Weiyi Zhang

Weiyi Zhang, Siyu Huang, Jiancheng Yang et al.

Fundus Fluorescein Angiography (FFA) is a critical tool for assessing retinal vascular dynamics and aiding in the diagnosis of eye diseases. However, its invasive nature and less accessibility compared to Color Fundus (CF) images pose significant challenges. Current CF to FFA translation methods are limited to static generation. In this work, we pioneer dynamic FFA video generation from static CF images. We introduce an autoregressive GAN for smooth, memory-saving frame-by-frame FFA synthesis. To enhance the focus on dynamic lesion changes in FFA regions, we design a knowledge mask based on clinical experience. Leveraging this mask, our approach integrates innovative knowledge mask-guided techniques, including knowledge-boosted attention, knowledge-aware discriminators, and mask-enhanced patchNCE loss, aimed at refining generation in critical areas and addressing the pixel misalignment challenge. Our method achieves the best FVD of 1503.21 and PSNR of 11.81 compared to other common video generation approaches. Human assessment by an ophthalmologist confirms its high generation quality. Notably, our knowledge mask surpasses supervised lesion segmentation masks, offering a promising non-invasive alternative to traditional FFA for research and clinical applications. The code is available at https://github.com/Michi-3000/Fundus2Video.

Danli Shi, Weiyi Zhang, Jiancheng Yang et al.

Early detection of eye diseases like glaucoma, macular degeneration, and diabetic retinopathy is crucial for preventing vision loss. While artificial intelligence (AI) foundation models hold significant promise for addressing these challenges, existing ophthalmic foundation models primarily focus on a single modality, whereas diagnosing eye diseases requires multiple modalities. A critical yet often overlooked aspect is harnessing the multi-view information across various modalities for the same patient. Additionally, due to the long-tail nature of ophthalmic diseases, standard fully supervised or unsupervised learning approaches often struggle. Therefore, it is essential to integrate clinical text to capture a broader spectrum of diseases. We propose EyeCLIP, a visual-language foundation model developed using over 2.77 million multi-modal ophthalmology images with partial text data. To fully leverage the large multi-modal unlabeled and labeled data, we introduced a pretraining strategy that combines self-supervised reconstructions, multi-modal image contrastive learning, and image-text contrastive learning to learn a shared representation of multiple modalities. Through evaluation using 14 benchmark datasets, EyeCLIP can be transferred to a wide range of downstream tasks involving ocular and systemic diseases, achieving state-of-the-art performance in disease classification, visual question answering, and cross-modal retrieval. EyeCLIP represents a significant advancement over previous methods, especially showcasing few-shot, even zero-shot capabilities in real-world long-tail scenarios.

Jianzhe Gao, Churan Wang, Weiyi Zhang et al.

Medical video diagnosis involves inferring clinical decisions from dynamic tissue responses throughout examination processes. Existing methods rely on an end-to-end learning paradigm that i) focuses on appearance rather than pathology, ii) lacks clinical priors, and iii) reasons solely from observations without counterfactual comparison. This work introduces MedVCR, a counterfactual reasoning framework that mimics clinical diagnostic thinking. MedVCR comprises three components: a Counterfactual Generator that synthesizes tissue evolution under specified pathological states via a diffusion-based manner; a Counterfactual Representation Learning module that encodes diagnostic knowledge through clinical rules (i.e., temporal consistency, pathological separability, and counterfactual alignment); and a Dual Diagnostic Prediction strategy that integrates video-level assessment with frame-level counterfactual analysis. MedVCR is evaluated under both fully supervised (e.g., colposcopy) and weakly supervised (e.g., colonoscopy) video diagnosis settings, yielding 2.6%-10.2% performance gains compared with leading baselines. Comprehensive ablation studies further validate the effectiveness of each component. The code will be released.

Ruoyu Chen, Kezheng Xu, Kangyan Zheng et al.

Ultrawide-field fluorescein angiography (UWF-FA) facilitates diabetic retinopathy (DR) detection by providing a clear visualization of peripheral retinal lesions. However, the intravenous dye injection with potential risks hamper its application. We aim to acquire dye-free UWF-FA images from noninvasive UWF retinal imaging (UWF-RI) using generative artificial intelligence (GenAI) and evaluate its effectiveness in DR screening. A total of 18,321 UWF-FA images of different phases were registered with corresponding UWF-RI images and fed into a generative adversarial networks (GAN)-based model for training. The quality of generated UWF-FA images was evaluated through quantitative metrics and human evaluation. The DeepDRiD dataset was used to externally assess the contribution of generated UWF-FA images to DR classification, using area under the receiver operating characteristic curve (AUROC) as outcome metrics. The generated early, mid, and late phase UWF-FA images achieved high authenticity, with multi-scale similarity scores ranging from 0.70 to 0.91 and qualitative visual scores ranging from 1.64 to 1.98 (1=real UWF-FA quality). In fifty randomly selected images, 56% to 76% of the generated images were difficult to distinguish from real images in the Turing test. Moreover, adding these generated UWF-FA images for DR classification significantly increased the AUROC from 0.869 to 0.904 compared to the baseline model using UWF-RI images (P < .001). The model successfully generates realistic multi-frame UWF-FA images for enhancing DR stratification without intravenous dye injection.

Xiaozheng Zheng, Chao Wen, Zhaohu Li et al.

In this paper, we present a novel 3D head avatar creation approach capable of generalizing from few-shot in-the-wild data with high-fidelity and animatable robustness. Given the underconstrained nature of this problem, incorporating prior knowledge is essential. Therefore, we propose a framework comprising prior learning and avatar creation phases. The prior learning phase leverages 3D head priors derived from a large-scale multi-view dynamic dataset, and the avatar creation phase applies these priors for few-shot personalization. Our approach effectively captures these priors by utilizing a Gaussian Splatting-based auto-decoder network with part-based dynamic modeling. Our method employs identity-shared encoding with personalized latent codes for individual identities to learn the attributes of Gaussian primitives. During the avatar creation phase, we achieve fast head avatar personalization by leveraging inversion and fine-tuning strategies. Extensive experiments demonstrate that our model effectively exploits head priors and successfully generalizes them to few-shot personalization, achieving photo-realistic rendering quality, multi-view consistency, and stable animation.

Aminul Huq, Weiyi Zhang, Xiaolin Hu

Automatic speech recognition (ASR) systems based on deep neural networks are weak against adversarial perturbations. We propose mixPGD adversarial training method to improve the robustness of the model for ASR systems. In standard adversarial training, adversarial samples are generated by leveraging supervised or unsupervised methods. We merge the capabilities of both supervised and unsupervised approaches in our method to generate new adversarial samples which aid in improving model robustness. Extensive experiments and comparison across various state-of-the-art defense methods and adversarial attacks have been performed to show that mixPGD gains 4.1% WER of better performance than previous best performing models under white-box adversarial attack setting. We tested our proposed defense method against both white-box and transfer based black-box attack settings to ensure that our defense strategy is robust against various types of attacks. Empirical results on several adversarial attacks validate the effectiveness of our proposed approach.

Tianlong Chen, Weiyi Zhang, Jingyang Zhou et al.

Learning to optimize (L2O) has gained increasing attention since classical optimizers require laborious problem-specific design and hyperparameter tuning. However, there is a gap between the practical demand and the achievable performance of existing L2O models. Specifically, those learned optimizers are applicable to only a limited class of problems, and often exhibit instability. With many efforts devoted to designing more sophisticated L2O models, we argue for another orthogonal, under-explored theme: the training techniques for those L2O models. We show that even the simplest L2O model could have been trained much better. We first present a progressive training scheme to gradually increase the optimizer unroll length, to mitigate a well-known L2O dilemma of truncation bias (shorter unrolling) versus gradient explosion (longer unrolling). We further leverage off-policy imitation learning to guide the L2O learning, by taking reference to the behavior of analytical optimizers. Our improved training techniques are plugged into a variety of state-of-the-art L2O models, and immediately boost their performance, without making any change to their model structures. Especially, by our proposed techniques, an earliest and simplest L2O model can be trained to outperform the latest complicated L2O models on a number of tasks. Our results demonstrate a greater potential of L2O yet to be unleashed, and urge to rethink the recent progress. Our codes are publicly available at: https://github.com/VITA-Group/L2O-Training-Techniques.

Danli Shi, Weiyi Zhang, Xiaolan Chen et al.

Artificial intelligence (AI) is vital in ophthalmology, tackling tasks like diagnosis, classification, and visual question answering (VQA). However, existing AI models in this domain often require extensive annotation and are task-specific, limiting their clinical utility. While recent developments have brought about foundation models for ophthalmology, they are limited by the need to train separate weights for each imaging modality, preventing a comprehensive representation of multi-modal features. This highlights the need for versatile foundation models capable of handling various tasks and modalities in ophthalmology. To address this gap, we present EyeFound, a multimodal foundation model for ophthalmic images. Unlike existing models, EyeFound learns generalizable representations from unlabeled multimodal retinal images, enabling efficient model adaptation across multiple applications. Trained on 2.78 million images from 227 hospitals across 11 ophthalmic modalities, EyeFound facilitates generalist representations and diverse multimodal downstream tasks, even for detecting challenging rare diseases. It outperforms previous work RETFound in diagnosing eye diseases, predicting systemic disease incidents, and zero-shot multimodal VQA. EyeFound provides a generalizable solution to improve model performance and lessen the annotation burden on experts, facilitating widespread clinical AI applications for retinal imaging.

Ruoyu Chen, Weiyi Zhang, Bowen Liu et al.

The rising prevalence of vision-threatening retinal diseases poses a significant burden on the global healthcare systems. Deep learning (DL) offers a promising solution for automatic disease screening but demands substantial data. Collecting and labeling large volumes of ophthalmic images across various modalities encounters several real-world challenges, especially for rare diseases. Here, we introduce EyeDiff, a text-to-image model designed to generate multimodal ophthalmic images from natural language prompts and evaluate its applicability in diagnosing common and rare diseases. EyeDiff is trained on eight large-scale datasets using the advanced latent diffusion model, covering 14 ophthalmic image modalities and over 80 ocular diseases, and is adapted to ten multi-country external datasets. The generated images accurately capture essential lesional characteristics, achieving high alignment with text prompts as evaluated by objective metrics and human experts. Furthermore, integrating generated images significantly enhances the accuracy of detecting minority classes and rare eye diseases, surpassing traditional oversampling methods in addressing data imbalance. EyeDiff effectively tackles the issue of data imbalance and insufficiency typically encountered in rare diseases and addresses the challenges of collecting large-scale annotated images, offering a transformative solution to enhance the development of expert-level diseases diagnosis models in ophthalmic field.

Xiaolan Chen, Ziwei Zhao, Weiyi Zhang et al.

Artificial intelligence (AI) has gained significant attention in healthcare consultation due to its potential to improve clinical workflow and enhance medical communication. However, owing to the complex nature of medical information, large language models (LLM) trained with general world knowledge might not possess the capability to tackle medical-related tasks at an expert level. Here, we introduce EyeGPT, a specialized LLM designed specifically for ophthalmology, using three optimization strategies including role-playing, finetuning, and retrieval-augmented generation. In particular, we proposed a comprehensive evaluation framework that encompasses a diverse dataset, covering various subspecialties of ophthalmology, different users, and diverse inquiry intents. Moreover, we considered multiple evaluation metrics, including accuracy, understandability, trustworthiness, empathy, and the proportion of hallucinations. By assessing the performance of different EyeGPT variants, we identify the most effective one, which exhibits comparable levels of understandability, trustworthiness, and empathy to human ophthalmologists (all Ps>0.05). Overall, ur study provides valuable insights for future research, facilitating comprehensive comparisons and evaluations of different strategies for developing specialized LLMs in ophthalmology. The potential benefits include enhancing the patient experience in eye care and optimizing ophthalmologists' services.

Weiyi Zhang, Jiancheng Yang, Ruoyu Chen et al.

Fundus fluorescein angiography (FFA) is crucial for diagnosing and monitoring retinal vascular issues but is limited by its invasive nature and restricted accessibility compared to color fundus (CF) imaging. Existing methods that convert CF images to FFA are confined to static image generation, missing the dynamic lesional changes. We introduce Fundus2Video, an autoregressive generative adversarial network (GAN) model that generates dynamic FFA videos from single CF images. Fundus2Video excels in video generation, achieving an FVD of 1497.12 and a PSNR of 11.77. Clinical experts have validated the fidelity of the generated videos. Additionally, the model's generator demonstrates remarkable downstream transferability across ten external public datasets, including blood vessel segmentation, retinal disease diagnosis, systemic disease prediction, and multimodal retrieval, showcasing impressive zero-shot and few-shot capabilities. These findings position Fundus2Video as a powerful, non-invasive alternative to FFA exams and a versatile retinal generative foundation model that captures both static and temporal retinal features, enabling the representation of complex inter-modality relationships.

Xinyuan Wu, Lili Wang, Ruoyu Chen et al.

Fundus fluorescein angiography (FFA) is critical for diagnosing retinal vascular diseases, but beginners often struggle with image interpretation. This study develops FFA Sora, a text-to-video model that converts FFA reports into dynamic videos via a Wavelet-Flow Variational Autoencoder (WF-VAE) and a diffusion transformer (DiT). Trained on an anonymized dataset, FFA Sora accurately simulates disease features from the input text, as confirmed by objective metrics: Frechet Video Distance (FVD) = 329.78, Learned Perceptual Image Patch Similarity (LPIPS) = 0.48, and Visual-question-answering Score (VQAScore) = 0.61. Specific evaluations showed acceptable alignment between the generated videos and textual prompts, with BERTScore of 0.35. Additionally, the model demonstrated strong privacy-preserving performance in retrieval evaluations, achieving an average Recall@K of 0.073. Human assessments indicated satisfactory visual quality, with an average score of 1.570(scale: 1 = best, 5 = worst). This model addresses privacy concerns associated with sharing large-scale FFA data and enhances medical education.

Bowen Liu, Weiyi Zhang, Peranut Chotcomwongse et al.

Optical Coherence Tomography (OCT) provides high-resolution, 3D, and non-invasive visualization of retinal layers in vivo, serving as a critical tool for lesion localization and disease diagnosis. However, its widespread adoption is limited by equipment costs and the need for specialized operators. In comparison, 2D color fundus photography offers faster acquisition and greater accessibility with less dependence on expensive devices. Although generative artificial intelligence has demonstrated promising results in medical image synthesis, translating 2D fundus images into 3D OCT images presents unique challenges due to inherent differences in data dimensionality and biological information between modalities. To advance generative models in the fundus-to-3D-OCT setting, the Asia Pacific Tele-Ophthalmology Society (APTOS-2024) organized a challenge titled Artificial Intelligence-based OCT Generation from Fundus Images. This paper details the challenge framework (referred to as APTOS-2024 Challenge), including: the benchmark dataset, evaluation methodology featuring two fidelity metrics-image-based distance (pixel-level OCT B-scan similarity) and video-based distance (semantic-level volumetric consistency), and analysis of top-performing solutions. The challenge attracted 342 participating teams, with 42 preliminary submissions and 9 finalists. Leading methodologies incorporated innovations in hybrid data preprocessing or augmentation (cross-modality collaborative paradigms), pre-training on external ophthalmic imaging datasets, integration of vision foundation models, and model architecture improvement. The APTOS-2024 Challenge is the first benchmark demonstrating the feasibility of fundus-to-3D-OCT synthesis as a potential solution for improving ophthalmic care accessibility in under-resourced healthcare settings, while helping to expedite medical research and clinical applications.

Weiyi Zhang, Peranut Chotcomwongse, Yinwen Li et al.

Diabetic macular edema (DME) significantly contributes to visual impairment in diabetic patients. Treatment responses to intravitreal therapies vary, highlighting the need for patient stratification to predict therapeutic benefits and enable personalized strategies. To our knowledge, this study is the first to explore pre-treatment stratification for predicting DME treatment responses. To advance this research, we organized the 2nd Asia-Pacific Tele-Ophthalmology Society (APTOS) Big Data Competition in 2021. The competition focused on improving predictive accuracy for anti-VEGF therapy responses using ophthalmic OCT images. We provided a dataset containing tens of thousands of OCT images from 2,000 patients with labels across four sub-tasks. This paper details the competition's structure, dataset, leading methods, and evaluation metrics. The competition attracted strong scientific community participation, with 170 teams initially registering and 41 reaching the final round. The top-performing team achieved an AUC of 80.06%, highlighting the potential of AI in personalized DME treatment and clinical decision-making.

Xiaolan Chen, Ruoyu Chen, Pusheng Xu et al.

Accurate diagnosis of ophthalmic diseases relies heavily on the interpretation of multimodal ophthalmic images, a process often time-consuming and expertise-dependent. Visual Question Answering (VQA) presents a potential interdisciplinary solution by merging computer vision and natural language processing to comprehend and respond to queries about medical images. This review article explores the recent advancements and future prospects of VQA in ophthalmology from both theoretical and practical perspectives, aiming to provide eye care professionals with a deeper understanding and tools for leveraging the underlying models. Additionally, we discuss the promising trend of large language models (LLM) in enhancing various components of the VQA framework to adapt to multimodal ophthalmic tasks. Despite the promising outlook, ophthalmic VQA still faces several challenges, including the scarcity of annotated multimodal image datasets, the necessity of comprehensive and unified evaluation methods, and the obstacles to achieving effective real-world applications. This article highlights these challenges and clarifies future directions for advancing ophthalmic VQA with LLMs. The development of LLM-based ophthalmic VQA systems calls for collaborative efforts between medical professionals and AI experts to overcome existing obstacles and advance the diagnosis and care of eye diseases.

Jialu Zhang, Qingyang Sun, Qianyi Wang et al.

The undergraduate thesis (UGTE) plays an indispensable role in assessing a student's cumulative academic development throughout their college years. Although large language models (LLMs) have advanced education intelligence, they typically focus on holistic assessment with only one single evaluation score, but ignore the intricate nuances across multifaceted criteria, limiting their ability to reflect structural criteria, pedagogical objectives, and diverse academic competencies. Meanwhile, pedagogical theories have long informed manual UGTE evaluation through multi-dimensional assessment of cognitive development, disciplinary thinking, and academic performance, yet remain underutilized in automated settings. Motivated by the research gap, we pioneer PEMUTA, a pedagogically-enriched framework that effectively activates domain-specific knowledge from LLMs for multi-granular UGTE assessment. Guided by Vygotsky's theory and Bloom's Taxonomy, PEMUTA incorporates a hierarchical prompting scheme that evaluates UGTEs across six fine-grained dimensions: Structure, Logic, Originality, Writing, Proficiency, and Rigor (SLOWPR), followed by holistic synthesis. Two in-context learning techniques, \ie, few-shot prompting and role-play prompting, are also incorporated to further enhance alignment with expert judgments without fine-tuning. We curate a dataset of authentic UGTEs with expert-provided SLOWPR-aligned annotations to support multi-granular UGTE assessment. Extensive experiments demonstrate that PEMUTA achieves strong alignment with expert evaluations, and exhibits strong potential for fine-grained, pedagogically-informed UGTE evaluations.

Pusheng Xu, Xia Gong, Xiaolan Chen et al.

Purpose: To develop a bilingual multimodal visual question answering (VQA) benchmark for evaluating VLMs in ophthalmology. Methods: Ophthalmic image posts and associated captions published between January 1, 2016, and December 31, 2024, were collected from WeChat Official Accounts. Based on these captions, bilingual question-answer (QA) pairs in Chinese and English were generated using GPT-4o-mini. QA pairs were categorized into six subsets by question type and language: binary (Binary_CN, Binary_EN), single-choice (Single-choice_CN, Single-choice_EN), and open-ended (Open-ended_CN, Open-ended_EN). The benchmark was used to evaluate the performance of three VLMs: GPT-4o, Gemini 2.0 Flash, and Qwen2.5-VL-72B-Instruct. Results: The final OphthalWeChat dataset included 3,469 images and 30,120 QA pairs across 9 ophthalmic subspecialties, 548 conditions, 29 imaging modalities, and 68 modality combinations. Gemini 2.0 Flash achieved the highest overall accuracy (0.548), outperforming GPT-4o (0.522, P < 0.001) and Qwen2.5-VL-72B-Instruct (0.514, P < 0.001). It also led in both Chinese (0.546) and English subsets (0.550). Subset-specific performance showed Gemini 2.0 Flash excelled in Binary_CN (0.687), Single-choice_CN (0.666), and Single-choice_EN (0.646), while GPT-4o ranked highest in Binary_EN (0.717), Open-ended_CN (BLEU-1: 0.301; BERTScore: 0.382), and Open-ended_EN (BLEU-1: 0.183; BERTScore: 0.240). Conclusions: This study presents the first bilingual VQA benchmark for ophthalmology, distinguished by its real-world context and inclusion of multiple examinations per patient. The dataset reflects authentic clinical decision-making scenarios and enables quantitative evaluation of VLMs, supporting the development of accurate, specialized, and trustworthy AI systems for eye care.

Xiaolin Hu, Kai Li, Weiyi Zhang et al.

Recent advances in the design of neural network architectures, in particular those specialized in modeling sequences, have provided significant improvements in speech separation performance. In this work, we propose to use a bio-inspired architecture called Fully Recurrent Convolutional Neural Network (FRCNN) to solve the separation task. This model contains bottom-up, top-down and lateral connections to fuse information processed at various time-scales represented by \textit{stages}. In contrast to the traditional approach updating stages in parallel, we propose to first update the stages one by one in the bottom-up direction, then fuse information from adjacent stages simultaneously and finally fuse information from all stages to the bottom stage together. Experiments showed that this asynchronous updating scheme achieved significantly better results with much fewer parameters than the traditional synchronous updating scheme. In addition, the proposed model achieved good balance between speech separation accuracy and computational efficiency as compared to other state-of-the-art models on three benchmark datasets.

Weiyi Zhang, Shuning Zhao, Le Liu et al.

In authentication scenarios, applications of practical speaker verification systems usually require a person to read a dynamic authentication text. Previous studies played an audio adversarial example as a digital signal to perform physical attacks, which would be easily rejected by audio replay detection modules. This work shows that by playing our crafted adversarial perturbation as a separate source when the adversary is speaking, the practical speaker verification system will misjudge the adversary as a target speaker. A two-step algorithm is proposed to optimize the universal adversarial perturbation to be text-independent and has little effect on the authentication text recognition. We also estimated room impulse response (RIR) in the algorithm which allowed the perturbation to be effective after being played over the air. In the physical experiment, we achieved targeted attacks with success rate of 100%, while the word error rate (WER) on speech recognition was only increased by 3.55%. And recorded audios could pass replay detection for the live person speaking.

Kai Yang, Jie Ren, Yanqiao Zhu et al.

Internet of Things (IoT) is becoming truly ubiquitous in our everyday life, but it also faces unique security challenges. Intrusion detection is critical for the security and safety of a wireless IoT network. This paper discusses the human-in-the-loop active learning approach for wireless intrusion detection. We first present the fundamental challenges against the design of a successful Intrusion Detection System (IDS) for wireless IoT network. We then briefly review the rudimentary concepts of active learning and propose its employment in the diverse applications of wireless intrusion detection. Experimental example is also presented to show the significant performance improvement of the active learning method over traditional supervised learning approach. While machine learning techniques have been widely employed for intrusion detection, the application of human-in-the-loop machine learning that leverages both machine and human intelligence to intrusion detection of IoT is still in its infancy. We hope this article can assist the readers in understanding the key concepts of active learning and spur further research in this area.

Zhiyuan Xu, Jian Tang, Jingsong Meng et al.

Modern communication networks have become very complicated and highly dynamic, which makes them hard to model, predict and control. In this paper, we develop a novel experience-driven approach that can learn to well control a communication network from its own experience rather than an accurate mathematical model, just as a human learns a new skill (such as driving, swimming, etc). Specifically, we, for the first time, propose to leverage emerging Deep Reinforcement Learning (DRL) for enabling model-free control in communication networks; and present a novel and highly effective DRL-based control framework, DRL-TE, for a fundamental networking problem: Traffic Engineering (TE). The proposed framework maximizes a widely-used utility function by jointly learning network environment and its dynamics, and making decisions under the guidance of powerful Deep Neural Networks (DNNs). We propose two new techniques, TE-aware exploration and actor-critic-based prioritized experience replay, to optimize the general DRL framework particularly for TE. To validate and evaluate the proposed framework, we implemented it in ns-3, and tested it comprehensively with both representative and randomly generated network topologies. Extensive packet-level simulation results show that 1) compared to several widely-used baseline methods, DRL-TE significantly reduces end-to-end delay and consistently improves the network utility, while offering better or comparable throughput; 2) DRL-TE is robust to network changes; and 3) DRL-TE consistently outperforms a state-ofthe-art DRL method (for continuous control), Deep Deterministic Policy Gradient (DDPG), which, however, does not offer satisfying performance.