Zhiwei Feng

Jiyang Chen, Zhiwei Feng, Jen-Yang Wen et al.

The Unmanned aerial vehicles (UAVs) sector is fast-expanding. Protection of real-time UAV applications against malicious attacks has become an urgent problem that needs to be solved. Denial-of-service (DoS) attack aims to exhaust system resources and cause important tasks to miss deadlines. DoS attack may be one of the common problems of UAV systems, due to its simple implementation. In this paper, we present a software framework that offers DoS attack-resilient control for real-time UAV systems using containers: ContainerDrone. The framework provides defense mechanisms for three critical system resources: CPU, memory, and communication channel. We restrict attacker's access to CPU core set and utilization. Memory bandwidth throttling limits attacker's memory usage. By simulating sensors and drivers in the container, a security monitor constantly checks DoS attacks over communication channels. Upon the detection of a security rule violation, the framework switches to the safety controller to mitigate the attack. We implemented a prototype quadcopter with commercially off-the-shelf (COTS) hardware and open-source software. Our experimental results demonstrated the effectiveness of the proposed framework defending against various DoS attacks.

Yue Wan, Jiayi Yuan, Zhiwei Feng et al.

Antigenic epitope presented by major histocompatibility complex II (MHC-II) proteins plays an essential role in immunotherapy. However, compared to the more widely studied MHC-I in computational immunotherapy, the study of MHC-II antigenic epitope poses significantly more challenges due to its complex binding specificity and ambiguous motif patterns. Consequently, existing datasets for MHC-II interactions are smaller and less standardized than those available for MHC-I. To address these challenges, we present a well-curated dataset derived from the Immune Epitope Database (IEDB) and other public sources. It not only extends and standardizes existing peptide-MHC-II datasets, but also introduces a novel antigen-MHC-II dataset with richer biological context. Leveraging this dataset, we formulate three major machine learning (ML) tasks of peptide binding, peptide presentation, and antigen presentation, which progressively capture the broader biological processes within the MHC-II antigen presentation pathway. We further employ a multi-scale evaluation framework to benchmark existing models, along with a comprehensive analysis over various modeling designs to this problem with a modular framework. Overall, this work serves as a valuable resource for advancing computational immunotherapy, providing a foundation for future research in ML guided epitope discovery and predictive modeling of immune responses.