John Santerre

Conor Nixon, Zachary Yahn, Ethan Duncan et al.

In this paper we present two examples of recent investigations that we have undertaken, applying Machine Learning (ML) neural networks (NN) to image datasets from outer planet missions to achieve feature recognition. Our first investigation was to recognize ice blocks (also known as rafts, plates, polygons) in the chaos regions of fractured ice on Europa. We used a transfer learning approach, adding and training new layers to an industry-standard Mask R-CNN (Region-based Convolutional Neural Network) to recognize labeled blocks in a training dataset. Subsequently, the updated model was tested against a new dataset, achieving 68% precision. In a different application, we applied the Mask R-CNN to recognize clouds on Titan, again through updated training followed by testing against new data, with a precision of 95% over 369 images. We evaluate the relative successes of our techniques and suggest how training and recognition could be further improved. The new approaches we have used for planetary datasets can further be applied to similar recognition tasks on other planets, including Earth. For imagery of outer planets in particular, the technique holds the possibility of greatly reducing the volume of returned data, via onboard identification of the most interesting image subsets, or by returning only differential data (images where changes have occurred) greatly enhancing the information content of the final data stream.

Lionel Levine, John Santerre, Alex S. Young et al.

We introduce PRISM (Predictive Reasoning in Sequential Medicine), a transformer-based architecture designed to model the sequential progression of clinical decision-making processes. Unlike traditional approaches that rely on isolated diagnostic classification, PRISM frames clinical trajectories as tokenized sequences of events - including diagnostic tests, laboratory results, and diagnoses - and learns to predict the most probable next steps in the patient diagnostic journey. Leveraging a large custom clinical vocabulary and an autoregressive training objective, PRISM demonstrates the ability to capture complex dependencies across longitudinal patient timelines. Experimental results show substantial improvements over random baselines in next-token prediction tasks, with generated sequences reflecting realistic diagnostic pathways, laboratory result progressions, and clinician ordering behaviors. These findings highlight the feasibility of applying generative language modeling techniques to structured medical event data, enabling applications in clinical decision support, simulation, and education. PRISM establishes a foundation for future advancements in sequence-based healthcare modeling, bridging the gap between machine learning architectures and real-world diagnostic reasoning.

Zachary Yahn, Douglas M Trent, Ethan Duncan et al.

Despite widespread adoption of deep learning models to address a variety of computer vision tasks, planetary science has yet to see extensive utilization of such tools to address its unique problems. On Titan, the largest moon of Saturn, tracking seasonal trends and weather patterns of clouds provides crucial insights into one of the most complex climates in the Solar System, yet much of the available image data are still analyzed in a conventional way. In this work, we apply a Mask R-CNN trained via transfer learning to perform instance segmentation of clouds in Titan images acquired by the Cassini spacecraft - a previously unexplored approach to a big data problem in planetary science. We demonstrate that an automated technique can provide quantitative measures for clouds, such as areas and centroids, that may otherwise be prohibitively time-intensive to produce by human mapping. Furthermore, despite Titan specific challenges, our approach yields accuracy comparable to contemporary cloud identification studies on Earth and other worlds. We compare the efficiencies of human-driven versus algorithmic approaches, showing that transfer learning provides speed-ups that may open new horizons for data investigation for Titan. Moreover, we suggest that such approaches have broad potential for application to similar problems in planetary science where they are currently under-utilized. Future planned missions to the planets and remote sensing initiatives for the Earth promise to provide a deluge of image data in the coming years that will benefit strongly from leveraging machine learning approaches to perform the analysis.

Lionel Levine, John Santerre, Alexander S. Young et al.

We present PRISM-Consult, a clinician-aligned panel-of-experts architecture that extends the compact PRISM sequence model into a routed family of domain specialists. Episodes are tokenized as structured clinical events; a light-weight router reads the first few tokens and dispatches to specialist models (Cardiac-Vascular, Pulmonary, Gastro-Oesophageal, Musculoskeletal, Psychogenic). Each specialist inherits PRISM's small transformer backbone and token template, enabling parameter efficiency and interpretability. On real-world Emergency Department cohorts, specialists exhibit smooth convergence with low development perplexities across domains, while the router achieves high routing quality and large compute savings versus consult-all under a safety-first policy. We detail the data methodology (initial vs. conclusive ICD-9 families), routing thresholds and calibration, and report per-domain results to avoid dominance by common events. The framework provides a practical path to safe, auditable, and low-latency consult at scale, and we outline validation steps-external/temporal replication, asymmetric life-threat thresholds, and multi-label arbitration-to meet prospective clinical deployment standards.

David Josephs, Carson Drake, Andrew Heroy et al.

Myoelectric control is one of the leading areas of research in the field of robotic prosthetics. We present our research in surface electromyography (sEMG) signal classification, where our simple and novel attention-based approach now leads the industry, universally beating more complex, state-of-the-art models. Our novel attention-based model achieves benchmark leading results on multiple industry-standard datasets including 53 finger, wrist, and grasping motions, improving over both sophisticated signal processing and CNN-based approaches. Our strong results with a straightforward model also indicate that sEMG represents a promising avenue for future machine learning research, with applications not only in prosthetics, but also in other important areas, such as diagnosis and prognostication of neurodegenerative diseases, computationally mediated surgeries, and advanced robotic control. We reinforce this suggestion with extensive ablative studies, demonstrating that a neural network can easily extract higher order spatiotemporal features from noisy sEMG data collected by affordable, consumer-grade sensors.