Zhen Zhou

Zixian Su, Hongkai Zhang, Fan Gao et al.

Multimodal Large Language Models (MLLMs) have shown strong performance on public medical benchmarks, yet existing evaluations often remain weak proxies for clinical use, relying on isolated inputs and simplified recognition-style tasks. We introduce CardioLens, a leakage-resistant evaluation testbed for multi-sequence Cardiovascular Magnetic Resonance (CMR), constructed from private hospital archives through a rigorous report-to-QA construction and verification pipeline. CardioLens contains 473,896 slices and 13,494 verified QA pairs across 4D Cine, LGE, perfusion, and T2-weighted imaging, and evaluates three stages of CMR interpretation: image understanding, report generation, and disease diagnosis. Across 24 state-of-the-art MLLMs, CardioLens reveals a substantial clinical reality gap: models perform poorly overall, with performance degrading along the real CMR workflow. Confusion analysis further shows a category-collapse failure mode, where models default to frequent abnormal categories rather than distinguishing clinically distinct findings. To rule out MLLM-compatible input construction as the primary cause, we compare random, clinically motivated, and data-driven slice selection protocols under different slice budgets; performance changes only marginally, typically by about 1%. Explicit reasoning prompts also fail to rescue performance, often making models more conservative rather than improving visual evidence use. These results show that current MLLMs remain far from reliable CMR interpretation, where clinical decisions require integrating distributed evidence across sequences, views, and temporal phases. CardioLens provides a clinically grounded testbed for developing next-generation MLLMs toward real-world clinical deployment.

Zhen Zhou, Yunkai Ma, Junfeng Fan et al.

Panoptic 3D reconstruction from a monocular video is a fundamental perceptual task in robotic scene understanding. However, existing efforts suffer from inefficiency in terms of inference speed and accuracy, limiting their practical applicability. We present EPRecon, an efficient real-time panoptic 3D reconstruction framework. Current volumetric-based reconstruction methods usually utilize multi-view depth map fusion to obtain scene depth priors, which is time-consuming and poses challenges to real-time scene reconstruction. To address this issue, we propose a lightweight module to directly estimate scene depth priors in a 3D volume for reconstruction quality improvement by generating occupancy probabilities of all voxels. In addition, compared with existing panoptic segmentation methods, EPRecon extracts panoptic features from both voxel features and corresponding image features, obtaining more detailed and comprehensive instance-level semantic information and achieving more accurate segmentation results. Experimental results on the ScanNetV2 dataset demonstrate the superiority of EPRecon over current state-of-the-art methods in terms of both panoptic 3D reconstruction quality and real-time inference. Code is available at https://github.com/zhen6618/EPRecon.

Gangming Zhao, Quanlong Feng, Chaoqi Chen et al.

During clinical practice, radiologists often use attributes, e.g. morphological and appearance characteristics of a lesion, to aid disease diagnosis. Effectively modeling attributes as well as all relationships involving attributes could boost the generalization ability and verifiability of medical image diagnosis algorithms. In this paper, we introduce a hybrid neuro-probabilistic reasoning algorithm for verifiable attribute-based medical image diagnosis. There are two parallel branches in our hybrid algorithm, a Bayesian network branch performing probabilistic causal relationship reasoning and a graph convolutional network branch performing more generic relational modeling and reasoning using a feature representation. Tight coupling between these two branches is achieved via a cross-network attention mechanism and the fusion of their classification results. We have successfully applied our hybrid reasoning algorithm to two challenging medical image diagnosis tasks. On the LIDC-IDRI benchmark dataset for benign-malignant classification of pulmonary nodules in CT images, our method achieves a new state-of-the-art accuracy of 95.36\% and an AUC of 96.54\%. Our method also achieves a 3.24\% accuracy improvement on an in-house chest X-ray image dataset for tuberculosis diagnosis. Our ablation study indicates that our hybrid algorithm achieves a much better generalization performance than a pure neural network architecture under very limited training data.

Zhen Zhou, Yunkai Ma, Junfeng Fan et al.

In oriented object detection, current representations of oriented bounding boxes (OBBs) often suffer from boundary discontinuity problem. Methods of designing continuous regression losses do not essentially solve this problem. Although Gaussian bounding box (GBB) representation avoids this problem, directly regressing GBB is susceptible to numerical instability. We propose linear GBB (LGBB), a novel OBB representation. By linearly transforming the elements of GBB, LGBB avoids the boundary discontinuity problem and has high numerical stability. In addition, existing convolution-based rotation-sensitive feature extraction methods only have local receptive fields, resulting in slow feature aggregation. We propose ring-shaped rotated convolution (RRC), which adaptively rotates feature maps to arbitrary orientations to extract rotation-sensitive features under a ring-shaped receptive field, rapidly aggregating features and contextual information. Experimental results demonstrate that LGBB and RRC achieve state-of-the-art performance. Furthermore, integrating LGBB and RRC into various models effectively improves detection accuracy.

Bojian Hou, Hongming Li, Zhicheng Jiao et al.

Conventional survival analysis methods are typically ineffective to characterize heterogeneity in the population while such information can be used to assist predictive modeling. In this study, we propose a hybrid survival analysis method, referred to as deep clustering survival machines, that combines the discriminative and generative mechanisms. Similar to the mixture models, we assume that the timing information of survival data is generatively described by a mixture of certain numbers of parametric distributions, i.e., expert distributions. We learn weights of the expert distributions for individual instances according to their features discriminatively such that each instance's survival information can be characterized by a weighted combination of the learned constant expert distributions. This method also facilitates interpretable subgrouping/clustering of all instances according to their associated expert distributions. Extensive experiments on both real and synthetic datasets have demonstrated that the method is capable of obtaining promising clustering results and competitive time-to-event predicting performance.

Han Gong, Zhen Zhou, Yunyang Shi et al.

Large language models (LLMs) and multimodal large models (MLLMs) are increasingly used for transportation tasks such as regulation question answering, traffic management support, engineering review, and autonomous-driving scene reasoning. Yet transportation workflows are rule-intensive, computation-intensive, safety-critical, and inherently multimodal. Existing general benchmarks provide limited evidence of whether a model can apply regulations correctly, perform verifiable engineering calculations, or interpret traffic scenes reliably, while the small number of public transportation benchmarks remain narrow in scope and rarely support fine-grained diagnosis across text, images, and point-cloud data. To address this gap, we present TRIP-Evaluate, an open multimodal benchmark for large models in transportation. The benchmark organizes 837 items using a role-task-knowledge taxonomy that covers vehicle, traffic-management, traveler, and planning-and-design functions. Each item is annotated with capability, modality, and difficulty labels, enabling diagnosis from overall accuracy down to specific failure modes. The current release includes 596 text items, 198 image items, and 43 point-cloud items. TRIP-Evaluate also standardizes item construction, quality control, prompting, decoding, and scoring to improve cross-model comparability. Results on a diverse panel of models show that text-based performance is improving, but substantial weaknesses remain in multi-step engineering calculation, rule-constrained reasoning, multimodal scene understanding, and point-cloud understanding. Overall, TRIP-Evaluate provides a reproducible, diagnosable, and engineering-aligned evaluation baseline for model selection, regression testing, and safer deployment in transportation applications.

Zhenchen Zhu, Ge Hu, Weixiong Tan et al.

The widespread adoption of CT has notably increased the number of detected lung nodules. However, current deep learning methods for classifying benign and malignant nodules often fail to comprehensively integrate global and local features, and most of them have not been validated through clinical trials. To address this, we developed DeepFAN, a transformer-based model trained on over 10K pathology-confirmed nodules and further conducted a multi-reader, multi-case clinical trial to evaluate its efficacy in assisting junior radiologists. DeepFAN achieved diagnostic area under the curve (AUC) of 0.939 (95% CI 0.930-0.948) on an internal test set and 0.954 (95% CI 0.934-0.973) on the clinical trial dataset involving 400 cases across three independent medical institutions. Explainability analysis indicated higher contributions from global than local features. Twelve readers' average performance significantly improved by 10.9% (95% CI 8.3%-13.5%) in AUC, 10.0% (95% CI 8.9%-11.1%) in accuracy, 7.6% (95% CI 6.1%-9.2%) in sensitivity, and 12.6% (95% CI 10.9%-14.3%) in specificity (P<0.001 for all). Nodule-level inter-reader diagnostic consistency improved from fair to moderate (overall k: 0.313 vs. 0.421; P=0.019). In conclusion, DeepFAN effectively assisted junior radiologists and may help homogenize diagnostic quality and reduce unnecessary follow-up of indeterminate pulmonary nodules. Chinese Clinical Trial Registry: ChiCTR2400084624.

Genyuan Zhang, Zihao Wang, Zhifan Gao et al.

The application of iodinated contrast media (ICM) improves the sensitivity and specificity of computed tomography (CT) for a wide range of clinical indications. However, overdose of ICM can cause problems such as kidney damage and life-threatening allergic reactions. Deep learning methods can generate CT images of normal-dose ICM from low-dose ICM, reducing the required dose while maintaining diagnostic power. However, existing methods are difficult to realize accurate enhancement with incompletely paired images, mainly because of the limited ability of the model to recognize specific structures. To overcome this limitation, we propose a Structure-constrained Language-informed Diffusion Model (SLDM), a unified medical generation model that integrates structural synergy and spatial intelligence. First, the structural prior information of the image is effectively extracted to constrain the model inference process, thus ensuring structural consistency in the enhancement process. Subsequently, semantic supervision strategy with spatial intelligence is introduced, which integrates the functions of visual perception and spatial reasoning, thus prompting the model to achieve accurate enhancement. Finally, the subtraction angiography enhancement module is applied, which serves to improve the contrast of the ICM agent region to suitable interval for observation. Qualitative analysis of visual comparison and quantitative results of several metrics demonstrate the effectiveness of our method in angiographic reconstruction for low-dose contrast medium CT angiography.

Huixin Xue, Guangjun Xu, Shihong Ren et al.

Home-based music therapy devices require accessible and cost-effective solutions for users to understand and track their therapeutic progress. Traditional physiological signal analysis, particularly EEG interpretation, relies heavily on domain experts, creating barriers to scalability and home adoption. Meanwhile, few experts are capable of interpreting physiological signal data while also making targeted music recommendations. While large language models (LLMs) have shown promise in various domains, their application to automated physiological report generation for music therapy represents an unexplored task. We present a prototype system that leverages LLMs to bridge this gap -- transforming raw EEG and cardiovascular data into human-readable therapeutic reports and personalized music recommendations. Unlike prior work focusing on real-time physiological adaptation during listening, our approach emphasizes post-session analysis and interpretable reporting, enabling non-expert users to comprehend their psychophysiological states and track therapeutic outcomes over time. By integrating signal processing modules with LLM-based reasoning agents, the system provides a practical and low-cost solution for short-term progress monitoring in home music therapy contexts. This work demonstrates the feasibility of applying LLMs to a novel task -- democratizing access to physiology-driven music therapy through automated, interpretable reporting.

Hong Li, Zhen Zhou, Honggang Zhang et al.

Data-parallel (DP) training with synchronous all-reduce is a dominant paradigm for full-parameter fine-tuning of large language models (LLMs). While parameter synchronization guarantees numerical equivalence of model weights after each iteration, it does not necessarily imply alignment of worker-level optimization dynamics before gradient aggregation. This paper identifies and studies this latent mismatch, termed \emph{silent inconsistency}, where cross-worker divergence in losses and gradients can remain invisible under conventional aggregated monitoring signals. We propose a lightweight, model-agnostic diagnostic framework that quantifies worker-level consistency using training signals readily available in standard pipelines. Specifically, we introduce three complementary metrics: loss dispersion, gradient-norm dispersion, and gradient-direction consistency measured by inter-worker cosine similarity. The proposed metrics incur negligible overhead and require no modification to model architecture, synchronization mechanisms, or optimization algorithms. We validate the framework by fully fine-tuning the 1B-parameter \texttt{openPangu-Embedded-1B-V1.1} model on the \texttt{tatsu-lab/alpaca} dataset using an 8-NPU DP setup, under controlled perturbations of cross-rank stochasticity. Experimental results show that progressively desynchronized data shuffling and random seeds lead to substantial increases in loss/gradient dispersion and reduced directional alignment, despite smooth globally averaged loss curves. These findings demonstrate that the proposed indicators provide actionable visibility into hidden instability modes in large-scale DP fine-tuning, enabling more reliable diagnosis and configuration assessment.

Taiping Qu, Hongkai Zhang, Lantian Zhang et al.

Cardiac magnetic resonance (CMR) is a cornerstone for diagnosing cardiovascular disease. However, it remains underutilized due to complex, time-consuming interpretation across multi-sequences, phases, quantitative measures that heavily reliant on specialized expertise. Here, we present BAAI Cardiac Agent, a multimodal intelligent system designed for end-to-end CMR interpretation. The agent integrates specialized cardiac expert models to perform automated segmentation of cardiac structures, functional quantification, tissue characterization and disease diagnosis, and generates structured clinical reports within a unified workflow. Evaluated on CMR datasets from two hospitals (2413 patients) spanning 7-types of major cardiovascular diseases, the agent achieved an area under the receiver-operating-characteristic curve exceeding 0.93 internally and 0.81 externally. In the task of estimating left ventricular function indices, the results generated by this system for core parameters such as ejection fraction, stroke volume, and left ventricular mass are highly consistent with clinical reports, with Pearson correlation coefficients all exceeding 0.90. The agent outperformed state-of-the-art models in segmentation and diagnostic tasks, and generated clinical reports showing high concordance with expert radiologists (six readers across three experience levels). By dynamically orchestrating expert models for coordinated multimodal analysis, this agent framework enables accurate, efficient CMR interpretation and highlights its potentials for complex clinical imaging workflows. Code is available at https://github.com/plantain-herb/Cardiac-Agent.

Zhen Zhou, Junfeng Fan, Yunkai Ma et al.

Instance segmentation in remote sensing images is a long-standing challenge. Since horizontal bounding boxes introduce many interference objects, oriented bounding boxes (OBBs) are usually used for instance identification. However, based on ``segmentation within bounding box'' paradigm, current instance segmentation methods using OBBs are overly dependent on bounding box detection performance. To tackle this problem, this paper proposes OBSeg, an accurate and fast instance segmentation framework using OBBs. OBSeg is based on box prompt-based segmentation foundation models (BSMs), e.g., Segment Anything Model. Specifically, OBSeg first detects OBBs to distinguish instances and provide coarse localization information. Then, it predicts OBB prompt-related masks for fine segmentation. Since OBBs only serve as prompts, OBSeg alleviates the over-dependence on bounding box detection performance of current instance segmentation methods using OBBs. Thanks to OBB prompts, OBSeg outperforms other current BSM-based methods using HBBs. In addition, to enable BSMs to handle OBB prompts, we propose a novel OBB prompt encoder. To make OBSeg more lightweight and further improve the performance of lightweight distilled BSMs, a Gaussian smoothing-based knowledge distillation method is introduced. Experiments demonstrate that OBSeg outperforms current instance segmentation methods on multiple datasets in terms of instance segmentation accuracy and has competitive inference speed. The code is available at https://github.com/zhen6618/OBBInstanceSegmentation.

Zhen Zhou, Xiaobo Chen, Yu Zhang et al.

Brain functional network has become an increasingly used approach in understanding brain functions and diseases. Many network construction methods have been developed, whereas the majority of the studies still used static pairwise Pearson's correlation-based functional connectivity. The goal of this work is to introduce a toolbox namely "Brain Network Construction and Classification" (BrainNetClass) to the field to promote more advanced brain network construction methods. It comprises various brain network construction methods, including some state-of-the-art methods that were recently developed to capture more complex interactions among brain regions along with connectome feature extraction, reduction, parameter optimization towards network-based individualized classification. BrainNetClass is a MATLAB-based, open-source, cross-platform toolbox with graphical user-friendly interfaces for cognitive and clinical neuroscientists to perform rigorous computer-aided diagnosis with interpretable result presentations even though they do not possess neuroimage computing and machine learning knowledge. We demonstrate the implementations of this toolbox on real resting-state functional MRI datasets. BrainNetClass (v1.0) can be downloaded from https://github.com/zzstefan/BrainNetClass.

Zhen Zhou, Zhirui Wang, Qi Hong et al.

Time series forecasting in real-world applications requires both high predictive accuracy and interpretable uncertainty quantification. Traditional point prediction methods often fail to capture the inherent uncertainty in time series data, while existing probabilistic approaches struggle to balance computational efficiency with interpretability. We propose a novel Multi-Expert Learning Distributional Labels (LDL) framework that addresses these challenges through mixture-of-experts architectures with distributional learning capabilities. Our approach introduces two complementary methods: (1) Multi-Expert LDL, which employs multiple experts with different learned parameters to capture diverse temporal patterns, and (2) Pattern-Aware LDL-MoE, which explicitly decomposes time series into interpretable components (trend, seasonality, changepoints, volatility) through specialized sub-experts. Both frameworks extend traditional point prediction to distributional learning, enabling rich uncertainty quantification through Maximum Mean Discrepancy (MMD). We evaluate our methods on aggregated sales data derived from the M5 dataset, demonstrating superior performance compared to baseline approaches. The continuous Multi-Expert LDL achieves the best overall performance, while the Pattern-Aware LDL-MoE provides enhanced interpretability through component-wise analysis. Our frameworks successfully balance predictive accuracy with interpretability, making them suitable for real-world forecasting applications where both performance and actionable insights are crucial.

Biwen Lei, Yang Li, Xinhai Liu et al.

The creation of high-quality 3D assets, a cornerstone of modern game development, has long been characterized by labor-intensive and specialized workflows. This paper presents Hunyuan3D Studio, an end-to-end AI-powered content creation platform designed to revolutionize the game production pipeline by automating and streamlining the generation of game-ready 3D assets. At its core, Hunyuan3D Studio integrates a suite of advanced neural modules (such as Part-level 3D Generation, Polygon Generation, Semantic UV, etc.) into a cohesive and user-friendly system. This unified framework allows for the rapid transformation of a single concept image or textual description into a fully-realized, production-quality 3D model complete with optimized geometry and high-fidelity PBR textures. We demonstrate that assets generated by Hunyuan3D Studio are not only visually compelling but also adhere to the stringent technical requirements of contemporary game engines, significantly reducing iteration time and lowering the barrier to entry for 3D content creation. By providing a seamless bridge from creative intent to technical asset, Hunyuan3D Studio represents a significant leap forward for AI-assisted workflows in game development and interactive media.

Jian Liu, Chunshi Wang, Song Guo et al.

The generation of quadrilateral-dominant meshes is a cornerstone of professional 3D content creation. However, existing generative models generate quad meshes by first generating triangle meshes and then merging triangles into quadrilaterals with some specific rules, which typically produces quad meshes with poor topology. In this paper, we introduce QuadGPT, the first autoregressive framework for generating quadrilateral meshes in an end-to-end manner. QuadGPT formulates this as a sequence prediction paradigm, distinguished by two key innovations: a unified tokenization method to handle mixed topologies of triangles and quadrilaterals, and a specialized Reinforcement Learning fine-tuning method tDPO for better generation quality. Extensive experiments demonstrate that QuadGPT significantly surpasses previous triangle-to-quad conversion pipelines in both geometric accuracy and topological quality. Our work establishes a new benchmark for native quad-mesh generation and showcases the power of combining large-scale autoregressive models with topology-aware RL refinement for creating structured 3D assets.

Hexiong Yang, Mingrui Chen, Huaibo Huang et al.

Inspired by the great success of Masked Language Modeling (MLM) in the natural language domain, the paradigm of self-supervised pre-training and fine-tuning has also achieved remarkable progress in the field of DNA sequence modeling. However, previous methods often relied on massive pre-training data or large-scale base models with huge parameters, imposing a significant computational burden. To address this, many works attempted to use more compact models to achieve similar outcomes but still fell short by a considerable margin. In this work, we propose a Hybrid Architecture Distillation (HAD) approach, leveraging both distillation and reconstruction tasks for more efficient and effective pre-training. Specifically, we employ the NTv2-500M as the teacher model and devise a grouping masking strategy to align the feature embeddings of visible tokens while concurrently reconstructing the invisible tokens during MLM pre-training. To validate the effectiveness of our proposed method, we conducted comprehensive experiments on the Nucleotide Transformer Benchmark and Genomic Benchmark. Compared to models with similar parameters, our model achieved excellent performance. More surprisingly, it even surpassed the distillation ceiling-teacher model on some sub-tasks, which is more than 500 $\times$ larger. Lastly, we utilize t-SNE for more intuitive visualization, which shows that our model can gain a sophisticated understanding of the intrinsic representation pattern in genomic sequences.

Benyuan Sun, Zhen Zhou, Fandong Zhang et al.

Lung nodules suffer large variation in size and appearance in CT images. Nodules less than 10mm can easily lose information after down-sampling in convolutional neural networks, which results in low sensitivity. In this paper, a combination of 3D image and feature pyramid is exploited to integrate lower-level texture features with high-level semantic features, thus leading to a higher recall. However, 3D operations are time and memory consuming, which aggravates the situation with the explosive growth of medical images. To tackle this problem, we propose a general curriculum training strategy to speed up training. An dynamic sampling method is designed to pick up partial samples which give the best contribution to network training, thus leading to much less time consuming. In experiments, we demonstrate that the proposed network outperforms previous state-of-the-art methods. Meanwhile, our sampling strategy halves the training time of the proposal network on LUNA16.

Botong Wu, Zhen Zhou, Jianwei Wang et al.

Refer to the literature of lung nodule classification, many studies adopt Convolutional Neural Networks (CNN) to directly predict the malignancy of lung nodules with original thoracic Computed Tomography (CT) and nodule location. However, these studies cannot tell how the CNN works in terms of predicting the malignancy of the given nodule, e.g., it's hard to conclude that whether the region within the nodule or the contextual information matters according to the output of the CNN. In this paper, we propose an interpretable and multi-task learning CNN -- Joint learning for \textbf{P}ulmonary \textbf{N}odule \textbf{S}egmentation \textbf{A}ttributes and \textbf{M}alignancy \textbf{P}rediction (PN-SAMP). It is able to not only accurately predict the malignancy of lung nodules, but also provide semantic high-level attributes as well as the areas of detected nodules. Moreover, the combination of nodule segmentation, attributes and malignancy prediction is helpful to improve the performance of each single task. In addition, inspired by the fact that radiologists often change window widths and window centers to help to make decision on uncertain nodules, PN-SAMP mixes multiple WW/WC together to gain information for the raw CT input images. To verify the effectiveness of the proposed method, the evaluation is implemented on the public LIDC-IDRI dataset, which is one of the largest dataset for lung nodule malignancy prediction. Experiments indicate that the proposed PN-SAMP achieves significant improvement with respect to lung nodule classification, and promising performance on lung nodule segmentation and attribute learning, compared with the-state-of-the-art methods.