Zhiwei Deng

Lujia Zhong, Shuo Huang, Jiaxin Yue et al.

The emergence of tau PET imaging over the last decade has enabled Alzheimer's disease (AD) researchers to examine tau pathology in vivo and more effectively characterize the disease trajectories of AD. Current tau PET analysis methods, however, typically perform inferences on large cortical ROIs and are limited in the detection of localized tau pathology that varies across subjects. Furthermore, a high-resolution MRI is required to carry out conventional tau PET analysis, which is not commonly acquired in clinical practices and may not be acquired for many elderly patients with dementia due to strong motion artifacts, claustrophobia, or certain metal implants. In this work, we propose a novel conditional diffusion model to perform MRI-free anomaly detection from tau PET imaging data. By including individualized conditions and two complementary loss maps from pseudo-healthy and pseudo-unhealthy reconstructions, our model computes an anomaly map across the entire brain area that allows simply training a support vector machine (SVM) for classifying disease severity. We train our model on ADNI subjects (n=534) and evaluate its performance on a separate dataset from the preclinical subjects of the A4 clinical trial (n=447). We demonstrate that our method outperforms baseline generative models and the conventional Z-score-based method in anomaly localization without mis-detecting off-target bindings in sub-cortical and out-of-brain areas. By classifying the A4 subjects according to their anomaly map using the SVM trained on ADNI data, we show that our method can successfully group preclinical subjects with significantly different cognitive functions, which further demonstrates the effectiveness of our method in capturing biologically relevant anomaly in tau PET imaging.

Zhiwei Deng, Karthik Narasimhan, Olga Russakovsky

The ability to perform effective planning is crucial for building an instruction-following agent. When navigating through a new environment, an agent is challenged with (1) connecting the natural language instructions with its progressively growing knowledge of the world; and (2) performing long-range planning and decision making in the form of effective exploration and error correction. Current methods are still limited on both fronts despite extensive efforts. In this paper, we introduce the Evolving Graphical Planner (EGP), a model that performs global planning for navigation based on raw sensory input. The model dynamically constructs a graphical representation, generalizes the action space to allow for more flexible decision making, and performs efficient planning on a proxy graph representation. We evaluate our model on a challenging Vision-and-Language Navigation (VLN) task with photorealistic images and achieve superior performance compared to previous navigation architectures. For instance, we achieve a 53% success rate on the test split of the Room-to-Room navigation task through pure imitation learning, outperforming previous navigation architectures by up to 5%.

Hexiang Hu, Zhiwei Deng, Guang-tong Zhou et al.

Semantic segmentation requires a detailed labeling of image pixels by object category. Information derived from local image patches is necessary to describe the detailed shape of individual objects. However, this information is ambiguous and can result in noisy labels. Global inference of image content can instead capture the general semantic concepts present. We advocate that high-recall holistic inference of image concepts provides valuable information for detailed pixel labeling. We build a two-stream neural network architecture that facilitates information flow from holistic information to local pixels, while keeping common image features shared among the low-level layers of both the holistic analysis and segmentation branches. We empirically evaluate our network on four standard semantic segmentation datasets. Our network obtains state-of-the-art performance on PASCAL-Context and NYUDv2, and ablation studies verify its effectiveness on ADE20K and SIFT-Flow.