Jiachen Yang

Haoyuan Tang, Zhuo Zhang, Jialin Li et al.

Coronary guidewire endpoint localization is a fundamental capability for computer-assisted PCI, and its importance increases as robot-assisted PCI is progressively adopted to reduce operator radiation exposure. However, the scarcity of annotated CAG images with guidewires and the limited adaptability of existing guidewire synthesis models remain key bottlenecks for guidewire endpoint localization. To address this issue, we propose VDSB-GWSyn, a Diffusion Schrödinger Bridge (DSB) model-based framework, enabling synthesis of controllable, high-fidelity guidewire samples under complex anatomical backgrounds. VDSB-GWSyn first uses our shape prior algorithm to learn the basic guidewire geometry. It then generates guidewire masks under constraints imposed by the vessel segmentation masks and outputs the corresponding endpoint coordinates. Finally, it synthesizes realistic guidewire samples on real CAG images using DSB conditioned with SPADE. Experimental results show that the guidewire samples synthesized by VDSB-GWSyn achieve favorable ROI-FID and ROI-KID, as well as high IPR scores. In addition, incorporating our synthesized data for synthetic pre-training followed by real fine-tuning substantially improves downstream guidewire endpoint localization, reducing MPE from 16.01~px to 7.71~px and increasing PCK at 3~px from 52.63\% to 86.27\%, leading to more clinically reliable deployment of robot-assisted guidewire delivery systems. Moreover, the core design philosophy of controllable device synthesis with strict background preservation and anatomical feasibility constraints has the potential to transfer to other interventional device perception tasks where annotated data are scarce.

Jiachen Yang, Zhuo Zhang, Yicheng Gong et al.

Data has now become a shortcoming of deep learning. Researchers in their own fields share the thinking that "deep neural networks might not always perform better when they eat more data," which still lacks experimental validation and a convincing guiding theory. Here to fill this lack, we design experiments from Identically Independent Distribution(IID) and Out of Distribution(OOD), which give powerful answers. For the purpose of guidance, based on the discussion of results, two theories are proposed: under IID condition, the amount of information determines the effectivity of each sample, the contribution of samples and difference between classes determine the amount of sample information and the amount of class information; under OOD condition, the cross-domain degree of samples determine the contributions, and the bias-fitting caused by irrelevant elements is a significant factor of cross-domain. The above theories provide guidance from the perspective of data, which can promote a wide range of practical applications of artificial intelligence.

Jiachen Yang, Ketan Mittal, Tarik Dzanic et al.

Adaptive mesh refinement (AMR) is necessary for efficient finite element simulations of complex physical phenomenon, as it allocates limited computational budget based on the need for higher or lower resolution, which varies over space and time. We present a novel formulation of AMR as a fully-cooperative Markov game, in which each element is an independent agent who makes refinement and de-refinement choices based on local information. We design a novel deep multi-agent reinforcement learning (MARL) algorithm called Value Decomposition Graph Network (VDGN), which solves the two core challenges that AMR poses for MARL: posthumous credit assignment due to agent creation and deletion, and unstructured observations due to the diversity of mesh geometries. For the first time, we show that MARL enables anticipatory refinement of regions that will encounter complex features at future times, thereby unlocking entirely new regions of the error-cost objective landscape that are inaccessible by traditional methods based on local error estimators. Comprehensive experiments show that VDGN policies significantly outperform error threshold-based policies in global error and cost metrics. We show that learned policies generalize to test problems with physical features, mesh geometries, and longer simulation times that were not seen in training. We also extend VDGN with multi-objective optimization capabilities to find the Pareto front of the tradeoff between cost and error.

Saaket Agashe, Kyle Wong, Vincent Tu et al.

Computer use agents automate digital tasks by directly interacting with graphical user interfaces (GUIs) on computers and mobile devices, offering significant potential to enhance human productivity by completing an open-ended space of user queries. However, current agents face significant challenges: imprecise grounding of GUI elements, difficulties with long-horizon task planning, and performance bottlenecks from relying on single generalist models for diverse cognitive tasks. To this end, we introduce Agent S2, a novel compositional framework that delegates cognitive responsibilities across various generalist and specialist models. We propose a novel Mixture-of-Grounding technique to achieve precise GUI localization and introduce Proactive Hierarchical Planning, dynamically refining action plans at multiple temporal scales in response to evolving observations. Evaluations demonstrate that Agent S2 establishes new state-of-the-art (SOTA) performance on three prominent computer use benchmarks. Specifically, Agent S2 achieves 18.9% and 32.7% relative improvements over leading baseline agents such as Claude Computer Use and UI-TARS on the OSWorld 15-step and 50-step evaluation. Moreover, Agent S2 generalizes effectively to other operating systems and applications, surpassing previous best methods by 52.8% on WindowsAgentArena and by 16.52% on AndroidWorld relatively. Code available at https://github.com/simular-ai/Agent-S.

Gonzalo Gonzalez-Pumariega, Saaket Agashe, Jiachen Yang et al.

Computer-use agents have rapidly improved on real-world tasks such as web navigation, desktop automation, and software interaction, in some cases surpassing human performance. Yet even when the task and model are unchanged, an agent that succeeds once may fail on a repeated execution of the same task. This raises a fundamental question: if an agent can succeed at a task once, what prevents it from doing so reliably? In this work, we study the sources of unreliability in computer-use agents through three factors: stochasticity during execution, ambiguity in task specification, and variability in agent behavior. We analyze these factors on OSWorld using repeated executions of the same task together with paired statistical tests that capture task-level changes across settings. Our analysis shows that reliability depends on both how tasks are specified and how agent behavior varies across executions. These findings suggest the need to evaluate agents under repeated execution, to allow agents to resolve task ambiguity through interaction, and to favor strategies that remain stable across runs.

Bin Lei, Caiwen Ding, Jiachen Yang et al.

Chain-of-Thought (CoT) reasoning has become a foundation for eliciting multi-step reasoning in large language models, but recent studies show that its benefits do not scale monotonically with chain length: while longer CoT generally enables a model to tackle harder problems, on a given problem, accuracy typically increases with CoT length up to a point, after which it declines. We identify a major cause of this phenomenon: as the CoT grows, the model's attention to critical insights produced earlier in the trace gradually weakens, making those insights progressively less accessible when they are most needed. Therefore, we propose \textbf{InsightReplay}, a stateful reasoning approach in which the model periodically extracts critical insights from its reasoning trace and replays them near the active generation frontier, keeping them accessible as the reasoning scales. Extensive experiments on a $\mathbf{2}\!\times\!\mathbf{3}\!\times\!\mathbf{4}$ benchmark grid, covering model scales $\{\text{8B}, \text{30B}\}$, model families $\{\text{Qwen3.5}, \text{DeepSeek-R1-Distill-Qwen}, \text{Gemma-4}\}$, and reasoning benchmarks $\{\text{AIME}, \text{HMMT}, \text{GPQA Diamond}, \text{LiveCodeBench v5}\}$, show that 3-round InsightReplay yields accuracy gains across \textbf{all 24 settings}, with an averaged improvement of $\mathbf{+1.65}$ points over standard CoT, and a largest single-setting gain of $\mathbf{+9.2}$ points on R1-Distill-32B's LiveCodeBench v5 subset. Our results suggest that the effectiveness of test-time scaling depends not only on how much a model reasons, but also on whether critical intermediate insights remain accessible throughout long reasoning trajectories.

Jialin Li, Zhuo Zhang, Yue Cao et al.

The scarcity of high-quality imaging data for coronary angiography (CAG) stenosis limits the clinical translation of automated stenosis detection. Synthetic stenosis data provides a practical avenue to augment training sets, improving data quality, diversity, and distributional coverage, and enhancing detection precision and generalization. However, diffusion-based editing commonly relies on soft guidance in a noise-initialized reverse process, offering limited pixel-level precision and structure preservation. We propose the OT-Bridge Editor, which reframes localized editing as a constrained entropic optimal transport (OT) problem and leverages geometric information to steer the generation path, enabling stronger geometric control. Extensive experiments show that our synthesized angiograms consistently improve downstream stenosis detection, yielding substantial relative gains of 27.8% on the public ARCADE benchmark and 23.0% on our multi-center dataset, supported by consistent qualitative results.

Jiachen Yang, Xianhui Lin, Yi Dong et al.

Face retouching requires removing subtle imperfections while preserving unique facial identity features, in order to enhance overall aesthetic appeal. However, existing methods suffer from a fundamental trade-off. Supervised learning on labeled data is constrained to pixel-level label mimicry, failing to capture complex subjective human aesthetic preferences. Conversely, while online reinforcement learning (RL) excels at preference alignment, its stochastic exploration paradigm conflicts with the high-fidelity demands of face retouching and often introduces noticeable noise artifacts due to accumulated stochastic drift. To address these limitations, we propose BeautyGRPO, a reinforcement learning framework that aligns face retouching with human aesthetic preferences. We construct FRPref-10K, a fine-grained preference dataset covering five key retouching dimensions, and train a specialized reward model capable of evaluating subtle perceptual differences. To reconcile exploration and fidelity, we introduce Dynamic Path Guidance (DPG). DPG stabilizes the stochastic sampling trajectory by dynamically computing an anchor-based ODE path and replanning a guided trajectory at each sampling timestep, effectively correcting stochastic drift while maintaining controlled exploration. Extensive experiments show that BeautyGRPO outperforms both specialized face retouching methods and general image editing models, achieving superior texture quality, more accurate blemish removal, and overall results that better align with human aesthetic preferences.

Jiazheng Sun, Mingxuan Li, Yingying Zhang et al.

Benchmarks are paramount for gauging progress in the domain of Mobile GUI Agents. In practical scenarios, users frequently fail to articulate precise directives containing full task details at the onset, and their expressions are typically ambiguous. Consequently, agents are required to converge on the user's true intent via active clarification and interaction during execution. However, existing benchmarks predominantly operate under the idealized assumption that user-issued instructions are complete and unequivocal. This paradigm focuses exclusively on assessing single-turn execution while overlooking the alignment capability of the agent. To address this limitation, we introduce AmbiBench, the first benchmark incorporating a taxonomy of instruction clarity to shift evaluation from unidirectional instruction following to bidirectional intent alignment. Grounded in Cognitive Gap theory, we propose a taxonomy of four clarity levels: Detailed, Standard, Incomplete, and Ambiguous. We construct a rigorous dataset of 240 ecologically valid tasks across 25 applications, subject to strict review protocols. Furthermore, targeting evaluation in dynamic environments, we develop MUSE (Mobile User Satisfaction Evaluator), an automated framework utilizing an MLLM-as-a-judge multi-agent architecture. MUSE performs fine-grained auditing across three dimensions: Outcome Effectiveness, Execution Quality, and Interaction Quality. Empirical results on AmbiBench reveal the performance boundaries of SoTA agents across different clarity levels, quantify the gains derived from active interaction, and validate the strong correlation between MUSE and human judgment. This work redefines evaluation standards, laying the foundation for next-generation agents capable of truly understanding user intent.

Gonzalo Gonzalez-Pumariega, Vincent Tu, Chih-Lun Lee et al.

Computer-use agents (CUAs) hold promise for automating everyday digital tasks, but their unreliability and high variance hinder their application to long-horizon, complex tasks. We introduce Behavior Best-of-N (bBoN), a method that scales over agents by generating multiple rollouts and selecting among them using behavior narratives that describe the agents' rollouts. It enables both wide exploration and principled trajectory selection, substantially improving robustness and success rates. On OSWorld, our bBoN scaling method establishes a new state of the art (SoTA) at 69.9%, significantly outperforming prior methods and approaching human-level performance at 72%, with comprehensive ablations validating key design choices. We further demonstrate strong generalization results to different operating systems on WindowsAgentArena and AndroidWorld. Crucially, our results highlight the unreasonable effectiveness of scaling CUAs, when you do it right: effective scaling requires structured trajectory understanding and selection, and bBoN provides a practical framework to achieve this.

Jacob F. Pettit, Chak Shing Lee, Jiachen Yang et al.

We consider the challenge of black-box optimization within hybrid discrete-continuous and variable-length spaces, a problem that arises in various applications, such as decision tree learning and symbolic regression. We propose DisCo-DSO (Discrete-Continuous Deep Symbolic Optimization), a novel approach that uses a generative model to learn a joint distribution over discrete and continuous design variables to sample new hybrid designs. In contrast to standard decoupled approaches, in which the discrete and continuous variables are optimized separately, our joint optimization approach uses fewer objective function evaluations, is robust against non-differentiable objectives, and learns from prior samples to guide the search, leading to significant improvement in performance and sample efficiency. Our experiments on a diverse set of optimization tasks demonstrate that the advantages of DisCo-DSO become increasingly evident as the complexity of the problem increases. In particular, we illustrate DisCo-DSO's superiority over the state-of-the-art methods for interpretable reinforcement learning with decision trees.

Zihao Chen, Wenyong Wang, Jiachen Yang et al.

Geometric representation learning in preserving the intrinsic geometric and topological properties for discrete non-Euclidean data is crucial in scientific applications. Previous research generally mapped non-Euclidean discrete data into Euclidean space during representation learning, which may lead to the loss of some critical geometric information. In this paper, we propose a novel Isometric Immersion Kernel Learning (IIKL) method to build Riemannian manifold and isometrically induce Riemannian metric from discrete non-Euclidean data. We prove that Isometric immersion is equivalent to the kernel function in the tangent bundle on the manifold, which explicitly guarantees the invariance of the inner product between vectors in the arbitrary tangent space throughout the learning process, thus maintaining the geometric structure of the original data. Moreover, a novel parameterized learning model based on IIKL is introduced, and an alternating training method for this model is derived using Maximum Likelihood Estimation (MLE), ensuring efficient convergence. Experimental results proved that using the learned Riemannian manifold and its metric, our model preserved the intrinsic geometric representation of data in both 3D and high-dimensional datasets successfully, and significantly improved the accuracy of downstream tasks, such as data reconstruction and classification. It is showed that our method could reduce the inner product invariant loss by more than 90% compared to state-of-the-art (SOTA) methods, also achieved an average 40% improvement in downstream reconstruction accuracy and a 90% reduction in error for geometric metrics involving isometric and conformal.

Yan Li, Lingxiao Wang, Jiachen Yang et al.

Multi-agent reinforcement learning (MARL) becomes more challenging in the presence of more agents, as the capacity of the joint state and action spaces grows exponentially in the number of agents. To address such a challenge of scale, we identify a class of cooperative MARL problems with permutation invariance, and formulate it as a mean-field Markov decision processes (MDP). To exploit the permutation invariance therein, we propose the mean-field proximal policy optimization (MF-PPO) algorithm, at the core of which is a permutation-invariant actor-critic neural architecture. We prove that MF-PPO attains the globally optimal policy at a sublinear rate of convergence. Moreover, its sample complexity is independent of the number of agents. We validate the theoretical advantages of MF-PPO with numerical experiments in the multi-agent particle environment (MPE). In particular, we show that the inductive bias introduced by the permutation-invariant neural architecture enables MF-PPO to outperform existing competitors with a smaller number of model parameters, which is the key to its generalization performance.

Jiachen Yang, Tarik Dzanic, Brenden Petersen et al.

Large-scale finite element simulations of complex physical systems governed by partial differential equations (PDE) crucially depend on adaptive mesh refinement (AMR) to allocate computational budget to regions where higher resolution is required. Existing scalable AMR methods make heuristic refinement decisions based on instantaneous error estimation and thus do not aim for long-term optimality over an entire simulation. We propose a novel formulation of AMR as a Markov decision process and apply deep reinforcement learning (RL) to train refinement policies directly from simulation. AMR poses a new problem for RL as both the state dimension and available action set changes at every step, which we solve by proposing new policy architectures with differing generality and inductive bias. The model sizes of these policy architectures are independent of the mesh size and hence can be deployed on larger simulations than those used at train time. We demonstrate in comprehensive experiments on static function estimation and time-dependent equations that RL policies can be trained on problems without using ground truth solutions, are competitive with a widely-used error estimator, and generalize to larger, more complex, and unseen test problems.

Rakshit Trivedi, Jiachen Yang, Hongyuan Zha

Formation mechanisms are fundamental to the study of complex networks, but learning them from observations is challenging. In real-world domains, one often has access only to the final constructed graph, instead of the full construction process, and observed graphs exhibit complex structural properties. In this work, we propose GraphOpt, an end-to-end framework that jointly learns an implicit model of graph structure formation and discovers an underlying optimization mechanism in the form of a latent objective function. The learned objective can serve as an explanation for the observed graph properties, thereby lending itself to transfer across different graphs within a domain. GraphOpt poses link formation in graphs as a sequential decision-making process and solves it using maximum entropy inverse reinforcement learning algorithm. Further, it employs a novel continuous latent action space that aids scalability. Empirically, we demonstrate that GraphOpt discovers a latent objective transferable across graphs with different characteristics. GraphOpt also learns a robust stochastic policy that achieves competitive link prediction performance without being explicitly trained on this task and further enables construction of graphs with properties similar to those of the observed graph.

Jiachen Yang, Ang Li, Mehrdad Farajtabar et al.

The challenge of developing powerful and general Reinforcement Learning (RL) agents has received increasing attention in recent years. Much of this effort has focused on the single-agent setting, in which an agent maximizes a predefined extrinsic reward function. However, a long-term question inevitably arises: how will such independent agents cooperate when they are continually learning and acting in a shared multi-agent environment? Observing that humans often provide incentives to influence others' behavior, we propose to equip each RL agent in a multi-agent environment with the ability to give rewards directly to other agents, using a learned incentive function. Each agent learns its own incentive function by explicitly accounting for its impact on the learning of recipients and, through them, the impact on its own extrinsic objective. We demonstrate in experiments that such agents significantly outperform standard RL and opponent-shaping agents in challenging general-sum Markov games, often by finding a near-optimal division of labor. Our work points toward more opportunities and challenges along the path to ensure the common good in a multi-agent future.

Jiachen Yang, Igor Borovikov, Hongyuan Zha

Human players in professional team sports achieve high level coordination by dynamically choosing complementary skills and executing primitive actions to perform these skills. As a step toward creating intelligent agents with this capability for fully cooperative multi-agent settings, we propose a two-level hierarchical multi-agent reinforcement learning (MARL) algorithm with unsupervised skill discovery. Agents learn useful and distinct skills at the low level via independent Q-learning, while they learn to select complementary latent skill variables at the high level via centralized multi-agent training with an extrinsic team reward. The set of low-level skills emerges from an intrinsic reward that solely promotes the decodability of latent skill variables from the trajectory of a low-level skill, without the need for hand-crafted rewards for each skill. For scalable decentralized execution, each agent independently chooses latent skill variables and primitive actions based on local observations. Our overall method enables the use of general cooperative MARL algorithms for training high level policies and single-agent RL for training low level skills. Experiments on a stochastic high dimensional team game show the emergence of useful skills and cooperative team play. The interpretability of the learned skills show the promise of the proposed method for achieving human-AI cooperation in team sports games.

Jiachen Yang, Brenden Petersen, Hongyuan Zha et al.

Transfer and adaptation to new unknown environmental dynamics is a key challenge for reinforcement learning (RL). An even greater challenge is performing near-optimally in a single attempt at test time, possibly without access to dense rewards, which is not addressed by current methods that require multiple experience rollouts for adaptation. To achieve single episode transfer in a family of environments with related dynamics, we propose a general algorithm that optimizes a probe and an inference model to rapidly estimate underlying latent variables of test dynamics, which are then immediately used as input to a universal control policy. This modular approach enables integration of state-of-the-art algorithms for variational inference or RL. Moreover, our approach does not require access to rewards at test time, allowing it to perform in settings where existing adaptive approaches cannot. In diverse experimental domains with a single episode test constraint, our method significantly outperforms existing adaptive approaches and shows favorable performance against baselines for robust transfer.

Zhi Zhang, Jiachen Yang, Hongyuan Zha

Traffic congestion in metropolitan areas is a world-wide problem that can be ameliorated by traffic lights that respond dynamically to real-time conditions. Recent studies applying deep reinforcement learning (RL) to optimize single traffic lights have shown significant improvement over conventional control. However, optimization of global traffic condition over a large road network fundamentally is a cooperative multi-agent control problem, for which single-agent RL is not suitable due to environment non-stationarity and infeasibility of optimizing over an exponential joint-action space. Motivated by these challenges, we propose QCOMBO, a simple yet effective multi-agent reinforcement learning (MARL) algorithm that combines the advantages of independent and centralized learning. We ensure scalability by selecting actions from individually optimized utility functions, which are shaped to maximize global performance via a novel consistency regularization loss between individual utility and a global action-value function. Experiments on diverse road topologies and traffic flow conditions in the SUMO traffic simulator show competitive performance of QCOMBO versus recent state-of-the-art MARL algorithms. We further show that policies trained on small sub-networks can effectively generalize to larger networks under different traffic flow conditions, providing empirical evidence for the suitability of MARL for intelligent traffic control.

Jiachen Yang, Alireza Nakhaei, David Isele et al.

A variety of cooperative multi-agent control problems require agents to achieve individual goals while contributing to collective success. This multi-goal multi-agent setting poses difficulties for recent algorithms, which primarily target settings with a single global reward, due to two new challenges: efficient exploration for learning both individual goal attainment and cooperation for others' success, and credit-assignment for interactions between actions and goals of different agents. To address both challenges, we restructure the problem into a novel two-stage curriculum, in which single-agent goal attainment is learned prior to learning multi-agent cooperation, and we derive a new multi-goal multi-agent policy gradient with a credit function for localized credit assignment. We use a function augmentation scheme to bridge value and policy functions across the curriculum. The complete architecture, called CM3, learns significantly faster than direct adaptations of existing algorithms on three challenging multi-goal multi-agent problems: cooperative navigation in difficult formations, negotiating multi-vehicle lane changes in the SUMO traffic simulator, and strategic cooperation in a Checkers environment.

Brenden K. Petersen, Jiachen Yang, Will S. Grathwohl et al.

Sepsis is a life-threatening condition affecting one million people per year in the US in which dysregulation of the body's own immune system causes damage to its tissues, resulting in a 28 - 50% mortality rate. Clinical trials for sepsis treatment over the last 20 years have failed to produce a single currently FDA approved drug treatment. In this study, we attempt to discover an effective cytokine mediation treatment strategy for sepsis using a previously developed agent-based model that simulates the innate immune response to infection: the Innate Immune Response agent-based model (IIRABM). Previous attempts at reducing mortality with multi-cytokine mediation using the IIRABM have failed to reduce mortality across all patient parameterizations and motivated us to investigate whether adaptive, personalized multi-cytokine mediation can control the trajectory of sepsis and lower patient mortality. We used the IIRABM to compute a treatment policy in which systemic patient measurements are used in a feedback loop to inform future treatment. Using deep reinforcement learning, we identified a policy that achieves 0% mortality on the patient parameterization on which it was trained. More importantly, this policy also achieves 0.8% mortality over 500 randomly selected patient parameterizations with baseline mortalities ranging from 1 - 99% (with an average of 49%) spanning the entire clinically plausible parameter space of the IIRABM. These results suggest that adaptive, personalized multi-cytokine mediation therapy could be a promising approach for treating sepsis. We hope that this work motivates researchers to consider such an approach as part of future clinical trials. To the best of our knowledge, this work is the first to consider adaptive, personalized multi-cytokine mediation therapy for sepsis, and is the first to exploit deep reinforcement learning on a biological simulation.

Jiachen Yang, Xiaojing Ye, Rakshit Trivedi et al.

We consider the problem of representing collective behavior of large populations and predicting the evolution of a population distribution over a discrete state space. A discrete time mean field game (MFG) is motivated as an interpretable model founded on game theory for understanding the aggregate effect of individual actions and predicting the temporal evolution of population distributions. We achieve a synthesis of MFG and Markov decision processes (MDP) by showing that a special MFG is reducible to an MDP. This enables us to broaden the scope of mean field game theory and infer MFG models of large real-world systems via deep inverse reinforcement learning. Our method learns both the reward function and forward dynamics of an MFG from real data, and we report the first empirical test of a mean field game model of a real-world social media population.

Mehrdad Farajtabar, Jiachen Yang, Xiaojing Ye et al.

We propose the first multistage intervention framework that tackles fake news in social networks by combining reinforcement learning with a point process network activity model. The spread of fake news and mitigation events within the network is modeled by a multivariate Hawkes process with additional exogenous control terms. By choosing a feature representation of states, defining mitigation actions and constructing reward functions to measure the effectiveness of mitigation activities, we map the problem of fake news mitigation into the reinforcement learning framework. We develop a policy iteration method unique to the multivariate networked point process, with the goal of optimizing the actions for maximal total reward under budget constraints. Our method shows promising performance in real-time intervention experiments on a Twitter network to mitigate a surrogate fake news campaign, and outperforms alternatives on synthetic datasets.