David Huang

Pengxiao Zang, Tristan T. Hormel, Jie Wang et al.

Deep learning classifiers provide the most accurate means of automatically diagnosing diabetic retinopathy (DR) based on optical coherence tomography (OCT) and its angiography (OCTA). The power of these models is attributable in part to the inclusion of hidden layers that provide the complexity required to achieve a desired task. However, hidden layers also render algorithm outputs difficult to interpret. Here we introduce a novel biomarker activation map (BAM) framework based on generative adversarial learning that allows clinicians to verify and understand classifiers decision-making. A data set including 456 macular scans were graded as non-referable or referable DR based on current clinical standards. A DR classifier that was used to evaluate our BAM was first trained based on this data set. The BAM generation framework was designed by combing two U-shaped generators to provide meaningful interpretability to this classifier. The main generator was trained to take referable scans as input and produce an output that would be classified by the classifier as non-referable. The BAM is then constructed as the difference image between the output and input of the main generator. To ensure that the BAM only highlights classifier-utilized biomarkers an assistant generator was trained to do the opposite, producing scans that would be classified as referable by the classifier from non-referable scans. The generated BAMs highlighted known pathologic features including nonperfusion area and retinal fluid. A fully interpretable classifier based on these highlights could help clinicians better utilize and verify automated DR diagnosis.

Guile Wu, David Huang, Dongfeng Bai et al.

Video generation has recently shown superiority in urban scene synthesis for autonomous driving. Existing video generation approaches to autonomous driving primarily focus on RGB video generation and lack the ability to support multi-modal video generation. However, multi-modal data, such as depth maps and semantic maps, are crucial for holistic urban scene understanding in autonomous driving. Although it is feasible to use multiple models to generate different modalities, this increases the difficulty of model deployment and does not leverage complementary cues for multi-modal data generation. To address this problem, in this work, we propose a novel multi-modal multi-view video generation approach to autonomous driving. Specifically, we construct a unified diffusion transformer model composed of modal-shared components and modal-specific components. Then, we leverage diverse conditioning inputs to encode controllable scene structure and content cues into the unified diffusion model for multi-modal multi-view video generation. In this way, our approach is capable of generating multi-modal multi-view driving scene videos in a unified framework. Our experiments on the challenging real-world autonomous driving dataset, nuScenes, show that our approach can generate multi-modal multi-view urban scene videos with high fidelity and controllability, surpassing the state-of-the-art methods.