Genpei Zhang

Yijiang Li, Genpei Zhang, Jiacheng Cheng et al.

While the rapid proliferation of wearable cameras has raised significant concerns about egocentric video privacy, prior work has largely overlooked the unique privacy threats posed to the camera wearer. This work investigates the core question: How much privacy information about the camera wearer can be inferred from their first-person view videos? We introduce EgoPrivacy, the first large-scale benchmark for the comprehensive evaluation of privacy risks in egocentric vision. EgoPrivacy covers three types of privacy (demographic, individual, and situational), defining seven tasks that aim to recover private information ranging from fine-grained (e.g., wearer's identity) to coarse-grained (e.g., age group). To further emphasize the privacy threats inherent to egocentric vision, we propose Retrieval-Augmented Attack, a novel attack strategy that leverages ego-to-exo retrieval from an external pool of exocentric videos to boost the effectiveness of demographic privacy attacks. An extensive comparison of the different attacks possible under all threat models is presented, showing that private information of the wearer is highly susceptible to leakage. For instance, our findings indicate that foundation models can effectively compromise wearer privacy even in zero-shot settings by recovering attributes such as identity, scene, gender, and race with 70-80% accuracy. Our code and data are available at https://github.com/williamium3000/ego-privacy.

Dazhou Yu, Genpei Zhang, Liang Zhao

Ubiquitous geometric objects can be precisely and efficiently represented as polyhedra. The transformation of a polyhedron into a vector, known as polyhedra representation learning, is crucial for manipulating these shapes with mathematical and statistical tools for tasks like classification, clustering, and generation. Recent years have witnessed significant strides in this domain, yet most efforts focus on the vertex sequence of a polyhedron, neglecting the complex surface modeling crucial in real-world polyhedral objects. This study proposes \textbf{PolyhedronNet}, a general framework tailored for learning representations of 3D polyhedral objects. We propose the concept of the surface-attributed graph to seamlessly model the vertices, edges, faces, and their geometric interrelationships within a polyhedron. To effectively learn the representation of the entire surface-attributed graph, we first propose to break it down into local rigid representations to effectively learn each local region's relative positions against the remaining regions without geometric information loss. Subsequently, we propose PolyhedronGNN to hierarchically aggregate the local rigid representation via intra-face and inter-face geometric message passing modules, to obtain a global representation that minimizes information loss while maintaining rotation and translation invariance. Our experimental evaluations on four distinct datasets, encompassing both classification and retrieval tasks, substantiate PolyhedronNet's efficacy in capturing comprehensive and informative representations of 3D polyhedral objects. Code and data are available at {https://github.com/dyu62/3D_polyhedron}.

Runmin Jiang, Genpei Zhang, Yuntian Yang et al. · cmu, harvard

Single-particle cryo-electron microscopy (cryo-EM) has become a cornerstone of structural biology, enabling near-atomic resolution analysis of macromolecules through advanced computational methods. However, the development of cryo-EM processing tools is constrained by the scarcity of high-quality annotated datasets. Synthetic data generation offers a promising alternative, but existing approaches lack thorough biophysical modeling of heterogeneity and fail to reproduce the complex noise observed in real imaging. To address these limitations, we present CryoCCD, a synthesis framework that unifies versatile biophysical modeling with the first conditional cycle-consistent diffusion model tailored for cryo-EM. The biophysical engine provides multi-functional generation capabilities to capture authentic biological organization, and the diffusion model is enhanced with cycle consistency and mask-guided contrastive learning to ensure realistic noise while preserving structural fidelity. Extensive experiments demonstrate that CryoCCD generates structurally faithful micrographs, enhances particle picking and pose estimation, as well as achieves superior performance over state-of-the-art baselines, while also generalizing effectively to held-out protein families.

Runmin Jiang, Wanyue Feng, Yuntian Yang et al. · cmu, harvard

Cryo-electron tomography (cryo-ET) enables in situ visualization of macromolecular structures, where subtomogram analysis tasks such as classification, alignment, and averaging are critical for structural determination. However, effective analysis is hindered by scarce annotations, severe noise, and poor generalization. To address these challenges, we take the first step towards foundation models for cryo-ET subtomograms. First, we introduce CryoEngine, a large-scale synthetic data generator that produces over 904k subtomograms from 452 particle classes for pretraining. Second, we design an Adaptive Phase Tokenization-enhanced Vision Transformer (APT-ViT), which incorporates adaptive phase tokenization as an equivariance-enhancing module that improves robustness to both geometric and semantic variations. Third, we introduce a Noise-Resilient Contrastive Learning (NRCL) strategy to stabilize representation learning under severe noise conditions. Evaluations across 24 synthetic and real datasets demonstrate state-of-the-art (SOTA) performance on all three major subtomogram tasks and strong generalization to unseen datasets, advancing scalable and robust subtomogram analysis in cryo-ET.