Stéphane Tremblay

Kai Ma, Pengcheng Xi, Karim Habashy et al.

Building AI models with trustworthiness is important especially in regulated areas such as healthcare. In tackling COVID-19, previous work uses convolutional neural networks as the backbone architecture, which has shown to be prone to over-caution and overconfidence in making decisions, rendering them less trustworthy -- a crucial flaw in the context of medical imaging. In this study, we propose a feature learning approach using Vision Transformers, which use an attention-based mechanism, and examine the representation learning capability of Transformers as a new backbone architecture for medical imaging. Through the task of classifying COVID-19 chest radiographs, we investigate into whether generalization capabilities benefit solely from Vision Transformers' architectural advances. Quantitative and qualitative evaluations are conducted on the trustworthiness of the models, through the use of "trust score" computation and a visual explainability technique. We conclude that the attention-based feature learning approach is promising in building trustworthy deep learning models for healthcare.

Kai Ma, Siyuan He, Pengcheng Xi et al.

Computer vision and machine learning are playing an increasingly important role in computer-assisted diagnosis; however, the application of deep learning to medical imaging has challenges in data availability and data imbalance, and it is especially important that models for medical imaging are built to be trustworthy. Therefore, we propose TRUDLMIA, a trustworthy deep learning framework for medical image analysis, which adopts a modular design, leverages self-supervised pre-training, and utilizes a novel surrogate loss function. Experimental evaluations indicate that models generated from the framework are both trustworthy and high-performing. It is anticipated that the framework will support researchers and clinicians in advancing the use of deep learning for dealing with public health crises including COVID-19.

Jessy Song, Ashkan Ebadi, Adrian Florea et al.

As the Coronavirus Disease 2019 (COVID-19) continues to impact many aspects of life and the global healthcare systems, the adoption of rapid and effective screening methods to prevent further spread of the virus and lessen the burden on healthcare providers is a necessity. As a cheap and widely accessible medical image modality, point-of-care ultrasound (POCUS) imaging allows radiologists to identify symptoms and assess severity through visual inspection of the chest ultrasound images. Combined with the recent advancements in computer science, applications of deep learning techniques in medical image analysis have shown promising results, demonstrating that artificial intelligence-based solutions can accelerate the diagnosis of COVID-19 and lower the burden on healthcare professionals. However, the lack of a huge amount of well-annotated data poses a challenge in building effective deep neural networks in the case of novel diseases and pandemics. Motivated by this, we present COVID-Net USPro, an explainable few-shot deep prototypical network, that monitors and detects COVID-19 positive cases with high precision and recall from minimal ultrasound images. COVID-Net USPro achieves 99.65% overall accuracy, 99.7% recall and 99.67% precision for COVID-19 positive cases when trained with only 5 shots. The analytic pipeline and results were verified by our contributing clinician with extensive experience in POCUS interpretation, ensuring that the network makes decisions based on actual patterns.

Ashkan Ebadi, Patrick Paul, Sofia Auer et al.

Automatic meter reading technology is not yet widespread. Gas, electricity, or water accumulation meters reading is mostly done manually on-site either by an operator or by the homeowner. In some countries, the operator takes a picture as reading proof to confirm the reading by checking offline with another operator and/or using it as evidence in case of conflicts or complaints. The whole process is time-consuming, expensive, and prone to errors. Automation can optimize and facilitate such labor-intensive and human error-prone processes. With the recent advances in the fields of artificial intelligence and computer vision, automatic meter reading systems are becoming more viable than ever. Motivated by the recent advances in the field of artificial intelligence and inspired by open-source open-access initiatives in the research community, we introduce a novel large benchmark dataset of real-life gas meter images, named the NRC-GAMMA dataset. The data were collected from an Itron 400A diaphragm gas meter on January 20, 2020, between 00:05 am and 11:59 pm. We employed a systematic approach to label the images, validate the labellings, and assure the quality of the annotations. The dataset contains 28,883 images of the entire gas meter along with 57,766 cropped images of the left and the right dial displays. We hope the NRC-GAMMA dataset helps the research community to design and implement accurate, innovative, intelligent, and reproducible automatic gas meter reading solutions.

Hilda Azimi, Jianxing Zhang, Pengcheng Xi et al.

Chest radiography is an effective screening tool for diagnosing pulmonary diseases. In computer-aided diagnosis, extracting the relevant region of interest, i.e., isolating the lung region of each radiography image, can be an essential step towards improved performance in diagnosing pulmonary disorders. Methods: In this work, we propose a deep learning approach to enhance abnormal chest x-ray (CXR) identification performance through segmentations. Our approach is designed in a cascaded manner and incorporates two modules: a deep neural network with criss-cross attention modules (XLSor) for localizing lung region in CXR images and a CXR classification model with a backbone of a self-supervised momentum contrast (MoCo) model pre-trained on large-scale CXR data sets. The proposed pipeline is evaluated on Shenzhen Hospital (SH) data set for the segmentation module, and COVIDx data set for both segmentation and classification modules. Novel statistical analysis is conducted in addition to regular evaluation metrics for the segmentation module. Furthermore, the results of the optimized approach are analyzed with gradient-weighted class activation mapping (Grad-CAM) to investigate the rationale behind the classification decisions and to interpret its choices. Results and Conclusion: Different data sets, methods, and scenarios for each module of the proposed pipeline are examined for designing an optimized approach, which has achieved an accuracy of 0.946 in distinguishing abnormal CXR images (i.e., Pneumonia and COVID-19) from normal ones. Numerical and visual validations suggest that applying automated segmentation as a pre-processing step for classification improves the generalization capability and the performance of the classification models.

Siyuan He, Pengcheng Xi, Ashkan Ebadi et al.

Effective representation learning is the key in improving model performance for medical image analysis. In training deep learning models, a compromise often must be made between performance and trust, both of which are essential for medical applications. Moreover, models optimized with cross-entropy loss tend to suffer from unwarranted overconfidence in the majority class and over-cautiousness in the minority class. In this work, we integrate a new surrogate loss with self-supervised learning for computer-aided screening of COVID-19 patients using radiography images. In addition, we adopt a new quantification score to measure a model's trustworthiness. Ablation study is conducted for both the performance and the trust on feature learning methods and loss functions. Comparisons show that leveraging the new surrogate loss on self-supervised models can produce label-efficient networks that are both high-performing and trustworthy.

Jianxing Zhang, Pengcheng Xi, Ashkan Ebadi et al.

The COVID-19 pandemic has had devastating effects on the well-being of the global population. The pandemic has been so prominent partly due to the high infection rate of the virus and its variants. In response, one of the most effective ways to stop infection is rapid diagnosis. The main-stream screening method, reverse transcription-polymerase chain reaction (RT-PCR), is time-consuming, laborious and in short supply. Chest radiography is an alternative screening method for the COVID-19 and computer-aided diagnosis (CAD) has proven to be a viable solution at low cost and with fast speed; however, one of the challenges in training the CAD models is the limited number of training data, especially at the onset of the pandemic. This becomes outstanding precisely when the quick and cheap type of diagnosis is critically needed for flattening the infection curve. To address this challenge, we propose the use of a low-shot learning approach named imprinted weights, taking advantage of the abundance of samples from known illnesses such as pneumonia to improve the detection performance on COVID-19.

Ashkan Ebadi, Pengcheng Xi, Alexander MacLean et al.

The COVID-19 pandemic continues to have a devastating effect on the health and well-being of the global population. Apart from the global health crises, the pandemic has also caused significant economic and financial difficulties and socio-physiological implications. Effective screening, triage, treatment planning, and prognostication of outcome plays a key role in controlling the pandemic. Recent studies have highlighted the role of point-of-care ultrasound imaging for COVID-19 screening and prognosis, particularly given that it is non-invasive, globally available, and easy-to-sanitize. Motivated by these attributes and the promise of artificial intelligence tools to aid clinicians, we introduce COVIDx-US, an open-access benchmark dataset of COVID-19 related ultrasound imaging data. The COVIDx-US dataset was curated from multiple sources and its current version, i.e., v1.2., consists of 150 lung ultrasound videos and 12,943 processed images of patients infected with COVID-19 infection, non-COVID-19 infection, other lung diseases/conditions, as well as normal control cases. The COVIDx-US is the largest open-access fully-curated dataset of its kind that has been systematically curated, processed, and validated specifically for the purpose of building and evaluating artificial intelligence algorithms and models.

Ashkan Ebadi, Pengcheng Xi, Stéphane Tremblay et al.

The outbreak of the novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been continuously affecting human lives and communities around the world in many ways, from cities under lockdown to new social experiences. Although in most cases COVID-19 results in mild illness, it has drawn global attention due to the extremely contagious nature of SARS-CoV-2. Governments and healthcare professionals, along with people and society as a whole, have taken any measures to break the chain of transition and flatten the epidemic curve. In this study, we used multiple data sources, i.e., PubMed and ArXiv, and built several machine learning models to characterize the landscape of current COVID-19 research by identifying the latent topics and analyzing the temporal evolution of the extracted research themes, publications similarity, and sentiments, within the time-frame of January- May 2020. Our findings confirm the types of research available in PubMed and ArXiv differ significantly, with the former exhibiting greater diversity in terms of COVID-19 related issues and the latter focusing more on intelligent systems/tools to predict/diagnose COVID-19. The special attention of the research community to the high-risk groups and people with complications was also confirmed.