Yizhou Lu

Sizhe Liu, Yizhou Lu, Siyu Chen et al.

Recent progress in Large Language Models (LLMs) has drawn attention to their potential for accelerating drug discovery. However, a central problem remains: translating theoretical ideas into robust implementations in the highly specialized context of pharmaceutical research. This limitation prevents practitioners from making full use of the latest AI developments in drug discovery. To address this challenge, we introduce DrugAgent, a multi-agent framework that automates machine learning (ML) programming for drug discovery tasks. DrugAgent employs an LLM Planner that formulates high-level ideas and an LLM Instructor that identifies and integrates domain knowledge when implementing those ideas. We present case studies on three representative drug discovery tasks. Our results show that DrugAgent consistently outperforms leading baselines, including a relative improvement of 4.92% in ROC-AUC compared to ReAct for drug-target interaction (DTI). DrugAgent is publicly available at https://anonymous.4open.science/r/drugagent-5C42/.

Chengshuai Shi, Wenzhe Li, Xinran Liang et al.

Given the rapidly growing capabilities of vision-language models (VLMs), extending them to interactive decision-making tasks such as video games has emerged as a promising frontier. However, existing approaches either rely on large-scale supervised fine-tuning (SFT) on human trajectories or apply reinforcement learning (RL) only in relatively short-horizon settings (typically around 20--30 turns). In this work, we study RL-based training of VLMs for long-horizon decision-making in Super Mario Land, a visually grounded environment requiring 100+ turns of interaction with coordinated perception, reasoning, and action. We begin with a systematic investigation of key algorithmic components and propose an adapted variant of PPO with a lightweight turn-level critic, which substantially improves training stability and sample efficiency over critic-free methods such as GRPO and Reinforce++. We further show that pretrained VLMs provide strong action priors, significantly improving sample efficiency during RL training and reducing the need for manual design choices such as action engineering, compared to classical deep RL trained from scratch. Building on these insights, we introduce Odysseus, an open training framework for VLM agents, achieving substantial gains across multiple levels of the game and at least 3 times average game progresses than frontier models. Moreover, the trained models exhibit consistent improvements under both in-game and cross-game generalization settings, while maintaining general-domain capabilities. Overall, our results identify key ingredients for making RL stable and effective in long-horizon, multi-modal settings, and provide practical guidance for developing VLMs as embodied agents.

Yizhou Min, Yizhou Lu, Lanqi Li et al.

Conformal prediction (CP) has become a cornerstone of distribution-free uncertainty quantification, conventionally evaluated by its coverage and interval length. This work critically examines the sufficiency of these standard metrics. We demonstrate that the interval length might be deceptively improved through a counter-intuitive approach termed Prejudicial Trick (PT), while the coverage remains valid. Specifically, for any given test sample, PT probabilistically returns an interval, which is either null or constructed using an adjusted confidence level, thereby preserving marginal coverage. While PT potentially yields a deceptively lower interval length, it introduces practical vulnerabilities: the same input can yield completely different prediction intervals across repeated runs of the algorithm. We formally derive the conditions under which PT achieves these misleading improvements and provides extensive empirical evidence across various regression and classification tasks. Furthermore, we introduce a new metric interval stability which helps detect whether a new CP method implicitly improves the length based on such PT-like techniques.

Mingyi Zheng, Hongyu Jiang, Yizhou Lu et al.

Conformal Prediction (CP) is a distribution-free framework for constructing statistically rigorous prediction sets. While popular variants such as CD-split improve CP's efficiency, they often yield prediction sets composed of multiple disconnected subintervals, which are difficult to interpret. In this paper, we propose SCD-split, which incorporates smoothing operations into the CP framework. Such smoothing operations potentially help merge the subintervals, thus leading to interpretable prediction sets. Experimental results on both synthetic and real-world datasets demonstrate that SCD-split balances the interval length and the number of disconnected subintervals. Theoretically, under specific conditions, SCD-split provably reduces the number of disconnected subintervals while maintaining comparable coverage guarantees and interval length compared with CD-split.

Tianle Pu, Changjun Fan, Mutian Shen et al.

Many complex problems encountered in both production and daily life can be conceptualized as combinatorial optimization problems (COPs) over graphs. Recent years, reinforcement learning (RL) based models have emerged as a promising direction, which treat the COPs solving as a heuristic learning problem. However, current finite-horizon-MDP based RL models have inherent limitations. They are not allowed to explore adquately for improving solutions at test time, which may be necessary given the complexity of NP-hard optimization tasks. Some recent attempts solve this issue by focusing on reward design and state feature engineering, which are tedious and ad-hoc. In this work, we instead propose a much simpler but more effective technique, named gauge transformation (GT). The technique is originated from physics, but is very effective in enabling RL agents to explore to continuously improve the solutions during test. Morever, GT is very simple, which can be implemented with less than 10 lines of Python codes, and can be applied to a vast majority of RL models. Experimentally, we show that traditional RL models with GT technique produce the state-of-the-art performances on the MaxCut problem. Furthermore, since GT is independent of any RL models, it can be seamlessly integrated into various RL frameworks, paving the way of these models for more effective explorations in the solving of general COPs.

Xian Shi, Fan Yu, Yizhou Lu et al.

The variety of accents has posed a big challenge to speech recognition. The Accented English Speech Recognition Challenge (AESRC2020) is designed for providing a common testbed and promoting accent-related research. Two tracks are set in the challenge -- English accent recognition (track 1) and accented English speech recognition (track 2). A set of 160 hours of accented English speech collected from 8 countries is released with labels as the training set. Another 20 hours of speech without labels is later released as the test set, including two unseen accents from another two countries used to test the model generalization ability in track 2. We also provide baseline systems for the participants. This paper first reviews the released dataset, track setups, baselines and then summarizes the challenge results and major techniques used in the submissions.

Chenpeng Du, Hao Li, Yizhou Lu et al.

Training a code-switching end-to-end automatic speech recognition (ASR) model normally requires a large amount of data, while code-switching data is often limited. In this paper, three novel approaches are proposed for code-switching data augmentation. Specifically, they are audio splicing with the existing code-switching data, and TTS with new code-switching texts generated by word translation or word insertion. Our experiments on 200 hours Mandarin-English code-switching dataset show that all the three proposed approaches yield significant improvements on code-switching ASR individually. Moreover, all the proposed approaches can be combined with recent popular SpecAugment, and an addition gain can be obtained. WER is significantly reduced by relative 24.0% compared to the system without any data augmentation, and still relative 13.0% gain compared to the system with only SpecAugment

Qi Liu, Zhehuai Chen, Hao Li et al.

End-to-end (E2E) systems have played a more and more important role in automatic speech recognition (ASR) and achieved great performance. However, E2E systems recognize output word sequences directly with the input acoustic feature, which can only be trained on limited acoustic data. The extra text data is widely used to improve the results of traditional artificial neural network-hidden Markov model (ANN-HMM) hybrid systems. The involving of extra text data to standard E2E ASR systems may break the E2E property during decoding. In this paper, a novel modular E2E ASR system is proposed. The modular E2E ASR system consists of two parts: an acoustic-to-phoneme (A2P) model and a phoneme-to-word (P2W) model. The A2P model is trained on acoustic data, while extra data including large scale text data can be used to train the P2W model. This additional data enables the modular E2E ASR system to model not only the acoustic part but also the language part. During the decoding phase, the two models will be integrated and act as a standard acoustic-to-word (A2W) model. In other words, the proposed modular E2E ASR system can be easily trained with extra text data and decoded in the same way as a standard E2E ASR system. Experimental results on the Switchboard corpus show that the modular E2E model achieves better word error rate (WER) than standard A2W models.