Siqi Zhang

Guangyu Wang, Jingkun Yue, Siqi Zhang et al.

A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation. We outline the data infrastructure, evaluation benchmarks, safety constraints and governance frameworks required. Biomedical world models may provide a foundation for simulation-guided, closed-loop and experimentally actionable biomedical discovery.

Siqi Zhang, Yifan Hu, Liang Zhang et al. · eth-zurich

This paper takes an initial step to systematically investigate the generalization bounds of algorithms for solving nonconvex-(strongly)-concave (NC-SC/NC-C) stochastic minimax optimization measured by the stationarity of primal functions. We first establish algorithm-agnostic generalization bounds via uniform convergence between the empirical minimax problem and the population minimax problem. The sample complexities for achieving $ε$-generalization are $\tilde{\mathcal{O}}(dκ^2ε^{-2})$ and $\tilde{\mathcal{O}}(dε^{-4})$ for NC-SC and NC-C settings, respectively, where $d$ is the dimension and $κ$ is the condition number. We further study the algorithm-dependent generalization bounds via stability arguments of algorithms. In particular, we introduce a novel stability notion for minimax problems and build a connection between generalization bounds and the stability notion. As a result, we establish algorithm-dependent generalization bounds for stochastic gradient descent ascent (SGDA) algorithm and the more general sampling-determined algorithms.

Siqi Zhang, Sayantan Choudhury, Sebastian U Stich et al.

Distributed and federated learning algorithms and techniques associated primarily with minimization problems. However, with the increase of minimax optimization and variational inequality problems in machine learning, the necessity of designing efficient distributed/federated learning approaches for these problems is becoming more apparent. In this paper, we provide a unified convergence analysis of communication-efficient local training methods for distributed variational inequality problems (VIPs). Our approach is based on a general key assumption on the stochastic estimates that allows us to propose and analyze several novel local training algorithms under a single framework for solving a class of structured non-monotone VIPs. We present the first local gradient descent-accent algorithms with provable improved communication complexity for solving distributed variational inequalities on heterogeneous data. The general algorithmic framework recovers state-of-the-art algorithms and their sharp convergence guarantees when the setting is specialized to minimization or minimax optimization problems. Finally, we demonstrate the strong performance of the proposed algorithms compared to state-of-the-art methods when solving federated minimax optimization problems.

Feihu Huang, Chunyu Xuan, Xinrui Wang et al.

Minimax optimization recently is widely applied in many machine learning tasks such as generative adversarial networks, robust learning and reinforcement learning. In the paper, we study a class of nonconvex-nonconcave minimax optimization with nonsmooth regularization, where the objective function is possibly nonconvex on primal variable $x$, and it is nonconcave and satisfies the Polyak-Lojasiewicz (PL) condition on dual variable $y$. Moreover, we propose a class of enhanced momentum-based gradient descent ascent methods (i.e., MSGDA and AdaMSGDA) to solve these stochastic nonconvex-PL minimax problems. In particular, our AdaMSGDA algorithm can use various adaptive learning rates in updating the variables $x$ and $y$ without relying on any specifical types. Theoretically, we prove that our methods have the best known sample complexity of $\tilde{O}(ε^{-3})$ only requiring one sample at each loop in finding an $ε$-stationary solution. Some numerical experiments on PL-game and Wasserstein-GAN demonstrate the efficiency of our proposed methods.

Zhikai Qin, Siqi Zhang, Junyi Zhu et al.

Patients with bladder dysfunction often lose the sensation of bladder fullness and cannot void naturally, forcing reliance on fixed-schedule catheterization that is uncomfortable and risks complications. We present WeeCare, a handheld conformable pad with fabric electrodes for on-demand bladder fullness sensing using electrical impedance tomography (EIT). The central challenge is that repeated removal and reattachment can introduce variation in electrode position and contact quality. We assess WeeCare along three axes: in-silico simulations characterizing electrode layout and noise robustness, in-vitro phantom experiments across urine salinities and filling levels, and an in-vivo human measurement for bladder fullness sensing, voiding, and filling dynamics.

Lu Zhang, Siqi Zhang, Xu Yang et al.

Segmenting unseen objects is a crucial ability for the robot since it may encounter new environments during the operation. Recently, a popular solution is leveraging RGB-D features of large-scale synthetic data and directly applying the model to unseen real-world scenarios. However, the domain shift caused by the sim2real gap is inevitable, posing a crucial challenge to the segmentation model. In this paper, we emphasize the adaptation process across sim2real domains and model it as a learning problem on the BatchNorm parameters of a simulation-trained model. Specifically, we propose a novel non-parametric entropy objective, which formulates the learning objective for the test-time adaptation in an open-world manner. Then, a cross-modality knowledge distillation objective is further designed to encourage the test-time knowledge transfer for feature enhancement. Our approach can be efficiently implemented with only test images, without requiring annotations or revisiting the large-scale synthetic training data. Besides significant time savings, the proposed method consistently improves segmentation results on the overlap and boundary metrics, achieving state-of-the-art performance on unseen object instance segmentation.

Zihan Qiu, Zeyu Huang, Kaiyue Wen et al.

We investigate the functional role of emergent outliers in large language models, specifically attention sinks (a few tokens that consistently receive large attention logits) and residual sinks (a few fixed dimensions with persistently large activations across most tokens). We hypothesize that these outliers, in conjunction with the corresponding normalizations (\textit{e.g.}, softmax attention and RMSNorm), effectively rescale other non-outlier components. We term this phenomenon \textit{outlier-driven rescaling} and validate this hypothesis across different model architectures and training token counts. This view unifies the origin and mitigation of both sink types. Our main conclusions and observations include: (1) Outliers function jointly with normalization: removing normalization eliminates the corresponding outliers but degrades training stability and performance; directly clipping outliers while retaining normalization leads to degradation, indicating that outlier-driven rescaling contributes to training stability. (2) Outliers serve more as rescale factors rather than contributors, as the final contributions of attention and residual sinks are significantly smaller than those of non-outliers. (3) Outliers can be absorbed into learnable parameters or mitigated via explicit gated rescaling, leading to improved training performance (average gain of 2 points) and enhanced quantization robustness (1.2 points degradation under W4A4 quantization).

Siqi Zhang, Lu Zhang, Zhiyong Liu

Domain adaptive object detection (DAOD) assumes that both labeled source data and unlabeled target data are available for training, but this assumption does not always hold in real-world scenarios. Thus, source-free DAOD is proposed to adapt the source-trained detectors to target domains with only unlabeled target data. Existing source-free DAOD methods typically utilize pseudo labeling, where the performance heavily relies on the selection of confidence threshold. However, most prior works adopt a single fixed threshold for all classes to generate pseudo labels, which ignore the imbalanced class distribution, resulting in biased pseudo labels. In this work, we propose a refined pseudo labeling framework for source-free DAOD. First, to generate unbiased pseudo labels, we present a category-aware adaptive threshold estimation module, which adaptively provides the appropriate threshold for each category. Second, to alleviate incorrect box regression, a localization-aware pseudo label assignment strategy is introduced to divide labels into certain and uncertain ones and optimize them separately. Finally, extensive experiments on four adaptation tasks demonstrate the effectiveness of our method.

Junyou Zhu, Yanyuan Qiao, Siqi Zhang et al.

In recent years, Embodied Artificial Intelligence (Embodied AI) has advanced rapidly, yet the increasing size of models conflicts with the limited computational capabilities of Embodied AI platforms. To address this challenge, we aim to achieve both high model performance and practical deployability. Specifically, we focus on Vision-and-Language Navigation (VLN), a core task in Embodied AI. This paper introduces a two-stage knowledge distillation framework, producing a student model, MiniVLN, and showcasing the significant potential of distillation techniques in developing lightweight models. The proposed method aims to capture fine-grained knowledge during the pretraining phase and navigation-specific knowledge during the fine-tuning phase. Our findings indicate that the two-stage distillation approach is more effective in narrowing the performance gap between the teacher model and the student model compared to single-stage distillation. On the public R2R and REVERIE benchmarks, MiniVLN achieves performance on par with the teacher model while having only about 12% of the teacher model's parameter count.

Siqi Zhang, Lu Zhang, Zhiyong Liu et al.

Domain adaptive object detection (DAOD) aims to adapt the detector from a labelled source domain to an unlabelled target domain. In recent years, DAOD has attracted massive attention since it can alleviate performance degradation due to the large shift of data distributions in the wild. To align distributions between domains, adversarial learning is widely used in existing DAOD methods. However, the decision boundary for the adversarial domain discriminator may be inaccurate, causing the model biased towards the source domain. To alleviate this bias, we propose a novel Frequency-based Image Translation (FIT) framework for DAOD. First, by keeping domain-invariant frequency components and swapping domain-specific ones, we conduct image translation to reduce domain shift at the input level. Second, hierarchical adversarial feature learning is utilized to further mitigate the domain gap at the feature level. Finally, we design a joint loss to train the entire network in an end-to-end manner without extra training to obtain translated images. Extensive experiments on three challenging DAOD benchmarks demonstrate the effectiveness of our method.

Siqi Zhang, Xiyuxing Zhang, Duc Vu et al.

We present LubDubDecoder, a system that enables fine-grained monitoring of micro-cardiac vibrations associated with the opening and closing of heart valves across a range of hearables. Our system transforms the built-in speaker, the only transducer common to all hearables, into an acoustic sensor that captures the coarse "lub-dub" heart sounds, leverages their shared temporal and spectral structure to reconstruct the subtle seismocardiography (SCG) and gyrocardiography (GCG) waveforms, and extract the timing of key micro-cardiac events. In an IRB-approved feasibility study with 25 users, our system achieves correlations of 0.88-0.95 compared to chest-mounted reference measurements in within-user and cross-user evaluations, and generalizes to unseen hearables using a zero-effort adaptation scheme with a correlation of 0.91. Our system is robust across remounting sessions and music playback.

Yanyuan Qiao, Haodong Hong, Wenqi Lyu et al.

Multimodal Large Language Models (MLLMs) have demonstrated strong generalization in vision-language tasks, yet their ability to understand and act within embodied environments remains underexplored. We present NavBench, a benchmark to evaluate the embodied navigation capabilities of MLLMs under zero-shot settings. NavBench consists of two components: (1) navigation comprehension, assessed through three cognitively grounded tasks including global instruction alignment, temporal progress estimation, and local observation-action reasoning, covering 3,200 question-answer pairs; and (2) step-by-step execution in 432 episodes across 72 indoor scenes, stratified by spatial, cognitive, and execution complexity. To support real-world deployment, we introduce a pipeline that converts MLLMs' outputs into robotic actions. We evaluate both proprietary and open-source models, finding that GPT-4o performs well across tasks, while lighter open-source models succeed in simpler cases. Results also show that models with higher comprehension scores tend to achieve better execution performance. Providing map-based context improves decision accuracy, especially in medium-difficulty scenarios. However, most models struggle with temporal understanding, particularly in estimating progress during navigation, which may pose a key challenge.

Shengkun Tang, Zekun Wang, Bo Zheng et al.

Structured pruning and knowledge distillation (KD) are typical techniques for compressing large language models, but it remains unclear how they should be applied at pretraining scale, especially to recent mixture-of-experts (MoE) models. In this work, we systematically study MoE compression in large-scale pretraining, focusing on three key questions: whether pruning provides a better initialization than training from scratch, how expert compression choices affect the final model after continued training, and which training strategy is most effective. We have the following findings: First, across depth, width, and expert compression, pruning a pretrained MoE consistently outperforms training the target architecture from scratch under the same training budget. Second, different one-shot expert compression methods converge to similar final performance after large-scale continual pretraining. Motivated by this, we introduce a simple partial-preservation expert merging strategy that improves downstream performance across most benchmarks. Third, combining KD with the language modeling loss outperforms KD alone, particularly on knowledge-intensive tasks. We further propose multi-token prediction (MTP) distillation, which yields consistent gains. Finally, given the same training tokens, progressive pruning schedules outperform one-shot compression, suggesting that gradual architecture transitions lead to better optimization trajectories. Putting it all together, we compress Qwen3-Next-80A3B to a 23A2B model that retains competitive performance. These results offer practical guidance for efficient MoE compression at scale.

Lubian Bai, Xiuyuan Zhang, Siqi Zhang et al.

Integrating ground-level geospatial data with rich geographic context, like OpenStreetMap (OSM), into remote sensing (RS) foundation models (FMs) is essential for advancing geospatial intelligence and supporting a broad spectrum of tasks. However, modality gap between RS and OSM data, including differences in data structure, content, and spatial granularity, makes effective synergy highly challenging, and most existing RS FMs focus on imagery alone. To this end, this study presents GeoLink, a multimodal framework that leverages OSM data to enhance RS FM during both the pretraining and downstream task stages. Specifically, GeoLink enhances RS self-supervised pretraining using multi-granularity learning signals derived from OSM data, guided by cross-modal spatial correlations for information interaction and collaboration. It also introduces image mask-reconstruction to enable sparse input for efficient pretraining. For downstream tasks, GeoLink generates both unimodal and multimodal fine-grained encodings to support a wide range of applications, from common RS interpretation tasks like land cover classification to more comprehensive geographic tasks like urban function zone mapping. Extensive experiments show that incorporating OSM data during pretraining enhances the performance of the RS image encoder, while fusing RS and OSM data in downstream tasks improves the FM's adaptability to complex geographic scenarios. These results underscore the potential of multimodal synergy in advancing high-level geospatial artificial intelligence. Moreover, we find that spatial correlation plays a crucial role in enabling effective multimodal geospatial data integration. Code, checkpoints, and using examples are released at https://github.com/bailubin/GeoLink_NeurIPS2025

Jingkun Yue, Siqi Zhang, Zinan Jia et al.

Visual grounding is essential for precise perception and reasoning in multimodal large language models (MLLMs), especially in medical imaging domains. While existing medical visual grounding benchmarks primarily focus on single-image scenarios, real-world clinical applications often involve sequential images, where accurate lesion localization across different modalities and temporal tracking of disease progression (e.g., pre- vs. post-treatment comparison) require fine-grained cross-image semantic alignment and context-aware reasoning. To remedy the underrepresentation of image sequences in existing medical visual grounding benchmarks, we propose MedSG-Bench, the first benchmark tailored for Medical Image Sequences Grounding. It comprises eight VQA-style tasks, formulated into two paradigms of the grounding tasks, including 1) Image Difference Grounding, which focuses on detecting change regions across images, and 2) Image Consistency Grounding, which emphasizes detection of consistent or shared semantics across sequential images. MedSG-Bench covers 76 public datasets, 10 medical imaging modalities, and a wide spectrum of anatomical structures and diseases, totaling 9,630 question-answer pairs. We benchmark both general-purpose MLLMs (e.g., Qwen2.5-VL) and medical-domain specialized MLLMs (e.g., HuatuoGPT-vision), observing that even the advanced models exhibit substantial limitations in medical sequential grounding tasks. To advance this field, we construct MedSG-188K, a large-scale instruction-tuning dataset tailored for sequential visual grounding, and further develop MedSeq-Grounder, an MLLM designed to facilitate future research on fine-grained understanding across medical sequential images. The benchmark, dataset, and model are available at https://huggingface.co/MedSG-Bench

Zheng Chen, Zongwei Wu, Eduard Zamfir et al.

This paper reviews the NTIRE 2024 challenge on image super-resolution ($\times$4), highlighting the solutions proposed and the outcomes obtained. The challenge involves generating corresponding high-resolution (HR) images, magnified by a factor of four, from low-resolution (LR) inputs using prior information. The LR images originate from bicubic downsampling degradation. The aim of the challenge is to obtain designs/solutions with the most advanced SR performance, with no constraints on computational resources (e.g., model size and FLOPs) or training data. The track of this challenge assesses performance with the PSNR metric on the DIV2K testing dataset. The competition attracted 199 registrants, with 20 teams submitting valid entries. This collective endeavour not only pushes the boundaries of performance in single-image SR but also offers a comprehensive overview of current trends in this field.

Siqi Zhang, Mayank Goel, Justin Chan

We present DropleX, the first system that enables liquid sensing using the capacitive touchscreen of commodity tablets. DropleX detects microliter-scale liquid samples, and performs non-invasive, through-container measurements for liquid analysis. These capabilities are made possible by a physics-informed mechanism that disables the touchscreen's built-in adaptive filters, originally designed to reject the effects of liquid drops such as rain, without any hardware modifications. We model the touchscreen's sensing capabilities, limits, and non-idealities to inform the design of a signal processing and learning-based pipeline for liquid sensing. Under controlled laboratory conditions, our system achieves 89-99% accuracy in detecting microliter-scale adulteration in soda, wine, and milk, 94-96% accuracy in threshold detection of trace chemical concentrations, and 86-96% accuracy in through-container adulterant detection. These exploratory results demonstrate the potential of repurposing commodity touchscreens as a liquid characterization platform for laboratory settings, food and beverage testing, and chemical analysis applications.

Siqi Zhang, Yanyuan Qiao, Qunbo Wang et al.

The aspiration of the Vision-and-Language Navigation (VLN) task has long been to develop an embodied agent with robust adaptability, capable of seamlessly transferring its navigation capabilities across various tasks. Despite remarkable advancements in recent years, most methods necessitate dataset-specific training, thereby lacking the capability to generalize across diverse datasets encompassing distinct types of instructions. Large language models (LLMs) have demonstrated exceptional reasoning and generalization abilities, exhibiting immense potential in robot action planning. In this paper, we propose FlexVLN, an innovative hierarchical approach to VLN that integrates the fundamental navigation ability of a supervised-learning-based Instruction Follower with the robust generalization ability of the LLM Planner, enabling effective generalization across diverse VLN datasets. Moreover, a verification mechanism and a multi-model integration mechanism are proposed to mitigate potential hallucinations by the LLM Planner and enhance execution accuracy of the Instruction Follower. We take REVERIE, SOON, and CVDN-target as out-of-domain datasets for assessing generalization ability. The generalization performance of FlexVLN surpasses that of all the previous methods to a large extent.

Shuming Liang, Yu Ding, Zhidong Li et al.

This paper explores the ability of Graph Neural Networks (GNNs) in learning various forms of information for link prediction, alongside a brief review of existing link prediction methods. Our analysis reveals that GNNs cannot effectively learn structural information related to the number of common neighbors between two nodes, primarily due to the nature of set-based pooling of the neighborhood aggregation scheme. Also, our extensive experiments indicate that trainable node embeddings can improve the performance of GNN-based link prediction models. Importantly, we observe that the denser the graph, the greater such the improvement. We attribute this to the characteristics of node embeddings, where the link state of each link sample could be encoded into the embeddings of nodes that are involved in the neighborhood aggregation of the two nodes in that link sample. In denser graphs, every node could have more opportunities to attend the neighborhood aggregation of other nodes and encode states of more link samples to its embedding, thus learning better node embeddings for link prediction. Lastly, we demonstrate that the insights gained from our research carry important implications in identifying the limitations of existing link prediction methods, which could guide the future development of more robust algorithms.

Siqi Zhang, Yanyuan Qiao, Qunbo Wang et al.

Vision-and-Language Navigation (VLN) tasks have gained prominence within artificial intelligence research due to their potential application in fields like home assistants. Many contemporary VLN approaches, while based on transformer architectures, have increasingly incorporated additional components such as external knowledge bases or map information to enhance performance. These additions, while boosting performance, also lead to larger models and increased computational costs. In this paper, to achieve both high performance and low computational costs, we propose a novel architecture with the COmbination of Selective MemOrization (COSMO). Specifically, COSMO integrates state-space modules and transformer modules, and incorporates two VLN-customized selective state space modules: the Round Selective Scan (RSS) and the Cross-modal Selective State Space Module (CS3). RSS facilitates comprehensive inter-modal interactions within a single scan, while the CS3 module adapts the selective state space module into a dual-stream architecture, thereby enhancing the acquisition of cross-modal interactions. Experimental validations on three mainstream VLN benchmarks, REVERIE, R2R, and R2R-CE, not only demonstrate competitive navigation performance of our model but also show a significant reduction in computational costs.

Fengping Wang, Jie Li, Siqi Zhang et al.

Micro-expressions are spontaneous, unconscious facial movements that show people's true inner emotions and have great potential in related fields of psychological testing. Since the face is a 3D deformation object, the occurrence of an expression can arouse spatial deformation of the face, but limited by the available databases are 2D videos, lacking the description of 3D spatial information of micro-expressions. Therefore, we proposed a new micro-expression database containing 2D video sequences and 3D point clouds sequences. The database includes 373 micro-expressions sequences, and these samples were classified using the objective method based on facial action coding system, as well as the non-objective method that combines video contents and participants' self-reports. We extracted 2D and 3D features using the local binary patterns on three orthogonal planes (LBP-TOP) and curvature algorithms, respectively, and evaluated the classification accuracies of these two features and their fusion results with leave-one-subject-out (LOSO) and 10-fold cross-validation. Further, we performed various neural network algorithms for database classification, the results show that classification accuracies are improved by fusing 3D features than using only 2D features. The database offers original and cropped micro-expression samples, which will facilitate the exploration and research on 3D Spatio-temporal features of micro-expressions.

Siqi Zhang, Junchi Yang, Cristóbal Guzmán et al.

This paper studies the complexity for finding approximate stationary points of nonconvex-strongly-concave (NC-SC) smooth minimax problems, in both general and averaged smooth finite-sum settings. We establish nontrivial lower complexity bounds of $Ω(\sqrtκΔLε^{-2})$ and $Ω(n+\sqrt{nκ}ΔLε^{-2})$ for the two settings, respectively, where $κ$ is the condition number, $L$ is the smoothness constant, and $Δ$ is the initial gap. Our result reveals substantial gaps between these limits and best-known upper bounds in the literature. To close these gaps, we introduce a generic acceleration scheme that deploys existing gradient-based methods to solve a sequence of crafted strongly-convex-strongly-concave subproblems. In the general setting, the complexity of our proposed algorithm nearly matches the lower bound; in particular, it removes an additional poly-logarithmic dependence on accuracy present in previous works. In the averaged smooth finite-sum setting, our proposed algorithm improves over previous algorithms by providing a nearly-tight dependence on the condition number.

Siqi Zhang, Mouhacine Benosman, Orlando Romero

In this study, we investigate the performance of two novel first-order optimization algorithms, namely the rescaled-gradient flow (RGF) and the signed-gradient flow (SGF). These algorithms are derived from the forward Euler discretization of finite-time convergent flows, comprised of non-Lipschitz dynamical systems, which locally converge to the minima of gradient-dominated functions. We first characterize the closeness between the continuous flows and the discretizations, then we proceed to present (linear) convergence guarantees of the discrete algorithms (in the general and the stochastic case). Furthermore, in cases where problem parameters remain unknown or exhibit non-uniformity, we further integrate the line-search strategy with RGF/SGF and provide convergence analysis in this setting. We then apply the proposed algorithms to academic examples and deep neural network training, our results show that our schemes demonstrate faster convergences against standard optimization alternatives.

Yifan Hu, Siqi Zhang, Xin Chen et al.

Conditional stochastic optimization covers a variety of applications ranging from invariant learning and causal inference to meta-learning. However, constructing unbiased gradient estimators for such problems is challenging due to the composition structure. As an alternative, we propose a biased stochastic gradient descent (BSGD) algorithm and study the bias-variance tradeoff under different structural assumptions. We establish the sample complexities of BSGD for strongly convex, convex, and weakly convex objectives under smooth and non-smooth conditions. Our lower bound analysis shows that the sample complexities of BSGD cannot be improved for general convex objectives and nonconvex objectives except for smooth nonconvex objectives with Lipschitz continuous gradient estimator. For this special setting, we propose an accelerated algorithm called biased SpiderBoost (BSpiderBoost) that matches the lower bound complexity. We further conduct numerical experiments on invariant logistic regression and model-agnostic meta-learning to illustrate the performance of BSGD and BSpiderBoost.