Mehmet Saygin Seyfioglu

Wisdom Oluchi Ikezogwo, Mehmet Saygin Seyfioglu, Fatemeh Ghezloo et al. · uw

Recent accelerations in multi-modal applications have been made possible with the plethora of image and text data available online. However, the scarcity of analogous data in the medical field, specifically in histopathology, has slowed comparable progress. To enable similar representation learning for histopathology, we turn to YouTube, an untapped resource of videos, offering $1,087$ hours of valuable educational histopathology videos from expert clinicians. From YouTube, we curate QUILT: a large-scale vision-language dataset consisting of $802, 144$ image and text pairs. QUILT was automatically curated using a mixture of models, including large language models, handcrafted algorithms, human knowledge databases, and automatic speech recognition. In comparison, the most comprehensive datasets curated for histopathology amass only around $200$K samples. We combine QUILT with datasets from other sources, including Twitter, research papers, and the internet in general, to create an even larger dataset: QUILT-1M, with $1$M paired image-text samples, marking it as the largest vision-language histopathology dataset to date. We demonstrate the value of QUILT-1M by fine-tuning a pre-trained CLIP model. Our model outperforms state-of-the-art models on both zero-shot and linear probing tasks for classifying new histopathology images across $13$ diverse patch-level datasets of $8$ different sub-pathologies and cross-modal retrieval tasks.

Wisdom Oluchi Ikezogwo, Mehmet Saygin Seyfioglu, Linda Shapiro

Self-supervised learning (SSL) enables learning useful inductive biases through utilizing pretext tasks that require no labels. The unlabeled nature of SSL makes it especially important for whole slide histopathological images (WSIs), where patch-level human annotation is difficult. Masked Autoencoders (MAE) is a recent SSL method suitable for digital pathology as it does not require negative sampling and requires little to no data augmentations. However, the domain shift between natural images and digital pathology images requires further research in designing MAE for patch-level WSIs. In this paper, we investigate several design choices for MAE in histopathology. Furthermore, we introduce a multi-modal MAE (MMAE) that leverages the specific compositionality of Hematoxylin & Eosin (H&E) stained WSIs. We performed our experiments on the public patch-level dataset NCT-CRC-HE-100K. The results show that the MMAE architecture outperforms supervised baselines and other state-of-the-art SSL techniques for an eight-class tissue phenotyping task, utilizing only 100 labeled samples for fine-tuning. Our code is available at https://github.com/wisdomikezogwo/MMAE_Pathology

Mehmet Saygin Seyfioglu, Wisdom O. Ikezogwo, Fatemeh Ghezloo et al.

Diagnosis in histopathology requires a global whole slide images (WSIs) analysis, requiring pathologists to compound evidence from different WSI patches. The gigapixel scale of WSIs poses a challenge for histopathology multi-modal models. Training multi-model models for histopathology requires instruction tuning datasets, which currently contain information for individual image patches, without a spatial grounding of the concepts within each patch and without a wider view of the WSI. Therefore, they lack sufficient diagnostic capacity for histopathology. To bridge this gap, we introduce Quilt-Instruct, a large-scale dataset of 107,131 histopathology-specific instruction question/answer pairs, grounded within diagnostically relevant image patches that make up the WSI. Our dataset is collected by leveraging educational histopathology videos from YouTube, which provides spatial localization of narrations by automatically extracting the narrators' cursor positions. Quilt-Instruct supports contextual reasoning by extracting diagnosis and supporting facts from the entire WSI. Using Quilt-Instruct, we train Quilt-LLaVA, which can reason beyond the given single image patch, enabling diagnostic reasoning across patches. To evaluate Quilt-LLaVA, we propose a comprehensive evaluation dataset created from 985 images and 1283 human-generated question-answers. We also thoroughly evaluate Quilt-LLaVA using public histopathology datasets, where Quilt-LLaVA significantly outperforms SOTA by over 10% on relative GPT-4 score and 4% and 9% on open and closed set VQA. Our code, data, and model are publicly accessible at quilt-llava.github.io.

Wisdom Ikezogwo, Mehmet Saygin Seyfioglu, Ranjay Krishna et al.

Reinforcement learning with verifiable rewards (RLVR) and Rubrics as Rewards (RaR) have driven strong gains in domains with clear correctness signals and even in subjective domains by synthesizing evaluation criteria from ideal reference answers. But many real-world tasks admit multiple valid outputs and lack the single ideal answer that rubric generation depends on. We identify this reference-free setting as a gap in current post-training methods and propose Implicit Error Counting (IEC) to fill it. Instead of checking what a response gets right against a rubric, IEC enumerates what it gets wrong, applying severity-weighted scores across task-relevant axes and converting them into calibrated per-aspect rewards. We show that naïve explicit enumeration is too noisy for stable optimization, and that two design choices: implicit score emission and group calibration are necessary to make error counting a reliable reward. As a case study, we validate IEC on virtual try-on (VTO), a domain that is simultaneously too constrained for holistic scoring and too permissive for rubric-based evaluation: subtle garment errors are unacceptable, yet many output variations are correct. We introduce Cascaded Error Counting (CEC) as an evaluation metric, which tracks human preferences well (60% top-1 vs. 30% others), and curate Mismatch-DressCode (MDressBench), a benchmark with maximal attribute mismatch to stress-test reward designs. On MDressBench, IEC outperforms RaR across all metrics (CEC: 5.31 vs. 5.60 on flat references; 5.20 vs. 5.53 on non-flat). On VITON-HD and DressCode, IEC matches or surpasses six baselines on 6 of 8 perceptual metrics. These results suggest that when ideal answers are unavailable, counting errors provide a stronger signal than constructing rubrics.

Fatemeh Ghezloo, Mehmet Saygin Seyfioglu, Rustin Soraki et al.

Diagnosing diseases through histopathology whole slide images (WSIs) is fundamental in modern pathology but is challenged by the gigapixel scale and complexity of WSIs. Trained histopathologists overcome this challenge by navigating the WSI, looking for relevant patches, taking notes, and compiling them to produce a final holistic diagnostic. Traditional AI approaches, such as multiple instance learning and transformer-based models, fail short of such a holistic, iterative, multi-scale diagnostic procedure, limiting their adoption in the real-world. We introduce PathFinder, a multi-modal, multi-agent framework that emulates the decision-making process of expert pathologists. PathFinder integrates four AI agents, the Triage Agent, Navigation Agent, Description Agent, and Diagnosis Agent, that collaboratively navigate WSIs, gather evidence, and provide comprehensive diagnoses with natural language explanations. The Triage Agent classifies the WSI as benign or risky; if risky, the Navigation and Description Agents iteratively focus on significant regions, generating importance maps and descriptive insights of sampled patches. Finally, the Diagnosis Agent synthesizes the findings to determine the patient's diagnostic classification. Our Experiments show that PathFinder outperforms state-of-the-art methods in skin melanoma diagnosis by 8% while offering inherent explainability through natural language descriptions of diagnostically relevant patches. Qualitative analysis by pathologists shows that the Description Agent's outputs are of high quality and comparable to GPT-4o. PathFinder is also the first AI-based system to surpass the average performance of pathologists in this challenging melanoma classification task by 9%, setting a new record for efficient, accurate, and interpretable AI-assisted diagnostics in pathology. Data, code and models available at https://pathfinder-dx.github.io/

Qi Li, Shuwen Qiu, Julien Han et al.

The rapid growth of e-commerce has intensified the demand for Virtual Try-On (VTO) technologies, enabling customers to realistically visualize products overlaid on their own images. Despite recent advances, existing VTO models face challenges with fine-grained detail preservation, robustness to real-world imagery, efficient sampling, image editing capabilities, and generalization across diverse product categories. In this paper, we present DiT-VTON, a novel VTO framework that leverages a Diffusion Transformer (DiT), renowned for its performance on text-conditioned image generation, adapted here for the image-conditioned VTO task. We systematically explore multiple DiT configurations, including in-context token concatenation, channel concatenation, and ControlNet integration, to determine the best setup for VTO image conditioning. To enhance robustness, we train the model on an expanded dataset encompassing varied backgrounds, unstructured references, and non-garment categories, demonstrating the benefits of data scaling for VTO adaptability. DiT-VTON also redefines the VTO task beyond garment try-on, offering a versatile Virtual Try-All (VTA) solution capable of handling a wide range of product categories and supporting advanced image editing functionalities such as pose preservation, localized editing, texture transfer, and object-level customization. Experimental results show that our model surpasses state-of-the-art methods on VITON-HD, achieving superior detail preservation and robustness without reliance on additional condition encoders. It also outperforms models with VTA and image editing capabilities on a diverse dataset spanning thousands of product categories.

Julien Han, Shuwen Qiu, Qi Li et al.

We present InstructVTON, an instruction-following interactive virtual try-on system that allows fine-grained and complex styling control of the resulting generation, guided by natural language, on single or multiple garments. A computationally efficient and scalable formulation of virtual try-on formulates the problem as an image-guided or image-conditioned inpainting task. These inpainting-based virtual try-on models commonly use a binary mask to control the generation layout. Producing a mask that yields desirable result is difficult, requires background knowledge, might be model dependent, and in some cases impossible with the masking-based approach (e.g. trying on a long-sleeve shirt with "sleeves rolled up" styling on a person wearing long-sleeve shirt with sleeves down, where the mask will necessarily cover the entire sleeve). InstructVTON leverages Vision Language Models (VLMs) and image segmentation models for automated binary mask generation. These masks are generated based on user-provided images and free-text style instructions. InstructVTON simplifies the end-user experience by removing the necessity of a precisely drawn mask, and by automating execution of multiple rounds of image generation for try-on scenarios that cannot be achieved with masking-based virtual try-on models alone. We show that InstructVTON is interoperable with existing virtual try-on models to achieve state-of-the-art results with styling control.

Wisdom O. Ikezogwo, Kevin Zhang, Mehmet Saygin Seyfioglu et al.

We propose MedicalNarratives, a dataset curated from medical pedagogical videos similar in nature to data collected in Think-Aloud studies and inspired by Localized Narratives, which collects grounded image-text data by curating instructors' speech and mouse cursor movements synchronized in time. MedicalNarratives enables pretraining of both semantic and dense objectives, alleviating the need to train medical semantic and dense tasks disparately due to the lack of reasonably sized datasets. Our dataset contains 4.7M image-text pairs from videos and articles, with 1M samples containing dense annotations in the form of traces and bounding boxes. To evaluate the utility of MedicalNarratives, we train GenMedClip based on the CLIP architecture using our dataset spanning 12 medical domains and demonstrate that it outperforms previous state-of-the-art models on a newly constructed medical imaging benchmark that comprehensively evaluates performance across all modalities. Data, demo, code and models available at https://medical-narratives.github.io

Qi Li, Shuwen Qiu, Julien Han et al.

As online shopping continues to grow, the demand for Virtual Try-On (VTON) technology has surged, allowing customers to visualize products on themselves by overlaying product images onto their own photos. An essential yet challenging condition for effective VTON is pose control, which ensures accurate alignment of products with the user's body while supporting diverse orientations for a more immersive experience. However, incorporating pose conditions into VTON models presents several challenges, including selecting the optimal pose representation, integrating poses without additional parameters, and balancing pose preservation with flexible pose control. In this work, we build upon a baseline VTON model that concatenates the reference image condition without external encoder, control network, or complex attention layers. We investigate methods to incorporate pose control into this pure concatenation paradigm by spatially concatenating pose data, comparing performance using pose maps and skeletons, without adding any additional parameters or module to the baseline model. Our experiments reveal that pose stitching with pose maps yields the best results, enhancing both pose preservation and output realism. Additionally, we introduce a mixed-mask training strategy using fine-grained and bounding box masks, allowing the model to support flexible product integration across varied poses and conditions.

Mengqi Zhang, Qi Li, Mehmet Saygin Seyfioglu et al.

Virtual Try-On is a promising research area with broad applications in e-commerce and everyday life, enabling users to visualize garments on themselves or others before purchase. Most existing methods depend on predefined or user-specified masks to guide garment placement, but their performance is highly sensitive to mask quality, often causing misalignment or artifacts, and introduces redundant steps for users. To overcome these limitations, we propose a mask-free virtual try-on framework that requires only minimal modifications to the underlying architecture while remaining compatible with common diffusion-based pipelines. To address the increased ambiguity in the absence of masks, we integrate an attention-based guidance mechanism that explicitly directs the model to focus on the target garment region and improves correspondence between the garment and the person. Additionally, we incorporate instruction prompts, allowing users to flexibly control garment categories and wearing styles, addressing the underutilization of prompts in prior work and improving interaction flexibility. Both qualitative and quantitative evaluations across multiple datasets demonstrate that our approach consistently outperforms existing methods, producing more accurate, robust, and user-friendly try-on results.

Mehmet Saygin Seyfioglu, Karim Bouyarmane, Suren Kumar et al.

As online shopping is growing, the ability for buyers to virtually visualize products in their settings-a phenomenon we define as "Virtual Try-All"-has become crucial. Recent diffusion models inherently contain a world model, rendering them suitable for this task within an inpainting context. However, traditional image-conditioned diffusion models often fail to capture the fine-grained details of products. In contrast, personalization-driven models such as DreamPaint are good at preserving the item's details but they are not optimized for real-time applications. We present "Diffuse to Choose," a novel diffusion-based image-conditioned inpainting model that efficiently balances fast inference with the retention of high-fidelity details in a given reference item while ensuring accurate semantic manipulations in the given scene content. Our approach is based on incorporating fine-grained features from the reference image directly into the latent feature maps of the main diffusion model, alongside with a perceptual loss to further preserve the reference item's details. We conduct extensive testing on both in-house and publicly available datasets, and show that Diffuse to Choose is superior to existing zero-shot diffusion inpainting methods as well as few-shot diffusion personalization algorithms like DreamPaint.

Mehmet Saygin Seyfioglu, Karim Bouyarmane, Suren Kumar et al.

We introduce DreamPaint, a framework to intelligently inpaint any e-commerce product on any user-provided context image. The context image can be, for example, the user's own image for virtual try-on of clothes from the e-commerce catalog on themselves, the user's room image for virtual try-on of a piece of furniture from the e-commerce catalog in their room, etc. As opposed to previous augmented-reality (AR)-based virtual try-on methods, DreamPaint does not use, nor does it require, 3D modeling of neither the e-commerce product nor the user context. Instead, it directly uses 2D images of the product as available in product catalog database, and a 2D picture of the context, for example taken from the user's phone camera. The method relies on few-shot fine tuning a pre-trained diffusion model with the masked latents (e.g., Masked DreamBooth) of the catalog images per item, whose weights are then loaded on a pre-trained inpainting module that is capable of preserving the characteristics of the context image. DreamPaint allows to preserve both the product image and the context (environment/user) image without requiring text guidance to describe the missing part (product/context). DreamPaint also allows to intelligently infer the best 3D angle of the product to place at the desired location on the user context, even if that angle was previously unseen in the product's reference 2D images. We compare our results against both text-guided and image-guided inpainting modules and show that DreamPaint yields superior performance in both subjective human study and quantitative metrics.

Tarik Arici, Mehmet Saygin Seyfioglu, Tal Neiman et al.

Vision-and-Language Pre-training (VLP) improves model performance for downstream tasks that require image and text inputs. Current VLP approaches differ on (i) model architecture (especially image embedders), (ii) loss functions, and (iii) masking policies. Image embedders are either deep models like ResNet or linear projections that directly feed image-pixels into the transformer. Typically, in addition to the Masked Language Modeling (MLM) loss, alignment-based objectives are used for cross-modality interaction, and RoI feature regression and classification tasks for Masked Image-Region Modeling (MIRM). Both alignment and MIRM objectives mostly do not have ground truth. Alignment-based objectives require pairings of image and text and heuristic objective functions. MIRM relies on object detectors. Masking policies either do not take advantage of multi-modality or are strictly coupled with alignments generated by other models. In this paper, we present Masked Language and Image Modeling (MLIM) for VLP. MLIM uses two loss functions: Masked Language Modeling (MLM) loss and image reconstruction (RECON) loss. We propose Modality Aware Masking (MAM) to boost cross-modality interaction and take advantage of MLM and RECON losses that separately capture text and image reconstruction quality. Using MLM + RECON tasks coupled with MAM, we present a simplified VLP methodology and show that it has better downstream task performance on a proprietary e-commerce multi-modal dataset.

Semih Yagcioglu, Mehmet Saygin Seyfioglu, Begum Citamak et al.

It is very critical to analyze messages shared over social networks for cyber threat intelligence and cyber-crime prevention. In this study, we propose a method that leverages both domain-specific word embeddings and task-specific features to detect cyber security events from tweets. Our model employs a convolutional neural network (CNN) and a long short-term memory (LSTM) recurrent neural network which takes word level meta-embeddings as inputs and incorporates contextual embeddings to classify noisy short text. We collected a new dataset of cyber security related tweets from Twitter and manually annotated a subset of 2K of them. We experimented with this dataset and concluded that the proposed model outperforms both traditional and neural baselines. The results suggest that our method works well for detecting cyber security events from noisy short text.