Xiaoming Zhang

Xiaoming Zhang, Ming Wang, Xiaocui Yang et al.

Multi-hop Question Answering (QA) necessitates complex reasoning by integrating multiple pieces of information to resolve intricate questions. However, existing QA systems encounter challenges such as outdated information, context window length limitations, and an accuracy-quantity trade-off. To address these issues, we propose a novel framework, the Hierarchical Retrieval-Augmented Generation Model with Rethink (HiRAG), comprising Decomposer, Definer, Retriever, Filter, and Summarizer five key modules. We introduce a new hierarchical retrieval strategy that incorporates both sparse retrieval at the document level and dense retrieval at the chunk level, effectively integrating their strengths. Additionally, we propose a single-candidate retrieval method to mitigate the limitations of multi-candidate retrieval. We also construct two new corpora, Indexed Wikicorpus and Profile Wikicorpus, to address the issues of outdated and insufficient knowledge. Our experimental results on four datasets demonstrate that HiRAG outperforms state-of-the-art models across most metrics, and our Indexed Wikicorpus is effective. The code for HiRAG is available at https://github.com/2282588541a/HiRAG

Chengxing Xie, Xiaoming Zhang, Linze Li et al.

Efficient and lightweight single-image super-resolution (SISR) has achieved remarkable performance in recent years. One effective approach is the use of large kernel designs, which have been shown to improve the performance of SISR models while reducing their computational requirements. However, current state-of-the-art (SOTA) models still face problems such as high computational costs. To address these issues, we propose the Large Kernel Distillation Network (LKDN) in this paper. Our approach simplifies the model structure and introduces more efficient attention modules to reduce computational costs while also improving performance. Specifically, we employ the reparameterization technique to enhance model performance without adding extra cost. We also introduce a new optimizer from other tasks to SISR, which improves training speed and performance. Our experimental results demonstrate that LKDN outperforms existing lightweight SR methods and achieves SOTA performance.

Bingyu Yan, Xiaoming Zhang, Jinyu Hou et al.

While Large Language Model-based Multi-Agent Systems (LLM-MAS) demonstrate remarkable capabilities in solving complex tasks by orchestrating specialized agents and external tools, the implicit trust in tool outputs creates a critical attack surface. Existing tool attacks are limited by domain specificity or fixed and static templates. To address these challenges, we propose Evo-Attacker, which formulates the tool attack as a self-evolving, memory-augmented reinforcement learning process. Evo-Attacker constructs a dynamic attack memory and employs deliberative reasoning to retrieve adversarial patterns and strategize modifying interventions at critical moments. Furthermore, we introduce Attack-Flow GRPO to optimize intermediate reasoning steps via terminal outcomes, addressing the long-horizon credit assignment challenge. Comprehensive experiments demonstrate that Evo-Attacker consistently outperforms baselines, highlighting its generalization and evolutionary capabilities and the urgent need for defensive tool safeguards.

Zhaoxing Li, Hai-Feng Zhang, Xiaoming Zhang

Conventional Graph Contrastive Learning (GCL) on Text-Attributed Graphs (TAGs) relies on blind stochastic augmentations, inadvertently entangling task-relevant signals with noise. We propose SDM-SCR, a robust framework anchored in Approximate Orthogonal Decomposition. First, the Semantic Decoupling Module (SDM) leverages the instruction-following capability of Large Language Models (LLMs) to actively parse raw attributes into asymmetric, task-oriented signal and noise views. This shifts the paradigm from random perturbation to semantic-aware disentanglement. Subsequently, Semantic Consistency Regularization (SCR) exploits the spectral observation that semantic signals are topologically smooth while residual noise is high-frequency. SCR functions as a selective spectral filter, enforcing consistency only on the signal subspace to eliminate LLM hallucinations without over-smoothing. This ``Disentangle-then-Refine'' mechanism ensures rigorous signal purification. Extensive experiments demonstrate that SDM-SCR achieves SOTA performance in accuracy and efficiency.

Ming Wang, Yuanzhong Liu, Xiaoyu Liang et al.

LLMs have demonstrated commendable performance across diverse domains. Nevertheless, formulating high-quality prompts to assist them in their work poses a challenge for non-AI experts. Existing research in prompt engineering suggests somewhat scattered optimization principles and designs empirically dependent prompt optimizers. Unfortunately, these endeavors lack a structural design, incurring high learning costs and it is not conducive to the iterative updating of prompts, especially for non-AI experts. Inspired by structured reusable programming languages, we propose LangGPT, a structural prompt design framework. Furthermore, we introduce Minstrel, a multi-generative agent system with reflection to automate the generation of structural prompts. Experiments and the case study illustrate that structural prompts generated by Minstrel or written manually significantly enhance the performance of LLMs. Furthermore, we analyze the ease of use of structural prompts through a user survey in our online community.

Wei Huang, Wei Liu, Xiaoming Zhang et al.

The early detection and precise diagnosis of liver tumors are tasks of critical clinical value, yet they pose significant challenges due to the high heterogeneity and variability of liver tumors. In this work, a precise LIver tumor DIAgnosis network on multi-phase contrast-enhance CT, named LIDIA, is proposed for real-world scenario. To fully utilize all available phases in contrast-enhanced CT, LIDIA first employs the iterative fusion module to aggregate variable numbers of image phases, thereby capturing the features of lesions at different phases for better tumor diagnosis. To effectively mitigate the high heterogeneity problem of liver tumors, LIDIA incorporates asymmetric contrastive learning to enhance the discriminability between different classes. To evaluate our method, we constructed a large-scale dataset comprising 1,921 patients and 8,138 lesions. LIDIA has achieved an average AUC of 93.6% across eight different types of lesions, demonstrating its effectiveness. Besides, LIDIA also demonstrated strong generalizability with an average AUC of 89.3% when tested on an external cohort of 828 patients.

Chunli Li, Xiaoming Zhang, Yuan Gao et al.

Esophageal varices (EV), a serious health concern resulting from portal hypertension, are traditionally diagnosed through invasive endoscopic procedures. Despite non-contrast computed tomography (NC-CT) imaging being a less expensive and non-invasive imaging modality, it has yet to gain full acceptance as a primary clinical diagnostic tool for EV evaluation. To overcome existing diagnostic challenges, we present the Multi-Organ-cOhesion-Network (MOON), a novel framework enhancing the analysis of critical organ features in NC-CT scans for effective assessment of EV. Drawing inspiration from the thorough assessment practices of radiologists, MOON establishes a cohesive multiorgan analysis model that unifies the imaging features of the related organs of EV, namely esophagus, liver, and spleen. This integration significantly increases the diagnostic accuracy for EV. We have compiled an extensive NC-CT dataset of 1,255 patients diagnosed with EV, spanning three grades of severity. Each case is corroborated by endoscopic diagnostic results. The efficacy of MOON has been substantiated through a validation process involving multi-fold cross-validation on 1,010 cases and an independent test on 245 cases, exhibiting superior diagnostic performance compared to methods focusing solely on the esophagus (for classifying severe grade: AUC of 0.864 versus 0.803, and for moderate to severe grades: AUC of 0.832 versus 0.793). To our knowledge, MOON is the first work to incorporate a synchronized multi-organ NC-CT analysis for EV assessment, providing a more acceptable and minimally invasive alternative for patients compared to traditional endoscopy.

Jinting Luo, Ru Li, Chengzhi Jiang et al.

We propose Diff-Shadow, a global-guided diffusion model for shadow removal. Previous transformer-based approaches can utilize global information to relate shadow and non-shadow regions but are limited in their synthesis ability and recover images with obvious boundaries. In contrast, diffusion-based methods can generate better content but they are not exempt from issues related to inconsistent illumination. In this work, we combine the advantages of diffusion models and global guidance to achieve shadow-free restoration. Specifically, we propose a parallel UNets architecture: 1) the local branch performs the patch-based noise estimation in the diffusion process, and 2) the global branch recovers the low-resolution shadow-free images. A Reweight Cross Attention (RCA) module is designed to integrate global contextual information of non-shadow regions into the local branch. We further design a Global-guided Sampling Strategy (GSS) that mitigates patch boundary issues and ensures consistent illumination across shaded and unshaded regions in the recovered image. Comprehensive experiments on datasets ISTD, ISTD+, and SRD have demonstrated the effectiveness of Diff-Shadow. Compared to state-of-the-art methods, our method achieves a significant improvement in terms of PSNR, increasing from 32.33dB to 33.69dB on the ISTD dataset.

Litian Zhang, Xiaoming Zhang, Ziming Guo et al.

Multimodal summarization (MS) aims to generate a summary from multimodal input. Previous works mainly focus on textual semantic coverage metrics such as ROUGE, which considers the visual content as supplemental data. Therefore, the summary is ineffective to cover the semantics of different modalities. This paper proposes a multi-task cross-modality learning framework (CISum) to improve multimodal semantic coverage by learning the cross-modality interaction in the multimodal article. To obtain the visual semantics, we translate images into visual descriptions based on the correlation with text content. Then, the visual description and text content are fused to generate the textual summary to capture the semantics of the multimodal content, and the most relevant image is selected as the visual summary. Furthermore, we design an automatic multimodal semantics coverage metric to evaluate the performance. Experimental results show that CISum outperforms baselines in multimodal semantics coverage metrics while maintaining the excellent performance of ROUGE and BLEU.

Yao Qin, Yangyang Yan, Jinhua Pang et al.

The integration of Large Language Models (LLMs) into life sciences has catalyzed the development of "AI Scientists." However, translating these theoretical capabilities into deployment-ready research environments exposes profound infrastructural vulnerabilities. Current frameworks are bottlenecked by fragile JSON-based tool-calling protocols, easily disrupted execution sandboxes that lose graphical outputs, and rigid conversational interfaces inherently ill-suited for high-dimensional scientific data.We introduce BloClaw, a unified, multi-modal operating system designed for Artificial Intelligence for Science (AI4S). BloClaw reconstructs the Agent-Computer Interaction (ACI) paradigm through three architectural innovations: (1) An XML-Regex Dual-Track Routing Protocol that statistically eliminates serialization failures (0.2% error rate vs. 17.6% in JSON); (2) A Runtime State Interception Sandbox that utilizes Python monkey-patching to autonomously capture and compile dynamic data visualizations (Plotly/Matplotlib), circumventing browser CORS policies; and (3) A State-Driven Dynamic Viewport UI that morphs seamlessly between a minimalist command deck and an interactive spatial rendering engine. We comprehensively benchmark BloClaw across cheminformatics (RDKit), de novo 3D protein folding via ESMFold, molecular docking, and autonomous Retrieval-Augmented Generation (RAG), establishing a highly robust, self-evolving paradigm for computational research assistants. The open-source repository is available at https://github.com/qinheming/BloClaw.

Jinxi Xiang, Siyu Hou, Yuchen Li et al.

Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present \textbf{\ours} (\textbf{S}patial \textbf{T}ranscriptomics and hist\textbf{O}logy \textbf{R}epresentation \textbf{M}odel), a foundation model trained on 1.2 million spatially resolved transcriptomic profiles with matched histology across 18 organs. Using a hierarchical architecture integrating morphological features, gene expression, and spatial context, STORM bridges imaging and omics through robust molecular--morphological representations. STORM enhances spatial domain discovery, producing biologically coherent tissue maps, and outperforms existing methods in predicting spatial gene expression from H\&E images across 11 tumor types. The model is platform-agnostic, performing consistently across Visium, Xenium, Visium HD, and CosMx. Applied to 23 independent cohorts comprising 7,245 patients, STORM significantly improves immunotherapy response prediction and prognostication over established biomarkers, providing a scalable framework for spatially informed discovery and clinical precision medicine.

Xiaoming Zhang, Chunli Li, Jiacheng Hao et al.

Esophageal varices (EV) represent a critical complication of portal hypertension, affecting approximately 60% of cirrhosis patients with a significant bleeding risk of ~30%. While traditionally diagnosed through invasive endoscopy, non-contrast computed tomography (NCCT) presents a potential non-invasive alternative that has yet to be fully utilized in clinical practice. We present Multi-Organ-COhesion Network++ (MOON++), a novel multimodal framework that enhances EV assessment through comprehensive analysis of NCCT scans. Inspired by clinical evidence correlating organ volumetric relationships with liver disease severity, MOON++ synthesizes imaging characteristics of the esophagus, liver, and spleen through multimodal learning. We evaluated our approach using 1,631 patients, those with endoscopically confirmed EV were classified into four severity grades. Validation in 239 patient cases and independent testing in 289 cases demonstrate superior performance compared to conventional single organ methods, achieving an AUC of 0.894 versus 0.803 for the severe grade EV classification (G3 versus <G3) and 0.921 versus 0.793 for the differentiation of moderate to severe grades (>=G2 versus <G2). We conducted a reader study involving experienced radiologists to further validate the performance of MOON++. To our knowledge, MOON++ represents the first comprehensive multi-organ NCCT analysis framework incorporating clinical knowledge priors for EV assessment, potentially offering a promising non-invasive diagnostic alternative.

Ziyi Zhou, Xiaoming Zhang, Litian Zhang et al.

Existing benchmarks for fake news detection have significantly contributed to the advancement of models in assessing the authenticity of news content. However, these benchmarks typically focus solely on news pertaining to a single semantic topic or originating from a single platform, thereby failing to capture the diversity of multi-domain news in real scenarios. In order to understand fake news across various domains, the external knowledge and fine-grained annotations are indispensable to provide precise evidence and uncover the diverse underlying strategies for fabrication, which are also ignored by existing benchmarks. To address this gap, we introduce a novel multi-domain knowledge-enhanced benchmark with fine-grained annotations, named \textbf{FineFake}. FineFake encompasses 16,909 data samples spanning six semantic topics and eight platforms. Each news item is enriched with multi-modal content, potential social context, semi-manually verified common knowledge, and fine-grained annotations that surpass conventional binary labels. Furthermore, we formulate three challenging tasks based on FineFake and propose a knowledge-enhanced domain adaptation network. Extensive experiments are conducted on FineFake under various scenarios, providing accurate and reliable benchmarks for future endeavors. The entire FineFake project is publicly accessible as an open-source repository at \url{https://github.com/Accuser907/FineFake}.

Xiaole Zhao, Linze Li, Chengxing Xie et al.

Transformer-based deep models for single image super-resolution (SISR) have greatly improved the performance of lightweight SISR tasks in recent years. However, they often suffer from heavy computational burden and slow inference due to the complex calculation of multi-head self-attention (MSA), seriously hindering their practical application and deployment. In this work, we present an efficient SR model to mitigate the dilemma between model efficiency and SR performance, which is dubbed Entropy Attention and Receptive Field Augmentation network (EARFA), and composed of a novel entropy attention (EA) and a shifting large kernel attention (SLKA). From the perspective of information theory, EA increases the entropy of intermediate features conditioned on a Gaussian distribution, providing more informative input for subsequent reasoning. On the other hand, SLKA extends the receptive field of SR models with the assistance of channel shifting, which also favors to boost the diversity of hierarchical features. Since the implementation of EA and SLKA does not involve complex computations (such as extensive matrix multiplications), the proposed method can achieve faster nonlinear inference than Transformer-based SR models while maintaining better SR performance. Extensive experiments show that the proposed model can significantly reduce the delay of model inference while achieving the SR performance comparable with other advanced models.

Zhangyang Gao, Hao Wang, Cheng Tan et al.

This study investigates the current landscape and future directions of protein foundation model research. While recent advancements have transformed protein science and engineering, the field lacks a comprehensive benchmark for fair evaluation and in-depth understanding. Since ESM-1B, numerous protein foundation models have emerged, each with unique datasets and methodologies. However, evaluations often focus on limited tasks tailored to specific models, hindering insights into broader generalization and limitations. Specifically, researchers struggle to understand the relationships between tasks, assess how well current models perform across them, and determine the criteria in developing new foundation models. To fill this gap, we present PFMBench, a comprehensive benchmark evaluating protein foundation models across 38 tasks spanning 8 key areas of protein science. Through hundreds of experiments on 17 state-of-the-art models across 38 tasks, PFMBench reveals the inherent correlations between tasks, identifies top-performing models, and provides a streamlined evaluation protocol. Code is available at \href{https://github.com/biomap-research/PFMBench}{\textcolor{blue}{GitHub}}.

Bingyu Yan, Xiaoming Zhang, Jinyu Hou et al.

LLM-based multi-agent systems (LLM-MAS) have become a promising paradigm for solving complex tasks through role specialization, tool use, memory, and collaborative reasoning. However, these interactions create new security risks that malicious instructions injected through messages, tools, or memories can propagate across agents and rounds, causing system-level compromise. Existing defenses largely rely on local filtering or graph-based anomaly detection, but they often fail to trace fine-grained propagation paths or remediate contaminated states without disrupting benign collaboration. We propose PropGuard, a propagation-aware framework for safeguarding LLM-MAS. PropGuard constructs a dual-view spatio-temporal graph that combines response-centric risk estimation with full-state evidence preservation. Guided by these risk priors, a GE-GRPO trained inspector sequentially explores the full-state graph to recover compact suspicious propagation subgraphs. PropGuard then verifies harmful propagation through subgraph-aware diagnosis and applies source-guided remediation to correct upstream contamination and replay affected downstream interactions. Experiments across four communication architectures and five attack settings demonstrate that PropGuard consistently lowers attack success while maintaining high task-level defense success, achieving a favorable effectiveness--efficiency trade-off.

Bingyu Yan, Zhibo Zhou, Litian Zhang et al.

Large language model-based multi-agent systems have recently gained significant attention due to their potential for complex, collaborative, and intelligent problem-solving capabilities. Existing surveys typically categorize LLM-based multi-agent systems (LLM-MAS) according to their application domains or architectures, overlooking the central role of communication in coordinating agent behaviors and interactions. To address this gap, this paper presents a comprehensive survey of LLM-MAS from a communication-centric perspective. Specifically, we propose a structured framework that integrates system-level communication (architecture, goals, and protocols) with system internal communication (strategies, paradigms, objects, and content), enabling a detailed exploration of how agents interact, negotiate, and achieve collective intelligence. Through an extensive analysis of recent literature, we identify key components in multiple dimensions and summarize their strengths and limitations. In addition, we highlight current challenges, including communication efficiency, security vulnerabilities, inadequate benchmarking, and scalability issues, and outline promising future research directions. This review aims to help researchers and practitioners gain a clear understanding of the communication mechanisms in LLM-MAS, thereby facilitating the design and deployment of robust, scalable, and secure multi-agent systems.

Ming Wang, Yuanzhong Liu, Xiaoyu Liang et al.

LLMs have demonstrated commendable performance across diverse domains. Nevertheless, formulating high-quality prompts to instruct LLMs proficiently poses a challenge for non-AI experts. Existing research in prompt engineering suggests somewhat scattered optimization principles and designs empirically dependent prompt optimizers. Unfortunately, these endeavors lack a structured design template, incurring high learning costs and resulting in low reusability. In addition, it is not conducive to the iterative updating of prompts. Inspired by structured reusable programming languages, we propose LangGPT, a dual-layer prompt design framework as the programming language for LLMs. LangGPT has an easy-to-learn normative structure and provides an extended structure for migration and reuse. Experiments illustrate that LangGPT significantly enhances the performance of LLMs. Moreover, the case study shows that LangGPT leads LLMs to generate higher-quality responses. Furthermore, we analyzed the ease of use and reusability of LangGPT through a user survey in our online community.

Haiping Ma, Changqian Wang, Hengshu Zhu et al.

Cognitive diagnosis is a crucial task in computational education, aimed at evaluating students' proficiency levels across various knowledge concepts through exercises. Current models, however, primarily rely on students' answered exercises, neglecting the complex and rich information contained in un-interacted exercises. While recent research has attempted to leverage the data within un-interacted exercises linked to interacted knowledge concepts, aiming to address the long-tail issue, these studies fail to fully explore the informative, un-interacted exercises related to broader knowledge concepts. This oversight results in diminished performance when these models are applied to comprehensive datasets. In response to this gap, we present the Collaborative-aware Mixed Exercise Sampling (CMES) framework, which can effectively exploit the information present in un-interacted exercises linked to un-interacted knowledge concepts. Specifically, we introduce a novel universal sampling module where the training samples comprise not merely raw data slices, but enhanced samples generated by combining weight-enhanced attention mixture techniques. Given the necessity of real response labels in cognitive diagnosis, we also propose a ranking-based pseudo feedback module to regulate students' responses on generated exercises. The versatility of the CMES framework bolsters existing models and improves their adaptability. Finally, we demonstrate the effectiveness and interpretability of our framework through comprehensive experiments on real-world datasets.

Bo Cheng, Songjun Cao, Xiaoming Zhang et al.

Achieving robust generalization against unseen attacks remains a challenge in Audio Deepfake Detection (ADD), driven by the rapid evolution of generative models. To address this, we propose a framework centered on hard sample classification. The core idea is that a model capable of distinguishing challenging hard samples is inherently equipped to handle simpler cases effectively. We investigate multiple reconstruction paradigms, identifying the diffusion-based method as optimal for generating hard samples. Furthermore, we leverage multi-layer feature aggregation and introduce a Regularization-Assisted Contrastive Learning (RACL) objective to enhance generalizability. Experiments demonstrate the superior generalization of our approach, with our best model achieving a significant reduction in the average Equal Error Rate (EER) compared to the baseline.

Chengxing Xie, Xiaoming Zhang, Linze Li et al.

Image super-resolution (SR) has significantly advanced through the adoption of Transformer architectures. However, conventional techniques aimed at enlarging the self-attention window to capture broader contexts come with inherent drawbacks, especially the significantly increased computational demands. Moreover, the feature perception within a fixed-size window of existing models restricts the effective receptive field (ERF) and the intermediate feature diversity. We demonstrate that a flexible integration of attention across diverse spatial extents can yield significant performance enhancements. In line with this insight, we introduce Multi-Range Attention Transformer (MAT) for SR tasks. MAT leverages the computational advantages inherent in dilation operation, in conjunction with self-attention mechanism, to facilitate both multi-range attention (MA) and sparse multi-range attention (SMA), enabling efficient capture of both regional and sparse global features. Combined with local feature extraction, MAT adeptly capture dependencies across various spatial ranges, improving the diversity and efficacy of its feature representations. We also introduce the MSConvStar module, which augments the model's ability for multi-range representation learning. Comprehensive experiments show that our MAT exhibits superior performance to existing state-of-the-art SR models with remarkable efficiency (~3.3 faster than SRFormer-light).

Zicheng Liu, Siyuan Li, Zhiyuan Chen et al.

The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. Although modern biological pre-trained models have achieved great success in analyzing these macromolecules individually, their interconnected nature remains underexplored. This paper follows the guidance of the central dogma to redesign both the data and model pipeline and offers a comprehensive framework, Life-Code, that spans different biological functions. As for data flow, we propose a unified pipeline to integrate multi-omics data by reverse-transcribing RNA and reverse-translating amino acids into nucleotide-based sequences. As for the model, we design a codon tokenizer and a hybrid long-sequence architecture to encode the interactions between coding and non-coding regions through masked modeling pre-training. To model the translation and folding process with coding sequences, Life-Code learns protein structures of the corresponding amino acids by knowledge distillation from off-the-shelf protein language models. Such designs enable Life-Code to capture complex interactions within genetic sequences, providing a more comprehensive understanding of multi-omics with the central dogma. Extensive experiments show that Life-Code achieves state-of-the-art results on various tasks across three omics, highlighting its potential for advancing multi-omics analysis and interpretation.

Xiangde Luo, Xiyue Wang, Feyisope Eweje et al.

Histopathology is essential for disease diagnosis and treatment decision-making. Recent advances in artificial intelligence (AI) have enabled the development of pathology foundation models that learn rich visual representations from large-scale whole-slide images (WSIs). However, existing models are often trained on disparate datasets using varying strategies, leading to inconsistent performance and limited generalizability. Here, we introduce ELF (Ensemble Learning of Foundation models), a novel framework that integrates five state-of-the-art pathology foundation models to generate unified slide-level representations. Trained on 53,699 WSIs spanning 20 anatomical sites, ELF leverages ensemble learning to capture complementary information from diverse models while maintaining high data efficiency. Unlike traditional tile-level models, ELF's slide-level architecture is particularly advantageous in clinical contexts where data are limited, such as therapeutic response prediction. We evaluated ELF across a wide range of clinical applications, including disease classification, biomarker detection, and response prediction to major anticancer therapies, cytotoxic chemotherapy, targeted therapy, and immunotherapy, across multiple cancer types. ELF consistently outperformed all constituent foundation models and existing slide-level models, demonstrating superior accuracy and robustness. Our results highlight the power of ensemble learning for pathology foundation models and suggest ELF as a scalable and generalizable solution for advancing AI-assisted precision oncology.

Ziyi Zhou, Xiaoming Zhang, Shenghan Tan et al.

The proliferation of fake news on social media platforms has exerted a substantial influence on society, leading to discernible impacts and deleterious consequences. Conventional deep learning methodologies employing small language models (SLMs) suffer from the necessity for extensive supervised training and the challenge of adapting to rapidly evolving circumstances. Large language models (LLMs), despite their robust zero-shot capabilities, have fallen short in effectively identifying fake news due to a lack of pertinent demonstrations and the dynamic nature of knowledge. In this paper, a novel framework Multi-Round Collaboration Detection (MRCD) is proposed to address these aforementioned limitations. The MRCD framework is capable of enjoying the merits from both LLMs and SLMs by integrating their generalization abilities and specialized functionalities, respectively. Our approach features a two-stage retrieval module that selects relevant and up-to-date demonstrations and knowledge, enhancing in-context learning for better detection of emerging news events. We further design a multi-round learning framework to ensure more reliable detection results. Our framework MRCD achieves SOTA results on two real-world datasets Pheme and Twitter16, with accuracy improvements of 7.4\% and 12.8\% compared to using only SLMs, which effectively addresses the limitations of current models and improves the detection of emergent fake news.

Bingyu Yan, Ziyi Zhou, Xiaoming Zhang et al.

Large language model-based multi-agent systems (LLM-MAS) effectively accomplish complex and dynamic tasks through inter-agent communication, but this reliance introduces substantial safety vulnerabilities. Existing attack methods targeting LLM-MAS either compromise agent internals or rely on direct and overt persuasion, which limit their effectiveness, adaptability, and stealthiness. In this paper, we propose MAST, a Multi-round Adaptive Stealthy Tampering framework designed to exploit communication vulnerabilities within the system. MAST integrates Monte Carlo Tree Search with Direct Preference Optimization to train an attack policy model that adaptively generates effective multi-round tampering strategies. Furthermore, to preserve stealthiness, we impose dual semantic and embedding similarity constraints during the tampering process. Comprehensive experiments across diverse tasks, communication architectures, and LLMs demonstrate that MAST consistently achieves high attack success rates while significantly enhancing stealthiness compared to baselines. These findings highlight the effectiveness, stealthiness, and adaptability of MAST, underscoring the need for robust communication safeguards in LLM-MAS.

Siyuan Li, Kai Yu, Anna Wang et al.

Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently designed DNA tokenizers, existing approaches with naive masked language modeling pre-training often fail to adapt to the varying complexities of genomic sequences. Leveraging Token Merging techniques, this paper introduces a hierarchical architecture that jointly optimizes a dynamic genomic tokenizer and latent Transformers with context-aware pre-training tasks. As for network structures, the tokenization module automatically chunks adjacent bases into words by stacking multiple layers of the differentiable token merging blocks with local-window constraints, then a Latent Encoder captures the global context of these merged words by full-attention blocks. Symmetrically employing a Latent Decoder and a Local Decoder, MergeDNA learns with two pre-training tasks: Merged Token Reconstruction simultaneously trains the dynamic tokenization module and adaptively filters important tokens, while Adaptive Masked Token Modeling learns to predict these filtered tokens to capture informative contents. Extensive experiments show that MergeDNA achieves superior performance on three popular DNA benchmarks and several multi-omics tasks with fine-tuning or zero-shot evaluation, outperforming typical tokenization methods and large-scale DNA foundation models.

Zekai Lin, Haoran Sun, Yucheng Guo et al.

Distinguishing pathogenic mutations from benign polymorphisms remains a critical challenge in precision medicine. EnTao-GPM, developed by Fudan University and BioMap, addresses this through three innovations: (1) Cross-species targeted pre-training on disease-relevant mammalian genomes (human, pig, mouse), leveraging evolutionary conservation to enhance interpretation of pathogenic motifs, particularly in non-coding regions; (2) Germline mutation specialization via fine-tuning on ClinVar and HGMD, improving accuracy for both SNVs and non-SNVs; (3) Interpretable clinical framework integrating DNA sequence embeddings with LLM-based statistical explanations to provide actionable insights. Validated against ClinVar, EnTao-GPM demonstrates superior accuracy in mutation classification. It revolutionizes genetic testing by enabling faster, more accurate, and accessible interpretation for clinical diagnostics (e.g., variant assessment, risk identification, personalized treatment) and research, advancing personalized medicine.

Litian Zhang, Xiaoming Zhang, Bingyu Yan et al.

The exponential growth of social media and generative AI has transformed information dissemination, fostering connectivity but also accelerating the spread of misinformation. Understanding information propagation dynamics and developing effective control strategies is essential to mitigate harmful content. Traditional models, such as SIR, provide basic insights but inadequately capture the complexities of online interactions. Advanced methods, including attention mechanisms and graph neural networks, enhance accuracy but typically overlook user psychology and behavioral dynamics. Large language models (LLMs), with their human-like reasoning, offer new potential for simulating psychological aspects of information spread. We introduce an LLM-based simulation environment capturing agents' evolving attitudes, emotions, and responses. Initial experiments, however, revealed significant gaps between LLM-generated behaviors and authentic human dynamics, especially in stance detection and psychological realism. A detailed evaluation through Social Information Processing Theory identified major discrepancies in goal-setting and feedback evaluation, stemming from the lack of emotional processing in standard LLM training. To address these issues, we propose the Social Information Processing-based Chain of Thought (SIP-CoT) mechanism enhanced by emotion-guided memory. This method improves the interpretation of social cues, personalization of goals, and evaluation of feedback. Experimental results confirm that SIP-CoT-enhanced LLM agents more effectively process social information, demonstrating behaviors, attitudes, and emotions closer to real human interactions. In summary, this research highlights critical limitations in current LLM-based propagation simulations and demonstrates how integrating SIP-CoT and emotional memory significantly enhances the social intelligence and realism of LLM agents.

Jiacheng Hao, Xiaoming Zhang, Wei Liu et al.

Focal liver lesions (FLL) are common clinical findings during physical examination. Early diagnosis and intervention of liver malignancies are crucial to improving patient survival. Although the current 3D segmentation paradigm can accurately detect lesions, it faces limitations in distinguishing between malignant and benign liver lesions, primarily due to its inability to differentiate subtle variations between different lesions. Furthermore, existing methods predominantly rely on specialized imaging modalities such as multi-phase contrast-enhanced CT and magnetic resonance imaging, whereas non-contrast CT (NCCT) is more prevalent in routine abdominal imaging. To address these limitations, we propose PLUS, a plug-and-play framework that enhances FLL analysis on NCCT images for arbitrary 3D segmentation models. In extensive experiments involving 8,651 patients, PLUS demonstrated a significant improvement with existing methods, improving the lesion-level F1 score by 5.66%, the malignant patient-level F1 score by 6.26%, and the benign patient-level F1 score by 4.03%. Our results demonstrate the potential of PLUS to improve malignant FLL screening using widely available NCCT imaging substantially.

Ziyi Zhou, Xiaoming Zhang, Litian Zhang et al.

The widespread dissemination of fake news on social media has significantly impacted society, resulting in serious consequences. Conventional deep learning methodologies employing small language models (SLMs) suffer from extensive supervised training requirements and difficulties adapting to evolving news environments due to data scarcity and distribution shifts. Large language models (LLMs), despite robust zero-shot capabilities, fall short in accurately detecting fake news owing to outdated knowledge and the absence of suitable demonstrations. In this paper, we propose a novel Continuous Collaborative Emergent Fake News Detection (C$^2$EFND) framework to address these challenges. The C$^2$EFND framework strategically leverages both LLMs' generalization power and SLMs' classification expertise via a multi-round collaborative learning framework. We further introduce a lifelong knowledge editing module based on a Mixture-of-Experts architecture to incrementally update LLMs and a replay-based continue learning method to ensure SLMs retain prior knowledge without retraining entirely. Extensive experiments on Pheme and Twitter16 datasets demonstrate that C$^2$EFND significantly outperforms existed methods, effectively improving detection accuracy and adaptability in continuous emergent fake news scenarios.

Zhaoxing Li, Xiaoming Zhang, Haifeng Zhang et al.

The integration of Large Language Models (LLMs) with Graph Neural Networks (GNNs) has recently been explored to enhance the capabilities of Text Attribute Graphs (TAGs). Most existing methods feed textual descriptions of the graph structure or neighbouring nodes' text directly into LLMs. However, these approaches often cause LLMs to treat structural information simply as general contextual text, thus limiting their effectiveness in graph-related tasks. In this paper, we introduce LanSAGNN (Language Semantic Anisotropic Graph Neural Network), a framework that extends the concept of anisotropic GNNs to the natural language level. This model leverages LLMs to extract tailor-made semantic information for node pairs, effectively capturing the unique interactions within node relationships. In addition, we propose an efficient dual-layer LLMs finetuning architecture to better align LLMs' outputs with graph tasks. Experimental results demonstrate that LanSAGNN significantly enhances existing LLM-based methods without increasing complexity while also exhibiting strong robustness against interference.

YiJun Tang, ChenChen Ying, ChengZhe Xia et al.

Asteroid shape inversion using photometric data has been a key area of study in planetary science and astronomical research.However, the current methods for asteroid shape inversion require extensive iterative calculations, making the process time-consuming and prone to becoming stuck in local optima. We directly established a mapping between photometric data and shape distribution through deep neural networks. In addition, we used 3D point clouds to represent asteroid shapes and utilized the deviation between the light curves of non-convex asteroids and their convex hulls to predict the concave areas of non-convex asteroids. We compared the results of different shape models using the Chamfer distance between traditional methods and ours and found that our method performs better, especially when handling special shapes. For the detection of concave areas on the convex hull, the intersection over union (IoU) of our predictions reached 0.89. We further validated this method using observational data from the Lowell Observatory to predict the convex shapes of the asteroids 3337 Milo and 1289 Kuta, and conducted light curve fitting experiments. The experimental results demonstrated the robustness and adaptability of the method

Yuxia Chen, Pengcheng Fang, Jianhui Yu et al.

High-resolution remote sensing (HRS) semantic segmentation extracts key objects from high-resolution coverage areas. However, objects of the same category within HRS images generally show significant differences in scale and shape across diverse geographical environments, making it difficult to fit the data distribution. Additionally, a complex background environment causes similar appearances of objects of different categories, which precipitates a substantial number of objects into misclassification as background. These issues make existing learning algorithms sub-optimal. In this work, we solve the above-mentioned problems by proposing a High-resolution remote sensing network (Hi-ResNet) with efficient network structure designs, which consists of a funnel module, a multi-branch module with stacks of information aggregation (IA) blocks, and a feature refinement module, sequentially, and Class-agnostic Edge Aware (CEA) loss. Specifically, we propose a funnel module to downsample, which reduces the computational cost, and extract high-resolution semantic information from the initial input image. Secondly, we downsample the processed feature images into multi-resolution branches incrementally to capture image features at different scales and apply IA blocks, which capture key latent information by leveraging attention mechanisms, for effective feature aggregation, distinguishing image features of the same class with variant scales and shapes. Finally, our feature refinement module integrate the CEA loss function, which disambiguates inter-class objects with similar shapes and increases the data distribution distance for correct predictions. With effective pre-training strategies, we demonstrated the superiority of Hi-ResNet over state-of-the-art methods on three HRS segmentation benchmarks.

Litian Zhang, Xiaoming Zhang, Junshu Pan et al.

Multimodal summarization with multimodal output (MSMO) generates a summary with both textual and visual content. Multimodal news report contains heterogeneous contents, which makes MSMO nontrivial. Moreover, it is observed that different modalities of data in the news report correlate hierarchically. Traditional MSMO methods indistinguishably handle different modalities of data by learning a representation for the whole data, which is not directly adaptable to the heterogeneous contents and hierarchical correlation. In this paper, we propose a hierarchical cross-modality semantic correlation learning model (HCSCL) to learn the intra- and inter-modal correlation existing in the multimodal data. HCSCL adopts a graph network to encode the intra-modal correlation. Then, a hierarchical fusion framework is proposed to learn the hierarchical correlation between text and images. Furthermore, we construct a new dataset with relevant image annotation and image object label information to provide the supervision information for the learning procedure. Extensive experiments on the dataset show that HCSCL significantly outperforms the baseline methods in automatic summarization metrics and fine-grained diversity tests.

Ruiqing Yan, Lanchang Sun, Fang Wang et al.

Though pre-trained language models such as Bert and XLNet, have rapidly advanced the state-of-the-art on many NLP tasks, they implicit semantics only relying on surface information between words in corpus. Intuitively, background knowledge influences the efficacy of understanding. Inspired by this common sense, we focus on improving model pretraining by leveraging explicit knowledge. Different from recent research that optimize pretraining model by knowledge masking strategies, we propose a simple but general method to combine explicit knowledge with pretraining. To be specific, we first match knowledge facts from knowledge graph (KG) and then add a knowledge injunction layer to transformer directly without changing its architecture. The present study seeks to find the direct impact of explicit knowledge on transformer per-training. We conduct experiments on various datasets for different downstream tasks. The experimental results show that solely by adding external knowledge to transformer can improve the learning performance on many NLP tasks.

Jun Chen, Xiaoming Zhang, Yu Wu et al.

In this paper, we study automatic keyphrase generation. Although conventional approaches to this task show promising results, they neglect correlation among keyphrases, resulting in duplication and coverage issues. To solve these problems, we propose a new sequence-to-sequence architecture for keyphrase generation named CorrRNN, which captures correlation among multiple keyphrases in two ways. First, we employ a coverage vector to indicate whether the word in the source document has been summarized by previous phrases to improve the coverage for keyphrases. Second, preceding phrases are taken into account to eliminate duplicate phrases and improve result coherence. Experiment results show that our model significantly outperforms the state-of-the-art method on benchmark datasets in terms of both accuracy and diversity.

Yang Yang, Haoyan Liu, Xia Hu et al.

The number of missing people (i.e., people who get lost) greatly increases in recent years. It is a serious worldwide problem, and finding the missing people consumes a large amount of social resources. In tracking and finding these missing people, timely data gathering and analysis actually play an important role. With the development of social media, information about missing people can get propagated through the web very quickly, which provides a promising way to solve the problem. The information in online social media is usually of heterogeneous categories, involving both complex social interactions and textual data of diverse structures. Effective fusion of these different types of information for addressing the missing people identification problem can be a great challenge. Motivated by the multi-instance learning problem and existing social science theory of "homophily", in this paper, we propose a novel r-instance (RI) learning model.

Feiran Huang, Xiaoming Zhang, Zhoujun Li et al.

Learning social media data embedding by deep models has attracted extensive research interest as well as boomed a lot of applications, such as link prediction, classification, and cross-modal search. However, for social images which contain both link information and multimodal contents (e.g., text description, and visual content), simply employing the embedding learnt from network structure or data content results in sub-optimal social image representation. In this paper, we propose a novel social image embedding approach called Deep Multimodal Attention Networks (DMAN), which employs a deep model to jointly embed multimodal contents and link information. Specifically, to effectively capture the correlations between multimodal contents, we propose a multimodal attention network to encode the fine-granularity relation between image regions and textual words. To leverage the network structure for embedding learning, a novel Siamese-Triplet neural network is proposed to model the links among images. With the joint deep model, the learnt embedding can capture both the multimodal contents and the nonlinear network information. Extensive experiments are conducted to investigate the effectiveness of our approach in the applications of multi-label classification and cross-modal search. Compared to state-of-the-art image embeddings, our proposed DMAN achieves significant improvement in the tasks of multi-label classification and cross-modal search.

Xiaoming Zhang, Zhoujun Li, Senzhang Wang et al.

The vast amount of geo-tagged social images has attracted great attention in research of predicting location using the plentiful content of images, such as visual content and textual description. Most of the existing researches use the text-based or vision-based method to predict location. There still exists a problem: how to effectively exploit the correlation between different types of content as well as their geographical distributions for location prediction. In this paper, we propose to predict image location by learning the latent relation between geographical location and multiple types of image content. In particularly, we propose a geographical topic model GTMI (geographical topic model of social image) to integrate multiple types of image content as well as the geographical distributions, In GTMI, image topic is modeled on both text vocabulary and visual feature. Each region has its own distribution over topics and hence has its own language model and vision pattern. The location of a new image is estimated based on the joint probability of image content and similarity measure on topic distribution between images. Experiment results demonstrate the performance of location prediction based on GTMI.