Zhou Zhang

Zeyu Cao, Yuchi Ma, Zhou Zhang

In the U.S., corn is the most produced crop and has been an essential part of the American diet. To meet the demand for supply chain management and regional food security, accurate and timely large-scale corn yield prediction is attracting more attention in precision agriculture. Recently, remote sensing technology and machine learning methods have been widely explored for crop yield prediction. Currently, most county-level yield prediction models use county-level mean variables for prediction, ignoring much detailed information. Moreover, inconsistent spatial resolution between crop area and satellite sensors results in mixed pixels, which may decrease the prediction accuracy. Only a few works have addressed the mixed pixels problem in large-scale crop yield prediction. To address the information loss and mixed pixels problem, we developed a variational autoencoder (VAE) based multiple instance regression (MIR) model for large-scaled corn yield prediction. We use all unlabeled data to train a VAE and the well-trained VAE for anomaly detection. As a preprocess method, anomaly detection can help MIR find a better representation of every bag than traditional MIR methods, thus better performing in large-scale corn yield prediction. Our experiments showed that variational autoencoder based multiple instance regression (VAEMIR) outperformed all baseline methods in large-scale corn yield prediction. Though a suitable meta parameter is required, VAEMIR shows excellent potential in feature learning and extraction for large-scale corn yield prediction.

Chenguang Pan, Zhou Zhang, Weixuan Xiao et al.

In this technical report, we present the Educational Data Mining Automated Research System (EDM-ARS), a domain-specific multi-agent pipeline that automates end-to-end educational data mining (EDM) research. We conceptualize EDM-ARS as a general framework for domain-aware automated research pipelines, where educational expertise is embedded into each stage of the research lifecycle. As a first instantiation of this framework, we focus on predictive modeling tasks. Within this scope, EDM-ARS orchestrates five specialized LLM-powered agents (ProblemFormulator, DataEngineer, Analyst, Critic, and Writer) through a state-machine coordinator that supports revision loops, checkpoint-based recovery, and sandboxed code execution. Given a research prompt and a dataset, EDM-ARS produces a complete LaTeX manuscript with real Semantic Scholar citations, validated machine learning analyses, and automated methodological peer review. We also provide a detailed description of the system architecture, the three-tier data registry design that encodes educational domain expertise, the specification of each agent, the inter-agent communication protocol, and mechanisms for error-handling and self-correction. Finally, we discuss current limitations, including single-dataset scope and formulaic paper output, and outline a phased roadmap toward causal inference, transfer learning, psychometric, and multi-dataset generalization. EDM-ARS is released as an open-source project to support the educational research community.

Zhou Zhang, Hanqun Cao, Cheng Tan et al.

Accurate RNA structure modeling remains difficult because RNA backbones are highly flexible, non-canonical interactions are prevalent, and experimentally determined 3D structures are comparatively scarce. We introduce \emph{RiboSphere}, a framework that learns \emph{discrete} geometric representations of RNA by combining vector quantization with flow matching. Our design is motivated by the modular organization of RNA architecture: complex folds are composed from recurring structural motifs. RiboSphere uses a geometric transformer encoder to produce SE(3)-invariant (rotation/translation-invariant) features, which are discretized with finite scalar quantization (FSQ) into a finite vocabulary of latent codes. Conditioned on these discrete codes, a flow-matching decoder reconstructs atomic coordinates, enabling high-fidelity structure generation. We find that the learned code indices are enriched for specific RNA motifs, suggesting that the model captures motif-level compositional structure rather than acting as a purely compressive bottleneck. Across benchmarks, RiboSphere achieves strong performance in structure reconstruction (RMSD 1.25\,Å, TM-score 0.84), and its pretrained discrete representations transfer effectively to inverse folding and RNA--ligand binding prediction, with robust generalization in data-scarce regimes.

Hanqun Cao, Hongrui Zhang, Junde Xu et al.

Protein language models (PLMs) have advanced computational protein science through large-scale pretraining and scalable architectures. In parallel, reinforcement learning (RL) has broadened exploration and enabled precise multi-objective optimization in protein design. Yet whether RL can push PLMs beyond their pretraining priors to uncover latent sequence-structure-function rules remains unclear. We address this by pairing RL with PLMs across four domains: antimicrobial peptide design, kinase variant optimization, antibody engineering, and inverse folding. Using diverse RL algorithms and model classes, we ask if RL improves sampling efficiency and, more importantly, if it reveals capabilities not captured by supervised learning. Across benchmarks, RL consistently boosts success rates and sample efficiency. Performance follows a three-factor interaction: task headroom, reward fidelity, and policy capacity jointly determine gains. When rewards are accurate and informative, policies have sufficient capacity, and tasks leave room beyond supervised baselines, improvements scale; when rewards are noisy or capacity is constrained, gains saturate despite exploration. This view yields practical guidance for RL in protein design: prioritize reward modeling and calibration before scaling policy size, match algorithm and regularization strength to task difficulty, and allocate capacity where marginal gains are largest. Implementation is available at https://github.com/chq1155/RL-PLM.

Ziwen Chen, Zhendong Wang, Chongjing Wang et al.

Dermatologic diseases impose a large and growing global burden, affecting billions and substantially reducing quality of life. While modern therapies can rapidly control acute symptoms, long-term outcomes are often limited by single-target paradigms, recurrent courses, and insufficient attention to systemic comorbidities. Traditional Chinese medicine (TCM) provides a complementary holistic approach via syndrome differentiation and individualized treatment, but practice is hindered by non-standardized knowledge, incomplete multimodal records, and poor scalability of expert reasoning. We propose DERM-3R, a resource-efficient multimodal agent framework to model TCM dermatologic diagnosis and treatment under limited data and compute. Based on real-world workflows, we reformulate decision-making into three core issues: fine-grained lesion recognition, multi-view lesion representation with specialist-level pathogenesis modeling, and holistic reasoning for syndrome differentiation and treatment planning. DERM-3R comprises three collaborative agents: DERM-Rec, DERM-Rep, and DERM-Reason, each targeting one component of this pipeline. Built on a lightweight multimodal LLM and partially fine-tuned on 103 real-world TCM psoriasis cases, DERM-3R performs strongly across dermatologic reasoning tasks. Evaluations using automatic metrics, LLM-as-a-judge, and physician assessment show that despite minimal data and parameter updates, DERM-3R matches or surpasses large general-purpose multimodal models. These results suggest structured, domain-aware multi-agent modeling can be a practical alternative to brute-force scaling for complex clinical tasks in dermatology and integrative medicine.

Zhou Zhang, Dongzeng Tan, Jiaan Wang et al.

Emojis have gained immense popularity on social platforms, serving as a common means to supplement or replace text. However, existing data mining approaches generally either completely ignore or simply treat emojis as ordinary Unicode characters, which may limit the model's ability to grasp the rich semantic information in emojis and the interaction between emojis and texts. Thus, it is necessary to release the emoji's power in social media data mining. To this end, we first construct a heterogeneous graph consisting of three types of nodes, i.e. post, word and emoji nodes to improve the representation of different elements in posts. The edges are also well-defined to model how these three elements interact with each other. To facilitate the sharing of information among post, word and emoji nodes, we propose a graph pre-train framework for text and emoji co-modeling, which contains two graph pre-training tasks: node-level graph contrastive learning and edge-level link reconstruction learning. Extensive experiments on the Xiaohongshu and Twitter datasets with two types of downstream tasks demonstrate that our approach proves significant improvement over previous strong baseline methods.

Fei Li, Lang Qiao, Jiahao Fan et al.

High-resolution UAV photogrammetry has become a key technology for precision agriculture, enabling centimeter-level crop monitoring and point-level plant localization. However, point-level maize localization in UAV imagery remains challenging due to (1) extremely small object-to-pixel ratios, typically less than 0.1%, (2) prohibitive computational costs of quadratic attention on ultra-high-resolution images larger than 3000 x 4000 pixels, and (3) agricultural scene-specific complexities such as sparse object distribution and environmental variability that are poorly handled by general-purpose vision models. To address these challenges, we propose the Additive Kolmogorov-Arnold Transformer (AKT), which replaces conventional multilayer perceptrons with Pade Kolmogorov-Arnold Network (PKAN) modules to enhance functional expressivity for small-object feature extraction, and introduces PKAN Additive Attention (PAA) to model multiscale spatial dependencies with reduced computational complexity. In addition, we present the Point-based Maize Localization (PML) dataset, consisting of 1,928 high-resolution UAV images with approximately 501,000 point annotations collected under real field conditions. Extensive experiments show that AKT achieves an average F1-score of 62.8%, outperforming state-of-the-art methods by 4.2%, while reducing FLOPs by 12.6% and improving inference throughput by 20.7%. For downstream tasks, AKT attains a mean absolute error of 7.1 in stand counting and a root mean square error of 1.95-1.97 cm in interplant spacing estimation. These results demonstrate that integrating Kolmogorov-Arnold representation theory with efficient attention mechanisms offers an effective framework for high-resolution agricultural remote sensing.

Xiaoyu Wang, Yijia Xu, Jingyi Huang et al.

Remote sensing (RS) technique, enabling the non-contact acquisition of extensive ground observations, is a valuable tool for crop yield predictions. Traditional process-based models struggle to incorporate large volumes of RS data, and most users lack understanding of crop growth mechanisms. In contrast, machine learning (ML) models are often criticized as "black boxes" due to their limited interpretability. To address these limitations, we utilized Knowledge-Guided Machine Learning (KGML), a framework that leverages the strengths of both process-based and ML models. Existing works have either overlooked the role of soil moisture in corn growth or did not embed this effect into their models. To bridge this gap, we developed the Knowledge-Guided Machine Learning with Soil Moisture (KGML-SM) framework, treating soil moisture as an intermediate variable in corn growth to emphasize its key role in plant development. Additionally, based on the prior knowledge that the model may overestimate under drought conditions, we designed a drought-aware loss function that penalized predicted yield in drought-affected areas. Our experiments showed that the KGML-SM model outperformed other traditional ML models. We explored the relationships between drought, soil moisture, and corn yield prediction by assessing the importance of different features within the model, and analyzing how soil moisture impacts predictions across different regions and time periods. Finally we provided interpretability for prediction errors to guide future model optimization.

Junhua Sun, Zhou Zhang, Jie Zhang

The wheel of the train is a 3D revolving geometrical structure. Reconstructing the normal section profile is an effective approach to determine the critical geometric parameter and wear of the wheel in the community of railway safety. The existing reconstruction methods typically require a sensor working in a constrained position and pose, suffering poor flexibility and limited viewangle. This paper proposes a pose-unconstrained normal section profile reconstruction framework for 3D revolving structures via multiple 3D general section profiles acquired by a multi-line structured light vision sensor. First, we establish a model to estimate the axis of 3D revolving geometrical structure and the normal section profile using corresponding points. Then, we embed the model into an iterative algorithm to optimize the corresponding points and finally reconstruct the accurate normal section profile. We conducted real experiment on reconstructing the normal section profile of a 3D wheel. The results demonstrate that our algorithm reaches the mean precision of 0.068mm and good repeatability with the STD of 0.007mm. It is also robust to varying pose variations of the sensor. Our proposed framework and models are generalized to any 3D wheeltype revolving components.