Jiahao Yang

Jiahao Yang, Ran Fang, Ming Zhang et al.

In high-frequency trading (HFT), leveraging limit order books (LOB) to model stock price movements is crucial for achieving profitable outcomes. However, this task is challenging due to the high-dimensional and volatile nature of the original data. Even recent deep learning models often struggle to capture price movement patterns effectively, particularly without well-designed features. We observed that raw LOB data exhibits inherent symmetry between the ask and bid sides, and the bid-ask differences demonstrate greater stability and lower complexity compared to the original data. Building on this insight, we propose a novel approach in which leverages the Siamese architecture to enhance the performance of existing deep learning models. The core idea involves processing the ask and bid sides separately using the same module with shared parameters. We applied our Siamese-based methods to several widely used strong baselines and validated their effectiveness using data from 14 military industry stocks in the Chinese A-share market. Furthermore, we integrated multi-head attention (MHA) mechanisms with the Long Short-Term Memory (LSTM) module to investigate its role in modeling stock price movements. Our experiments used raw data and widely used Order Flow Imbalance (OFI) features as input with some strong baseline models. The results show that our method improves the performance of strong baselines in over 75$% of cases, excluding the Multi-Layer Perception (MLP) baseline, which performed poorly and is not considered practical. Furthermore, we found that Multi-Head Attention can enhance model performance, particularly over shorter forecasting horizons.

Li Wang, Xiangzheng Fu, Jiahao Yang et al.

Deep learning holds a big promise for optimizing existing peptides with more desirable properties, a critical step towards accelerating new drug discovery. Despite the recent emergence of several optimized Antimicrobial peptides(AMP) generation methods, multi-objective optimizations remain still quite challenging for the idealism-realism tradeoff. Here, we establish a multi-objective AMP synthesis pipeline (MoFormer) for the simultaneous optimization of multi-attributes of AMPs. MoFormer improves the desired attributes of AMP sequences in a highly structured latent space, guided by conditional constraints and fine-grained multi-descriptor.We show that MoFormer outperforms existing methods in the generation task of enhanced antimicrobial activity and minimal hemolysis. We also utilize a Pareto-based non-dominated sorting algorithm and proxies based on large model fine-tuning to hierarchically rank the candidates. We demonstrate substantial property improvement using MoFormer from two perspectives: (1) employing molecular simulations and scoring interactions among amino acids to decipher the structure and functionality of AMPs; (2) visualizing latent space to examine the qualities and distribution features, verifying an effective means to facilitate multi-objective optimization AMPs with design constraints