Sergi Abadal

Jorge Torres Gómez, Pit Hofmann, Lisa Y. Debus et al.

Recent developments in the Internet of Bio-Nano-Things (IoBNT) are laying the foundation for innovative healthcare applications that envision a network of remotely coordinated nanodevices within the human body to monitor and actuate over potential diseases. However, interconnecting such nanodevices requires communication strategies that can cope with molecular communication (MC) channels, whose complex, stochastic, and dynamic behavior often makes accurate physical modeling infeasible. To explore the limits of nanodevice interconnectivity under these conditions, this survey focuses on data-driven communication strategies for MC systems, with particular emphasis on machine learning (ML) methods and neural network (NN) architectures for a robust and adaptive communication scheme at the nanoscale. Research on NN-enabled MC spans several aspects covered in this survey, including NNs for communication in IoBNT networks, the feasibility of biocompatible NN realization, explainable approaches, and the generation of training datasets. We also include open-source code examples to support reproducible research across key MC scenarios. Finally, we identify emerging challenges, including the need for robust NN architectures, biologically integrated NN modules, and scalable training strategies.

Medina Bandic, Pablo le Henaff, Anabel Ovide et al.

Application-specific quantum computers offer the most efficient means to tackle problems intractable by classical computers. Realizing these architectures necessitates a deep understanding of quantum circuit properties and their relationship to execution outcomes on quantum devices. Our study aims to perform for the first time a rigorous examination of quantum circuits by introducing graph theory-based metrics extracted from their qubit interaction graph and gate dependency graph alongside conventional parameters describing the circuit itself. This methodology facilitates a comprehensive analysis and clustering of quantum circuits. Furthermore, it uncovers a connection between parameters rooted in both qubit interaction and gate dependency graphs, and the performance metrics for quantum circuit mapping, across a range of established quantum device and mapping configurations. Among the various device configurations, we particularly emphasize modular (i.e., multi-core) quantum computing architectures due to their high potential as a viable solution for quantum device scalability. This thorough analysis will help us to: i) identify key attributes of quantum circuits that affect the quantum circuit mapping performance metrics; ii) predict the performance on a specific chip for similar circuit structures; iii) determine preferable combinations of mapping techniques and hardware setups for specific circuits; and iv) define representative benchmark sets by clustering similarly structured circuits.

Axel Wassington, Sergi Abadal

In general, to draw robust conclusions from a dataset, all the analyzed population must be represented on said dataset. Having a dataset that does not fulfill this condition normally leads to selection bias. Additionally, graphs have been used to model a wide variety of problems. Although synthetic graphs can be used to augment available real graph datasets to overcome selection bias, the generation of unbiased synthetic datasets is complex with current tools. In this work, we propose a method to find a synthetic graph dataset that has an even representation of graphs with different metrics. The resulting dataset can then be used, among others, for benchmarking graph processing techniques as the accuracy of different Graph Neural Network (GNN) models or the speedups obtained by different graph processing acceleration frameworks.

Axel Wassington, Sergi Abadal

Graph Neural Networks (GNN) show great promise in problems dealing with graph-structured data. One of the unique points of GNNs is their flexibility to adapt to multiple problems, which not only leads to wide applicability, but also poses important challenges when finding the best model or acceleration technique for a particular problem. An example of such challenges resides in the fact that the accuracy or effectiveness of a GNN model or acceleration technique generally depends on the structure of the underlying graph. In this paper, in an attempt to address the problem of graph-dependent acceleration, we propose ProGNNosis, a data-driven model that can predict the GNN training time of a given GNN model running over a graph of arbitrary characteristics by inspecting the input graph metrics. Such prediction is made based on a regression that was previously trained offline using a diverse synthetic graph dataset. In practice, our method allows making informed decisions on which design to use for a specific problem. In the paper, the methodology to build ProGNNosis is defined and applied for a specific use case, where it helps to decide which graph representation is better. Our results show that ProGNNosis helps achieve an average speedup of 1.22X over randomly selecting a graph representation in multiple widely used GNN models such as GCN, GIN, GAT, or GraphSAGE.

Pablo Galván, Filip Lemic, Gerard Calvo Bartra et al.

Flow-guided localization using in-body nanodevices in the bloodstream is expected to be beneficial for early disease detection, continuous monitoring of biological conditions, and targeted treatment. The nanodevices face size and power constraints that produce erroneous raw data for localization purposes. On-body anchors receive this data, and use it to derive the locations of diagnostic events of interest. Different Machine Learning (ML) approaches have been recently proposed for this task, yet they are currently restricted to a reference bloodstream of a resting patient. As such, they are unable to deal with the physical diversity of patients' bloodstreams and cannot provide continuous monitoring due to changes in individual patient's activities. Toward addressing these issues for the current State-of-the-Art (SotA) flow-guided localization approach based on Graph Neural Networks (GNNs), we propose a pipeline for GNN adaptation based on individual physiological indicators including height, weight, and heart rate. Our results indicate that the proposed adaptions are beneficial in reconciling the individual differences between bloodstreams and activities.

Laura Rayón Ropero, Jasper De Laet, Filip Lemic et al.

Facial Emotion Recognition is a critical research area within Affective Computing due to its wide-ranging applications in Human Computer Interaction, mental health assessment and fatigue monitoring. Current FER methods predominantly rely on Deep Learning techniques trained on 2D image data, which pose significant privacy concerns and are unsuitable for continuous, real-time monitoring. As an alternative, we propose High-Frequency Wireless Sensing (HFWS) as an enabler of continuous, privacy-aware FER, through the generation of detailed 3D facial pointclouds via on-person sensors embedded in wearables. We present arguments supporting the privacy advantages of HFWS over traditional 2D imaging, particularly under increasingly stringent data protection regulations. A major barrier to adopting HFWS for FER is the scarcity of labeled 3D FER datasets. Towards addressing this issue, we introduce a FLAME-based method to generate 3D facial pointclouds from existing public 2D datasets. Using this approach, we create AffectNet3D, a 3D version of the AffectNet database. To evaluate the quality and usability of the generated data, we design a pointcloud refinement pipeline focused on isolating the facial region, and train the popular PointNet++ model on the refined pointclouds. Fine-tuning the model on a small subset of the unseen 3D FER dataset BU-3DFE yields a classification accuracy exceeding 70%, comparable to oracle-level performance. To further investigate the potential of HFWS-based FER for continuous monitoring, we simulate wearable sensing conditions by masking portions of the generated pointclouds. Experimental results show that models trained on AffectNet3D and fine-tuned with just 25% of BU-3DFE outperform those trained solely on BU-3DFE. These findings highlight the viability of our pipeline and support the feasibility of continuous, privacy-aware FER via wearable HFWS systems.

Ida Kleger-Rudomin, Filip Lemic, Sergi Abadal et al.

Liquid biopsy can detect tumor-derived biomarkers such as circulating tumor DNA (ctDNA), but ultra-low-fraction assays remain costly, slow, and difficult to scale. This motivates interest in intravascular in vivo sensing in the context of intrabody nanonetworks, where nanosensors could support local biomarker monitoring. BioFET-based nanosensors are relevant here because they are label-free, highly miniaturizable, and have shown strong ctDNA sensitivity in controlled media. We examine whether this sensitivity still yields reliable ctDNA detection in whole blood using a reduced-order stochastic simulation model that links operating-point selection, Debye-screened charge transduction, stochastic finite-capacity binding, nonspecific adsorption, background fluctuations, and intrinsic electronic noise to blank-threshold detection. Monte Carlo evaluation with physiologically grounded parameters shows that short Debye length and several-nanometer charge-to-channel separation attenuate the current shift, while low-frequency noise and background fluctuations reduce the margin between target-present and blank responses. Under the tested quasi-static charge-gating regime, the simulated current shifts do not reliably exceed the blank-derived threshold at low ctDNA concentrations. The model therefore provides a whole-blood boundary analysis that identifies which interface configurations and operating conditions most strongly limit reliable BioFET-based intravascular ctDNA detection.

Abdollah Rezagholi, Sergi Abadal, Filip Lemic et al.

Early detection of cancer is essential for timely diagnosis and improved patient outcomes. Among emerging technologies, intra-body nanoscale communication offers an innovative solution to identify molecular cues within the human bloodstream. This study investigates a minimally invasive approach for early-stage cancer biomarker detection using nanomachines introduced into the bloodstream. To assess the feasibility of this approach, computational simulations are used to emulate the vascular environment and evaluate biomarker detection performance under different physiological conditions. Current modeling approaches often fail to capture essential vascular characteristics, including non-uniform flow structures, size-dependent particle mobility, and particle margination driven by red blood cell interactions. To address these limitations, our study incorporates these factors into the simulation framework and quantifies their individual and combined effects on biomarker detection efficiency. Baseline detection performance is first obtained under uniform flow assumptions, after which introducing realistic vascular transport mechanisms progressively reduces detection probability for all vessel types and nanomachine sizes. Among the considered vessels, capillary consistently achieves the highest detection probability across all nanomachine sizes.

Arnau Pastor, Pau Escofet, Sahar Ben Rached et al.

Quantum computing holds immense potential for solving classically intractable problems by leveraging the unique properties of quantum mechanics. The scalability of quantum architectures remains a significant challenge. Multi-core quantum architectures are proposed to solve the scalability problem, arising a new set of challenges in hardware, communications and compilation, among others. One of these challenges is to adapt a quantum algorithm to fit within the different cores of the quantum computer. This paper presents a novel approach for circuit partitioning using Deep Reinforcement Learning, contributing to the advancement of both quantum computing and graph partitioning. This work is the first step in integrating Deep Reinforcement Learning techniques into Quantum Circuit Mapping, opening the door to a new paradigm of solutions to such problems.

Genís Castillo Gómez-Raya, Álmos Veres-Vitályos, Filip Lemic et al.

The increasing miniaturization of Unmanned Aerial Vehicles (UAVs) has expanded their deployment potential to indoor and hard-to-reach areas. However, this trend introduces distinct challenges, particularly in terms of flight dynamics and power consumption, which limit the UAVs' autonomy and mission capabilities. This paper presents a novel approach to overcoming these limitations by integrating Neural 3D Reconstruction (N3DR) with small UAV systems for fine-grained 3-Dimensional (3D) digital reconstruction of small static objects. Specifically, we design, implement, and evaluate an N3DR-based pipeline that leverages advanced models, i.e., Instant-ngp, Nerfacto, and Splatfacto, to improve the quality of 3D reconstructions using images of the object captured by a fleet of small UAVs. We assess the performance of the considered models using various imagery and pointcloud metrics, comparing them against the baseline Structure from Motion (SfM) algorithm. The experimental results demonstrate that the N3DR-enhanced pipeline significantly improves reconstruction quality, making it feasible for small UAVs to support high-precision 3D mapping and anomaly detection in constrained environments. In more general terms, our results highlight the potential of N3DR in advancing the capabilities of miniaturized UAV systems.

Angela Lopez-Cardona, Sebastian Idesis, Miguel Barreda-Ángeles et al.

While Large Language Models (LLMs) have significantly advanced natural language processing, aligning them with human preferences remains an open challenge. Although current alignment methods rely primarily on explicit feedback, eye-tracking (ET) data offers insights into real-time cognitive processing during reading. In this paper, we present OASST-ETC, a novel eye-tracking corpus capturing reading patterns from 24 participants, while evaluating LLM-generated responses from the OASST1 dataset. Our analysis reveals distinct reading patterns between preferred and non-preferred responses, which we compare with synthetic eye-tracking data. Furthermore, we examine the correlation between human reading measures and attention patterns from various transformer-based models, discovering stronger correlations in preferred responses. This work introduces a unique resource for studying human cognitive processing in LLM evaluation and suggests promising directions for incorporating eye-tracking data into alignment methods. The dataset and analysis code are publicly available.

Emmanuel Irabor, Mariam Musavi, Abhijit Das et al.

The insatiable appetite of Artificial Intelligence (AI) workloads for computing power is pushing the industry to develop faster and more efficient accelerators. The rigidity of custom hardware, however, conflicts with the need for scalable and versatile architectures capable of catering to the needs of the evolving and heterogeneous pool of Machine Learning (ML) models in the literature. In this context, multi-chiplet architectures assembling multiple (perhaps heterogeneous) accelerators are an appealing option that is unfortunately hindered by the still rigid and inefficient chip-to-chip interconnects. In this paper, we explore the potential of wireless technology as a complement to existing wired interconnects in this multi-chiplet approach. Using an evaluation framework from the state-of-the-art, we show that wireless interconnects can lead to speedups of 10% on average and 20% maximum. We also highlight the importance of load balancing between the wired and wireless interconnects, which will be further explored in future work.

Ángela López-Cardona, Sebastián Idesis, Mireia Masias-Bruns et al.

Do brains and language models converge toward the same internal representations of the world? Recent years have seen a rise in studies of neural activations and model alignment. In this work, we review 25 fMRI-based studies published between 2023 and 2025 and explicitly confront their findings with two key hypotheses: (i) the Platonic Representation Hypothesis -- that as models scale and improve, they converge to a representation of the real world, and (ii) the Intermediate-Layer Advantage -- that intermediate (mid-depth) layers often encode richer, more generalizable features. Our findings provide converging evidence that models and brains may share abstract representational structures, supporting both hypotheses and motivating further research on brain-model alignment.

Àlmos Veres-Vitàlyos, Genis Castillo Gomez-Raya, Filip Lemic et al.

Small Unmanned Aerial Vehicles (UAVs) exhibit immense potential for navigating indoor and hard-to-reach areas, yet their significant constraints in payload and autonomy have largely prevented their use for complex tasks like high-quality 3-Dimensional (3D) reconstruction. To overcome this challenge, we introduce a novel system architecture that enables fully autonomous, high-fidelity 3D scanning of static objects using UAVs weighing under 100 grams. Our core innovation lies in a dual-reconstruction pipeline that creates a real-time feedback loop between data capture and flight control. A near-real-time (near-RT) process uses Structure from Motion (SfM) to generate an instantaneous pointcloud of the object. The system analyzes the model quality on the fly and dynamically adapts the UAV's trajectory to intelligently capture new images of poorly covered areas. This ensures comprehensive data acquisition. For the final, detailed output, a non-real-time (non-RT) pipeline employs a Neural Radiance Fields (NeRF)-based Neural 3D Reconstruction (N3DR) approach, fusing SfM-derived camera poses with precise Ultra Wide-Band (UWB) location data to achieve superior accuracy. We implemented and validated this architecture using Crazyflie 2.1 UAVs. Our experiments, conducted in both single- and multi-UAV configurations, conclusively show that dynamic trajectory adaptation consistently improves reconstruction quality over static flight paths. This work demonstrates a scalable and autonomous solution that unlocks the potential of miniaturized UAVs for fine-grained 3D reconstruction in constrained environments, a capability previously limited to much larger platforms.

Sebastian Macaluso, Giovanni Geraci, Elías F. Combarro et al.

The complexity of large-scale 6G-and-beyond networks demands innovative approaches for multi-objective optimization over vast search spaces, a task often intractable. Quantum computing (QC) emerges as a promising technology for efficient large-scale optimization. We present our vision of leveraging QC to tackle key classes of problems in future mobile networks. By analyzing and identifying common features, particularly their graph-centric representation, we propose a unified strategy involving QC algorithms. Specifically, we outline a methodology for optimization using quantum annealing as well as quantum reinforcement learning. Additionally, we discuss the main challenges that QC algorithms and hardware must overcome to effectively optimize future networks.

Mika Leo Hube, Filip Lemic, Ethungshan Shitiri et al.

Flow-guided Localization (FGL) enables the identification of spatial regions within the human body that contain an event of diagnostic interest. FGL does that by leveraging the passive movement of energy-constrained nanodevices circulating through the bloodstream. Existing FGL solutions rely on graph models with fixed topologies or handcrafted features, which limit their adaptability to anatomical variability and hinder scalability. In this work, we explore the use of Set Transformer architectures to address these limitations. Our formulation treats nanodevices' circulation time reports as unordered sets, enabling permutation-invariant, variable-length input processing without relying on spatial priors. To improve robustness under data scarcity and class imbalance, we integrate synthetic data generation via deep generative models, including CGAN, WGAN, WGAN-GP, and CVAE. These models are trained to replicate realistic circulation time distributions conditioned on vascular region labels, and are used to augment the training data. Our results show that the Set Transformer achieves comparable classification accuracy compared to Graph Neural Networks (GNN) baselines, while simultaneously providing by-design improved generalization to anatomical variability. The findings highlight the potential of permutation-invariant models and synthetic augmentation for robust and scalable nanoscale localization.

Pol Puigdemont, Enrico Russo, Axel Wassington et al.

Graph Neural Networks (GNNs) have shown significant promise in various domains, such as recommendation systems, bioinformatics, and network analysis. However, the irregularity of graph data poses unique challenges for efficient computation, leading to the development of specialized GNN accelerator architectures that surpass traditional CPU and GPU performance. Despite this, the structural diversity of input graphs results in varying performance across different GNN accelerators, depending on their dataflows. This variability in performance due to differing dataflows and graph properties remains largely unexplored, limiting the adaptability of GNN accelerators. To address this, we propose a data-driven framework for dataflow-aware latency prediction in GNN inference. Our approach involves training regressors to predict the latency of executing specific graphs on particular dataflows, using simulations on synthetic graphs. Experimental results indicate that our regressors can predict the optimal dataflow for a given graph with up to 91.28% accuracy and a Mean Absolute Percentage Error (MAPE) of 3.78%. Additionally, we introduce an online scheduling algorithm that uses these regressors to enhance scheduling decisions. Our experiments demonstrate that this algorithm achieves up to $3.17\times$ speedup in mean completion time and $6.26\times$ speedup in mean execution time compared to the best feasible baseline across all datasets.

Filip Lemic, Gerard Calvo Bartra, Arnau Brosa López et al.

Nanodevices with Terahertz (THz)-based wireless communication capabilities are providing a primer for flow-guided localization within the human bloodstreams. Such localization is allowing for assigning the locations of sensed events with the events themselves, providing benefits along the lines of early and precise diagnostics, and reduced costs and invasiveness. Flow-guided localization is still in a rudimentary phase, with only a handful of works targeting the problem. Nonetheless, the performance assessments of the proposed solutions are already carried out in a non-standardized way, usually along a single performance metric, and ignoring various aspects that are relevant at such a scale (e.g., nanodevices' limited energy) and for such a challenging environment (e.g., extreme attenuation of in-body THz propagation). As such, these assessments feature low levels of realism and cannot be compared in an objective way. Toward addressing this issue, we account for the environmental and scale-related peculiarities of the scenario and assess the performance of two state-of-the-art flow-guided localization approaches along a set of heterogeneous performance metrics such as the accuracy and reliability of localization.

Sergi Abadal, Akshay Jain, Robert Guirado et al.

Graph Neural Networks (GNNs) have exploded onto the machine learning scene in recent years owing to their capability to model and learn from graph-structured data. Such an ability has strong implications in a wide variety of fields whose data is inherently relational, for which conventional neural networks do not perform well. Indeed, as recent reviews can attest, research in the area of GNNs has grown rapidly and has lead to the development of a variety of GNN algorithm variants as well as to the exploration of groundbreaking applications in chemistry, neurology, electronics, or communication networks, among others. At the current stage of research, however, the efficient processing of GNNs is still an open challenge for several reasons. Besides of their novelty, GNNs are hard to compute due to their dependence on the input graph, their combination of dense and very sparse operations, or the need to scale to huge graphs in some applications. In this context, this paper aims to make two main contributions. On the one hand, a review of the field of GNNs is presented from the perspective of computing. This includes a brief tutorial on the GNN fundamentals, an overview of the evolution of the field in the last decade, and a summary of operations carried out in the multiple phases of different GNN algorithm variants. On the other hand, an in-depth analysis of current software and hardware acceleration schemes is provided, from which a hardware-software, graph-aware, and communication-centric vision for GNN accelerators is distilled.

Hamidreza Taghvaee, Akshay Jain, Xavier Timoneda et al.

As the current standardization for the 5G networks nears completion, work towards understanding the potential technologies for the 6G wireless networks is already underway. One of these potential technologies for the 6G networks are Reconfigurable Intelligent Surfaces (RISs). They offer unprecedented degrees of freedom towards engineering the wireless channel, i.e., the ability to modify the characteristics of the channel whenever and however required. Nevertheless, such properties demand that the response of the associated metasurface (MSF) is well understood under all possible operational conditions. While an understanding of the radiation pattern characteristics can be obtained through either analytical models or full wave simulations, they suffer from inaccuracy under certain conditions and extremely high computational complexity, respectively. Hence, in this paper we propose a novel neural networks based approach that enables a fast and accurate characterization of the MSF response. We analyze multiple scenarios and demonstrate the capabilities and utility of the proposed methodology. Concretely, we show that this method is able to learn and predict the parameters governing the reflected wave radiation pattern with an accuracy of a full wave simulation (98.8%-99.8%) and the time and computational complexity of an analytical model. The aforementioned result and methodology will be of specific importance for the design, fault tolerance and maintenance of the thousands of RISs that will be deployed in the 6G network environment.