Ajo Babu George

Yaqi Wang, Zhi Li, Chengyu Wu et al.

Cone-Beam Computed Tomography (CBCT) and Intraoral Scanning (IOS) are essential for digital dentistry, but annotated data scarcity limits automated solutions for pulp canal segmentation and cross-modal registration. To benchmark semi-supervised learning (SSL) in this domain, we organized the STSR 2025 Challenge at MICCAI 2025, featuring two tasks: (1) semi-supervised segmentation of teeth and pulp canals in CBCT, and (2) semi-supervised rigid registration of CBCT and IOS. We provided 60 labeled and 640 unlabeled IOS samples, plus 30 labeled and 250 unlabeled CBCT scans with varying resolutions and fields of view. The challenge attracted strong community participation, with top teams submitting open-source deep learning-based SSL solutions. For segmentation, leading methods used nnU-Net and Mamba-like State Space Models with pseudo-labeling and consistency regularization, achieving a Dice score of 0.967 and Instance Affinity of 0.738 on the hidden test set. For registration, effective approaches combined PointNetLK with differentiable SVD and geometric augmentation to handle modality gaps; hybrid neural-classical refinement enabled accurate alignment despite limited labels. All data and code are publicly available at https://github.com/ricoleehduu/STS-Challenge-2025 to ensure reproducibility.

Ajo Babu George, Anna Mariam John, Athul Anoop et al.

Artificial intelligence (AI)-enabled diagnostics in maxillofacial pathology require structured, high-quality multimodal datasets. However, existing resources provide limited ameloblastoma coverage and lack the format consistency needed for direct model training. We present a newly curated multimodal dataset specifically focused on ameloblastoma, integrating annotated radiological, histopathological, and intraoral clinical images with structured data derived from case reports. Natural language processing techniques were employed to extract clinically relevant features from textual reports, while image data underwent domain specific preprocessing and augmentation. Using this dataset, a multimodal deep learning model was developed to classify ameloblastoma variants, assess behavioral patterns such as recurrence risk, and support surgical planning. The model is designed to accept clinical inputs such as presenting complaint, age, and gender during deployment to enhance personalized inference. Quantitative evaluation demonstrated substantial improvements; variant classification accuracy increased from 46.2 percent to 65.9 percent, and abnormal tissue detection F1-score improved from 43.0 percent to 90.3 percent. Benchmarked against resources like MultiCaRe, this work advances patient-specific decision support by providing both a robust dataset and an adaptable multimodal AI framework.

Ajo Babu George, Pranav S, Kunal Agarwal

Objectives: To overcome challenges in diagnosing pericoronitis on panoramic radiographs, an AI-assisted assessment system integrating anatomical localization, pathological classification, and interpretability. Methods: A two-stage deep learning pipeline was implemented. The first stage used YOLOv8 to detect third molars and classify their anatomical positions and angulations based on Winter's classification. Detected regions were then fed into a second-stage classifier, a modified ResNet-50 architecture, for detecting radiographic features suggestive of pericoronitis. To enhance clinical trust, Grad-CAM was used to highlight key diagnostic regions on the radiographs. Results: The YOLOv8 component achieved 92% precision and 92.5% mean average precision. The ResNet-50 classifier yielded F1-scores of 88% for normal cases and 86% for pericoronitis. Radiologists reported 84% alignment between Grad-CAM and their diagnostic impressions, supporting the radiographic relevance of the interpretability output. Conclusion: The system shows strong potential for AI-assisted panoramic assessment, with explainable AI features that support clinical confidence.

Ajo Babu George, Sreehari J R Ajo Babu George, Sreehari J R Ajo Babu George et al.

Aims Late diagnosis of Oral Squamous Cell Carcinoma (OSCC) contributes significantly to its high global mortality rate, with over 50\% of cases detected at advanced stages and a 5-year survival rate below 50\% according to WHO statistics. This study aims to improve early detection of OSCC by developing a multimodal deep learning framework that integrates clinical, radiological, and histopathological images using a weighted ensemble of DenseNet-121 convolutional neural networks (CNNs). Material and Methods A retrospective study was conducted using publicly available datasets representing three distinct medical imaging modalities. Each modality-specific dataset was used to train a DenseNet-121 CNN via transfer learning. Augmentation and modality-specific preprocessing were applied to increase robustness. Predictions were fused using a validation-weighted ensemble strategy. Evaluation was performed using accuracy, precision, recall, F1-score. Results High validation accuracy was achieved for radiological (100\%) and histopathological (95.12\%) modalities, with clinical images performing lower (63.10\%) due to visual heterogeneity. The ensemble model demonstrated improved diagnostic robustness with an overall accuracy of 84.58\% on a multimodal validation dataset of 55 samples. Conclusion The multimodal ensemble framework bridges gaps in the current diagnostic workflow by offering a non-invasive, AI-assisted triage tool that enhances early identification of high-risk lesions. It supports clinicians in decision-making, aligning with global oncology guidelines to reduce diagnostic delays and improve patient outcomes.

Ajo Babu George, Sadhvik Bathini, Niranjana S R

Objective: The aim of this study was to systematically evaluate and compare the performance of five state-of-the-art transformer-based architectures - Vision Transformer (ViT), Data-efficient Image Transformer (DeiT), ConvNeXt, Swin Transformer, and Bidirectional Encoder Representation from Image Transformers (BEiT) - for multi-class dental disease classification. The study specifically focused on addressing real-world challenges such as data imbalance, which is often overlooked in existing literature. Study Design: The Oral Diseases dataset was used to train and validate the selected models. Performance metrics, including validation accuracy, precision, recall, and F1-score, were measured, with special emphasis on how well each architecture managed imbalanced classes. Results: ConvNeXt achieved the highest validation accuracy at 81.06, followed by BEiT at 80.00 and Swin Transformer at 79.73, all demonstrating strong F1-scores. ViT and DeiT achieved accuracies of 79.37 and 78.79, respectively, but both struggled particularly with Caries-related classes. Conclusions: ConvNeXt, Swin Transformer, and BEiT showed reliable diagnostic performance, making them promising candidates for clinical application in dental imaging. These findings provide guidance for model selection in future AI-driven oral disease diagnostic tools and highlight the importance of addressing data imbalance in real-world scenarios