Runze Shi

Haoxuan Li, Tianci Gao, Jianhe Li et al.

Understanding the brain increasingly depends on integrating evidence across scales, modalities, and disciplines. Addressing a single research question therefore requires a coordinated sequence of operations, from surveying prior work to executing analyses and interpreting results in light of domain knowledge. AI agents promise to accelerate this process, but current agents lack domain expertise in brain science, may fabricate claims, drift during multi-step reasoning, and offer few defined points for expert intervention. These failures are especially costly in brain science, where conclusions feed into downstream scientific claims and depend on laboratory-specific expertise and careful human judgment. We present \textbf{BrainPilot} a \textbf{fully open-source} multi-agent system that accelerates brain science research with traceable logs and agent-verified results. A principal investigator (PI) agent coordinates specialist agents grounded in curated domain knowledge: a unified brain science knowledge base containing 7{,}233 indexed items and a skill library of 72 reusable methodology units across seven research domains. Every major step is recorded in the Graph of Trace, an auditable record that links subgoals, tool use, evidence, and claims and allows researchers to follow and inspect the workflow. An Auditor agent further integrates fabrication checking into the workflow. For evaluation, we run three brain science tasks from Agents' Last Exam, introduce our own benchmark, \textbf{BrainPilotBench-v0}, and present additional end-to-end case studies. Across these evaluations, BrainPilot with an open-source backbone model attains performance comparable to state-of-the-art agent framework with less costs.

Runze Shi, Shengyu Yan, Yuecheng Cai et al.

Automated alpha discovery is difficult because the search space of formulaic factors is combinatorial, the signal-to-noise ratio in daily equity data is low, and unconstrained program generation is operationally unsafe. We present Hubble, an agentic factor mining framework that combines large language models (LLMs) with a domain-specific operator language, an abstract syntax tree (AST) execution sandbox, a dual-channel retrieval-augmented generation (RAG) module, and a family-aware selection mechanism. Instead of treating the LLM as an unconstrained code generator, Hubble restricts generation to interpretable operator trees, evaluates every candidate through a deterministic cross-sectional pipeline, and feeds back both top formulas and structured family-level diagnostics to subsequent rounds. The current system additionally introduces positive/negative RAG, formula-similarity penalties, standardized multi-metric scoring, dual reporting of RankIC and Pearson IC, and persistent diagnostics artifacts for post-hoc research analysis. On a U.S. equity universe of roughly 500 stocks, our main run evaluates 104 valid candidates across three rounds with zero runtime crashes and discovers a top set dominated by range, volatility, and trend families rather than crowded volume-only motifs. We then fix the resulting top-5 factors and validate them on a held-out period from 2025-06-01 to 2026-03-13. In this out-of-sample window, the two range factors and two volatility factors remain positive and several achieve HAC-significant Pearson IC and long-short evidence, whereas the weakest in-sample trend factor decays materially. These results suggest that safe LLM-guided search can be upgraded from a syntax-compliant generator into a reproducible alpha-research workflow that jointly optimizes validity, diversity, interpretability, and family-level generalization.