Yizhou Yu

Boyang Dai, Zeng Fan, Zihao Qi et al.

Source-Free Domain Adaptive Object Detection (SF-DAOD) aims to adapt a detector trained on a labeled source domain to an unlabeled target domain without retaining any source data. Despite recent progress, most popular approaches focus on tuning pseudo-label thresholds or refining the teacher-student framework, while overlooking object-level structural cues within cross-domain data. In this work, we present CGSA, the first framework that brings Object-Centric Learning (OCL) into SF-DAOD by integrating slot-aware adaptation into the DETR-based detector. Specifically, our approach integrates a Hierarchical Slot Awareness (HSA) module into the detector to progressively disentangle images into slot representations that act as visual priors. These slots are then guided toward class semantics via a Class-Guided Slot Contrast (CGSC) module, maintaining semantic consistency and prompting domain-invariant adaptation. Extensive experiments on multiple cross-domain datasets demonstrate that our approach outperforms previous SF-DAOD methods, with theoretical derivations and experimental analysis further demonstrating the effectiveness of the proposed components and the framework, thereby indicating the promise of object-centric design in privacy-sensitive adaptation scenarios. Code is released at https://github.com/Michael-McQueen/CGSA.

Meng Lou, Yunxiang Fu, Yizhou Yu

Continual learning, especially class-incremental learning (CIL), on the basis of a pre-trained model (PTM) has garnered substantial research interest in recent years. However, how to effectively learn both discriminative and comprehensive feature representations while maintaining stability and plasticity over very long task sequences remains an open problem. We propose CaRE, a scalable {C}ontinual Le{a}rner with efficient Bi-Level {R}outing Mixture-of-{E}xperts (BR-MoE). The core idea of BR-MoE is a bi-level routing mechanism: a router selection stage that dynamically activates relevant task-specific routers, followed by an expert routing phase that dynamically activates and aggregates experts, aiming to inject discriminative and comprehensive representations into every intermediate network layer. On the other hand, we introduce a challenging evaluation protocol for comprehensively assessing CIL methods across very long task sequences spanning hundreds of tasks. Extensive experiments show that CaRE demonstrates leading performance across a variety of datasets and task settings, including commonly used CIL datasets with classical CIL settings (e.g., 5-20 tasks). To the best of our knowledge, CaRE is the first continual learner that scales to very long task sequences (ranging from 100 to over 300 non-overlapping tasks), while outperforming all baselines by a large margin on such task sequences. Code will be publicly released at https://github.com/LMMMEng/CaRE.git.

Cheng Shi, Yizhou Yu, Sibei Yang

Vision Transformers (ViTs), when pre-trained on large-scale data, provide general-purpose representations for diverse downstream tasks. However, artifacts in ViTs are widely observed across different supervision paradigms and downstream tasks. Through systematic analysis of artifacts in ViTs, we find that their fundamental mechanisms have yet to be sufficiently elucidated. In this paper, through systematic analysis, we conclude that these artifacts originate from a lazy aggregation behavior: ViT uses semantically irrelevant background patches as shortcuts to represent global semantics, driven by global attention and Coarse-grained semantic supervision. Our solution selectively integrates patch features into the CLS token, reducing the influence of background-dominated shortcuts and consistently improving performance across 12 benchmarks under label-, text-, and self-supervision. We hope this work offers a new perspective on ViT behavior.

Jiarun Liu, Hao Yang, Hong-Yu Zhou et al.

Accurate medical image segmentation demands the integration of multi-scale information, spanning from local features to global dependencies. However, it is challenging for existing methods to model long-range global information, where convolutional neural networks (CNNs) are constrained by their local receptive fields, and vision transformers (ViTs) suffer from high quadratic complexity of their attention mechanism. Recently, Mamba-based models have gained great attention for their impressive ability in long sequence modeling. Several studies have demonstrated that these models can outperform popular vision models in various tasks, offering higher accuracy, lower memory consumption, and less computational burden. However, existing Mamba-based models are mostly trained from scratch and do not explore the power of pretraining, which has been proven to be quite effective for data-efficient medical image analysis. This paper introduces a novel Mamba-based model, Swin-UMamba, designed specifically for medical image segmentation tasks, leveraging the advantages of ImageNet-based pretraining. Our experimental results reveal the vital role of ImageNet-based training in enhancing the performance of Mamba-based models. Swin-UMamba demonstrates superior performance with a large margin compared to CNNs, ViTs, and latest Mamba-based models. Notably, on AbdomenMRI, Encoscopy, and Microscopy datasets, Swin-UMamba outperforms its closest counterpart U-Mamba_Enc by an average score of 2.72%.

Meng Lou, Stanley Yu, Yizhou Yu

Adapting pre-trained vision models using parameter-efficient fine-tuning (PEFT) remains challenging, as it aims to achieve performance comparable to full fine-tuning using a minimal number of trainable parameters. When applied to complex dense prediction tasks, existing methods exhibit limitations, including input-agnostic modeling and redundant cross-layer representations. To this end, we propose AdaRoute, a new adapter-style method featuring a simple mixture-of-experts (MoE) architecture. Specifically, we introduce shared expert centers, where each expert is a trainable parameter matrix. During a feedforward pass, each AdaRoute module in the network dynamically generates weight matrices tailored for the current module via a simple dynamic parameter routing mechanism, which selectively aggregates parameter matrices in the corresponding expert center. Dynamic weight matrices in AdaRoute modules facilitate low-rank adaptation in an input-dependent manner, thus generating more customized and powerful feature representations. Moreover, since AdaRoute modules across multiple network layers share the same expert center, they improve feature diversity by promoting implicit cross-layer feature interaction. Extensive experiments demonstrate the superiority of AdaRoute on diverse vision tasks, including semantic segmentation, object detection and instance segmentation, and panoptic segmentation. Code will be available at: https://bit.ly/3NZcr0H.

Cheng Wang, Qiyu Gao, Fandong Zhang et al.

Most of the deep learning based medical image registration algorithms focus on brain image registration tasks.Compared with brain registration, the chest CT registration has larger deformation, more complex background and region over-lap. In this paper, we propose a fast unsupervised deep learning method, LDRNet, for large deformation image registration of chest CT images. We first predict a coarse resolution registration field, then refine it from coarse to fine. We propose two innovative technical components: 1) a refine block that is used to refine the registration field in different resolutions, 2) a rigid block that is used to learn transformation matrix from high-level features. We train and evaluate our model on the private dataset and public dataset SegTHOR. We compare our performance with state-of-the-art traditional registration methods as well as deep learning registration models VoxelMorph, RCN, and LapIRN. The results demonstrate that our model achieves state-of-the-art performance for large deformation images registration and is much faster.

Cheng Shi, Yizhou Yu, Sibei Yang

This study identifies that visual-related functional decoding is distributed across different decoder layers in Multimodal Large Language Models (MLLMs). Typically, each function, such as counting, grounding, or OCR recognition, narrows down to two or three layers, which we define as Vision Function Layers (VFL). Additionally, the depth and its order of different VFLs exhibits a consistent pattern across different MLLMs, which is well-aligned with human behaviors (e.g., recognition occurs first, followed by counting, and then grounding). These findings are derived from Visual Token Swapping, our novel analytical framework that modifies targeted KV cache entries to precisely elucidate layer-specific functions during decoding. Furthermore, these insights offer substantial utility in tailoring MLLMs for real-world downstream applications. For instance, when LoRA training is selectively applied to VFLs whose functions align with the training data, VFL-LoRA not only outperform full-LoRA but also prevent out-of-domain function forgetting. Moreover, by analyzing the performance differential on training data when particular VFLs are ablated, VFL-select automatically classifies data by function, enabling highly efficient data selection to directly bolster corresponding capabilities. Consequently, VFL-select surpasses human experts in data selection, and achieves 98% of full-data performance with only 20% of the original dataset. This study delivers deeper comprehension of MLLM visual processing, fostering the creation of more efficient, interpretable, and robust models.

Gang Yu, Zhongzhi Yu, Yemin Shi et al.

Respiratory diseases, including asthma, bronchitis, pneumonia, and upper respiratory tract infection (RTI), are among the most common diseases in clinics. The similarities among the symptoms of these diseases precludes prompt diagnosis upon the patients' arrival. In pediatrics, the patients' limited ability in expressing their situation makes precise diagnosis even harder. This becomes worse in primary hospitals, where the lack of medical imaging devices and the doctors' limited experience further increase the difficulty of distinguishing among similar diseases. In this paper, a pediatric fine-grained diagnosis-assistant system is proposed to provide prompt and precise diagnosis using solely clinical notes upon admission, which would assist clinicians without changing the diagnostic process. The proposed system consists of two stages: a test result structuralization stage and a disease identification stage. The first stage structuralizes test results by extracting relevant numerical values from clinical notes, and the disease identification stage provides a diagnosis based on text-form clinical notes and the structured data obtained from the first stage. A novel deep learning algorithm was developed for the disease identification stage, where techniques including adaptive feature infusion and multi-modal attentive fusion were introduced to fuse structured and text data together. Clinical notes from over 12000 patients with respiratory diseases were used to train a deep learning model, and clinical notes from a non-overlapping set of about 1800 patients were used to evaluate the performance of the trained model. The average precisions (AP) for pneumonia, RTI, bronchitis and asthma are 0.878, 0.857, 0.714, and 0.825, respectively, achieving a mean AP (mAP) of 0.819.

Sheng Wang, Zhen Li, Yizhou Yu et al.

Computational elucidation of membrane protein (MP) structures is challenging partially due to lack of sufficient solved structures for homology modeling. Here we describe a high-throughput deep transfer learning method that first predicts MP contacts by learning from non-membrane proteins (non-MPs) and then predicting three-dimensional structure models using the predicted contacts as distance restraints. Tested on 510 non-redundant MPs, our method has contact prediction accuracy at least 0.18 better than existing methods, predicts correct folds for 218 MPs (TMscore at least 0.6), and generates three-dimensional models with RMSD less than 4 Angstrom and 5 Angstrom for 57 and 108 MPs, respectively. A rigorous blind test in the continuous automated model evaluation (CAMEO) project shows that our method predicted high-resolution three-dimensional models for two recent test MPs of 210 residues with RMSD close to 2 Angstrom. We estimated that our method could predict correct folds for between 1,345 and 1,871 reviewed human multi-pass MPs including a few hundred new folds, which shall facilitate the discovery of drugs targeting at membrane proteins.