Wenzhe Shan

Yiyang Wen, Liu Shi, Zekun Zhou et al.

Limited-angle computed tomography (LACT) offers the advantages of reduced radiation dose and shortened scanning time. Traditional reconstruction algorithms exhibit various inherent limitations in LACT. Currently, most deep learning-based LACT reconstruction methods focus on multi-domain fusion or the introduction of generic priors, failing to fully align with the core imaging characteristics of LACT-such as the directionality of artifacts and directional loss of structural information, which are caused by the absence of projection angles in certain directions. Inspired by the theory of visible and invisible singularities, taking into account the aforementioned core imaging characteristics of LACT, we propose a Visible Singularities Guided Correlation network for LACT reconstruction (VSGC). The design philosophy of VSGC consists of two core steps: First, extract VS edge features from LACT images and focus the model's attention on these VS. Second, establish correlations between the VS edge features and other regions of the image. Additionally, a multi-scale loss function with anisotropic constraint is employed to constrain the model to converge in multiple aspects. Finally, qualitative and quantitative validations are conducted on both simulated and real datasets to verify the effectiveness and feasibility of the proposed design. Particularly, in comparison with alternative methods, VSGC delivers more prominent performance in small angular ranges, with the PSNR improvement of 2.45 dB and the SSIM enhancement of 1.5\%. The code is publicly available at https://github.com/yqx7150/VSGC.

Guoquan Wei, Liu Shi, Zekun Zhou et al.

Current models based on deep learning for low-dose CT denoising rely heavily on paired data and generalize poorly. Even the more concerned diffusion models need to learn the distribution of clean data for reconstruction, which is difficult to satisfy in medical clinical applications. At the same time, self-supervised-based methods face the challenge of significant degradation of generalizability of models pre-trained for the current dose to expand to other doses. To address these issues, this work proposes a novel method of TUnable-geneRalizatioN Diffusion (TurnDiff) powered by self-supervised contextual sub-data for low-dose CT reconstruction. Firstly, a contextual subdata self-enhancing similarity strategy is designed for denoising centered on the LDCT projection domain, which provides an initial prior for the subsequent progress. Subsequently, the initial prior is used to combine knowledge distillation with a deep combination of latent diffusion models for optimizing image details. The pre-trained model is used for inference reconstruction, and the pixel-level self-correcting fusion technique is proposed for fine-grained reconstruction of the image domain to enhance the image fidelity, using the initial prior and the LDCT image as a guide. In addition, the technique is flexibly applied to the generalization of upper and lower doses or even unseen doses. Dual-domain strategy cascade for self-supervised LDCT denoising, TurnDiff requires only LDCT projection domain data for training and testing. Comprehensive evaluation on both benchmark datasets and real-world data demonstrates that TurnDiff consistently outperforms state-of-the-art methods in both reconstruction and generalization.