CLNov 14, 2025
Evaluating Large Language Models on Rare Disease Diagnosis: A Case Study using House M.DArsh Gupta, Ajay Narayanan Sridhar, Bonam Mingole et al.
Large language models (LLMs) have demonstrated capabilities across diverse domains, yet their performance on rare disease diagnosis from narrative medical cases remains underexplored. We introduce a novel dataset of 176 symptom-diagnosis pairs extracted from House M.D., a medical television series validated for teaching rare disease recognition in medical education. We evaluate four state-of-the-art LLMs such as GPT 4o mini, GPT 5 mini, Gemini 2.5 Flash, and Gemini 2.5 Pro on narrative-based diagnostic reasoning tasks. Results show significant variation in performance, ranging from 16.48% to 38.64% accuracy, with newer model generations demonstrating a 2.3 times improvement. While all models face substantial challenges with rare disease diagnosis, the observed improvement across architectures suggests promising directions for future development. Our educationally validated benchmark establishes baseline performance metrics for narrative medical reasoning and provides a publicly accessible evaluation framework for advancing AI-assisted diagnosis research.
CVMay 6
When Relations Break: Analyzing Relation Hallucination in Vision-Language Model Under Rotation and NoisePhilip Wootaek Shin, Ajay Narayanan Sridhar, Sivani Devarapalli et al.
Vision-language models (VLMs) achieve strong multimodal performance but remain prone to relation hallucination, which requires accurate reasoning over inter-object interactions. We study the impact of visual perturbations, specifically rotation and noise, and show that even mild distortions significantly degrade relational reasoning across models and datasets. We further evaluate prompt-based augmentation and preprocessing strategies (orientation correction and denoising), finding that while they offer partial improvements, they do not fully resolve hallucinations. Our results reveal a gap between perceptual robustness and relational understanding, highlighting the need for more robust, geometry-aware VLMs.
HCSep 23, 2025
NaviSense: A Multimodal Assistive Mobile application for Object Retrieval by Persons with Visual ImpairmentAjay Narayanan Sridhar, Fuli Qiao, Nelson Daniel Troncoso Aldas et al.
People with visual impairments often face significant challenges in locating and retrieving objects in their surroundings. Existing assistive technologies present a trade-off: systems that offer precise guidance typically require pre-scanning or support only fixed object categories, while those with open-world object recognition lack spatial feedback for reaching the object. To address this gap, we introduce 'NaviSense', a mobile assistive system that combines conversational AI, vision-language models, augmented reality (AR), and LiDAR to support open-world object detection with real-time audio-haptic guidance. Users specify objects via natural language and receive continuous spatial feedback to navigate toward the target without needing prior setup. Designed with insights from a formative study and evaluated with 12 blind and low-vision participants, NaviSense significantly reduced object retrieval time and was preferred over existing tools, demonstrating the value of integrating open-world perception with precise, accessible guidance.