Jessica Zhang

Yuxuan Yu, Jiashuo Liu, Hua Tong et al.

Polycube structures provide parametric domains for all-hexahedral (all-hex) mesh generation and analysis-suitable volumetric spline construction in isogeometric analysis (IGA). Recent learning-based polycube pipelines have improved automation, yet several challenges remain when handling complex CAD geometries. These challenges include the limited diversity of primitive geometries, restricted grid configurations, and the increasing cost of genus-guided context search during inference as both the primitive set and the grid size grow. In this paper, we present {Scalable DDPM-Polycube}, an extended diffusion-based polycube construction method that addresses these limitations. First, we expand the primitive set from two primitive geometries to three by introducing a blind-hole cube primitive, thereby improving the representation of local hole-like features that do not change the global genus. Second, we extend the grid configuration from the previous $2\times 1$ setting to an enlarged three-dimensional grid configuration, which increases representational capacity and reduces mapping distortion for complex geometries. Third, we develop a genus-guided context generation strategy together with a hierarchical verification procedure, enabling robust context generation in both user-guided and automated modes. Once a valid polycube structure is generated, it is used for parametric mapping, all-hex control mesh generation, and volumetric spline construction. Experimental results demonstrate that scalable DDPM-Polycube improves the generality, scalability, and automation of diffusion-based polycube generation, and supports hex mesh generation and volumetric spline construction for IGA applications on complex geometries.

Leslie Gu, Jason Ken Adhinarta, Mikhail Bessmeltsev et al. · harvard

Accurately segmenting 3D curvilinear structures in medical imaging remains challenging due to their complex geometry and the scarcity of diverse, large-scale datasets for algorithm development and evaluation. In this paper, we use dendritic spine segmentation as a case study and address these challenges by introducing a novel Frenet--Serret Frame-based Decomposition, which decomposes 3D curvilinear structures into a globally \( C^2 \) continuous curve that captures the overall shape, and a cylindrical primitive that encodes local geometric properties. This approach leverages Frenet--Serret Frames and arc length parameterization to preserve essential geometric features while reducing representational complexity, facilitating data-efficient learning, improved segmentation accuracy, and generalization on 3D curvilinear structures. To rigorously evaluate our method, we introduce two datasets: CurviSeg, a synthetic dataset for 3D curvilinear structure segmentation that validates our method's key properties, and DenSpineEM, a benchmark for dendritic spine segmentation, which comprises 4,476 manually annotated spines from 70 dendrites across three public electron microscopy datasets, covering multiple brain regions and species. Our experiments on DenSpineEM demonstrate exceptional cross-region and cross-species generalization: models trained on the mouse somatosensory cortex subset achieve 91.9\% Dice, maintaining strong performance in zero-shot segmentation on both mouse visual cortex (94.1\% Dice) and human frontal lobe (81.8\% Dice) subsets. Moreover, we test the generalizability of our method on the IntrA dataset, where it achieves 77.08\% Dice (5.29\% higher than prior arts) on intracranial aneurysm segmentation. These findings demonstrate the potential of our approach for accurately analyzing complex curvilinear structures across diverse medical imaging fields.