L. Wang

Longwei Wang, Ifrat Ikhtear Uddin, KC Santosh

Medical image analysis faces two critical challenges: scarcity of labeled data and lack of model interpretability, both hindering clinical AI deployment. Few-shot learning (FSL) addresses data limitations but lacks transparency in predictions. Active learning (AL) methods optimize data acquisition but overlook interpretability of acquired samples. We propose a dual-framework solution: Expert-Guided Explainable Few-Shot Learning (EGxFSL) and Explainability-Guided AL (xGAL). EGxFSL integrates radiologist-defined regions-of-interest as spatial supervision via Grad-CAM-based Dice loss, jointly optimized with prototypical classification for interpretable few-shot learning. xGAL introduces iterative sample acquisition prioritizing both predictive uncertainty and attention misalignment, creating a closed-loop framework where explainability guides training and sample selection synergistically. On the BraTS (MRI), VinDr-CXR (chest X-ray), and SIIM-COVID-19 (chest X-ray) datasets, we achieve accuracies of 92\%, 76\%, and 62\%, respectively, consistently outperforming non-guided baselines across all datasets. Under severe data constraints, xGAL achieves 76\% accuracy with only 680 samples versus 57\% for random sampling. Grad-CAM visualizations demonstrate guided models focus on diagnostically relevant regions, with generalization validated on breast ultrasound confirming cross-modality applicability.

Longwei Wang, Mohammad Navid Nayyem, Abdullah Al Rakin et al.

The growing reliance on deep learning models in safety-critical domains such as healthcare and autonomous navigation underscores the need for defenses that are both robust to adversarial perturbations and transparent in their decision-making. In this paper, we identify a connection between interpretability and robustness that can be directly leveraged during training. Specifically, we observe that spurious, unstable, or semantically irrelevant features identified through Local Interpretable Model-Agnostic Explanations (LIME) contribute disproportionately to adversarial vulnerability. Building on this insight, we introduce an attribution-guided refinement framework that transforms LIME from a passive diagnostic into an active training signal. Our method systematically suppresses spurious features using feature masking, sensitivity-aware regularization, and adversarial augmentation in a closed-loop refinement pipeline. This approach does not require additional datasets or model architectures and integrates seamlessly into standard adversarial training. Theoretically, we derive an attribution-aware lower bound on adversarial distortion that formalizes the link between explanation alignment and robustness. Empirical evaluations on CIFAR-10, CIFAR-10-C, and CIFAR-100 demonstrate substantial improvements in adversarial robustness and out-of-distribution generalization.