Marcus Haywood-Alexander

Marcus Haywood-Alexander, Wei Liu, Kiran Bacsa et al.

The intersection of physics and machine learning has given rise to the physics-enhanced machine learning (PEML) paradigm, aiming to improve the capabilities and reduce the individual shortcomings of data- or physics-only methods. In this paper, the spectrum of physics-enhanced machine learning methods, expressed across the defining axes of physics and data, is discussed by engaging in a comprehensive exploration of its characteristics, usage, and motivations. In doing so, we present a survey of recent applications and developments of PEML techniques, revealing the potency of PEML in addressing complex challenges. We further demonstrate application of select such schemes on the simple working example of a single degree-of-freedom Duffing oscillator, which allows to highlight the individual characteristics and motivations of different `genres' of PEML approaches. To promote collaboration and transparency, and to provide practical examples for the reader, the code generating these working examples is provided alongside this paper. As a foundational contribution, this paper underscores the significance of PEML in pushing the boundaries of scientific and engineering research, underpinned by the synergy of physical insights and machine learning capabilities.

Nathan Khosla, Jake M. Lesinski, Marcus Haywood-Alexander et al.

CRISPR-based diagnostics have gained increasing attention as biosensing tools able to address limitations in contemporary molecular diagnostic tests. To maximise the performance of CRISPR-based assays, much effort has focused on optimizing the chemistry and biology of the biosensing reaction. However, less attention has been paid to improving the techniques used to analyse CRISPR-based diagnostic data. To date, diagnostic decisions typically involve various forms of slope-based classification. Such methods are superior to traditional methods based on assessing absolute signals, but still have limitations. Herein, we establish performance benchmarks (total accuracy, sensitivity, and specificity) using common slope-based methods. We compare the performance of these benchmark methods with three different quadratic empirical distribution function statistical tests, finding significant improvements in diagnostic speed and accuracy when applied to a clinical data set. Two of the three statistical techniques, the Kolmogorov-Smirnov and Anderson-Darling tests, report the lowest time-to-result and highest total test accuracy. Furthermore, we developed a long short-term memory recurrent neural network to classify CRISPR-biosensing data, achieving 100% specificity on our model data set. Finally, we provide guidelines on choosing the classification method and classification method parameters that best suit a diagnostic assays needs.

Marcus Haywood-Alexander, Nikolaos Dervilis, Keith Worden et al.

The use of ultrasonic guided waves to probe the materials/structures for damage continues to increase in popularity for non-destructive evaluation (NDE) and structural health monitoring (SHM). The use of high-frequency waves such as these offers an advantage over low-frequency methods from their ability to detect damage on a smaller scale. However, in order to assess damage in a structure, and implement any NDE or SHM tool, knowledge of the behaviour of a guided wave throughout the material/structure is important (especially when designing sensor placement for SHM systems). Determining this behaviour is extremely diffcult in complex materials, such as fibre-matrix composites, where unique phenomena such as continuous mode conversion takes place. This paper introduces a novel method for modelling the feature-space of guided waves in a composite material. This technique is based on a data-driven model, where prior physical knowledge can be used to create structured machine learning tools; where constraints are applied to provide said structure. The method shown makes use of Gaussian processes, a full Bayesian analysis tool, and in this paper it is shown how physical knowledge of the guided waves can be utilised in modelling using an ML tool. This paper shows that through careful consideration when applying machine learning techniques, more robust models can be generated which offer advantages such as extrapolation ability and physical interpretation.