g., irregular motion and mitosis). Adversarial simulations have provided successful solutions to alleviate the lack of such annotations in dynamics scenes in computer vision, such as using simulated environments (e.g., computer games) to train real-world self-driving systems. Methods: In this paper, we propose an annotation-free synthetic instance segmentation and tracking (ASIST) method with adversarial simulation and single-stage pixel-embedding based learning. Contribution: The contribution of this paper is three-fold: (1) the proposed method aggregates adversarial simulations and single-stage pixel-embedding based deep learning; (2) the method is assessed with both the cellular (i.e., HeLa cells) and subcellular (i.e., microvilli) objects; and (3) to the best of our knowledge, this is the first study to explore annotation-free instance segmentation and tracking study for microscope videos. Results: The ASIST method achieved an important step forward, when compared with fully supervised approaches: ASIST shows 7% to 11% higher segmentation, detection and tracking performance on microvilli relative to fully supervised methods, and comparable performance on Hela cell videos.

Quan Liu, Isabella M. Gaeta, Mengyang Zhao et al.

Instance object segmentation and tracking provide comprehensive quantification of objects across microscope videos. The recent single-stage pixel-embedding based deep learning approach has shown its superior performance compared with "segment-then-associate" two-stage solutions. However, one major limitation of applying a supervised pixel-embedding based method to microscope videos is the resource-intensive manual labeling, which involves tracing hundreds of overlapped objects with their temporal associations across video frames. Inspired by the recent generative adversarial network (GAN) based annotation-free image segmentation, we propose a novel annotation-free synthetic instance segmentation and tracking (ASIST) algorithm for analyzing microscope videos of sub-cellular microvilli. The contributions of this paper are three-fold: (1) proposing a new annotation-free video analysis paradigm is proposed. (2) aggregating the embedding based instance segmentation and tracking with annotation-free synthetic learning as a holistic framework; and (3) to the best of our knowledge, this is first study to investigate microvilli instance segmentation and tracking using embedding based deep learning. From the experimental results, the proposed annotation-free method achieved superior performance compared with supervised learning.