Lucas Liu

Haoyue Zhang, Meera Chappidi, Erolcan Sayar et al.

Recent deep learning frameworks in histopathology, particularly multiple instance learning (MIL) combined with pathology foundational models (PFMs), have shown strong performance. However, PFMs exhibit limitations on certain cancer or specimen types due to domain shifts - these cancer types were rarely used for pretraining or specimens contain tissue-based artifacts rarely seen within the pretraining population. Such is the case for transurethral resection of bladder tumor (TURBT), which are essential for diagnosing muscle-invasive bladder cancer (MIBC), but contain fragmented tissue chips and electrocautery artifacts and were not widely used in publicly available PFMs. To address this, we propose a simple yet effective domain-adaptive self-supervised adaptor (DA-SSL) that realigns pretrained PFM features to the TURBT domain without fine-tuning the foundational model itself. We pilot this framework for predicting treatment response in TURBT, where histomorphological features are currently underutilized and identifying patients who will benefit from neoadjuvant chemotherapy (NAC) is challenging. In our multi-center study, DA-SSL achieved an AUC of 0.77+/-0.04 in five-fold cross-validation and an external test accuracy of 0.84, sensitivity of 0.71, and specificity of 0.91 using majority voting. Our results demonstrate that lightweight domain adaptation with self-supervision can effectively enhance PFM-based MIL pipelines for clinically challenging histopathology tasks. Code is Available at https://github.com/zhanghaoyue/DA_SSL_TURBT.

Yinghao Li, Pranav Shetty, Lucas Liu et al.

We study the problem of learning a named entity recognition (NER) tagger using noisy labels from multiple weak supervision sources. Though cheap to obtain, the labels from weak supervision sources are often incomplete, inaccurate, and contradictory, making it difficult to learn an accurate NER model. To address this challenge, we propose a conditional hidden Markov model (CHMM), which can effectively infer true labels from multi-source noisy labels in an unsupervised way. CHMM enhances the classic hidden Markov model with the contextual representation power of pre-trained language models. Specifically, CHMM learns token-wise transition and emission probabilities from the BERT embeddings of the input tokens to infer the latent true labels from noisy observations. We further refine CHMM with an alternate-training approach (CHMM-ALT). It fine-tunes a BERT-NER model with the labels inferred by CHMM, and this BERT-NER's output is regarded as an additional weak source to train the CHMM in return. Experiments on four NER benchmarks from various domains show that our method outperforms state-of-the-art weakly supervised NER models by wide margins.