Guanting Chen

Fangyu Hao, Jiayu Yang, Yifan Zhu et al.

Lung cancer clinical decision support demands precise reasoning across complex, multi-stage oncological workflows. Existing multimodal large language models (MLLMs) fail to handle guideline-constrained staging and treatment reasoning. We formalize three oncological precision treatment (OPT) tasks for lung cancer, spanning TNM staging, treatment recommendation, and end-to-end clinical decision support. We introduce LungCURE, the first standardized multimodal benchmark built from 1,000 real-world, clinician-labeled cases across more than 10 hospitals. We further propose LCAgent, a multi-agent framework that ensures guideline-compliant lung cancer clinical decision-making by suppressing cascading reasoning errors across the clinical pathway. Experiments reveal large differences across various large language models (LLMs) in their capabilities for complex medical reasoning, when given precise treatment requirements. We further verify that LCAgent, as a simple yet effective plugin, enhances the reasoning performance of LLMs in real-world medical scenarios.

Yifan Zhu, Guanting Chen, Bing Wei et al.

Large language models perform well in short text generation but still struggle with long text generation, particularly under complex constraints. Such tasks involve multiple tightly coupled objectives, including global structural consistency, local semantic coherence, and constraint feasibility, forming a challenging constrained optimization problem. Existing approaches mainly rely on static planning or offline supervision, limiting effective coordination between global and local objectives during generation. To address these challenges, we propose HiFlow, a hierarchical feedback-driven optimization framework for constrained long text generation. HiFlow formulates generation as a two-level optimization process, consisting of a planning layer for global structure and constraint modeling, and a generation layer for conditioned text generation. By incorporating constraint-aware plan screening and closed-loop feedback at both levels, HiFlow enables joint optimization of planning quality and generation behavior, progressively guiding the model toward high-quality, constraint-satisfying outputs. Experiments on multiple backbones confirm HiFlow's effectiveness over baseline methods.