Hao Chang

Wei-Wen Hsu, Yongfang Wu, Chang Hao et al.

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification from the convolutional neural networks (CNN) are demonstrated in this study to provide comprehensive interpretability for the proposed CAD system using pathological knowledge. Methods: In the experiment, a total of 186 slides of WSIs were collected and classified into three categories: Non-Carcinoma, Ductal Carcinoma in Situ (DCIS), and Invasive Ductal Carcinoma (IDC). Instead of conducting pixel-wise classification into three classes directly, we designed a hierarchical framework with the multi-view scheme that performs lesion detection for region proposal at higher magnification first and then conducts lesion classification at lower magnification for each detected lesion. Results: The slide-level accuracy rate for three-category classification reaches 90.8% (99/109) through 5-fold cross-validation and achieves 94.8% (73/77) on the testing set. The experimental results show that the morphological characteristics and co-occurrence properties learned by the deep learning models for lesion classification are accordant with the clinical rules in diagnosis. Conclusion: The pathological interpretability of the deep features not only enhances the reliability of the proposed CAD system to gain acceptance from medical specialists, but also facilitates the development of deep learning frameworks for various tasks in pathology. Significance: This paper presents a CAD system for pathological image analysis, which fills the clinical requirements and can be accepted by medical specialists with providing its interpretability from the pathological perspective.

Hao Chang, Guochen Xie, Jun Yu et al.

Semi-supervised Fine-Grained Recognition is a challenge task due to the difficulty of data imbalance, high inter-class similarity and domain mismatch. Recent years, this field has witnessed great progress and many methods has gained great performance. However, these methods can hardly generalize to the large-scale datasets, such as Semi-iNat, as they are prone to suffer from noise in unlabeled data and the incompetence for learning features from imbalanced fine-grained data. In this work, we propose Bilateral-Branch Self-Training Framework (BiSTF), a simple yet effective framework to improve existing semi-supervised learning methods on class-imbalanced and domain-shifted fine-grained data. By adjusting the update frequency through stochastic epoch update, BiSTF iteratively retrains a baseline SSL model with a labeled set expanded by selectively adding pseudo-labeled samples from an unlabeled set, where the distribution of pseudo-labeled samples are the same as the labeled data. We show that BiSTF outperforms the existing state-of-the-art SSL algorithm on Semi-iNat dataset.

Hao Chang

As one kind of skin cancer, melanoma is very dangerous. Dermoscopy based early detection and recarbonization strategy is critical for melanoma therapy. However, well-trained dermatologists dominant the diagnostic accuracy. In order to solve this problem, many effort focus on developing automatic image analysis systems. Here we report a novel strategy based on deep learning technique, and achieve very high skin lesion segmentation and melanoma diagnosis accuracy: 1) we build a segmentation neural network (skin_segnn), which achieved very high lesion boundary detection accuracy; 2) We build another very deep neural network based on Google inception v3 network (skin_recnn) and its well-trained weight. The novel designed transfer learning based deep neural network skin_inceptions_v3_nn helps to achieve a high prediction accuracy.