Ning Gao, Sanping Zhou, Le Wang et al.
Semi-supervised learning has emerged as a widely adopted technique in the field of medical image segmentation. The existing works either focuses on the construction of consistency constraints or the generation of pseudo labels to provide high-quality supervisory signals, whose main challenge mainly comes from how to keep the continuous improvement of model capabilities. In this paper, we propose a simple yet effective semi-supervised learning framework, termed Progressive Mean Teachers (PMT), for medical image segmentation, whose goal is to generate high-fidelity pseudo labels by learning robust and diverse features in the training process. Specifically, our PMT employs a standard mean teacher to penalize the consistency of the current state and utilizes two sets of MT architectures for co-training. The two sets of MT architectures are individually updated for prolonged periods to maintain stable model diversity established through performance gaps generated by iteration differences. Additionally, a difference-driven alignment regularizer is employed to expedite the alignment of lagging models with the representation capabilities of leading models. Furthermore, a simple yet effective pseudo-label filtering algorithm is employed for facile evaluation of models and selection of high-fidelity pseudo-labels outputted when models are operating at high performance for co-training purposes. Experimental results on two datasets with different modalities, i.e., CT and MRI, demonstrate that our method outperforms the state-of-the-art medical image segmentation approaches across various dimensions. The code is available at https://github.com/Axi404/PMT.