Ming Huang

Li Yan, Pengcheng Wei, Hong Xie et al.

Registration is a basic yet crucial task in point cloud processing. In correspondence-based point cloud registration, matching correspondences by point feature techniques may lead to an extremely high outlier ratio. Current methods still suffer from low efficiency, accuracy, and recall rate. We use a simple and intuitive method to describe the 6-DOF (degree of freedom) curtailment process in point cloud registration and propose an outlier removal strategy based on the reliability of the correspondence graph. The method constructs the corresponding graph according to the given correspondences and designs the concept of the reliability degree of the graph node for optimal candidate selection and the reliability degree of the graph edge to obtain the global maximum consensus set. The presented method could achieve fast and accurate outliers removal along with gradual aligning parameters estimation. Extensive experiments on simulations and challenging real-world datasets demonstrate that the proposed method can still perform effective point cloud registration even the correspondence outlier ratio is over 99%, and the efficiency is better than the state-of-the-art. Code is available at https://github.com/WPC-WHU/GROR.

Yu Liu, Ming Huang, Xiao Ren et al.

Accurate pedestrian trajectory prediction is essential for safe navigation in autonomous driving and intelligent transportation systems. Despite substantial progress made by recent methods, most existing approaches are limited in fully exploiting diverse observations and often overlook the scale dependency of future motion, treating multiscale features uniformly regardless of underlying motion dynamics. This limits their robustness across diverse pedestrian behaviors. To address these challenges, we propose a Predicted-MUltiSCale-Aware Network (MUSCLE-NET) for Pedestrian Trajectory Forecasting that integrates complementary multimodal cues with scale-adaptive prediction mechanisms. The proposed framework is built upon a Multiscale Multimodal Feature Extraction (MMFE) module, which combines multiscale representation, modality-aware recalibration, and directional cross-modal fusion to construct semantically aligned representations from bounding boxes, velocities, and pose information. Building on these features, a Multiscale Enhanced Hierarchical Prediction (MEHP) module performs prediction-aware future-motion refinement via a probabilistic coarse predictor, scale-aligned fusion, and progressive refinement, adaptively selecting scale-relevant cues to mitigate spatial drift. Extensive experiments on the JAAD and PIE benchmarks demonstrate that the proposed MUSCLE-Net achieves competitive performance and consistent gains compared with state-of-the-art trajectory prediction methods.

Zheng Chen, Ziwei Yang, Lingwei Zhu et al.

This paper proposes a novel framework for automatically capturing the time-frequency nature of electroencephalogram (EEG) signals of human sleep based on the authoritative sleep medicine guidance. The framework consists of two parts: the first part extracts informative features by partitioning the input EEG spectrograms into a sequence of time-frequency patches. The second part is constituted by an attention-based architecture to efficiently search for the correlation between partitioned time-frequency patches and defining factors of sleep stages in parallel. The proposed pipeline is validated on the Sleep Heart Health Study dataset with new state-of-the-art results for the stages wake, N2, and N3, obtaining respective F1 scores of 0.93, 0.88, and 0.87, with only EEG signals used. The proposed method also has a high inter-rater reliability of 0.80 kappa. We also visualize the correspondence between sleep staging decisions and features extracted by the proposed method, providing strong interpretability for our model.

Ziyi Chen, Ren Yang, Sunyang Fu et al.

Depression is a widespread mental health issue, affecting an estimated 3.8% of the global population. It is also one of the main contributors to disability worldwide. Recently it is becoming popular for individuals to use social media platforms (e.g., Reddit) to express their difficulties and health issues (e.g., depression) and seek support from other users in online communities. It opens great opportunities to automatically identify social media users with depression by parsing millions of posts for potential interventions. Deep learning methods have begun to dominate in the field of machine learning and natural language processing (NLP) because of their ease of use, efficient processing, and state-of-the-art results on many NLP tasks. In this work, we propose a hybrid deep learning model which combines a pretrained sentence BERT (SBERT) and convolutional neural network (CNN) to detect individuals with depression with their Reddit posts. The sentence BERT is used to learn the meaningful representation of semantic information in each post. CNN enables the further transformation of those embeddings and the temporal identification of behavioral patterns of users. We trained and evaluated the model performance to identify Reddit users with depression by utilizing the Self-reported Mental Health Diagnoses (SMHD) data. The hybrid deep learning model achieved an accuracy of 0.86 and an F1 score of 0.86 and outperformed the state-of-the-art documented result (F1 score of 0.79) by other machine learning models in the literature. The results show the feasibility of the hybrid model to identify individuals with depression. Although the hybrid model is validated to detect depression with Reddit posts, it can be easily tuned and applied to other text classification tasks and different clinical applications.

Ziwei Yang, Lingwei Zhu, Zheng Chen et al.

Cancer is one of the deadliest diseases worldwide. Accurate diagnosis and classification of cancer subtypes are indispensable for effective clinical treatment. Promising results on automatic cancer subtyping systems have been published recently with the emergence of various deep learning methods. However, such automatic systems often overfit the data due to the high dimensionality and scarcity. In this paper, we propose to investigate automatic subtyping from an unsupervised learning perspective by directly constructing the underlying data distribution itself, hence sufficient data can be generated to alleviate the issue of overfitting. Specifically, we bypass the strong Gaussianity assumption that typically exists but fails in the unsupervised learning subtyping literature due to small-sized samples by vector quantization. Our proposed method better captures the latent space features and models the cancer subtype manifestation on a molecular basis, as demonstrated by the extensive experimental results.

Zehan Li, Yan Hu, Scott Lane et al.

Accurate identification and categorization of suicidal events can yield better suicide precautions, reducing operational burden, and improving care quality in high-acuity psychiatric settings. Pre-trained language models offer promise for identifying suicidality from unstructured clinical narratives. We evaluated the performance of four BERT-based models using two fine-tuning strategies (multiple single-label and single multi-label) for detecting coexisting suicidal events from 500 annotated psychiatric evaluation notes. The notes were labeled for suicidal ideation (SI), suicide attempts (SA), exposure to suicide (ES), and non-suicidal self-injury (NSSI). RoBERTa outperformed other models using multiple single-label classification strategy (acc=0.86, F1=0.78). MentalBERT (acc=0.83, F1=0.74) also exceeded BioClinicalBERT (acc=0.82, F1=0.72) which outperformed BERT (acc=0.80, F1=0.70). RoBERTa fine-tuned with single multi-label classification further improved the model performance (acc=0.88, F1=0.81). The findings highlight that the model optimization, pretraining with domain-relevant data, and the single multi-label classification strategy enhance the model performance of suicide phenotyping. Keywords: EHR-based Phenotyping; Natural Language Processing; Secondary Use of EHR Data; Suicide Classification; BERT-based Model; Psychiatry; Mental Health

Ming Huang, Shuting Xu, Leying Yang et al.

Direction-of-arrival (DOA) estimation is an important task in microphone array processing and many downstream applications. The steered response power with phase transform (SRP-PHAT) method has been widely adopted for DOA estimation in recent years. However, accurate SRP-PHAT estimation in 3D scenarios requires evaluating steering responses over thousands of candidate directions, severely limiting real-time performance on resource-constrained platforms. This challenge becomes even more critical for planar arrays, which are widely used in robotics due to their structural simplicity. Motivated by the fact that azimuth estimation is usually more reliable than elevation estimation for most arrays, we propose ASAP, an azimuth-priority strip-based search approach to planar microphone array DOA estimation in 3D. In the first stage, ASAP performs coarse-to-fine region contraction within azimuthal strips to lock azimuth angles while retaining multiple maxima through spherical caps. In the second stage, it refines elevation along the great-circle arc between two close candidates. Extensive simulations and real-world experiments validate the efficiency and merits of the proposed method over existing approaches.

Shaode Yu, Enqi Chen, Ming Huang et al.

Blind image quality assessment (BIQA) for ultrahighdefinition (UHD) images remains challenging because native-resolution inference is computationally expensive, whereas aggressive resizing or isolated cropping may suppress scale-sensitive distortions and weaken the relationship between local artifacts and global scene context. This paper aims to improve UHD-BIQA by explicitly modeling the structural dependencies among sampled image regions rather than treating them as independent views, and a graph representation learning framework UHD-GCN-BIQA is proposed. The framework samples aspect-ratio-aligned patches from each UHD image, encodes them as graph nodes, and constructs a hybrid k-nearest-neighbor graph using spatial proximity and feature similarity. Residual graph convolution is used to propagate contextual information across regions, and gated attention pooling aggregates patchlevel evidence into an imagelevel quality prediction. An exponential moving average normalized multiobjective loss function is adopted to stabilize the joint optimization of regression, correlation, and ranking objectives. Experiments on the UHD-IQA benchmark show that UHD-GCN-BIQA achieves PLCC = 0.7784, SRCC = 0.8019, and RMSE = 0.0519, obtaining competitive correlation performance and the lowest RMSE among the compared methods. These results indicate that graph-based region relation modeling is effective for UHD image quality assessment, particularly for improving absolute quality score estimation under high-resolution visual content.

Sota Kudo, Naoaki Ono, Shigehiko Kanaya et al.

Information Bottleneck (IB) is a widely used framework that enables the extraction of information related to a target random variable from a source random variable. In the objective function, IB controls the trade-off between data compression and predictiveness through the Lagrange multiplier $β$. Traditionally, to find the trade-off to be learned, IB requires a search for $β$ through multiple training cycles, which is computationally expensive. In this study, we introduce Flexible Variational Information Bottleneck (FVIB), an innovative framework for classification task that can obtain optimal models for all values of $β$ with single, computationally efficient training. We theoretically demonstrate that across all values of reasonable $β$, FVIB can simultaneously maximize an approximation of the objective function for Variational Information Bottleneck (VIB), the conventional IB method. Then we empirically show that FVIB can learn the VIB objective as effectively as VIB. Furthermore, in terms of calibration performance, FVIB outperforms other IB and calibration methods by enabling continuous optimization of $β$. Our codes are available at https://github.com/sotakudo/fvib.

Fali Wang, Zhiwei Zhang, Xianren Zhang et al.

Large language models (LLMs) have demonstrated emergent abilities in text generation, question answering, and reasoning, facilitating various tasks and domains. Despite their proficiency in various tasks, LLMs like PaLM 540B and Llama-3.1 405B face limitations due to large parameter sizes and computational demands, often requiring cloud API use which raises privacy concerns, limits real-time applications on edge devices, and increases fine-tuning costs. Additionally, LLMs often underperform in specialized domains such as healthcare and law due to insufficient domain-specific knowledge, necessitating specialized models. Therefore, Small Language Models (SLMs) are increasingly favored for their low inference latency, cost-effectiveness, efficient development, and easy customization and adaptability. These models are particularly well-suited for resource-limited environments and domain knowledge acquisition, addressing LLMs' challenges and proving ideal for applications that require localized data handling for privacy, minimal inference latency for efficiency, and domain knowledge acquisition through lightweight fine-tuning. The rising demand for SLMs has spurred extensive research and development. However, a comprehensive survey investigating issues related to the definition, acquisition, application, enhancement, and reliability of SLM remains lacking, prompting us to conduct a detailed survey on these topics. The definition of SLMs varies widely, thus to standardize, we propose defining SLMs by their capability to perform specialized tasks and suitability for resource-constrained settings, setting boundaries based on the minimal size for emergent abilities and the maximum size sustainable under resource constraints. For other aspects, we provide a taxonomy of relevant models/methods and develop general frameworks for each category to enhance and utilize SLMs effectively.

Congying Liu, Taihao Li, Ming Huang et al.

Protein analysis tasks arising in healthcare settings often require accurate reasoning under protein sequence constraints, involving tasks such as functional interpretation of disease-related variants, protein-level analysis for clinical research, and similar scenarios. To address such tasks, search agents are introduced to search protein-related information, providing support for disease-related variant analysis and protein function reasoning in protein-centric inference. However, such search agents are mostly limited to single-round, text-only modality search, which prevents the protein sequence modality from being incorporated as a multimodal input into the search decision-making process. Meanwhile, their reliance on reinforcement learning (RL) supervision that focuses solely on the final answer results in a lack of search process constraints, making deviations in keyword selection and reasoning directions difficult to identify and correct in a timely manner. To address these limitations, we propose ProtRLSearch, a multi-round protein search agent trained with multi-dimensional reward based RL, which jointly leverages protein sequence and text as multimodal inputs during real-time search to produce high quality reports. To evaluate the ability of models to integrate protein sequence information and text-based multimodal inputs in realistic protein query settings, we construct ProtMCQs, a benchmark of 3,000 multiple choice questions (MCQs) organized into three difficulty levels. The benchmark evaluates protein query tasks that range from sequence constrained reasoning about protein function and phenotype changes to comprehensive protein reasoning that integrates multi-dimensional sequence features with signal pathways and regulatory networks.

Siyang Li, Yize Chen, Zijie Zhu et al.

Time Series Foundation Models (TSFMs) advance generalization and data efficiency in time series forecasting by unified large-scale pretraining. But TSFMs remain lacking when adapting to specific downstream forecasting tasks for two reasons. First, the non-stationary and uncertain nature of time series data lead to inevitable temporal distribution shifts between historical training and future testing data, while current Supervised FineTuning (SFT)-based methods are prone to overfitting and may degrade generalization. Second, training data availability varies across forecasting tasks, requiring TSFMs to generalize well under diverse data regimes. To address these challenges, we introduce the Time series Reinforcement Finetuning (TimeRFT) paradigm for TSFM downstream adaptation, which consists of two task-specific training recipes: i) A forecasting quality-based temporal reward mechanism that conducts a multi-faceted evaluation of the contribution of each prediction step to overall forecasting accuracy. ii) A forecasting difficulty-based data selection strategy to identify time series samples with generalizable predictive patterns and informative training signals. Extensive experiments demonstrate TimeRFT can consistently outperform SFT-based adaptation methods across various real-world forecasting tasks and training data regimes, enhancing prediction accuracy and generalization against unforeseen distribution shifts.

Fengze Li, Yue Wang, Yangle Liu et al.

Multivariate time series forecasting requires models to simultaneously capture variable-wise structural dependencies and generalize across diverse tasks. While structural encoders are effective in modeling feature interactions, they lack the capacity to support semantic-level reasoning or task adaptation. Conversely, large language models (LLMs) possess strong generalization capabilities but remain incompatible with raw time series inputs. This gap limits the development of unified, transferable prediction systems. Therefore, we introduce SEED, a structural encoder for embedding-driven decoding, which integrates four stages: a token-aware encoder for patch extraction, a projection module that aligns patches with language model embeddings, a semantic reprogramming mechanism that maps patches to task-aware prototypes, and a frozen language model for prediction. This modular architecture decouples representation learning from inference, enabling efficient alignment between numerical patterns and semantic reasoning. Empirical results demonstrate that the proposed method achieves consistent improvements over strong baselines, and comparative studies on various datasets confirm SEED's role in addressing the structural-semantic modeling gap.

Sai Krishna Revanth Vuruma, Dezhi Wu, Saborny Sen Gupta et al.

The widespread adoption of social media platforms globally not only enhances users' connectivity and communication but also emerges as a vital channel for the dissemination of health-related information, thereby establishing social media data as an invaluable organic data resource for public health research. The surge in popularity of vaping or e-cigarette use in the United States and other countries has caused an outbreak of e-cigarette and vaping use-associated lung injury (EVALI), leading to hospitalizations and fatalities in 2019, highlighting the urgency to comprehend vaping behaviors and develop effective strategies for cession. In this study, we extracted a sample dataset from one vaping sub-community on Reddit to analyze users' quit vaping intentions. Leveraging large language models including both the latest GPT-4 and traditional BERT-based language models for sentence-level quit-vaping intention prediction tasks, this study compares the outcomes of these models against human annotations. Notably, when compared to human evaluators, GPT-4 model demonstrates superior consistency in adhering to annotation guidelines and processes, showcasing advanced capabilities to detect nuanced user quit-vaping intentions that human evaluators might overlook. These preliminary findings emphasize the potential of GPT-4 in enhancing the accuracy and reliability of social media data analysis, especially in identifying subtle users' intentions that may elude human detection.

Siyang Li, Yize Chen, Yan Guo et al.

Advanced deep learning-based approaches have been actively applied to forecast the spatiotemporal physical dynamics governed by partial differential equations (PDEs), which acts as a critical procedure in tackling many science and engineering problems. As real-world physical environments like PDE system parameters are always capricious, how to generalize across unseen out-of-distribution (OOD) forecasting scenarios using limited training data is of great importance. To bridge this barrier, existing methods focus on discovering domain-generalizable representations across various PDE dynamics trajectories. However, their zero-shot OOD generalization capability remains deficient, since extra test-time samples for domain-specific adaptation are still required. This is because the fundamental physical invariance in PDE dynamical systems are yet to be investigated or integrated. To this end, we first explicitly define a two-fold PDE invariance principle, which points out that ingredient operators and their composition relationships remain invariant across different domains and PDE system evolution. Next, to capture this two-fold PDE invariance, we propose a physics-guided invariant learning method termed iMOOE, featuring an Invariance-aligned Mixture Of Operator Expert architecture and a frequency-enriched invariant learning objective. Extensive experiments across simulated benchmarks and real-world applications validate iMOOE's superior in-distribution performance and zero-shot generalization capabilities on diverse OOD forecasting scenarios.

Ming Huang, Zehan Li, Yan Hu et al.

Suicide remains a pressing global health crisis, with over 720,000 deaths annually and millions more affected by suicide ideation (SI) and suicide attempts (SA). Early identification of suicidality-related factors (SrFs), including SI, SA, exposure to suicide (ES), and non-suicidal self-injury (NSSI), is critical for timely intervention. While prior studies have applied AI to detect SrFs in clinical notes, most treat suicidality as a binary classification task, overlooking the complexity of cooccurring risk factors. This study explores the use of generative large language models (LLMs), specifically GPT-3.5 and GPT-4.5, for multi-label classification (MLC) of SrFs from psychiatric electronic health records (EHRs). We present a novel end to end generative MLC pipeline and introduce advanced evaluation methods, including label set level metrics and a multilabel confusion matrix for error analysis. Finetuned GPT-3.5 achieved top performance with 0.94 partial match accuracy and 0.91 F1 score, while GPT-4.5 with guided prompting showed superior performance across label sets, including rare or minority label sets, indicating a more balanced and robust performance. Our findings reveal systematic error patterns, such as the conflation of SI and SA, and highlight the models tendency toward cautious over labeling. This work not only demonstrates the feasibility of using generative AI for complex clinical classification tasks but also provides a blueprint for structuring unstructured EHR data to support large scale clinical research and evidence based medicine.

Sai Krishna Revanth Vuruma, Dezhi Wu, Saborny Sen Gupta et al.

In recent years, the United States has witnessed a significant surge in the popularity of vaping or e-cigarette use, leading to a notable rise in cases of e-cigarette and vaping use-associated lung injury (EVALI) that caused hospitalizations and fatalities during the EVALI outbreak in 2019, highlighting the urgency to comprehend vaping behaviors and develop effective strategies for cessation. Due to the ubiquity of social media platforms, over 4.7 billion users worldwide use them for connectivity, communications, news, and entertainment with a significant portion of the discourse related to health, thereby establishing social media data as an invaluable organic data resource for public health research. In this study, we extracted a sample dataset from one vaping sub-community on Reddit to analyze users' quit-vaping intentions. Leveraging OpenAI's latest large language model GPT-4 for sentence-level quit vaping intention detection, this study compares the outcomes of this model against layman and clinical expert annotations. Using different prompting strategies such as zero-shot, one-shot, few-shot and chain-of-thought prompting, we developed 8 prompts with varying levels of detail to explain the task to GPT-4 and also evaluated the performance of the strategies against each other. These preliminary findings emphasize the potential of GPT-4 in social media data analysis, especially in identifying users' subtle intentions that may elude human detection.