Feng Jiang

Siyuan Liu, Jiahui Xu, Feng Jiang et al.

Achieving human-like responsiveness is a critical yet challenging goal for cascaded spoken dialogue systems. Conventional ASR-LLM-TTS pipelines follow a strictly sequential paradigm, requiring complete transcription and full reasoning before speech synthesis can begin, which results in high response latency. We propose the Discourse-Aware Dual-Track Streaming Response (DDTSR) framework, a low-latency architecture that enables listen-while-thinking and speak-while-thinking. DDTSR is built upon three key mechanisms: (1) connective-guided small-large model synergy, where an auxiliary small model generates minimal-committal discourse connectives while a large model performs knowledge-intensive reasoning in parallel; (2) streaming-based cross-modal collaboration, which dynamically overlaps ASR, LLM inference, and TTS to advance the earliest speakable moment; and (3) curriculum-learning-based discourse continuity enhancement, which maintains coherence and logical consistency between early responses and subsequent reasoning outputs. Experiments on two spoken dialogue benchmarks demonstrate that DDTSR reduces response latency by 19%-51% while preserving discourse quality. Further analysis shows that DDTSR functions as a plug-and-play module compatible with diverse LLM backbones, and remains robust across varying utterance lengths, indicating strong practicality and scalability for real-time spoken interaction.

Jiahao Zhao, Feng Jiang, Shaowei Qin et al.

Large language models (LLMs) are increasingly applied in scientific research, offering new capabilities for knowledge discovery and reasoning. In single-cell biology, however, evaluation practices for both general and specialized LLMs remain inadequate: existing benchmarks are fragmented across tasks, adopt formats such as multiple-choice classification that diverge from real-world usage, and rely on metrics lacking interpretability and biological grounding. We present SC-ARENA, a natural language evaluation framework tailored to single-cell foundation models. SC-ARENA formalizes a virtual cell abstraction that unifies evaluation targets by representing both intrinsic attributes and gene-level interactions. Within this paradigm, we define five natural language tasks (cell type annotation, captioning, generation, perturbation prediction, and scientific QA) that probe core reasoning capabilities in cellular biology. To overcome the limitations of brittle string-matching metrics, we introduce knowledge-augmented evaluation, which incorporates external ontologies, marker databases, and scientific literature to support biologically faithful and interpretable judgments. Experiments and analysis across both general-purpose and domain-specialized LLMs demonstrate that (i) under the Virtual Cell unified evaluation paradigm, current models achieve uneven performance on biologically complex tasks, particularly those demanding mechanistic or causal understanding; and (ii) our knowledge-augmented evaluation framework ensures biological correctness, provides interpretable, evidence-grounded rationales, and achieves high discriminative capacity, overcoming the brittleness and opacity of conventional metrics. SC-Arena thus provides a unified and interpretable framework for assessing LLMs in single-cell biology, pointing toward the development of biology-aligned, generalizable foundation models.