Junzhuo Liu

Junzhuo Liu, Qiaosong Chen, Ye Zhang et al.

Clinically, automated polyp segmentation techniques have the potential to significantly improve the efficiency and accuracy of medical diagnosis, thereby reducing the risk of colorectal cancer in patients. Unfortunately, existing methods suffer from two significant weaknesses that can impact the accuracy of segmentation. Firstly, features extracted by encoders are not adequately filtered and utilized. Secondly, semantic conflicts and information redundancy caused by feature fusion are not attended to. To overcome these limitations, we propose a novel approach for polyp segmentation, named MLFF-Net, which leverages multi-level feature fusion and attention mechanisms. Specifically, MLFF-Net comprises three modules: Multi-scale Attention Module (MAM), High-level Feature Enhancement Module (HFEM), and Global Attention Module (GAM). Among these, MAM is used to extract multi-scale information and polyp details from the shallow output of the encoder. In HFEM, the deep features of the encoders complement each other by aggregation. Meanwhile, the attention mechanism redistributes the weight of the aggregated features, weakening the conflicting redundant parts and highlighting the information useful to the task. GAM combines features from the encoder and decoder features, as well as computes global dependencies to prevent receptive field locality. Experimental results on five public datasets show that the proposed method not only can segment multiple types of polyps but also has advantages over current state-of-the-art methods in both accuracy and generalization ability.

Junzhuo Liu, Xuzheng Yang, Weiwei Li et al.

Referring Expression Comprehension (REC) is a crucial cross-modal task that objectively evaluates the capabilities of language understanding, image comprehension, and language-to-image grounding. Consequently, it serves as an ideal testing ground for Multi-modal Large Language Models (MLLMs). In pursuit of this goal, we have established a new REC dataset characterized by two key features: Firstly, it is designed with controllable varying levels of difficulty, necessitating multi-level fine-grained reasoning across object categories, attributes, and multi-hop relationships. Secondly, it includes negative text and images created through fine-grained editing and generation based on existing data, thereby testing the model's ability to correctly reject scenarios where the target object is not visible in the image--an essential aspect often overlooked in existing datasets and approaches. Utilizing this high-quality dataset, we conducted comprehensive evaluations of both state-of-the-art specialist models and MLLMs. Our findings indicate that there remains a significant gap in achieving satisfactory grounding performance. We anticipate that our dataset will inspire new approaches to enhance visual reasoning and develop more advanced cross-modal interaction strategies, ultimately unlocking the full potential of MLLMs. Our code and the datasets are available at https://github.com/liujunzhuo/FineCops-Ref.

Junzhuo Liu, Xuemei Du, Daniel Reisenbuchler et al.

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene sequences and slide level classification tasks, with limited attention to spatial transcriptomics and patch level applications. To address this limitation, we propose a multimodal network, BioMorphNet, which automatically integrates tissue morphological features and spatial gene expression to support tissue classification and differential gene analysis. For considering morphological features, BioMorphNet constructs a graph to model the relationships between target patches and their neighbors, and adjusts the response strength based on morphological and molecular level similarity, to better characterize the tumor microenvironment. In terms of multimodal interactions, BioMorphNet derives clinical pathway features from spatial transcriptomic data based on a predefined pathway database, serving as a bridge between tissue morphology and gene expression. In addition, a novel learnable pathway module is designed to automatically simulate the biological pathway formation process, providing a complementary representation to existing clinical pathways. Compared with the latest morphology gene multimodal methods, BioMorphNet's average classification metrics improve by 2.67%, 5.48%, and 6.29% for prostate cancer, colorectal cancer, and breast cancer datasets, respectively. BioMorphNet not only classifies tissue categories within WSIs accurately to support tumor localization, but also analyzes differential gene expression between tissue categories based on prediction confidence, contributing to the discovery of potential tumor biomarkers.

Weiwei Li, Junzhuo Liu, Yuanyuan Ren et al.

Deep learning models are known to often learn features that spuriously correlate with the class label during training but are irrelevant to the prediction task. Existing methods typically address this issue by annotating potential spurious attributes, or filtering spurious features based on some empirical assumptions (e.g., simplicity of bias). However, these methods may yield unsatisfactory performance due to the intricate and elusive nature of spurious correlations in real-world data. In this paper, we propose a data-oriented approach to mitigate the spurious correlation in deep learning models. We observe that samples that are influenced by spurious features tend to exhibit a dispersed distribution in the learned feature space. This allows us to identify the presence of spurious features. Subsequently, we obtain a bias-invariant representation by neutralizing the spurious features based on a simple grouping strategy. Then, we learn a feature transformation to eliminate the spurious features by aligning with this bias-invariant representation. Finally, we update the classifier by incorporating the learned feature transformation and obtain an unbiased model. By integrating the aforementioned identifying, neutralizing, eliminating and updating procedures, we build an effective pipeline for mitigating spurious correlation. Experiments on image and NLP debiasing benchmarks show an improvement in worst group accuracy of more than 20% compared to standard empirical risk minimization (ERM). Codes and checkpoints are available at https://github.com/davelee-uestc/nsf_debiasing .

Xuzheng Yang, Junzhuo Liu, Peng Wang et al.

Referring Expression Comprehension (REC) is a foundational cross-modal task that evaluates the interplay of language understanding, image comprehension, and language-to-image grounding. It serves as an essential testing ground for Multimodal Large Language Models (MLLMs). To advance this field, we introduced a new REC dataset in our previous conference paper, characterized by two key features. First, it is designed with controllable difficulty levels, requiring multi-level fine-grained reasoning across object categories, attributes, and multi-hop relationships. Second, it incorporates negative text and images generated through fine-grained editing and augmentation, explicitly testing a model's ability to reject scenarios where the target object is absent, an often overlooked yet critical challenge in existing datasets. In this extended work, we propose two new methods to tackle the challenges of fine-grained REC by combining the strengths of Specialist Models and MLLMs. The first method adaptively assigns simple cases to faster, lightweight models and reserves complex ones for powerful MLLMs, balancing accuracy and efficiency. The second method lets a specialist generate a set of possible object regions, and the MLLM selects the most plausible one using its reasoning ability. These collaborative strategies lead to significant improvements on our dataset and other challenging benchmarks. Our results show that combining specialized and general-purpose models offers a practical path toward solving complex real-world vision-language tasks. Our dataset and code are available at https://github.com/sleepyshep/FineCops-Ref.

Xinhao Huang, Jinke Yu, Wenhao Xu et al.

While Vision Language Models (VLMs) have shown promise in Design-to-Code generation, they suffer from a "holistic bottleneck-failing to reconcile high-level structural hierarchy with fine-grained visual details, often resulting in layout distortions or generic placeholders. To bridge this gap, we propose DOne, an end-to-end framework that decouples structure understanding from element rendering. DOne introduces (1) a learned layout segmentation module to decompose complex designs, avoiding the limitations of heuristic cropping; (2) a specialized hybrid element retriever to handle the extreme aspect ratios and densities of UI components; and (3) a schema-guided generation paradigm that bridges layout and code. To rigorously assess performance, we introduce HiFi2Code, a benchmark featuring significantly higher layout complexity than existing datasets. Extensive evaluations on the HiFi2Code demonstrate that DOne outperforms exiting methods in both high-level visual similarity (e.g., over 10% in GPT Score) and fine-grained element alignment. Human evaluations confirm a 3 times productivity gain with higher visual fidelity.

Bing Liu, Wenqiang Yv, Xuzheng Yang et al.

AI-driven geometric problem solving is a complex vision-language task that requires accurate diagram interpretation, mathematical reasoning, and robust cross-modal grounding. A foundational yet underexplored capability for this task is the ability to identify and interpret geometric elements based on natural language queries. To address this, we introduce the task of Referring Expression Comprehension (REC) for geometric problems, which evaluates whether models can localize points, shapes, and spatial relations in diagrams in response to textual prompts. We present GeoRef, a benchmark dataset constructed from existing geometric problem corpora, featuring diverse, high-quality annotations and queries. Due to the lack of annotated data for this task, we generate a large-scale synthetic training dataset using a structured geometric formal language, enabling broad coverage of geometric concepts and facilitating model adaptation. We explore two fine-tuning approaches: Supervised Fine-Tuning (SFT) and Group Relative Policy Optimization (GRPO). Our results show that GRPO significantly outperforms SFT by better aligning model behavior with task-specific rewards. Furthermore, we propose a verify-and-regenerate mechanism that detects incorrect predictions and re-infers answers using contextual reasoning history, further boosting accuracy. Notably, even state-of-the-art Multimodal Large Language Models (MLLMs) struggle with this task, underscoring the necessity of explicitly evaluating and strengthening geometric grounding as a prerequisite for robust geometric problem solving. Moreover, models trained on GeoRef demonstrate measurable improvements on downstream geometric reasoning tasks, highlighting the broader value of REC as a foundation for multimodal mathematical understanding.

Junzhuo Liu, Markus Eckstein, Zhixiang Wang et al.

Spatial transcriptomics is a technology that captures gene expression levels at different spatial locations, widely used in tumor microenvironment analysis and molecular profiling of histopathology, providing valuable insights into resolving gene expression and clinical diagnosis of cancer. Due to the high cost of data acquisition, large-scale spatial transcriptomics data remain challenging to obtain. In this study, we develop a contrastive learning-based deep learning method to predict spatially resolved gene expression from whole-slide images. Evaluation across six different disease datasets demonstrates that, compared to existing studies, our method improves Pearson Correlation Coefficient (PCC) in the prediction of highly expressed genes, highly variable genes, and marker genes by 6.27%, 6.11%, and 11.26% respectively. Further analysis indicates that our method preserves gene-gene correlations and applies to datasets with limited samples. Additionally, our method exhibits potential in cancer tissue localization based on biomarker expression.