John Marshall

Ehsan Vaghefi, David Squirrell, Songyang An et al.

Purpose: To create and evaluate the accuracy of an artificial intelligence Deep learning platform (ORAiCLE) capable of using only retinal fundus images to predict both an individuals overall 5 year cardiovascular risk (CVD) and the relative contribution of the component risk factors that comprise this risk. Methods: We used 165,907 retinal images from a database of 47,236 patient visits. Initially, each image was paired with biometric data age, ethnicity, sex, presence and duration of diabetes a HDL/LDL ratios as well as any CVD event wtihin 5 years of the retinal image acquisition. A risk score based on Framingham equations was calculated. The real CVD event rate was also determined for the individuals and overall population. Finally, ORAiCLE was trained using only age, ethnicity, sex plus retinal images. Results: Compared to Framingham-based score, ORAiCLE was up to 12% more accurate in prediciting cardiovascular event in he next 5-years, especially for the highest risk group of people. The reliability and accuracy of each of the restrictive models was suboptimal to ORAiCLE performance ,indicating that it was using data from both sets of data to derive its final results. Conclusion: Retinal photography is inexpensive and only minimal training is required to acquire them as fully automated, inexpensive camera systems are now widely available. As such, AI-based CVD risk algorithms such as ORAiCLE promise to make CV health screening more accurate, more afforadable and more accessible for all. Furthermore, ORAiCLE unique ability to assess the relative contribution of the components that comprise an individuals overall risk would inform treatment decisions based on the specific needs of an individual, thereby increasing the likelihood of positive health outcomes.

Prateek Chhikara, Ujjwal Pasupulety, John Marshall et al.

Social media platforms have enabled individuals suffering from mental illnesses to share their lived experiences and find the online support necessary to cope. However, many users fail to receive genuine clinical support, thus exacerbating their symptoms. Screening users based on what they post online can aid providers in administering targeted healthcare and minimize false positives. Pre-trained Language Models (LMs) can assess users' social media data and classify them in terms of their mental health risk. We propose a Question-Answering (QA) approach to assess mental health risk using the Unified-QA model on two large mental health datasets. To protect user data, we extend Unified-QA by anonymizing the model training process using differential privacy. Our results demonstrate the effectiveness of modeling risk assessment as a QA task, specifically for mental health use cases. Furthermore, the model's performance decreases by less than 1% with the inclusion of differential privacy. The proposed system's performance is indicative of a promising research direction that will lead to the development of privacy-aware diagnostic systems.

Xin Kai Lee, Ali Ramadhan, Andre Souza et al.

NORi is a machine-learned (ML) parameterization of ocean boundary layer turbulence that is physics-based and augmented with neural networks. NORi stands for neural ordinary differential equations (NODEs) Richardson number (Ri) closure. The physical parameterization is controlled by a Richardson number-dependent diffusivity and viscosity. The NODEs are trained to capture the entrainment through the base of the boundary layer, which cannot be represented with a local diffusive closure. The parameterization is trained using large-eddy simulations in an "a posteriori" fashion, where parameters are calibrated with a loss function that explicitly depends on the actual time-integrated variables of interest rather than the instantaneous subgrid fluxes, which are inherently noisy. NORi is designed for the realistic nonlinear equation of state of seawater and demonstrates excellent prediction and generalization capabilities in capturing entrainment dynamics under different convective strengths, oceanic background stratifications, rotation strengths, and surface wind forcings. NORi is numerically stable for at least 100 years of integration time in large-scale simulations, despite only being trained on 2-day horizons, and can be run with time steps as long as one hour. The highly expressive neural networks, combined with a physically-rigorous base closure, prove to be a robust paradigm for designing parameterizations for climate models where data requirements are drastically reduced, inference performance can be directly targeted and optimized, and numerical stability is implicitly encouraged during training.