Martin Brown

Gholamali Aminian, Andrew Elliott, Tiger Li et al.

Detecting payment fraud in real-world banking streams requires models that can exploit both the order of events and the irregular time gaps between them. We introduce FraudTransformer, a sequence model that augments a vanilla GPT-style architecture with (i) a dedicated time encoder that embeds either absolute timestamps or inter-event values, and (ii) a learned positional encoder that preserves relative order. Experiments on a large industrial dataset -- tens of millions of transactions and auxiliary events -- show that FraudTransformer surpasses four strong classical baselines (Logistic Regression, XGBoost and LightGBM) as well as transformer ablations that omit either the time or positional component. On the held-out test set it delivers the highest AUROC and PRAUC.

Philip T. Jackson, Yinhai Wang, Sinead Knight et al.

While deep learning has seen many recent applications to drug discovery, most have focused on predicting activity or toxicity directly from chemical structure. Phenotypic changes exhibited in cellular images are also indications of the mechanism of action (MoA) of chemical compounds. In this paper, we show how pre-trained convolutional image features can be used to assist scientists in discovering interesting chemical clusters for further investigation. Our method reduces the dimensionality of raw fluorescent stained images from a high throughput imaging (HTI) screen, producing an embedding space that groups together images with similar cellular phenotypes. Running standard unsupervised clustering on this embedding space yields a set of distinct phenotypic clusters. This allows scientists to further select and focus on interesting clusters for downstream analyses. We validate the consistency of our embedding space qualitatively with t-sne visualizations, and quantitatively by measuring embedding variance among images that are known to be similar. Results suggested the usefulness of our proposed workflow using deep learning and clustering and it can lead to robust HTI screening and compound triage.