Jyri Kivinen

Jaakko Sahlsten, Joel Jaskari, Jyri Kivinen et al.

Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening. This labor-intensive task could greatly benefit from automatic detection using deep learning technique. Here we present a deep learning system that identifies referable diabetic retinopathy comparably or better than presented in the previous studies, although we use only a small fraction of images (<1/4) in training but are aided with higher image resolutions. We also provide novel results for five different screening and clinical grading systems for diabetic retinopathy and macular edema classification, including results for accurately classifying images according to clinical five-grade diabetic retinopathy and four-grade diabetic macular edema scales. These results suggest, that a deep learning system could increase the cost-effectiveness of screening while attaining higher than recommended performance, and that the system could be applied in clinical examinations requiring finer grading.

Joel Jaskari, Jyri J. Kivinen

We develop a novel probabilistic generative model based on the variational autoencoder approach. Notable aspects of our architecture are: a novel way of specifying the latent variables prior, and the introduction of an ordinality enforcing unit. We describe how to do supervised, unsupervised and semi-supervised learning, and nominal and ordinal classification, with the model. We analyze generative properties of the approach, and the classification effectiveness under nominal and ordinal classification, using two benchmark datasets. Our results show that our model can achieve comparable results with relevant baselines in both of the classification tasks.