Rui Sun

Rui Sun, Yiwen Yang, Kaiyu Guo et al.

Accurate cell instance segmentation is foundational for digital pathology analysis. Existing methods based on contour detection and distance mapping still face significant challenges in processing complex and dense cellular regions. Graph coloring-based methods provide a new paradigm for this task, yet the effectiveness of this paradigm in real-world scenarios with dense overlaps and complex topologies has not been verified. Addressing this issue, we release a large-scale dataset GBC-FS 2025, which contains highly complex and dense sub-cellular nuclear arrangements. We conduct the first systematic analysis of the chromatic properties of cell adjacency graphs across four diverse datasets and reveal an important discovery: most real-world cell graphs are non-bipartite, with a high prevalence of odd-length cycles (predominantly triangles). This makes simple 2-coloring theory insufficient for handling complex tissues, while higher-chromaticity models would cause representational redundancy and optimization difficulties. Building on this observation of complex real-world contexts, we propose Disco (Densely-overlapping Cell Instance Segmentation via Adjacency-aware COllaborative Coloring), an adjacency-aware framework based on the "divide and conquer" principle. It uniquely combines a data-driven topological labeling strategy with a constrained deep learning system to resolve complex adjacency conflicts. First, "Explicit Marking" strategy transforms the topological challenge into a learnable classification task by recursively decomposing the cell graph and isolating a "conflict set." Second, "Implicit Disambiguation" mechanism resolves ambiguities in conflict regions by enforcing feature dissimilarity between different instances, enabling the model to learn separable feature representations.

Chenghua Gong, Yihang Jiang, Hao Li et al.

Advanced opinion dynamics modeling is vital for deciphering social behavior, emphasizing its role in mitigating polarization and securing cyberspace. To synergize mechanistic interpretability with data-driven flexibility, recent studies have explored the integration of Physics-Informed Neural Networks (PINNs) for opinion modeling. Despite this promise, existing methods are tailored to incomplete priors, lacking a comprehensive physical system to integrate dynamics from local, global, and endogenous levels. Moreover, penalty-based constraints adopted in existing methods struggle to deeply encode physical priors, leading to optimization pathologies and discrepancy between latent representations and physical transparency. To this end, we offer a physical view to interpret opinion dynamics via Diffusion-Convection-Reaction (DCR) system inspired by interacting particle theory. Building upon the Neural ODEs, we define the neural opinion dynamics to coordinate neural networks with physical priors, and further present the OPINN, a physics-informed neural framework for opinion dynamics modeling. Evaluated on real-world and synthetic datasets, OPINN achieves state-of-the-art performance in opinion evolution forecasting, offering a promising paradigm for the nexus of cyber, physical, and social systems.