Hao Wang

Zhangyang Gao, Hao Wang, Cheng Tan et al.

This study investigates the current landscape and future directions of protein foundation model research. While recent advancements have transformed protein science and engineering, the field lacks a comprehensive benchmark for fair evaluation and in-depth understanding. Since ESM-1B, numerous protein foundation models have emerged, each with unique datasets and methodologies. However, evaluations often focus on limited tasks tailored to specific models, hindering insights into broader generalization and limitations. Specifically, researchers struggle to understand the relationships between tasks, assess how well current models perform across them, and determine the criteria in developing new foundation models. To fill this gap, we present PFMBench, a comprehensive benchmark evaluating protein foundation models across 38 tasks spanning 8 key areas of protein science. Through hundreds of experiments on 17 state-of-the-art models across 38 tasks, PFMBench reveals the inherent correlations between tasks, identifies top-performing models, and provides a streamlined evaluation protocol. Code is available at \href{https://github.com/biomap-research/PFMBench}{\textcolor{blue}{GitHub}}.

Yong Huang, Wei Wang, Hao Wang et al.

By adding users as a new dimension to connectivity, on-body Internet-of-Things (IoT) devices have gained considerable momentum in recent years, while raising serious privacy and safety issues. Existing approaches to authenticate these devices limit themselves to dedicated sensors or specified user motions, undermining their widespread acceptance. This paper overcomes these limitations with a general authentication solution by integrating wireless physical layer (PHY) signatures with upper-layer protocols. The key enabling techniques are constructing representative radio propagation profiles from received signals, and developing an adversarial multi-player neural network to accurately recognize underlying radio propagation patterns and facilitate on-body device authentication. Once hearing a suspicious transmission, our system triggers a PHY-based challenge-response protocol to defend in depth against active attacks. We prove that at equilibrium, our adversarial model can extract all information about propagation patterns and eliminate any irrelevant information caused by motion variances and environment changes. We build a prototype of our system using Universal Software Radio Peripheral (USRP) devices and conduct extensive experiments with various static and dynamic body motions in typical indoor and outdoor environments. The experimental results show that our system achieves an average authentication accuracy of 91.6%, with a high area under the receiver operating characteristic curve (AUROC) of 0.96 and a better generalization performance compared with the conventional non-adversarial approach.

Yong Huang, Mengnian Xu, Wei Wang et al.

As the rapid proliferation of on-body Internet of Things (IoT) devices, their security vulnerabilities have raised serious privacy and safety issues. Traditional efforts to secure these devices against impersonation attacks mainly rely on either dedicated sensors or specified user motions, impeding their wide-scale adoption. This paper transcends these limitations with a general security solution by leveraging ubiquitous wireless chips available in IoT devices. Particularly, representative time and frequency features are first extracted from received signal strengths (RSSs) to characterize radio propagation profiles. Then, an adversarial multi-player network is developed to recognize underlying radio propagation patterns and facilitate on-body device authentication. We prove that at equilibrium, our adversarial model can extract all information about propagation patterns and eliminate any irrelevant information caused by motion variances. We build a prototype of our system using universal software radio peripheral (USRP) devices and conduct extensive experiments with both static and dynamic body motions in typical indoor and outdoor environments. The experimental results show that our system achieves an average authentication accuracy of 90.4%, with a high area under the receiver operating characteristic curve (AUROC) of 0.958 and better generalization performance in comparison with the conventional non-adversarial-based approach.