Qicheng Lao

Shurui Gui, Hao Yuan, Jie Wang et al.

We investigate the explainability of graph neural networks (GNNs) as a step toward elucidating their working mechanisms. While most current methods focus on explaining graph nodes, edges, or features, we argue that, as the inherent functional mechanism of GNNs, message flows are more natural for performing explainability. To this end, we propose a novel method here, known as FlowX, to explain GNNs by identifying important message flows. To quantify the importance of flows, we propose to follow the philosophy of Shapley values from cooperative game theory. To tackle the complexity of computing all coalitions' marginal contributions, we propose a flow sampling scheme to compute Shapley value approximations as initial assessments of further training. We then propose an information-controlled learning algorithm to train flow scores toward diverse explanation targets: necessary or sufficient explanations. Experimental studies on both synthetic and real-world datasets demonstrate that our proposed FlowX and its variants lead to improved explainability of GNNs. The code is available at https://github.com/divelab/DIG.

Dongjie Cheng, Ziyuan Qin, Zekun Jiang et al.

The Segment Anything Model (SAM) made an eye-catching debut recently and inspired many researchers to explore its potential and limitation in terms of zero-shot generalization capability. As the first promptable foundation model for segmentation tasks, it was trained on a large dataset with an unprecedented number of images and annotations. This large-scale dataset and its promptable nature endow the model with strong zero-shot generalization. Although the SAM has shown competitive performance on several datasets, we still want to investigate its zero-shot generalization on medical images. As we know, the acquisition of medical image annotation usually requires a lot of effort from professional practitioners. Therefore, if there exists a foundation model that can give high-quality mask prediction simply based on a few point prompts, this model will undoubtedly become the game changer for medical image analysis. To evaluate whether SAM has the potential to become the foundation model for medical image segmentation tasks, we collected more than 12 public medical image datasets that cover various organs and modalities. We also explore what kind of prompt can lead to the best zero-shot performance with different modalities. Furthermore, we find that a pattern shows that the perturbation of the box size will significantly change the prediction accuracy. Finally, Extensive experiments show that the predicted mask quality varied a lot among different datasets. And providing proper prompts, such as bounding boxes, to the SAM will significantly increase its performance.

Ziyuan Qin, Huahui Yi, Qicheng Lao et al.

The large-scale pre-trained vision language models (VLM) have shown remarkable domain transfer capability on natural images. However, it remains unknown whether this capability can also apply to the medical image domain. This paper thoroughly studies the knowledge transferability of pre-trained VLMs to the medical domain, where we show that well-designed medical prompts are the key to elicit knowledge from pre-trained VLMs. We demonstrate that by prompting with expressive attributes that are shared between domains, the VLM can carry the knowledge across domains and improve its generalization. This mechanism empowers VLMs to recognize novel objects with fewer or without image samples. Furthermore, to avoid the laborious manual designing process, we develop three approaches for automatic generation of medical prompts, which can inject expert-level medical knowledge and image-specific information into the prompts for fine-grained grounding. We conduct extensive experiments on thirteen different medical datasets across various modalities, showing that our well-designed prompts greatly improve the zero-shot performance compared to the default prompts, and our fine-tuned models surpass the supervised models by a significant margin.

Huahui Yi, Ziyuan Qin, Qicheng Lao et al.

Inevitable domain and task discrepancies in real-world scenarios can impair the generalization performance of the pre-trained deep models for medical data. Therefore, we audaciously propose that we should build a general-purpose medical AI system that can be seamlessly adapted to downstream domains/tasks. Since the domain/task adaption procedures usually involve additional labeling work for the target data, designing a data-efficient adaption algorithm is desired to save the cost of transferring the learned knowledge. Our recent work found that vision-language models (VLMs) are efficient learners with extraordinary cross-domain ability. Therefore, in this work, we further explore the possibility of leveraging pre-trained VLMs as medical foundation models for building general-purpose medical AI, where we thoroughly investigate three machine-learning paradigms, i.e., domain/task-specialized learning, joint learning, and continual learning, for training the VLMs and evaluate their generalization performance on cross-domain and cross-task test sets. To alleviate the catastrophic forgetting during sequential training, we employ rehearsal learning and receive a sharp boost in terms of generalization capability. In a nutshell, our empirical evidence suggests that continual learning may be a practical and efficient learning paradigm for the medical foundation model. And we hope researchers can use our empirical evidence as basement to further explore the path toward medical foundation model.

Guangjing Yang, Ziyuan Qin, Chaoran Zhang et al.

Medical visual grounding serves as a crucial foundation for fine-grained multimodal reasoning and interpretable clinical decision support. Despite recent advances in reinforcement learning (RL) for grounding tasks, existing approaches such as Group Relative Policy Optimization~(GRPO) suffer from severe reward sparsity when directly applied to medical images, primarily due to the inherent difficulty of localizing small or ambiguous regions of interest, which is further exacerbated by the rigid and suboptimal nature of fixed IoU-based reward schemes in RL. This leads to vanishing policy gradients and stagnated optimization, particularly during early training. To address this challenge, we propose MedLoc-R1, a performance-aware reward scheduling framework that progressively tightens the reward criterion in accordance with model readiness. MedLoc-R1 introduces a sliding-window performance tracker and a multi-condition update rule that automatically adjust the reward schedule from dense, easily obtainable signals to stricter, fine-grained localization requirements, while preserving the favorable properties of GRPO without introducing auxiliary networks or additional gradient paths. Experiments on three medical visual grounding benchmarks demonstrate that MedLoc-R1 consistently improves both localization accuracy and training stability over GRPO-based baselines. Our framework offers a general, lightweight, and effective solution for RL-based grounding in high-stakes medical applications. Code \& checkpoints are available at \hyperlink{}{https://github.com/MembrAI/MedLoc-R1}.

Xiuqi Zheng, Yuhang Zhang, Haoran Zhang et al.

Adapting large pre-trained foundation models, e.g., SAM, for medical image segmentation remains a significant challenge. A crucial step involves the formulation of a series of specialized prompts that incorporate specific clinical instructions. Past works have been heavily reliant on a singular type of prompt for each instance, necessitating manual input of an ideally correct prompt, which is less efficient. To tackle this issue, we propose to utilize prompts of different granularity, which are sourced from original images to provide a broader scope of clinical insights. However, combining prompts of varying types can pose a challenge due to potential conflicts. In response, we have designed a coarse-to-fine mechanism, referred to as curriculum prompting, that progressively integrates prompts of different types. Through extensive experiments on three public medical datasets across various modalities, we demonstrate the effectiveness of our proposed approach, which not only automates the prompt generation process but also yields superior performance compared to other SAM-based medical image segmentation methods. Code is available at: https://github.com/AnnaZzz-zxq/Curriculum-Prompting.

Qingbo Kang, Jun Gao, Kang Li et al.

Masked autoencoder (MAE) has attracted unprecedented attention and achieves remarkable performance in many vision tasks. It reconstructs random masked image patches (known as proxy task) during pretraining and learns meaningful semantic representations that can be transferred to downstream tasks. However, MAE has not been thoroughly explored in ultrasound imaging. In this work, we investigate the potential of MAE for ultrasound image recognition. Motivated by the unique property of ultrasound imaging in high noise-to-signal ratio, we propose a novel deblurring MAE approach that incorporates deblurring into the proxy task during pretraining. The addition of deblurring facilitates the pretraining to better recover the subtle details presented in the ultrasound images, thus improving the performance of the downstream classification task. Our experimental results demonstrate the effectiveness of our deblurring MAE, achieving state-of-the-art performance in ultrasound image classification. Overall, our work highlights the potential of MAE for ultrasound image recognition and presents a novel approach that incorporates deblurring to further improve its effectiveness.

Guangjing Yang, ZhangYuan Yu, Ziyuan Qin et al.

While recent advances in Reinforcement Fine-Tuning (RFT) have shown that rule-based reward schemes can enable effective post-training for large language models, their extension to cross-modal, vision-centric domains remains largely underexplored. This limitation is especially pronounced in the medical imaging domain, where effective performance requires both robust visual perception and structured reasoning. In this work, we address this gap by proposing VRFT-Aug, a visual reinforcement fine-tuning framework tailored for the medical domain. VRFT-Aug introduces a series of training strategies designed to augment both perception and reasoning, including prior knowledge injection, perception-driven policy refinement, medically informed reward shaping, and behavioral imitation. Together, these methods aim to stabilize and improve the RFT process. Through extensive experiments across multiple medical datasets, we show that our approaches consistently outperform both standard supervised fine-tuning and RFT baselines. Moreover, we provide empirically grounded insights and practical training heuristics that can be generalized to other medical image tasks. We hope this work contributes actionable guidance and fresh inspiration for the ongoing effort to develop reliable, reasoning-capable models for high-stakes medical applications.

Xiaosong Wang, Xiaofan Zhang, Guotai Wang et al.

The emerging trend of advancing generalist artificial intelligence, such as GPTv4 and Gemini, has reshaped the landscape of research (academia and industry) in machine learning and many other research areas. However, domain-specific applications of such foundation models (e.g., in medicine) remain untouched or often at their very early stages. It will require an individual set of transfer learning and model adaptation techniques by further expanding and injecting these models with domain knowledge and data. The development of such technologies could be largely accelerated if the bundle of data, algorithms, and pre-trained foundation models were gathered together and open-sourced in an organized manner. In this work, we present OpenMEDLab, an open-source platform for multi-modality foundation models. It encapsulates not only solutions of pioneering attempts in prompting and fine-tuning large language and vision models for frontline clinical and bioinformatic applications but also building domain-specific foundation models with large-scale multi-modal medical data. Importantly, it opens access to a group of pre-trained foundation models for various medical image modalities, clinical text, protein engineering, etc. Inspiring and competitive results are also demonstrated for each collected approach and model in a variety of benchmarks for downstream tasks. We welcome researchers in the field of medical artificial intelligence to continuously contribute cutting-edge methods and models to OpenMEDLab, which can be accessed via https://github.com/openmedlab.

Junjie Wang, Pan Zhou, Yiming Dong et al.

Large language models (LLMs) have demonstrated impressive generalization and emergent capabilities, yet their pre-training remains computationally expensive and sensitive to optimization dynamics. While Adam-based optimizers offer fast convergence by adapting learning rates coordinate-wise, recent studies reveal that their updates often suffer from poor spectral conditioning and low-rank structures, hindering efficiency. Muon addresses this issue via global spectral normalization but lacks the per-coordinate adaptivity of Adam. In this work, we propose Column-Normalized Adam (Conda), a novel optimizer that bridges the strengths of both approaches. Conda projects updates into an orthogonal subspace and applies column-wise second moment normalization based on the projected gradients, thereby achieving both improved spectral conditioning and maintaining coordinate-wise adaptivity. This design alleviates the spectral pathologies of Adam while preserving its fast convergence behavior. Extensive experiments on the LLaMA and GPT-2 series show that Conda consistently outperforms AdamW, Muon, and other baselines in pre-training. Remarkably, on the LLaMA series, Conda achieves 2-2.5 the convergence speed of AdamW, measured in both training steps and training time. Further ablations demonstrate its robustness under diverse training setups. These results collectively highlight Conda as an effective and broadly applicable optimizer for large-scale LLM training. The code is released on https://github.com/jie040109/Conda

Mengmeng Chen, Xiaohu Wu, Qiqi Liu et al.

Multi-objective optimization (MOO) exists extensively in machine learning, and aims to find a set of Pareto-optimal solutions, called the Pareto front, e.g., it is fundamental for multiple avenues of research in federated learning (FL). Pareto-Front Learning (PFL) is a powerful method implemented using Hypernetworks (PHNs) to approximate the Pareto front. This method enables the acquisition of a mapping function from a given preference vector to the solutions on the Pareto front. However, most existing PFL approaches still face two challenges: (a) sampling rays in high-dimensional spaces; (b) failing to cover the entire Pareto Front which has a convex shape. Here, we introduce a novel PFL framework, called as PHN-HVVS, which decomposes the design space into Voronoi grids and deploys a genetic algorithm (GA) for Voronoi grid partitioning within high-dimensional space. We put forward a new loss function, which effectively contributes to more extensive coverage of the resultant Pareto front and maximizes the HV Indicator. Experimental results on multiple MOO machine learning tasks demonstrate that PHN-HVVS outperforms the baselines significantly in generating Pareto front. Also, we illustrate that PHN-HVVS advances the methodologies of several recent problems in the FL field. The code is available at https://github.com/buptcmm/phnhvvs}{https://github.com/buptcmm/phnhvvs.

Zekun Jiang, Dongjie Cheng, Ziyuan Qin et al.

This study presents a novel multimodal medical image zero-shot segmentation algorithm named the text-visual-prompt segment anything model (TV-SAM) without any manual annotations. The TV-SAM incorporates and integrates the large language model GPT-4, the vision language model GLIP, and the SAM to autonomously generate descriptive text prompts and visual bounding box prompts from medical images, thereby enhancing the SAM's capability for zero-shot segmentation. Comprehensive evaluations are implemented on seven public datasets encompassing eight imaging modalities to demonstrate that TV-SAM can effectively segment unseen targets across various modalities without additional training. TV-SAM significantly outperforms SAM AUTO and GSAM, closely matching the performance of SAM BBOX with gold standard bounding box prompts and surpasses the state-of-the-art methods on specific datasets such as ISIC and WBC. The study indicates that TV-SAM serves as an effective multimodal medical image zero-shot segmentation algorithm, highlighting the significant contribution of GPT-4 to zero-shot segmentation. By integrating foundational models such as GPT-4, GLIP, and SAM, the ability to address complex problems in specialized domains can be enhanced.

Yiyue Li, Shaoting Zhang, Kang Li et al.

Traditional Anomaly Detection (AD) methods have predominantly relied on unsupervised learning from extensive normal data. Recent AD methods have evolved with the advent of large pre-trained vision-language models, enhancing few-shot anomaly detection capabilities. However, these latest AD methods still exhibit limitations in accuracy improvement. One contributing factor is their direct comparison of a query image's features with those of few-shot normal images. This direct comparison often leads to a loss of precision and complicates the extension of these techniques to more complex domains--an area that remains underexplored in a more refined and comprehensive manner. To address these limitations, we introduce the anomaly personalization method, which performs a personalized one-to-normal transformation of query images using an anomaly-free customized generation model, ensuring close alignment with the normal manifold. Moreover, to further enhance the stability and robustness of prediction results, we propose a triplet contrastive anomaly inference strategy, which incorporates a comprehensive comparison between the query and generated anomaly-free data pool and prompt information. Extensive evaluations across eleven datasets in three domains demonstrate our model's effectiveness compared to the latest AD methods. Additionally, our method has been proven to transfer flexibly to other AD methods, with the generated image data effectively improving the performance of other AD methods.

Mengmeng Chen, Xiaohu Wu, Xiaoli Tang et al.

Federated learning (FL) is a machine learning paradigm that allows multiple FL participants (FL-PTs) to collaborate on training models without sharing private data. Due to data heterogeneity, negative transfer may occur in the FL training process. This necessitates FL-PT selection based on their data complementarity. In cross-silo FL, organizations that engage in business activities are key sources of FL-PTs. The resulting FL ecosystem has two features: (i) self-interest, and (ii) competition among FL-PTs. This requires the desirable FL-PT selection strategy to simultaneously mitigate the problems of free riders and conflicts of interest among competitors. To this end, we propose an optimal FL collaboration formation strategy -- FedEgoists -- which ensures that: (1) a FL-PT can benefit from FL if and only if it benefits the FL ecosystem, and (2) a FL-PT will not contribute to its competitors or their supporters. It provides an efficient clustering solution to group FL-PTs into coalitions, ensuring that within each coalition, FL-PTs share the same interest. We theoretically prove that the FL-PT coalitions formed are optimal since no coalitions can collaborate together to improve the utility of any of their members. Extensive experiments on widely adopted benchmark datasets demonstrate the effectiveness of FedEgoists compared to nine state-of-the-art baseline methods, and its ability to establish efficient collaborative networks in cross-silos FL with FL-PTs that engage in business activities.

Ziyuan Qin, Dongjie Cheng, Haoyu Wang et al.

Contemporary Text-to-Image (T2I) models frequently depend on qualitative human evaluations to assess the consistency between synthesized images and the text prompts. There is a demand for quantitative and automatic evaluation tools, given that human evaluation lacks reproducibility. We believe that an effective T2I evaluation metric should accomplish the following: detect instances where the generated images do not align with the textual prompts, a discrepancy we define as the `hallucination problem' in T2I tasks; record the types and frequency of hallucination issues, aiding users in understanding the causes of errors; and provide a comprehensive and intuitive scoring that close to human standard. To achieve these objectives, we propose a method based on large language models (LLMs) for conducting question-answering with an extracted scene-graph and created a dataset with human-rated scores for generated images. From the methodology perspective, we combine knowledge-enhanced question-answering tasks with image evaluation tasks, making the evaluation metrics more controllable and easier to interpret. For the contribution on the dataset side, we generated 12,000 synthesized images based on 1,000 composited prompts using three advanced T2I models. Subsequently, we conduct human scoring on all synthesized images and prompt pairs to validate the accuracy and effectiveness of our method as an evaluation metric. All generated images and the human-labeled scores will be made publicly available in the future to facilitate ongoing research on this crucial issue. Extensive experiments show that our method aligns more closely with human scoring patterns than other evaluation metrics.

Kangyu Zhu, Ziyuan Qin, Huahui Yi et al.

While mainstream vision-language models (VLMs) have advanced rapidly in understanding image level information, they still lack the ability to focus on specific areas designated by humans. Rather, they typically rely on large volumes of high-quality image-text paired data to learn and generate posterior attention maps. To address this critical issue, we propose leveraging visual prompts:simple visual markers in various forms to guide and enhance the formation of region-specific attention. Thus, we introduce MedVP, a pioneering framework that integrates medical entity extraction, visual prompt generation, and dataset adaptation for visual prompt guided fine-tuning. We successfully outperform recent state-of-the-art large models across multiple medical VQA datasets. Extensive experiments and Human evaluation are conducted to analyze the impact of different visual prompt forms and how they contribute to performance improvement. The results demonstrate both the effectiveness and clinical significance of our approach.

Zhihao Li, Gezheng Xu, Jiale Cai et al.

Unlearnable Examples (UEs) serve as a data protection strategy that generates imperceptible perturbations to mislead models into learning spurious correlations instead of underlying semantics. In this paper, we uncover a fundamental vulnerability of UEs that emerges when learning starts from a pretrained model. Crucially, our empirical analysis shows that even when data are protected by carefully crafted perturbations, pretraining priors still furnish rich semantic representations that allow the model to circumvent the shortcuts introduced by UEs and capture genuine features, thereby nullifying unlearnability. To address this, we propose BAIT (Binding Artificial perturbations to Incorrect Targets), a novel bi-level optimization formulation. Specifically, the inner level aims at associating the perturbed samples with real labels to simulate standard data-label alignment, while the outer level actively disrupts this alignment by enforcing a mislabel-perturbation binding that maps samples to designated incorrect targets. This mechanism effectively overrides the semantic guidance of priors, forcing the model to rely on the injected perturbations and consequently preventing the acquisition of true semantics. Extensive experiments on standard benchmarks and multiple pretrained backbones demonstrate that BAIT effectively mitigates the influence of pretraining priors and maintains data unlearnability.

Jiayu Huang, Xiaohu Wu, Tiantian He et al.

Large Language Models (LLMs) are pivotal in natural language processing. The impracticality of full fine-tuning has prompted Parameter-Efficient Fine-Tuning (PEFT) methods like Low-Rank Adaptation (LoRA), optimizing low-rank matrices A and B. In distributed scenarios where privacy constraints necessitate Federated Learning (FL), however, the integration of LoRA is often unstable. Specifically, we identify that aggregating updates from multiple clients introduces statistical variance that scales with the client count, causing gradient collapse when using high-rank adapters. Existing scaling factor candidates, such as the one used by Rank-Stabilized LoRA, ignore the interaction caused by the aggregation process. To bridge this gap, this paper introduces Stabilized Federated LoRA (SFed-LoRA), a framework that theoretically characterizes the interaction between adapter rank and federated aggregation. We derive an optimal scaling factor designed to effectively mitigate the aggregation error accumulating across N clients. By correcting the scaling mismatch inherent in previous approaches, SFed-LoRA restores the efficacy of high-rank adaptation without altering the original model architecture or increasing inference latency. Extensive experiments in diverse tasks, model architectures, and heterogeneous data distributions are conducted to validate our results. We demonstrate that SFed-LoRA prevents high-rank collapse, and achieves significantly improved stability and faster convergence compared with state-of-the-art baselines for high-rank adaptation.

Anyang Ji, Qingbo Kang, Wei Xu et al.

The emergence of large-scale pre-trained vision foundation models has greatly advanced the medical imaging field through the pre-training and fine-tuning paradigm. However, selecting appropriate medical data for downstream fine-tuning remains a significant challenge considering its annotation cost, privacy concerns, and the detrimental effects of confounding variables. In this work, we present a confounder-aware medical data selection approach for medical dataset curation aiming to select minimal representative data by strategically mitigating the undesirable impact of confounding variables while preserving the natural distribution of the dataset. Our approach first identifies confounding variables within data and then develops a distance-based data selection strategy for confounder-aware sampling with a constrained budget in the data size. We validate the superiority of our approach through extensive experiments across diverse medical imaging modalities, highlighting its effectiveness in addressing the substantial impact of confounding variables and enhancing the fine-tuning efficiency in the medical imaging domain, compared to other data selection approaches.

Huahui Yi, Wei Xu, Ziyuan Qin et al.

Existing prompt-based approaches have demonstrated impressive performance in continual learning, leveraging pre-trained large-scale models for classification tasks; however, the tight coupling between foreground-background information and the coupled attention between prompts and image-text tokens present significant challenges in incremental medical object detection tasks, due to the conceptual gap between medical and natural domains. To overcome these challenges, we introduce the \method~framework, which comprises two main components: 1) Instance-level Prompt Generation (\ipg), which decouples fine-grained instance-level knowledge from images and generates prompts that focus on dense predictions, and 2) Decoupled Prompt Attention (\dpa), which decouples the original prompt attention, enabling a more direct and efficient transfer of prompt information while reducing memory usage and mitigating catastrophic forgetting. We collect 13 clinical, cross-modal, multi-organ, and multi-category datasets, referred to as \dataset, and experiments demonstrate that \method~outperforms existing SOTA methods, with FAP improvements of 5.44\%, 4.83\%, 12.88\%, and 4.59\% in full data, 1-shot, 10-shot, and 50-shot settings, respectively.

Huahui Yi, Ziyuan Qin, Wei Xu et al.

Large pre-trained vision-language models have shown great prominence in transferring pre-acquired knowledge to various domains and downstream tasks with appropriate prompting or tuning. Existing prevalent tuning methods can be generally categorized into three genres: 1) prompt engineering by creating suitable prompt texts, which is time-consuming and requires domain expertise; 2) or simply fine-tuning the whole model, which is extremely inefficient; 3) prompt tuning through parameterized prompt embeddings with the text encoder. Nevertheless, all methods rely on the text encoder for bridging the modality gap between vision and language. In this work, we question the necessity of the cumbersome text encoder for a more lightweight and efficient tuning paradigm as well as more representative prompt embeddings closer to the image representations. To achieve this, we propose a Concept Embedding Search (ConES) approach by optimizing prompt embeddings -- without the need of the text encoder -- to capture the 'concept' of the image modality through a variety of task objectives. By dropping the text encoder, we are able to significantly speed up the learning process, \eg, from about an hour to just ten minutes in our experiments for personalized text-to-image generation without impairing the generation quality. Moreover, our proposed approach is orthogonal to current existing tuning methods since the searched concept embeddings can be further utilized in the next stage of fine-tuning the pre-trained large models for boosting performance. Extensive experiments show that our approach can beat the prompt tuning and textual inversion methods in a variety of downstream tasks including objection detection, instance segmentation, and image generation. Our approach also shows better generalization capability for unseen concepts in specialized domains, such as the medical domain.

Jiefeng Chen, Yang Guo, Xi Wu et al.

There has been emerging interest to use transductive learning for adversarial robustness (Goldwasser et al., NeurIPS 2020; Wu et al., ICML 2020). Compared to traditional "test-time" defenses, these defense mechanisms "dynamically retrain" the model based on test time input via transductive learning; and theoretically, attacking these defenses boils down to bilevel optimization, which seems to raise the difficulty for adaptive attacks. In this paper, we first formalize and analyze modeling aspects of transductive robustness. Then, we propose the principle of attacking model space for solving bilevel attack objectives, and present an instantiation of the principle which breaks previous transductive defenses. These attacks thus point to significant difficulties in the use of transductive learning to improve adversarial robustness. To this end, we present new theoretical and empirical evidence in support of the utility of transductive learning.

Qicheng Lao, Xiang Jiang, Mohammad Havaei

We propose a hypothesis disparity regularized mutual information maximization~(HDMI) approach to tackle unsupervised hypothesis transfer -- as an effort towards unifying hypothesis transfer learning (HTL) and unsupervised domain adaptation (UDA) -- where the knowledge from a source domain is transferred solely through hypotheses and adapted to the target domain in an unsupervised manner. In contrast to the prevalent HTL and UDA approaches that typically use a single hypothesis, HDMI employs multiple hypotheses to leverage the underlying distributions of the source and target hypotheses. To better utilize the crucial relationship among different hypotheses -- as opposed to unconstrained optimization of each hypothesis independently -- while adapting to the unlabeled target domain through mutual information maximization, HDMI incorporates a hypothesis disparity regularization that coordinates the target hypotheses jointly learn better target representations while preserving more transferable source knowledge with better-calibrated prediction uncertainty. HDMI achieves state-of-the-art adaptation performance on benchmark datasets for UDA in the context of HTL, without the need to access the source data during the adaptation.

Mohammad Havaei, Ximeng Mao, Yiping Wang et al.

Synthetic medical image generation has a huge potential for improving healthcare through many applications, from data augmentation for training machine learning systems to preserving patient privacy. Conditional Adversarial Generative Networks (cGANs) use a conditioning factor to generate images and have shown great success in recent years. Intuitively, the information in an image can be divided into two parts: 1) content which is presented through the conditioning vector and 2) style which is the undiscovered information missing from the conditioning vector. Current practices in using cGANs for medical image generation, only use a single variable for image generation (i.e., content) and therefore, do not provide much flexibility nor control over the generated image. In this work we propose a methodology to learn from the image itself, disentangled representations of style and content, and use this information to impose control over the generation process. In this framework, style is learned in a fully unsupervised manner, while content is learned through both supervised learning (using the conditioning vector) and unsupervised learning (with the inference mechanism). We undergo two novel regularization steps to ensure content-style disentanglement. First, we minimize the shared information between content and style by introducing a novel application of the gradient reverse layer (GRL); second, we introduce a self-supervised regularization method to further separate information in the content and style variables. We show that in general, two latent variable models achieve better performance and give more control over the generated image. We also show that our proposed model (DRAI) achieves the best disentanglement score and has the best overall performance.

Xiang Jiang, Qicheng Lao, Stan Matwin et al.

We present an approach for unsupervised domain adaptation---with a strong focus on practical considerations of within-domain class imbalance and between-domain class distribution shift---from a class-conditioned domain alignment perspective. Current methods for class-conditioned domain alignment aim to explicitly minimize a loss function based on pseudo-label estimations of the target domain. However, these methods suffer from pseudo-label bias in the form of error accumulation. We propose a method that removes the need for explicit optimization of model parameters from pseudo-labels directly. Instead, we present a sampling-based implicit alignment approach, where the sample selection procedure is implicitly guided by the pseudo-labels. Theoretical analysis reveals the existence of a domain-discriminator shortcut in misaligned classes, which is addressed by the proposed implicit alignment approach to facilitate domain-adversarial learning. Empirical results and ablation studies confirm the effectiveness of the proposed approach, especially in the presence of within-domain class imbalance and between-domain class distribution shift.

Qicheng Lao, Xiang Jiang, Mohammad Havaei et al.

Learning in non-stationary environments is one of the biggest challenges in machine learning. Non-stationarity can be caused by either task drift, i.e., the drift in the conditional distribution of labels given the input data, or the domain drift, i.e., the drift in the marginal distribution of the input data. This paper aims to tackle this challenge in the context of continuous domain adaptation, where the model is required to learn new tasks adapted to new domains in a non-stationary environment while maintaining previously learned knowledge. To deal with both drifts, we propose variational domain-agnostic feature replay, an approach that is composed of three components: an inference module that filters the input data into domain-agnostic representations, a generative module that facilitates knowledge transfer, and a solver module that applies the filtered and transferable knowledge to solve the queries. We address the two fundamental scenarios in continuous domain adaptation, demonstrating the effectiveness of our proposed approach for practical usage.

Qicheng Lao, Mehrzad Mortazavi, Marzieh Tahaei et al.

In this paper, we propose a general framework in continual learning for generative models: Feature-oriented Continual Learning (FoCL). Unlike previous works that aim to solve the catastrophic forgetting problem by introducing regularization in the parameter space or image space, FoCL imposes regularization in the feature space. We show in our experiments that FoCL has faster adaptation to distributional changes in sequentially arriving tasks, and achieves the state-of-the-art performance for generative models in task incremental learning. We discuss choices of combined regularization spaces towards different use case scenarios for boosted performance, e.g., tasks that have high variability in the background. Finally, we introduce a forgetfulness measure that fairly evaluates the degree to which a model suffers from forgetting. Interestingly, the analysis of our proposed forgetfulness score also implies that FoCL tends to have a mitigated forgetting for future tasks.

Qicheng Lao, Mohammad Havaei, Ahmad Pesaranghader et al.

Synthesizing images from a given text description involves engaging two types of information: the content, which includes information explicitly described in the text (e.g., color, composition, etc.), and the style, which is usually not well described in the text (e.g., location, quantity, size, etc.). However, in previous works, it is typically treated as a process of generating images only from the content, i.e., without considering learning meaningful style representations. In this paper, we aim to learn two variables that are disentangled in the latent space, representing content and style respectively. We achieve this by augmenting current text-to-image synthesis frameworks with a dual adversarial inference mechanism. Through extensive experiments, we show that our model learns, in an unsupervised manner, style representations corresponding to certain meaningful information present in the image that are not well described in the text. The new framework also improves the quality of synthesized images when evaluated on Oxford-102, CUB and COCO datasets.

Qicheng Lao, Thomas Fevens

In practice, histopathological diagnosis of tumor malignancy often requires a human expert to scan through histopathological images at multiple magnification levels, after which a final diagnosis can be accurately determined. However, previous research on such classification tasks using convolutional neural networks primarily determine a diagnosis for a single magnification level. In this paper, we propose a case-based approach using deep residual neural networks for histopathological malignancy diagnosis, where a case is defined as a sequence of images from the patient at all available levels of magnification. Effectively, through mimicking what a human expert would actually do, our approach makes a diagnosis decision based on features learned in combination at multiple magnification levels. Our results show that the case-based approach achieves better performance than the state-of-the-art methods when evaluated on BreaKHis, a histopathological image dataset for breast tumors.

Qicheng Lao, Thomas Fevens, Boyu Wang

Unlike natural images, medical images often have intrinsic characteristics that can be leveraged for neural network learning. For example, images that belong to different stages of a disease may continuously follow a certain progression pattern. In this paper, we propose a novel method that leverages disease progression learning for medical image recognition. In our method, sequences of images ordered by disease stages are learned by a neural network that consists of a shared vision model for feature extraction and a long short-term memory network for the learning of stage sequences. Auxiliary vision outputs are also included to capture stage features that tend to be discrete along the disease progression. Our proposed method is evaluated on a public diabetic retinopathy dataset, and achieves about 3.3% improvement in disease staging accuracy, compared to the baseline method that does not use disease progression learning.