Jane W. Z. Lu

Sicong Leng, Yang Zhou, Mohammed Haroon Dupty et al.

We consider the task of generating designs directly from natural language descriptions, and consider floor plan generation as the initial research area. Language conditional generative models have recently been very successful in generating high-quality artistic images. However, designs must satisfy different constraints that are not present in generating artistic images, particularly spatial and relational constraints. We make multiple contributions to initiate research on this task. First, we introduce a novel dataset, \textit{Tell2Design} (T2D), which contains more than $80k$ floor plan designs associated with natural language instructions. Second, we propose a Sequence-to-Sequence model that can serve as a strong baseline for future research. Third, we benchmark this task with several text-conditional image generation models. We conclude by conducting human evaluations on the generated samples and providing an analysis of human performance. We hope our contributions will propel the research on language-guided design generation forward.

Ke Niu, Haiyang Yu, Mengyang Zhao et al.

Person re-identification (Re-ID) is a crucial task in computer vision, aiming to recognize individuals across non-overlapping camera views. While recent advanced vision-language models (VLMs) excel in logical reasoning and multi-task generalization, their applications in Re-ID tasks remain limited. They either struggle to perform accurate matching based on identity-relevant features or assist image-dominated branches as auxiliary semantics. In this paper, we propose a novel framework ChatReID, that shifts the focus towards a text-side-dominated retrieval paradigm, enabling flexible and interactive re-identification. To integrate the reasoning abilities of language models into Re-ID pipelines, We first present a large-scale instruction dataset, which contains more than 8 million prompts to promote the model fine-tuning. Next. we introduce a hierarchical progressive tuning strategy, which endows Re-ID ability through three stages of tuning, i.e., from person attribute understanding to fine-grained image retrieval and to multi-modal task reasoning. Extensive experiments across ten popular benchmarks demonstrate that ChatReID outperforms existing methods, achieving state-of-the-art performance in all Re-ID tasks. More experiments demonstrate that ChatReID not only has the ability to recognize fine-grained details but also to integrate them into a coherent reasoning process.

Zhongyue Zhang, Jiahua Rao, Jie Zhong et al.

Most human proteins remain undrugged, over 96% of human proteins remain unexploited by approved therapeutics. While structure-based virtual screening promises to expand the druggable proteome, existing methods lack atomic-level precision and fail to predict binding fitness, limiting translational impact. We present AuroBind, a scalable virtual screening framework that fine-tunes a custom atomic-level structural model on million-scale chemogenomic data. AuroBind integrates direct preference optimization, self-distillation from high-confidence complexes, and a teacher-student acceleration strategy to jointly predict ligand-bound structures and binding fitness. The proposed models outperform state-of-the-art models on structural and functional benchmarks while enabling 100,000-fold faster screening across ultra-large compound libraries. In a prospective screen across ten disease-relevant targets, AuroBind achieved experimental hit rates of 7-69%, with top compounds reaching sub-nanomolar to picomolar potency. For the orphan GPCRs GPR151 and GPR160, AuroBind identified both agonists and antagonists with success rates of 16-30%, and functional assays confirmed GPR160 modulation in liver and prostate cancer models. AuroBind offers a generalizable framework for structure-function learning and high-throughput molecular screening, bridging the gap between structure prediction and therapeutic discovery.