Alexander Chen

Yuntian Wang, Alexander Chen, Md Sadman Sakib Rahman et al.

We demonstrate that nonlinear computing can be achieved with a single linear diffractive surface under coherent illumination. We introduce a compact encoder-decoder co-localization (E+D) architecture in which an input-dependent dynamic encoder and a static optimized decoder are integrated within the same phase-only diffractive plane. Following free-space propagation, coherent interference between the encoder and decoder fields, combined with intensity detection, generates programmable nonlinear input-output mappings without requiring nonlinear optical materials or multiple diffractive layers. We prove that the proposed E+D optical processor is a universal approximator for arbitrary real-valued band-limited nonlinear functions and identify the physical factors governing its approximation fidelity, including the decoder degrees-of-freedom, detector aperture, and axial propagation distance. Crucially, we demonstrate that introducing a trained, frozen phase bias to the encoder region systematically enhances functional expressivity, providing robustness against coarse phase quantization on spatial light modulators. Using this framework, we accurately synthesize diverse nonlinear functions, including commonly used neural network activation functions and complex-valued nonlinear functions. Finally, we experimentally validate the proposed approach using a visible-light optical set-up trained through in situ learning, demonstrating the parallel approximation of 9 nonlinear functions in a single optical forward pass. By collapsing nonlinear optical computation into a single diffractive surface, the E+D architecture substantially reduces hardware and alignment complexity while preserving powerful function-approximation capabilities, providing a compact and scalable framework for analog information processing.

Paloma Casteleiro Costa, Parnian Ghapandar Kashani, Xuhui Liu et al.

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical adoption remains limited by long pixel dwell times and low signal-to-noise ratio (SNR), which impose a stricter resolution-speed trade-off than conventional optical imaging approaches. Here, we introduce FLIM_PSR_k, a deep learning-based multi-channel pixel super-resolution (PSR) framework that reconstructs high-resolution FLIM images from data acquired with up to a 5-fold increased pixel size. The model is trained using the conditional generative adversarial network (cGAN) framework, which, compared to diffusion model-based alternatives, delivers a more robust PSR reconstruction with substantially shorter inference times, a crucial advantage for practical deployment. FLIM_PSR_k not only enables faster image acquisition but can also alleviate SNR limitations in autofluorescence-based FLIM. Blind testing on held-out patient-derived tumor tissue samples demonstrates that FLIM_PSR_k reliably achieves a super-resolution factor of k = 5, resulting in a 25-fold increase in the space-bandwidth product of the output images and revealing fine architectural features lost in lower-resolution inputs, with statistically significant improvements across various image quality metrics. By increasing FLIM's effective spatial resolution, FLIM_PSR_k advances lifetime imaging toward faster, higher-resolution, and hardware-flexible implementations compatible with low-numerical-aperture and miniaturized platforms, better positioning FLIM for translational applications.

Alexander Chen, Yuntian Wang, Md Sadman Sakib Rahman et al.

Nonlinear computation is essential for various information processing tasks. Optical implementations are attractive because passive light propagation can manipulate high-dimensional signals with extreme throughput and parallelism; yet realizing nonlinear mappings in optical hardware remains challenging due to the weak nonlinearity of optical materials and the large intensities required to induce nonlinear interactions. This challenge is further amplified in many systems that operate with incoherent illumination, motivating a coherence-aware framework for scalable optical nonlinear processing. Here, we show that linear optical systems, in particular, optimized diffractive processors comprising passive surfaces, can perform large-scale nonlinear function approximation under spatially incoherent or partially coherent illumination, when preceded by intensity-only input encoding. We quantify how the accuracy of the nonlinear function approximation varies with the degree of parallelism, the number of diffractive layers, and the number of trainable diffractive features. Numerical results demonstrate snapshot computation of up to one million distinct nonlinear functions in a single forward pass through a diffractive processor, with the function outputs spatially multiplexed and read out using densely packed detectors at the output. We further provide a proof-of-concept experimental demonstration under incoherent illumination from a liquid crystal display (LCD), enabled by a model-free in situ learning strategy that jointly optimizes the diffractive profile and detector readout geometry in the presence of hardware imperfections and misalignments. Our findings establish diffractive processors as a massively parallel universal function approximator for both spatially incoherent and partially coherent illumination.

Cagatay Isil, Alexander Chen, Yuhang Li et al.

3D image display is essential for next-generation volumetric imaging; however, dense depth multiplexing for 3D image projection remains challenging because diffraction-induced cross-talk rapidly increases as the axial image planes get closer. Here, we introduce a 3D display system comprising a digital encoder and a diffractive optical decoder, which simultaneously projects different images onto multiple target axial planes with high axial resolution. By leveraging multi-layer diffractive wavefront decoding and deep learning-based end-to-end optimization, the system achieves high-fidelity depth-resolved 3D image projection in a snapshot, enabling axial plane separations on the order of a wavelength. The digital encoder leverages a Fourier encoder network to capture multi-scale spatial and frequency-domain features from input images, integrates axial position encoding, and generates a unified phase representation that simultaneously encodes all images to be axially projected in a single snapshot through a jointly-optimized diffractive decoder. We characterized the impact of diffractive decoder depth, output diffraction efficiency, spatial light modulator resolution, and axial encoding density, revealing trade-offs that govern axial separation and 3D image projection quality. We further demonstrated the capability to display volumetric images containing 28 axial slices, as well as the ability to dynamically reconfigure the axial locations of the image planes, performed on demand. Finally, we experimentally validated the presented approach, demonstrating close agreement between the measured results and the target images. These results establish the diffractive 3D display system as a compact and scalable framework for depth-resolved snapshot 3D image projection, with potential applications in holographic displays, AR/VR interfaces, and volumetric optical computing.

Gemini Team, Petko Georgiev, Ving Ian Lei et al. · deepmind, mila

In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.

Ben Mechels, Ryan Billmeyer, Alexander Chen et al.

Modern high-performance computing and Internet-of-Things deployments increasingly generate large volumes of signal data that must be compressed efficiently on resource-constrained acquisition devices and decompressed at scale on centralized servers. Lossy compression is widely adopted to minimize storage and transmission costs on low-power hardware sensors, yet existing methods rarely optimize for both reconstruction quality and decompression throughput simultaneously, nor do they apply methods that generalize across signal domains. In this work, we introduce FPTC, a high-throughput asymmetric signal codec that pairs a lightweight sequential encoder with a massively parallel GPU decoder designed for server-side batch decompression. FPTC applies a windowed discrete cosine transform (DCT) to exploit frequency-domain sparsity, quantizes spectral coefficients with a hybrid three-zone mapping, and entropy codes the result using Huffman coding with a novel packing scheme. The pipeline used in FPTC is designed to be throughput oriented on the GPU, maximizing performance without sacrificing reconstruction quality. We evaluate FPTC on ten datasets spanning four signal domains: biomedical diagnostic, seismic reflections, power-grid production metrics, and meteorological recordings. Our results demonstrate that FPTC outperforms existing frameworks in compression ratio while maintaining competitive throughput, achieving multiplicative compression performance of 3.6x (power), 3.1x (meteorological), 1.5x (biomedical), and 1.2x (seismic) over existing frameworks.

Aritra Roy, Kevin Shen, Andrew MacBride et al.

Large language models (LLMs) are rapidly changing how researchers in materials science and chemistry discover, organize, and act on scientific knowledge. This paper analyzes a broad set of community-developed LLM applications in an effort to identify emerging patterns in how these systems can be used across the scientific research lifecycle. We organize the projects into two complementary categories: Knowledge Infrastructure, systems that structure, retrieve, synthesize, and validate scientific information; and Action Systems, systems that execute, coordinate, or automate scientific work across computational and experimental environments. The submissions reveal a shift from single-purpose LLM tools toward integrated, multi-agent workflows that combine retrieval, reasoning, tool use, and domain-specific validation. Prominent themes include retrieval-augmented generation as grounding infrastructure, persistent structured knowledge representations, multimodal and multilingual scientific inputs, and early progress toward laboratory-integrated closed-loop systems. Together, these results suggest that LLMs are evolving from general-purpose assistants into composable infrastructure for scientific reasoning and action. This work provides a community snapshot of that transition and a practical taxonomy for understanding emerging LLM-enabled workflows in materials science and chemistry.

Paul Kassianik, Baturay Saglam, Alexander Chen et al.

As transformer-based large language models (LLMs) increasingly permeate society, they have revolutionized domains such as software engineering, creative writing, and digital arts. However, their adoption in cybersecurity remains limited due to challenges like scarcity of specialized training data and complexity of representing cybersecurity-specific knowledge. To address these gaps, we present Foundation-Sec-8B, a cybersecurity-focused LLM built on the Llama 3.1 architecture and enhanced through continued pretraining on a carefully curated cybersecurity corpus. We evaluate Foundation-Sec-8B across both established and new cybersecurity benchmarks, showing that it matches Llama 3.1-70B and GPT-4o-mini in certain cybersecurity-specific tasks. By releasing our model to the public, we aim to accelerate progress and adoption of AI-driven tools in both public and private cybersecurity contexts.

Meng Zhang, Dennis Yin, Nicholas Gangi et al.

Electronic-photonic computing systems offer immense potential in energy-efficient artificial intelligence (AI) acceleration tasks due to the superior computing speed and efficiency of optics, especially for real-time, low-energy deep neural network (DNN) inference tasks on resource-restricted edge platforms. However, current optical neural accelerators based on foundry-available devices and conventional system architecture still encounter a performance gap compared to highly customized electronic counterparts. To bridge the performance gap due to lack of domain specialization, we present a time-multiplexed dynamic photonic tensor accelerator, dubbed TeMPO, with cross-layer device/circuit/architecture customization. At the device level, we present foundry-compatible, customized photonic devices, including a slow-light electro-optic modulator with experimental demonstration, optical splitters, and phase shifters that significantly reduce the footprint and power in input encoding and dot-product calculation. At the circuit level, partial products are hierarchically accumulated via parallel photocurrent aggregation, lightweight capacitive temporal integration, and sequential digital summation, considerably relieving the analog-to-digital conversion bottleneck. We also employ a multi-tile, multi-core architecture to maximize hardware sharing for higher efficiency. Across diverse edge AI workloads, TeMPO delivers digital-comparable task accuracy with superior quantization/noise tolerance. We achieve a 368.6 TOPS peak performance, 22.3 TOPS/W energy efficiency, and 1.2 TOPS/mm$^2$ compute density, pushing the Pareto frontier in edge AI hardware. This work signifies the power of cross-layer co-design and domain-specific customization, paving the way for future electronic-photonic accelerators with even greater performance and efficiency.

Taoyuze Lv, Alexander Chen, Fengyu Xie et al.

Large Language Models (LLMs) excel at textual reasoning and are beginning to develop spatial understanding, prompting the question of whether these abilities can be combined for complex, domain-specific tasks. This question is essential in fields like materials science, where deep understanding of 3D atomic structures is fundamental. While initial studies have successfully applied LLMs to tasks involving pure crystal generation or coordinate understandings, a standardized benchmark to systematically evaluate their core reasoning abilities across diverse atomic structures has been notably absent. To address this gap, we introduce the AtomWorld benchmark to evaluate LLMs on tasks based in Crystallographic Information Files (CIFs), a standard structure representation format. These tasks, including structural editing, CIF perception, and property-guided modeling, reveal a critical limitation: current models, despite establishing promising baselines, consistently fail in structural understanding and spatial reasoning. Our experiments show that these models make frequent errors on structure modification tasks, and even in the basic CIF format understandings, potentially leading to cumulative errors in subsequent analysis and materials insights. By defining these standardized tasks, AtomWorld lays the ground for advancing LLMs toward robust atomic-scale modeling, crucial for accelerating materials research and automating scientific workflows.

Adam Swanda, Amy Chang, Alexander Chen et al.

The widespread adoption of Large Language Models (LLMs) has revolutionized AI deployment, enabling autonomous and semi-autonomous applications across industries through intuitive language interfaces and continuous improvements in model development. However, the attendant increase in autonomy and expansion of access permissions among AI applications also make these systems compelling targets for malicious attacks. Their inherent susceptibility to security flaws necessitates robust defenses, yet no known approaches can prevent zero-day or novel attacks against LLMs. This places AI protection systems in a category similar to established malware protection systems: rather than providing guaranteed immunity, they minimize risk through enhanced observability, multi-layered defense, and rapid threat response, supported by a threat intelligence function designed specifically for AI-related threats. Prior work on LLM protection has largely evaluated individual detection models rather than end-to-end systems designed for continuous, rapid adaptation to a changing threat landscape. We present a production-grade defense system rooted in established malware detection and threat intelligence practices. Our platform integrates three components: a threat intelligence system that turns emerging threats into protections; a data platform that aggregates and enriches information while providing observability, monitoring, and ML operations; and a release platform enabling safe, rapid detection updates without disrupting customer workflows. Together, these components deliver layered protection against evolving LLM threats while generating training data for continuous model improvement and deploying updates without interrupting production.