Khanh Nguyen

Amala Sanjay Deshmukh, Kateryna Chumachenko, Tuomas Rintamaki et al. · nvidia

We introduce Nemotron Nano V2 VL, the latest model of the Nemotron vision-language series designed for strong real-world document understanding, long video comprehension, and reasoning tasks. Nemotron Nano V2 VL delivers significant improvements over our previous model, Llama-3.1-Nemotron-Nano-VL-8B, across all vision and text domains through major enhancements in model architecture, datasets, and training recipes. Nemotron Nano V2 VL builds on Nemotron Nano V2, a hybrid Mamba-Transformer LLM, and innovative token reduction techniques to achieve higher inference throughput in long document and video scenarios. We are releasing model checkpoints in BF16, FP8, and FP4 formats and sharing large parts of our datasets, recipes and training code.

Yunzhe Zhang, Yifei Wang, Khanh Vinh Nguyen et al.

Current SMILES-based diffusion models for molecule generation typically support only unimodal constraint. They inject conditioning signals at the start of the training process and require retraining a new model from scratch whenever the constraint changes. However, real-world applications often involve multiple constraints across different modalities, and additional constraints may emerge over the course of a study. This raises a challenge: how to extend a pre-trained diffusion model not only to support cross-modality constraints but also to incorporate new ones without retraining. To tackle this problem, we propose the Cross-Modality Controlled Molecule Generation with Diffusion Language Model (CMCM-DLM), demonstrated by two distinct cross modalities: molecular structure and chemical properties. Our approach builds upon a pre-trained diffusion model, incorporating two trainable modules, the Structure Control Module (SCM) and the Property Control Module (PCM), and operates in two distinct phases during the generation process. In Phase I, we employs the SCM to inject structural constraints during the early diffusion steps, effectively anchoring the molecular backbone. Phase II builds on this by further introducing PCM to guide the later stages of inference to refine the generated molecules, ensuring their chemical properties match the specified targets. Experimental results on multiple datasets demonstrate the efficiency and adaptability of our approach, highlighting CMCM-DLM's significant advancement in molecular generation for drug discovery applications.