Yang Claire Yang

Xiaojing Guo, Jiatai Lin, Yumian Jia et al.

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.

Benlei Cui, Shaoxuan He, Bukun Huang et al.

Despite achieving state-of-the-art generation quality, diffusion models are hindered by the substantial computational burden of their iterative sampling process. While feature caching techniques achieve effective acceleration at higher step counts (e.g., 50 steps), they exhibit critical limitations in the practical low-step regime of 20-30 steps. As the interval between steps increases, polynomial-based extrapolators like TaylorSeer suffer from error accumulation and trajectory drift. Meanwhile, conventional caching strategies often overlook the distinct dynamical properties of different denoising phases. To address these challenges, we propose Trajectory-Consistent Padé approximation, a feature prediction framework grounded in Padé approximation. By modeling feature evolution through rational functions, our approach captures asymptotic and transitional behaviors more accurately than Taylor-based methods. To enable stable and trajectory-consistent sampling under reduced step counts, TC-Padé incorporates (1) adaptive coefficient modulation that leverages historical cached residuals to detect subtle trajectory transitions, and (2) step-aware prediction strategies tailored to the distinct dynamics of early, mid, and late sampling stages. Extensive experiments on DiT-XL/2, FLUX.1-dev, and Wan2.1 across both image and video generation demonstrate the effectiveness of TC-Padé. For instance, TC-Padé achieves 2.88x acceleration on FLUX.1-dev and 1.72x on Wan2.1 while maintaining high quality across FID, CLIP, Aesthetic, and VBench-2.0 metrics, substantially outperforming existing feature caching methods.

Kaiyang Xing, Han Fang, Zhaoyun Chen et al.

Recent studies show that quantum neural networks (QNNs) generalize well in few-shot regimes. To extend this advantage to large-scale tasks, we propose Q-LoRA, a quantum-enhanced fine-tuning scheme that integrates lightweight QNNs into the low-rank adaptation (LoRA) adapter. Applied to AI-generated content (AIGC) detection, Q-LoRA consistently outperforms standard LoRA under few-shot settings. We analyze the source of this improvement and identify two possible structural inductive biases from QNNs: (i) phase-aware representations, which encode richer information across orthogonal amplitude-phase components, and (ii) norm-constrained transformations, which stabilize optimization via inherent orthogonality. However, Q-LoRA incurs non-trivial overhead due to quantum simulation. Motivated by our analysis, we further introduce H-LoRA, a fully classical variant that applies the Hilbert transform within the LoRA adapter to retain similar phase structure and constraints. Experiments on few-shot AIGC detection show that both Q-LoRA and H-LoRA outperform standard LoRA by over 5% accuracy, with H-LoRA achieving comparable accuracy at significantly lower cost in this task.