Zhaocheng Li

Tianwei Lin, Zhongwei Qiu, Wenqiao Zhang et al.

Computed Tomography (CT) is one of the most widely used and diagnostically information-dense imaging modalities, covering critical organs such as the heart, lungs, liver, and colon. Clinical interpretation relies on both slice-driven local features (e.g., sub-centimeter nodules, lesion boundaries) and volume-driven spatial representations (e.g., tumor infiltration, inter-organ anatomical relations). However, existing Large Vision-Language Models (LVLMs) remain fragmented in CT slice versus volumetric understanding: slice-driven LVLMs show strong generalization but lack cross-slice spatial consistency, while volume-driven LVLMs explicitly capture volumetric semantics but suffer from coarse granularity and poor compatibility with slice inputs. The absence of a unified modeling paradigm constitutes a major bottleneck for the clinical translation of medical LVLMs. We present OmniCT, a powerful unified slice-volume LVLM for CT scenarios, which makes three contributions: (i) Spatial Consistency Enhancement (SCE): volumetric slice composition combined with tri-axial positional embedding that introduces volumetric consistency, and an MoE hybrid projection enables efficient slice-volume adaptation; (ii) Organ-level Semantic Enhancement (OSE): segmentation and ROI localization explicitly align anatomical regions, emphasizing lesion- and organ-level semantics; (iii) MedEval-CT: the largest slice-volume CT dataset and hybrid benchmark integrates comprehensive metrics for unified evaluation. OmniCT consistently outperforms existing methods with a substantial margin across diverse clinical tasks and satisfies both micro-level detail sensitivity and macro-level spatial reasoning. More importantly, it establishes a new paradigm for cross-modal medical imaging understanding.

Yuqian Yuan, Wentong Li, Zhaocheng Li et al.

In this paper, we introduce InstructSAM, a unified and streamlined framework designed for multi-instance segmentation under arbitrary instructions. We formulates instruction-driven instance segmentation as a set-structured query prediction problem and propose an explicit reasoning-to-instance query interface that elegantly bridges a vision-language model (VLM) and SAM3. Specifically, a bank of learnable instance queries is injected into the VLM and contextualized with instruction and visual information, enabling each query to serve as an instance-aware slot. A hybrid-attention mechanism further promotes interaction among these queries, visual tokens, and instruction tokens, improving instance enumeration and reducing duplicate predictions. The resulting LLM-conditioned queries are projected into SAM3's detector query space to drive accurate multi-instance segmentation in a single forward pass. This design equips SAM3 with high-level instruction understanding, compositional reasoning, and instance-level set prediction without modifying its core architecture. To support training and evaluation, we further construct Inst2Seg, a high-quality and large-scale instruction-based instance segmentation dataset and benchmark that couples free-form instructions with instance-level masks. Extensive experiments show that only 2B-scale InstructSAM achieves strong results across complex instruction-driven and phrase-level referring segmentation benchmarks, outperforming prior end-to-end methods and SAM3's agentic pipeline while enabling efficient single-pass multi-instance prediction.