Min Zhu

Jin Ye, Junlong Cheng, Jianpin Chen et al.

Segment Anything Model (SAM) has achieved impressive results for natural image segmentation with input prompts such as points and bounding boxes. Its success largely owes to massive labeled training data. However, directly applying SAM to medical image segmentation cannot perform well because SAM lacks medical knowledge -- it does not use medical images for training. To incorporate medical knowledge into SAM, we introduce SA-Med2D-20M, a large-scale segmentation dataset of 2D medical images built upon numerous public and private datasets. It consists of 4.6 million 2D medical images and 19.7 million corresponding masks, covering almost the whole body and showing significant diversity. This paper describes all the datasets collected in SA-Med2D-20M and details how to process these datasets. Furthermore, comprehensive statistics of SA-Med2D-20M are presented to facilitate the better use of our dataset, which can help the researchers build medical vision foundation models or apply their models to downstream medical applications. We hope that the large scale and diversity of SA-Med2D-20M can be leveraged to develop medical artificial intelligence for enhancing diagnosis, medical image analysis, knowledge sharing, and education. The data with the redistribution license is publicly available at https://github.com/OpenGVLab/SAM-Med2D.

Junlong Cheng, Jin Ye, Zhongying Deng et al.

The Segment Anything Model (SAM) represents a state-of-the-art research advancement in natural image segmentation, achieving impressive results with input prompts such as points and bounding boxes. However, our evaluation and recent research indicate that directly applying the pretrained SAM to medical image segmentation does not yield satisfactory performance. This limitation primarily arises from significant domain gap between natural images and medical images. To bridge this gap, we introduce SAM-Med2D, the most comprehensive studies on applying SAM to medical 2D images. Specifically, we first collect and curate approximately 4.6M images and 19.7M masks from public and private datasets, constructing a large-scale medical image segmentation dataset encompassing various modalities and objects. Then, we comprehensively fine-tune SAM on this dataset and turn it into SAM-Med2D. Unlike previous methods that only adopt bounding box or point prompts as interactive segmentation approach, we adapt SAM to medical image segmentation through more comprehensive prompts involving bounding boxes, points, and masks. We additionally fine-tune the encoder and decoder of the original SAM to obtain a well-performed SAM-Med2D, leading to the most comprehensive fine-tuning strategies to date. Finally, we conducted a comprehensive evaluation and analysis to investigate the performance of SAM-Med2D in medical image segmentation across various modalities, anatomical structures, and organs. Concurrently, we validated the generalization capability of SAM-Med2D on 9 datasets from MICCAI 2023 challenge. Overall, our approach demonstrated significantly superior performance and generalization capability compared to SAM.

Min Zhu, Handi Zhang, Anran Jiao et al.

Deep neural operators can learn nonlinear mappings between infinite-dimensional function spaces via deep neural networks. As promising surrogate solvers of partial differential equations (PDEs) for real-time prediction, deep neural operators such as deep operator networks (DeepONets) provide a new simulation paradigm in science and engineering. Pure data-driven neural operators and deep learning models, in general, are usually limited to interpolation scenarios, where new predictions utilize inputs within the support of the training set. However, in the inference stage of real-world applications, the input may lie outside the support, i.e., extrapolation is required, which may result to large errors and unavoidable failure of deep learning models. Here, we address this challenge of extrapolation for deep neural operators. First, we systematically investigate the extrapolation behavior of DeepONets by quantifying the extrapolation complexity via the 2-Wasserstein distance between two function spaces and propose a new behavior of bias-variance trade-off for extrapolation with respect to model capacity. Subsequently, we develop a complete workflow, including extrapolation determination, and we propose five reliable learning methods that guarantee a safe prediction under extrapolation by requiring additional information -- the governing PDEs of the system or sparse new observations. The proposed methods are based on either fine-tuning a pre-trained DeepONet or multifidelity learning. We demonstrate the effectiveness of the proposed framework for various types of parametric PDEs. Our systematic comparisons provide practical guidelines for selecting a proper extrapolation method depending on the available information, desired accuracy, and required inference speed.

Lei Ma, Jingyang Zhang, Ke Deng et al.

Dental template and parametric dental models are important tools for various applications in digital dentistry. However, constructing an unbiased dental template and accurate parametric dental models remains a challenging task due to the complex anatomical and morphological dental structures and also low volume ratio of the teeth. In this study, we develop an unbiased dental template by constructing an accurate dental atlas from CBCT images with guidance of teeth segmentation. First, to address the challenges, we propose to enhance the CBCT images and their segmentation images, including image cropping, image masking and segmentation intensity reassigning. Then, we further use the segmentation images to perform co-registration with the CBCT images to generate an accurate dental atlas, from which an unbiased dental template can be generated. By leveraging the unbiased dental template, we construct parametric dental models by estimating point-to-point correspondences between the dental models and employing Principal Component Analysis to determine shape subspaces of the parametric dental models. A total of 159 CBCT images of real subjects are collected to perform the constructions. Experimental results demonstrate effectiveness of our proposed method in constructing unbiased dental template and parametric dental model. The developed dental template and parametric dental models are available at https://github.com/Marvin0724/Teeth_template.

Xin-Yang Liu, Min Zhu, Lu Lu et al.

Traditional data-driven deep learning models often struggle with high training costs, error accumulation, and poor generalizability in complex physical processes. Physics-informed deep learning (PiDL) addresses these challenges by incorporating physical principles into the model. Most PiDL approaches regularize training by embedding governing equations into the loss function, yet this depends heavily on extensive hyperparameter tuning to weigh each loss term. To this end, we propose to leverage physics prior knowledge by ``baking'' the discretized governing equations into the neural network architecture via the connection between the partial differential equations (PDE) operators and network structures, resulting in a PDE-preserved neural network (PPNN). This method, embedding discretized PDEs through convolutional residual networks in a multi-resolution setting, largely improves the generalizability and long-term prediction accuracy, outperforming conventional black-box models. The effectiveness and merit of the proposed methods have been demonstrated across various spatiotemporal dynamical systems governed by spatiotemporal PDEs, including reaction-diffusion, Burgers', and Navier-Stokes equations.

Shihang Feng, Hanchen Wang, Chengyuan Deng et al.

Elastic geophysical properties (such as P- and S-wave velocities) are of great importance to various subsurface applications like CO$_2$ sequestration and energy exploration (e.g., hydrogen and geothermal). Elastic full waveform inversion (FWI) is widely applied for characterizing reservoir properties. In this paper, we introduce $\mathbf{\mathbb{E}^{FWI}}$, a comprehensive benchmark dataset that is specifically designed for elastic FWI. $\mathbf{\mathbb{E}^{FWI}}$ encompasses 8 distinct datasets that cover diverse subsurface geologic structures (flat, curve, faults, etc). The benchmark results produced by three different deep learning methods are provided. In contrast to our previously presented dataset (pressure recordings) for acoustic FWI (referred to as OpenFWI), the seismic dataset in $\mathbf{\mathbb{E}^{FWI}}$ has both vertical and horizontal components. Moreover, the velocity maps in $\mathbf{\mathbb{E}^{FWI}}$ incorporate both P- and S-wave velocities. While the multicomponent data and the added S-wave velocity make the data more realistic, more challenges are introduced regarding the convergence and computational cost of the inversion. We conduct comprehensive numerical experiments to explore the relationship between P-wave and S-wave velocities in seismic data. The relation between P- and S-wave velocities provides crucial insights into the subsurface properties such as lithology, porosity, fluid content, etc. We anticipate that $\mathbf{\mathbb{E}^{FWI}}$ will facilitate future research on multiparameter inversions and stimulate endeavors in several critical research topics of carbon-zero and new energy exploration. All datasets, codes and relevant information can be accessed through our website at https://efwi-lanl.github.io/

Jianben He, Xingbo Wang, Kam Kwai Wong et al.

Constructing supervised machine learning models for real-world video analysis require substantial labeled data, which is costly to acquire due to scarce domain expertise and laborious manual inspection. While data programming shows promise in generating labeled data at scale with user-defined labeling functions, the high dimensional and complex temporal information in videos poses additional challenges for effectively composing and evaluating labeling functions. In this paper, we propose VideoPro, a visual analytics approach to support flexible and scalable video data programming for model steering with reduced human effort. We first extract human-understandable events from videos using computer vision techniques and treat them as atomic components of labeling functions. We further propose a two-stage template mining algorithm that characterizes the sequential patterns of these events to serve as labeling function templates for efficient data labeling. The visual interface of VideoPro facilitates multifaceted exploration, examination, and application of the labeling templates, allowing for effective programming of video data at scale. Moreover, users can monitor the impact of programming on model performance and make informed adjustments during the iterative programming process. We demonstrate the efficiency and effectiveness of our approach with two case studies and expert interviews.

Chenxi Wu, Min Zhu, Qinyang Tan et al.

Physics-informed neural networks (PINNs) have shown to be an effective tool for solving forward and inverse problems of partial differential equations (PDEs). PINNs embed the PDEs into the loss of the neural network, and this PDE loss is evaluated at a set of scattered residual points. The distribution of these points are highly important to the performance of PINNs. However, in the existing studies on PINNs, only a few simple residual point sampling methods have mainly been used. Here, we present a comprehensive study of two categories of sampling: non-adaptive uniform sampling and adaptive nonuniform sampling. We consider six uniform sampling, including (1) equispaced uniform grid, (2) uniformly random sampling, (3) Latin hypercube sampling, (4) Halton sequence, (5) Hammersley sequence, and (6) Sobol sequence. We also consider a resampling strategy for uniform sampling. To improve the sampling efficiency and the accuracy of PINNs, we propose two new residual-based adaptive sampling methods: residual-based adaptive distribution (RAD) and residual-based adaptive refinement with distribution (RAR-D), which dynamically improve the distribution of residual points based on the PDE residuals during training. Hence, we have considered a total of 10 different sampling methods, including six non-adaptive uniform sampling, uniform sampling with resampling, two proposed adaptive sampling, and an existing adaptive sampling. We extensively tested the performance of these sampling methods for four forward problems and two inverse problems in many setups. Our numerical results presented in this study are summarized from more than 6000 simulations of PINNs. We show that the proposed adaptive sampling methods of RAD and RAR-D significantly improve the accuracy of PINNs with fewer residual points. The results obtained in this study can also be used as a practical guideline in choosing sampling methods.

Lei Ma, Peng Xue, Yuning Gu et al.

In recent years, the demand for dental implants has surged, driven by their high success rates and esthetic advantages. However, accurate prediction of missing teeth for precise digital implant planning remains a challenge due to the intricate nature of dental structures and the variability in tooth loss patterns. This study presents a novel framework for accurate prediction of missing teeth in different patterns, facilitating digital implant planning. The proposed framework begins by estimating point-to-point correspondence among a dataset of dental mesh models reconstructed from CBCT images of healthy subjects. Subsequently, tooth dictionaries are constructed for each tooth type, encoding their position and shape information based on the established point-to-point correspondence. To predict missing teeth in a given dental mesh model, sparse coefficients are learned by sparsely representing adjacent teeth of the missing teeth using the corresponding tooth dictionaries. These coefficients are then applied to the dictionaries of the missing teeth to generate accurate predictions of their positions and shapes. The evaluation results on real subjects shows that our proposed framework achieves an average prediction error of 1.04mm for predictions of single missing tooth and an average prediction error of 1.33mm for the prediction of 14 missing teeth, which demonstrates its capability of accurately predicting missing teeth in various patterns. By accurately predicting missing teeth, dental professionals can improve the planning and placement of dental implants, leading to better esthetic and functional outcomes for patients undergoing dental implant procedures.

Zhongyi Jiang, Min Zhu, Lu Lu

Geologic carbon sequestration (GCS) is a safety-critical technology that aims to reduce the amount of carbon dioxide in the atmosphere, which also places high demands on reliability. Multiphase flow in porous media is essential to understand CO$_2$ migration and pressure fields in the subsurface associated with GCS. However, numerical simulation for such problems in 4D is computationally challenging and expensive, due to the multiphysics and multiscale nature of the highly nonlinear governing partial differential equations (PDEs). It prevents us from considering multiple subsurface scenarios and conducting real-time optimization. Here, we develop a Fourier-enhanced multiple-input neural operator (Fourier-MIONet) to learn the solution operator of the problem of multiphase flow in porous media. Fourier-MIONet utilizes the recently developed framework of the multiple-input deep neural operators (MIONet) and incorporates the Fourier neural operator (FNO) in the network architecture. Once Fourier-MIONet is trained, it can predict the evolution of saturation and pressure of the multiphase flow under various reservoir conditions, such as permeability and porosity heterogeneity, anisotropy, injection configurations, and multiphase flow properties. Compared to the enhanced FNO (U-FNO), the proposed Fourier-MIONet has 90% fewer unknown parameters, and it can be trained in significantly less time (about 3.5 times faster) with much lower CPU memory ($<$ 15%) and GPU memory ($<$ 35%) requirements, to achieve similar prediction accuracy. In addition to the lower computational cost, Fourier-MIONet can be trained with only 6 snapshots of time to predict the PDE solutions for 30 years. The excellent generalizability of Fourier-MIONet is enabled by its adherence to the physical principle that the solution to a PDE is continuous over time.

Junlong Cheng, Chengrui Gao, Fengjie Wang et al.

Recently, U-shaped networks have dominated the field of medical image segmentation due to their simple and easily tuned structure. However, existing U-shaped segmentation networks: 1) mostly focus on designing complex self-attention modules to compensate for the lack of long-term dependence based on convolution operation, which increases the overall number of parameters and computational complexity of the network; 2) simply fuse the features of encoder and decoder, ignoring the connection between their spatial locations. In this paper, we rethink the above problem and build a lightweight medical image segmentation network, called SegNetr. Specifically, we introduce a novel SegNetr block that can perform local-global interactions dynamically at any stage and with only linear complexity. At the same time, we design a general information retention skip connection (IRSC) to preserve the spatial location information of encoder features and achieve accurate fusion with the decoder features. We validate the effectiveness of SegNetr on four mainstream medical image segmentation datasets, with 59\% and 76\% fewer parameters and GFLOPs than vanilla U-Net, while achieving segmentation performance comparable to state-of-the-art methods. Notably, the components proposed in this paper can be applied to other U-shaped networks to improve their segmentation performance.

Min Zhu, Jingmin Sun, Zecheng Zhang et al.

Partial differential equations (PDEs) govern a wide range of physical systems, and recent multimodal foundation models have shown promise for learning PDE solution operators across diverse equation families. However, existing multi-operator learning approaches are data-hungry and neglect physics during training. Here, we propose a physics-informed multimodal foundation model (PI-MFM) framework that directly enforces governing equations during pretraining and adaptation. PI-MFM takes symbolic representations of PDEs as the input, and automatically assembles PDE residual losses from the input expression via a vectorized derivative computation. These designs enable any PDE-encoding multimodal foundation model to be trained or adapted with unified physics-informed objectives across equation families. On a benchmark of 13 parametric one-dimensional time-dependent PDE families, PI-MFM consistently outperforms purely data-driven counterparts, especially with sparse labeled spatiotemporal points, partially observed time domains, or few labeled function pairs. Physics losses further improve robustness against noise, and simple strategies such as resampling collocation points substantially improve accuracy. We also analyze the accuracy, precision, and computational cost of automatic differentiation and finite differences for derivative computation within PI-MFM. Finally, we demonstrate zero-shot physics-informed fine-tuning to unseen PDE families: starting from a physics-informed pretrained model, adapting using only PDE residuals and initial/boundary conditions, without any labeled solution data, rapidly reduces test errors to around 1% and clearly outperforms physics-only training from scratch. These results show that PI-MFM provides a practical and scalable path toward data-efficient, transferable PDE solvers.

Jiahui Peng, He Yao, Jingwen Li et al.

Contrastive Language-Image Pre-training (CLIP) has demonstrated outstanding performance in global image understanding and zero-shot transfer through large-scale text-image alignment. However, the core of medical image analysis often lies in the fine-grained understanding of specific anatomical structures or lesion regions. Therefore, precisely comprehending region-of-interest (RoI) information provided by medical professionals or perception models becomes crucial. To address this need, we propose MedP-CLIP, a region-aware medical vision-language model (VLM). MedP-CLIP innovatively integrates medical prior knowledge and designs a feature-level region prompt integration mechanism, enabling it to flexibly respond to various prompt forms (e.g., points, bounding boxes, masks) while maintaining global contextual awareness when focusing on local regions. We pre-train the model on a meticulously constructed large-scale dataset (containing over 6.4 million medical images and 97.3 million region-level annotations), equipping it with cross-disease and cross-modality fine-grained spatial semantic understanding capabilities. Experiments demonstrate that MedP-CLIP significantly outperforms baseline methods in various medical tasks, including zero-shot recognition, interactive segmentation, and empowering multimodal large language models. This model provides a scalable, plug-and-play visual backbone for medical AI, combining holistic image understanding with precise regional analysis.

Junlong Cheng, Bin Fu, Jin Ye et al.

Interactive Medical Image Segmentation (IMIS) has long been constrained by the limited availability of large-scale, diverse, and densely annotated datasets, which hinders model generalization and consistent evaluation across different models. In this paper, we introduce the IMed-361M benchmark dataset, a significant advancement in general IMIS research. First, we collect and standardize over 6.4 million medical images and their corresponding ground truth masks from multiple data sources. Then, leveraging the strong object recognition capabilities of a vision foundational model, we automatically generated dense interactive masks for each image and ensured their quality through rigorous quality control and granularity management. Unlike previous datasets, which are limited by specific modalities or sparse annotations, IMed-361M spans 14 modalities and 204 segmentation targets, totaling 361 million masks-an average of 56 masks per image. Finally, we developed an IMIS baseline network on this dataset that supports high-quality mask generation through interactive inputs, including clicks, bounding boxes, text prompts, and their combinations. We evaluate its performance on medical image segmentation tasks from multiple perspectives, demonstrating superior accuracy and scalability compared to existing interactive segmentation models. To facilitate research on foundational models in medical computer vision, we release the IMed-361M and model at https://github.com/uni-medical/IMIS-Bench.

Jonathan E. Lee, Min Zhu, Ziqiao Xi et al.

Geological carbon sequestration (GCS) involves injecting CO$_2$ into subsurface geological formations for permanent storage. Numerical simulations could guide decisions in GCS projects by predicting CO$_2$ migration pathways and the pressure distribution in storage formation. However, these simulations are often computationally expensive due to highly coupled physics and large spatial-temporal simulation domains. Surrogate modeling with data-driven machine learning has become a promising alternative to accelerate physics-based simulations. Among these, the Fourier neural operator (FNO) has been applied to three-dimensional synthetic subsurface models. Here, to further improve performance, we have developed a nested Fourier-DeepONet by combining the expressiveness of the FNO with the modularity of a deep operator network (DeepONet). This new framework is twice as efficient as a nested FNO for training and has at least 80% lower GPU memory requirement due to its flexibility to treat temporal coordinates separately. These performance improvements are achieved without compromising prediction accuracy. In addition, the generalization and extrapolation ability of nested Fourier-DeepONet beyond the training range has been thoroughly evaluated. Nested Fourier-DeepONet outperformed the nested FNO for extrapolation in time with more than 50% reduced error. It also exhibited good extrapolation accuracy beyond the training range in terms of reservoir properties, number of wells, and injection rate.

Chengrui Gao, Ziyuan Yang, Min Zhu et al.

Palmprint biometrics garner heightened attention in palm-scanning payment and social security due to their distinctive attributes. However, prevailing methodologies singularly prioritize texture orientation, neglecting the significant texture scale dimension. We design an innovative network for concurrently extracting intra-scale and inter-scale features to redress this limitation. This paper proposes a scale-aware competitive network (SAC-Net), which includes the Inner-Scale Competition Module (ISCM) and the Across-Scale Competition Module (ASCM) to capture texture characteristics related to orientation and scale. ISCM efficiently integrates learnable Gabor filters and a self-attention mechanism to extract rich orientation data and discern textures with long-range discriminative properties. Subsequently, ASCM leverages a competitive strategy across various scales to effectively encapsulate the competitive texture scale elements. By synergizing ISCM and ASCM, our method adeptly characterizes palmprint features. Rigorous experimentation across three benchmark datasets unequivocally demonstrates our proposed approach's exceptional recognition performance and resilience relative to state-of-the-art alternatives.

Peng Kuai, Yukun Yang, Shaolun Ruan et al.

Rare disease diagnosis is inherently challenging due to heterogeneous symptoms, limited clinical familiarity, and fragmented evidence across specialties. Recent large language model (LLM)-based agentic systems have shown promise by simulating multidisciplinary team discussions to generate and evaluate diagnostic hypotheses. However, fully automated diagnosis remains unrealistic, and existing human-in-the-loop approaches provide limited support for effective clinician-agent collaboration. In practice, clinicians are often presented with final diagnostic outputs and lengthy, unstructured agent discussion logs, making it difficult to inspect reasoning, intervene in a timely manner, or guide agent deliberation effectively. To address these challenges, we developed MDTRoom, an interactive system that transforms multi-agent discussions from linear transcripts into a structured, inspectable workspace. The system externalizes patient data, evidence provenance, hypothesis evolution, and inter-agent conflicts as interconnected visual objects, enabling clinicians to efficiently examine, intervene in, and guide agent reasoning. Our evaluation demonstrates the effectiveness of MDTRoom in supporting clinician-agent collaboration.

Zhikai Wu, Sifan Wang, Shiyang Zhang et al.

Operator learning for time-dependent partial differential equations (PDEs) has seen rapid progress in recent years, enabling efficient approximation of complex spatiotemporal dynamics. However, most existing methods rely on fixed time step sizes during rollout, which limits their ability to adapt to varying temporal complexity and often leads to error accumulation. Here, we propose the Time-Adaptive Transformer with Neural Taylor Expansion (TANTE), a novel operator-learning framework that produces continuous-time predictions with adaptive step sizes. TANTE predicts future states by performing a Taylor expansion at the current state, where neural networks learn both the higher-order temporal derivatives and the local radius of convergence. This allows the model to dynamically adjust its rollout based on the local behavior of the solution, thereby reducing cumulative error and improving computational efficiency. We demonstrate the effectiveness of TANTE across a wide range of PDE benchmarks, achieving superior accuracy and adaptability compared to fixed-step baselines, delivering accuracy gains of 60-80 % and speed-ups of 30-40 % at inference time. The code is publicly available at https://github.com/zwu88/TANTE for transparency and reproducibility.

Chengrui Gao, Ziyuan Yang, Tiong-Sik Ng et al.

Palmprint recognition has emerged as a prominent biometric authentication method, owing to its high discriminative power and user-friendly nature. This paper introduces a novel Cross-Chirality Palmprint Verification (CCPV) framework that challenges the conventional wisdom in traditional palmprint verification systems. Unlike existing methods that typically require storing both left and right palmprints, our approach enables verification using either palm while storing only one palmprint template. The core of our CCPV framework lies in a carefully designed matching rule. This rule involves flipping both the gallery and query palmprints and calculating the average distance between each pair as the final matching distance. This approach effectively reduces matching variance and enhances overall system robustness. We introduce a novel cross-chirality loss function to construct a discriminative and robust cross-chirality feature space. This loss enforces representation consistency across four palmprint variants: left, right, flipped left, and flipped right. The resulting compact feature space, coupled with the model's enhanced discriminative representation capability, ensures robust performance across various scenarios. We conducted extensive experiments to validate the efficacy of our proposed method. The evaluation encompassed multiple public datasets and considered both closed-set and open-set settings. The results demonstrate the CCPV framework's effectiveness and highlight its potential for real-world applications in palmprint authentication systems.

Hailin Liu, Eugene Ilyushin, Jie Ni et al.

Large language model (LLM) agents are vulnerable to prompt-injection attacks that propagate through multi-step workflows, tool interactions, and persistent context, making input-output filtering alone insufficient for reliable protection. This paper presents SafeAgent, a runtime security architecture that treats agent safety as a stateful decision problem over evolving interaction trajectories. The proposed design separates execution governance from semantic risk reasoning through two coordinated components: a runtime controller that mediates actions around the agent loop and a context-aware decision core that operates over persistent session state. The core is formalized as a context-aware advanced machine intelligence and instantiated through operators for risk encoding, utility-cost evaluation, consequence modeling, policy arbitration, and state synchronization. Experiments on Agent Security Bench (ASB) and InjecAgent show that SafeAgent consistently improves robustness over baseline and text-level guardrail methods while maintaining competitive benign-task performance. Ablation studies further show that recovery confidence and policy weighting determine distinct safety-utility operating points.

Han Wu, Chong Wang, Lanzhuju Mei et al.

Automated cephalometric landmark detection is crucial in real-world orthodontic diagnosis. Current studies mainly focus on only adult subjects, neglecting the clinically crucial scenario presented by adolescents whose landmarks often exhibit significantly different appearances compared to adults. Hence, an open question arises about how to develop a unified and effective detection algorithm across various age groups, including adolescents and adults. In this paper, we propose CeLDA, the first work for Cephalometric Landmark Detection across Ages. Our method leverages a prototypical network for landmark detection by comparing image features with landmark prototypes. To tackle the appearance discrepancy of landmarks between age groups, we design new strategies for CeLDA to improve prototype alignment and obtain a holistic estimation of landmark prototypes from a large set of training images. Moreover, a novel prototype relation mining paradigm is introduced to exploit the anatomical relations between the landmark prototypes. Extensive experiments validate the superiority of CeLDA in detecting cephalometric landmarks on both adult and adolescent subjects. To our knowledge, this is the first effort toward developing a unified solution and dataset for cephalometric landmark detection across age groups. Our code and dataset will be made public on https://github.com/ShanghaiTech-IMPACT/Cephalometric-Landmark-Detection-across-Ages-with-Prototypical-Network

Yujie Lu, Jingwen Li, Sibo Ju et al.

Medical image segmentation is vital for clinical diagnosis and quantitative analysis, yet remains challenging due to the heterogeneity of imaging modalities and the high cost of pixel-level annotations. Although general interactive segmentation models like SAM have achieved remarkable progress, their transfer to medical imaging still faces two key bottlenecks: (i) the lack of adaptive mechanisms for modality- and anatomy-specific tasks, which limits generalization in out-of-distribution medical scenarios; and (ii) current medical adaptation methods fine-tune on large, heterogeneous datasets without selection, leading to noisy supervision, higher cost, and negative transfer. To address these issues, we propose SegMoTE, an efficient and adaptive framework for medical image segmentation. SegMoTE preserves SAM's original prompt interface, efficient inference, and zero-shot generalization while introducing only a small number of learnable parameters to dynamically adapt across modalities and tasks. In addition, we design a progressive prompt tokenization mechanism that enables fully automatic segmentation, significantly reducing annotation dependence. Trained on MedSeg-HQ, a curated dataset less than 1% of existing large-scale datasets, SegMoTE achieves SOTA performance across diverse imaging modalities and anatomical tasks. It represents the first efficient, robust, and scalable adaptation of general segmentation models to the medical domain under extremely low annotation cost, advancing the practical deployment of foundation vision models in clinical applications.

Qipeng Wang, Rui Sheng, Yafei Li et al.

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios. Specifically, current LLMs suffer from three critical limitations: (1) generating hallucinated medical content due to weak grounding in verified knowledge, (2) asking redundant or inefficient questions rather than discriminative ones that hinder diagnostic progress, and (3) losing coherence over multi-turn dialogues, leading to contradictory or inconsistent conclusions. To address these challenges, we propose MedKGI, a diagnostic framework grounded in clinical practices. MedKGI integrates a medical knowledge graph (KG) to constrain reasoning to validated medical ontologies, selects questions based on information gain to maximize diagnostic efficiency, and adopts an OSCE-format structured state to maintain consistent evidence tracking across turns. Experiments on clinical benchmarks show that MedKGI outperforms strong LLM baselines in both diagnostic accuracy and inquiry efficiency, improving dialogue efficiency by 30% on average while maintaining state-of-the-art accuracy.

Weihang Ouyang, Min Zhu, Wei Xiong et al.

Physics-informed neural networks (PINNs) and neural operators, two leading scientific machine learning (SciML) paradigms, have emerged as powerful tools for solving partial differential equations (PDEs). Although increasing the training sample size generally enhances network performance, it also increases computational costs for physics-informed or data-driven training. To address this trade-off, different sampling strategies have been developed to sample more points in regions with high PDE residuals. However, existing sampling methods are computationally demanding for high-dimensional problems, such as high-dimensional PDEs or operator learning tasks. Here, we propose a residual-based adversarial-gradient moving sample (RAMS) method, which moves samples according to the adversarial gradient direction to maximize the PDE residual via gradient-based optimization. RAMS can be easily integrated into existing sampling methods. Extensive experiments, ranging from PINN applied to high-dimensional PDEs to physics-informed and data-driven operator learning problems, have been conducted to demonstrate the effectiveness of RAMS. Notably, RAMS represents the first efficient adaptive sampling approach for operator learning, marking a significant advancement in the SciML field.

Yixiao Liu, Yizhou Yang, Jinwen Li et al.

Remote Sensing Change Detection (RSCD) typically identifies changes in land cover or surface conditions by analyzing multi-temporal images. Currently, most deep learning-based methods primarily focus on learning unimodal visual information, while neglecting the rich semantic information provided by multimodal data such as text. To address this limitation, we propose a novel Language-Guided Change Detection model (LG-CD). This model leverages natural language prompts to direct the network's attention to regions of interest, significantly improving the accuracy and robustness of change detection. Specifically, LG-CD utilizes a visual foundational model (SAM2) as a feature extractor to capture multi-scale pyramid features from high-resolution to low-resolution across bi-temporal remote sensing images. Subsequently, multi-layer adapters are employed to fine-tune the model for downstream tasks, ensuring its effectiveness in remote sensing change detection. Additionally, we design a Text Fusion Attention Module (TFAM) to align visual and textual information, enabling the model to focus on target change regions using text prompts. Finally, a Vision-Semantic Fusion Decoder (V-SFD) is implemented, which deeply integrates visual and semantic information through a cross-attention mechanism to produce highly accurate change detection masks. Our experiments on three datasets (LEVIR-CD, WHU-CD, and SYSU-CD) demonstrate that LG-CD consistently outperforms state-of-the-art change detection methods. Furthermore, our approach provides new insights into achieving generalized change detection by leveraging multimodal information.

Siming Shan, Min Zhu, Youzuo Lin et al.

Partial differential equation (PDE)-governed inverse problems are fundamental across various scientific and engineering applications; yet they face significant challenges due to nonlinearity, ill-posedness, and sensitivity to noise. Here, we introduce a new computational framework, RED-DiffEq, by integrating physics-driven inversion and data-driven learning. RED-DiffEq leverages pretrained diffusion models as a regularization mechanism for PDE-governed inverse problems. We apply RED-DiffEq to solve the full waveform inversion problem in geophysics, a challenging seismic imaging technique that seeks to reconstruct high-resolution subsurface velocity models from seismic measurement data. Our method shows enhanced accuracy and robustness compared to conventional methods. Additionally, it exhibits strong generalization ability to more complex velocity models that the diffusion model is not trained on. Our framework can also be directly applied to diverse PDE-governed inverse problems.

Chengrui Gao, Ziyuan Yang, Andrew Beng Jin Teoh et al.

Recently, finger knuckle prints (FKPs) have gained attention due to their rich textural patterns, positioning them as a promising biometric for identity recognition. Prior FKP recognition methods predominantly leverage first-order feature descriptors, which capture intricate texture details but fail to account for structural information. Emerging research, however, indicates that second-order textures, which describe the curves and arcs of the textures, encompass this overlooked structural information. This paper introduces a novel FKP recognition approach, the Dual-Order Texture Competition Network (DOTCNet), designed to capture texture information in FKP images comprehensively. DOTCNet incorporates three dual-order texture competitive modules (DTCMs), each targeting textures at different scales. Each DTCM employs a learnable texture descriptor, specifically a learnable Gabor filter (LGF), to extract texture features. By leveraging LGFs, the network extracts first and second order textures to describe fine textures and structural features thoroughly. Furthermore, an attention mechanism enhances relevant features in the first-order features, thereby highlighting significant texture details. For second-order features, a competitive mechanism emphasizes structural information while reducing noise from higher-order features. Extensive experimental results reveal that DOTCNet significantly outperforms several standard algorithms on the publicly available PolyU-FKP dataset.

Min Zhu, Shihang Feng, Youzuo Lin et al.

Full waveform inversion (FWI) infers the subsurface structure information from seismic waveform data by solving a non-convex optimization problem. Data-driven FWI has been increasingly studied with various neural network architectures to improve accuracy and computational efficiency. Nevertheless, the applicability of pre-trained neural networks is severely restricted by potential discrepancies between the source function used in the field survey and the one utilized during training. Here, we develop a Fourier-enhanced deep operator network (Fourier-DeepONet) for FWI with the generalization of seismic sources, including the frequencies and locations of sources. Specifically, we employ the Fourier neural operator as the decoder of DeepONet, and we utilize source parameters as one input of Fourier-DeepONet, facilitating the resolution of FWI with variable sources. To test Fourier-DeepONet, we develop three new and realistic FWI benchmark datasets (FWI-F, FWI-L, and FWI-FL) with varying source frequencies, locations, or both. Our experiments demonstrate that compared with existing data-driven FWI methods, Fourier-DeepONet obtains more accurate predictions of subsurface structures in a wide range of source parameters. Moreover, the proposed Fourier-DeepONet exhibits superior robustness when handling data with Gaussian noise or missing traces and sources with Gaussian noise, paving the way for more reliable and accurate subsurface imaging across diverse real conditions.

Zhangqiang Ming, Min Zhu, Xiangkun Wang et al.

In recent years, with the increasing demand for public safety and the rapid development of intelligent surveillance networks, person re-identification (Re-ID) has become one of the hot research topics in the computer vision field. The main research goal of person Re-ID is to retrieve persons with the same identity from different cameras. However, traditional person Re-ID methods require manual marking of person targets, which consumes a lot of labor cost. With the widespread application of deep neural networks, many deep learning-based person Re-ID methods have emerged. Therefore, this paper is to facilitate researchers to understand the latest research results and the future trends in the field. Firstly, we summarize the studies of several recently published person Re-ID surveys and complement the latest research methods to systematically classify deep learning-based person Re-ID methods. Secondly, we propose a multi-dimensional taxonomy that classifies current deep learning-based person Re-ID methods into four categories according to metric and representation learning, including methods for deep metric learning, local feature learning, generative adversarial learning and sequence feature learning. Furthermore, we subdivide the above four categories according to their methodologies and motivations, discussing the advantages and limitations of part subcategories. Finally, we discuss some challenges and possible research directions for person Re-ID.

Zhangqiang Ming, Yong Yang, Xiaoyong Wei et al.

The misalignment of human images caused by bounding box detection errors or partial occlusions is one of the main challenges in person Re-Identification (Re-ID) tasks. Previous local-based methods mainly focus on learning local features in predefined semantic regions of pedestrians. These methods usually use local hard alignment methods or introduce auxiliary information such as key human pose points to match local features, which are often not applicable when large scene differences are encountered. To solve these problems, we propose a simple and efficient Local Sliding Alignment (LSA) strategy to dynamically align the local features of two images by setting a sliding window on the local stripes of the pedestrian. LSA can effectively suppress spatial misalignment and does not need to introduce extra supervision information. Then, we design a Global-Local Dynamic Feature Alignment Network (GLDFA-Net) framework, which contains both global and local branches. We introduce LSA into the local branch of GLDFA-Net to guide the computation of distance metrics, which can further improve the accuracy of the testing phase. Evaluation experiments on several mainstream evaluation datasets including Market-1501, DukeMTMC-reID, CUHK03 and MSMT17 show that our method has competitive accuracy over the several state-of-the-art person Re-ID methods. Specifically, it achieves 86.1% mAP and 94.8% Rank-1 accuracy on Market1501.

Zhuotao Liu, Yuan Cao, Min Zhu et al.

Defending against distributed denial of service (DDoS) attacks in the Internet is a fundamental problem. However, recent industrial interviews with over 100 security experts from more than ten industry segments indicate that DDoS problems have not been fully addressed. The reasons are twofold. On one hand, many academic proposals that are provably secure witness little real-world deployment. On the other hand, the operation model for existing DDoS-prevention service providers (e.g., Cloudflare, Akamai) is privacy invasive for large organizations (e.g., government). In this paper, we present Umbrella, a new DDoS defense mechanism enabling Internet Service Providers (ISPs) to offer readily deployable and privacy-preserving DDoS prevention services to their customers. At its core, Umbrella develops a multi-layered defense architecture to defend against a wide spectrum of DDoS attacks. In particular, the flood throttling layer stops amplification-based DDoS attacks; the congestion resolving layer, aiming to prevent sophisticated attacks that cannot be easily filtered, enforces congestion accountability to ensure that legitimate flows are guaranteed to receive their fair shares regardless of attackers' strategies; and finally the userspecific layer allows DDoS victims to enforce self-desired traffic control policies that best satisfy their business requirements. Based on Linux implementation, we demonstrate that Umbrella is capable to deal with large scale attacks involving millions of attack flows, meanwhile imposing negligible packet processing overhead. Further, our physical testbed experiments and large scale simulations prove that Umbrella is effective to mitigate various DDoS attacks.