Rong Fu

Rong Fu, Zijian Zhang, Wenxin Zhang et al.

Comparative analysis of adaptive immune repertoires at population scale is hampered by two practical bottlenecks: the near-quadratic cost of pairwise affinity evaluations and dataset imbalances that obscure clinically important minority clonotypes. We introduce SubQuad, an end-to-end pipeline that addresses these challenges by combining antigen-aware, near-subquadratic retrieval with GPU-accelerated affinity kernels, learned multimodal fusion, and fairness-constrained clustering. The system employs compact MinHash prefiltering to sharply reduce candidate comparisons, a differentiable gating module that adaptively weights complementary alignment and embedding channels on a per-pair basis, and an automated calibration routine that enforces proportional representation of rare antigen-specific subgroups. On large viral and tumor repertoires SubQuad achieves measured gains in throughput and peak memory usage while preserving or improving recall@k, cluster purity, and subgroup equity. By co-designing indexing, similarity fusion, and equity-aware objectives, SubQuad offers a scalable, bias-aware platform for repertoire mining and downstream translational tasks such as vaccine target prioritization and biomarker discovery.

Rong Fu, Muge Qi, Chunlei Meng et al.

Graph neural networks frequently encounter significant performance degradation when confronted with structural noise or non-homophilous topologies. To address these systemic vulnerabilities, we present AdvSynGNN, a comprehensive architecture designed for resilient node-level representation learning. The proposed framework orchestrates multi-resolution structural synthesis alongside contrastive objectives to establish geometry-sensitive initializations. We develop a transformer backbone that adaptively accommodates heterophily by modulating attention mechanisms through learned topological signals. Central to our contribution is an integrated adversarial propagation engine, where a generative component identifies potential connectivity alterations while a discriminator enforces global coherence. Furthermore, label refinement is achieved through a residual correction scheme guided by per-node confidence metrics, which facilitates precise control over iterative stability. Empirical evaluations demonstrate that this synergistic approach effectively optimizes predictive accuracy across diverse graph distributions while maintaining computational efficiency. The study concludes with practical implementation protocols to ensure the robust deployment of the AdvSynGNN system in large-scale environments.

Rong Fu, Zijian Zhang, Haiyun Wei et al.

The continuous expansion of digital learning environments has catalyzed the demand for intelligent systems capable of providing personalized educational content. While current exercise recommendation frameworks have made significant strides, they frequently encounter obstacles regarding the long-tailed distribution of student engagement and the failure to adapt to idiosyncratic learning trajectories. We present LiveGraph, a novel active-structure neural re-ranking framework designed to overcome these limitations. Our approach utilizes a graph-based representation enhancement strategy to bridge the information gap between active and inactive students while integrating a dynamic re-ranking mechanism to foster content diversity. By prioritizing the structural relationships within learning histories, the proposed model effectively balances recommendation precision with pedagogical variety. Comprehensive experimental evaluations conducted on multiple real-world datasets demonstrate that LiveGraph surpasses contemporary baselines in both predictive accuracy and the breadth of exercise diversity.