Xuhua Duan

Yaowei Bai, Ruiheng Zhang, Yu Lei et al.

A global shortage of radiologists has been exacerbated by the significant volume of chest X-ray workloads, particularly in primary care. Although multimodal large language models show promise, existing evaluations predominantly rely on automated metrics or retrospective analyses, lacking rigorous prospective clinical validation. Janus-Pro-CXR (1B), a chest X-ray interpretation system based on DeepSeek Janus-Pro model, was developed and rigorously validated through a multicenter prospective trial (NCT07117266). Our system outperforms state-of-the-art X-ray report generation models in automated report generation, surpassing even larger-scale models including ChatGPT 4o (200B parameters), while demonstrating reliable detection of six clinically critical radiographic findings. Retrospective evaluation confirms significantly higher report accuracy than Janus-Pro and ChatGPT 4o. In prospective clinical deployment, AI assistance significantly improved report quality scores, reduced interpretation time by 18.3% (P < 0.001), and was preferred by a majority of experts in 54.3% of cases. Through lightweight architecture and domain-specific optimization, Janus-Pro-CXR improves diagnostic reliability and workflow efficiency, particularly in resource-constrained settings. The model architecture and implementation framework will be open-sourced to facilitate the clinical translation of AI-assisted radiology solutions.

Haoshen Wang, Lei Chen, Wei-Hua Zhang et al.

Cone beam computed tomography (CBCT)-guided puncture has become an established approach for diagnosing and treating early- to mid-stage thoracic tumours, yet the associated radiation exposure substantially elevates the risk of secondary malignancies. Although multiple low-dose CBCT strategies have been introduced, none have undergone validation using large-scale multicenter retrospective datasets, and prospective clinical evaluation remains lacking. Here, we propose DeepPriorCBCT - a three-stage deep learning framework that achieves diagnostic-grade reconstruction using only one-sixth of the conventional radiation dose. 4102 patients with 8675 CBCT scans from 12 centers were included to develop and validate DeepPriorCBCT. Additionally, a prospective cross-over trial (Registry number: NCT07035977) which recruited 138 patients scheduled for percutaneous thoracic puncture was conducted to assess the model's clinical applicability. Assessment by 11 physicians confirmed that reconstructed images were indistinguishable from original scans. Moreover, diagnostic performance and overall image quality were comparable to those generated by standard reconstruction algorithms. In the prospective trial, five radiologists reported no significant differences in image quality or lesion assessment between DeepPriorCBCT and the clinical standard (all P>0.05). Likewise, 25 interventionalists expressed no preference between model-based and full-sampling images for surgical guidance (Kappa<0.2). Radiation exposure with DeepPriorCBCT was reduced to approximately one-sixth of that with the conventional approach, and collectively, the findings confirm that it enables high-quality CBCT reconstruction under sparse sampling conditions while markedly decreasing intraoperative radiation risk.