Yanna Cruz Cavalcanti

Yanna Cruz Cavalcanti, Thomas Oberlin, Nicolas Dobigeon et al.

Factor analysis has proven to be a relevant tool for extracting tissue time-activity curves (TACs) in dynamic PET images, since it allows for an unsupervised analysis of the data. Reliable and interpretable results are possible only if considered with respect to suitable noise statistics. However, the noise in reconstructed dynamic PET images is very difficult to characterize, despite the Poissonian nature of the count-rates. Rather than explicitly modeling the noise distribution, this work proposes to study the relevance of several divergence measures to be used within a factor analysis framework. To this end, the $β$-divergence, widely used in other applicative domains, is considered to design the data-fitting term involved in three different factor models. The performances of the resulting algorithms are evaluated for different values of $β$, in a range covering Gaussian, Poissonian and Gamma-distributed noises. The results obtained on two different types of synthetic images and one real image show the interest of applying non-standard values of $β$ to improve factor analysis.

Vinicius Ferraris, Nicolas Dobigeon, Yanna Cavalcanti et al.

Archetypal scenarios for change detection generally consider two images acquired through sensors of the same modality. However, in some specific cases such as emergency situations, the only images available may be those acquired through sensors of different modalities. This paper addresses the problem of unsupervisedly detecting changes between two observed images acquired by sensors of different modalities with possibly different resolutions. These sensor dissimilarities introduce additional issues in the context of operational change detection that are not addressed by most of the classical methods. This paper introduces a novel framework to effectively exploit the available information by modelling the two observed images as a sparse linear combination of atoms belonging to a pair of coupled overcomplete dictionaries learnt from each observed image. As they cover the same geographical location, codes are expected to be globally similar, except for possible changes in sparse spatial locations. Thus, the change detection task is envisioned through a dual code estimation which enforces spatial sparsity in the difference between the estimated codes associated with each image. This problem is formulated as an inverse problem which is iteratively solved using an efficient proximal alternating minimization algorithm accounting for nonsmooth and nonconvex functions. The proposed method is applied to real images with simulated yet realistic and real changes. A comparison with state-of-the-art change detection methods evidences the accuracy of the proposed strategy.

Yanna Cruz Cavalcanti, Thomas Oberlin, Nicolas Dobigeon et al.

To analyze dynamic positron emission tomography (PET) images, various generic multivariate data analysis techniques have been considered in the literature, such as principal component analysis (PCA), independent component analysis (ICA), factor analysis and nonnegative matrix factorization (NMF). Nevertheless, these conventional approaches neglect any possible nonlinear variations in the time activity curves describing the kinetic behavior of tissues with specific binding, which limits their ability to recover a reliable, understandable and interpretable description of the data. This paper proposes an alternative analysis paradigm that accounts for spatial fluctuations in the exchange rate of the tracer between a free compartment and a specifically bound ligand compartment. The method relies on the concept of linear unmixing, usually applied on the hyperspectral domain, which combines NMF with a sum-to-one constraint that ensures an exhaustive description of the mixtures. The spatial variability of the signature corresponding to the specific binding tissue is explicitly modeled through a perturbed component. The performance of the method is assessed on both synthetic and real data and is shown to compete favorably when compared to other conventional analysis methods. The proposed method improved both factor estimation and proportions extraction for specific binding. Modeling the variability of the specific binding factor has a strong potential impact for dynamic PET image analysis.