William M. Gallagher

Jean-Baptiste Truong, William Gallagher, Tian Guo et al.

This study identifies and proposes techniques to alleviate two key bottlenecks to executing deep neural networks in trusted execution environments (TEEs): page thrashing during the execution of convolutional layers and the decryption of large weight matrices in fully-connected layers. For the former, we propose a novel partitioning scheme, y-plane partitioning, designed to (i) provide consistent execution time when the layer output is large compared to the TEE secure memory; and (ii) significantly reduce the memory footprint of convolutional layers. For the latter, we leverage quantization and compression. In our evaluation, the proposed optimizations incurred latency overheads ranging from 1.09X to 2X baseline for a wide range of TEE sizes; in contrast, an unmodified implementation incurred latencies of up to 26X when running inside of the TEE.

Trevor Doherty, Susan McKeever, Nebras Al-Attar et al.

The diagnosis of prostate cancer is challenging due to the heterogeneity of its presentations, leading to the over diagnosis and treatment of non-clinically important disease. Accurate diagnosis can directly benefit a patient's quality of life and prognosis. Towards addressing this issue, we present a learning model for the automatic identification of prostate cancer. While many prostate cancer studies have adopted Raman spectroscopy approaches, none have utilised the combination of Raman Chemical Imaging (RCI) and other imaging modalities. This study uses multimodal images formed from stained Digital Histopathology (DP) and unstained RCI. The approach was developed and tested on a set of 178 clinical samples from 32 patients, containing a range of non-cancerous, Gleason grade 3 (G3) and grade 4 (G4) tissue microarray samples. For each histological sample, there is a pathologist labelled DP - RCI image pair. The hypothesis tested was whether multimodal image models can outperform single modality baseline models in terms of diagnostic accuracy. Binary non-cancer/cancer models and the more challenging G3/G4 differentiation were investigated. Regarding G3/G4 classification, the multimodal approach achieved a sensitivity of 73.8% and specificity of 88.1% while the baseline DP model showed a sensitivity and specificity of 54.1% and 84.7% respectively. The multimodal approach demonstrated a statistically significant 12.7% AUC advantage over the baseline with a value of 85.8% compared to 73.1%, also outperforming models based solely on RCI and median Raman spectra. Feature fusion of DP and RCI does not improve the more trivial task of tumour identification but does deliver an observed advantage in G3/G4 discrimination. Building on these promising findings, future work could include the acquisition of larger datasets for enhanced model generalization.